Lab-grown mini-brains upgraded
Nature Cell Biology 19, 1010 (2017).
doi:10.1038/ncb3601
Authors: Lin Yang & Huck-Hui Ng
Three-dimensional brain organoid models have come into the spotlight as in vitro tools to recapitulate complex features of the brain. Four recent papers now leverage current technologies to generate new flavours of brain organoids and address aspects of brain biology which, to date, have been challenging to explore. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Lin Yang Huck-Hui Ng Tags: News and Views Source Type: research
DNA sensing in senescence
Nature Cell Biology 19, 1008 (2017).
doi:10.1038/ncb3603
Authors: Marina Ruiz de Galarreta & Amaia Lujambio
Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Marina Ruiz de Galarreta Amaia Lujambio Tags: News and Views Source Type: research
Enhancing brown fat with NFIA
Nature Cell Biology 19, 1006 (2017).
doi:10.1038/ncb3591
Authors: Suzanne N. Shapira & Patrick Seale
Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Authors: Suzanne N. Shapira Patrick Seale Tags: News and Views Source Type: research
Principles of refereeing
Nature Cell Biology 19, 1005 (2017).
doi:10.1038/ncb3606
Peer review is a key element of scientific publishing. Here we discuss what constitutes the ideal referee report. (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 31, 2017 Category: Cytology Tags: Editorial Source Type: research
Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress
Nature Cell Biology 19, 1202 (2017).
doi:10.1038/ncb3600
Authors: Shady Saad, Gea Cereghetti, Yuehan Feng, Paola Picotti, Matthias Peter & Reinhard Dechant (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Shady Saad Gea Cereghetti Yuehan Feng Paola Picotti Matthias Peter Reinhard Dechant Tags: Article Source Type: research
Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert  syndrome
Nature Cell Biology 19, 1178 (2017).
doi:10.1038/ncb3599
Authors: Xiaoyu Shi, Galo Garcia, Julie C. Van De Weghe, Ryan McGorty, Gregory J. Pazour, Dan Doherty, Bo Huang & Jeremy F. Reiter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Xiaoyu Shi Galo Garcia Julie C. Van De Weghe Ryan McGorty Gregory J. Pazour Dan Doherty Bo Huang Jeremy F. Reiter Tags: Article Source Type: research
Mitochondrial permeabilization engages NF- κ B-dependent anti-tumour activity under caspase  deficiency
Nature Cell Biology 19, 1116 (2017).
doi:10.1038/ncb3596
Authors: Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, Florian Bock, Catherine Cloix, Kai Cao, Alba Roca, Jonathan Lopez, Gabriel Ichim, Emma Proïcs, Camila Rubio-Patiño, Loic Fort, Nader Yatim, Emma Woodham, Susana Orozco, Lucia Taraborrelli, Nieves Peltzer, Daniele Lecis, Laura Machesky, Henning Walczak, Matthew L. Albert, Simon Milling, Andrew Oberst, Jean-Ehrland Ricci, Kevin M. Ryan, Karen Blyth & Stephen W. G. Tait (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Evangelos Giampazolias Barbara Zunino Sandeep Dhayade Florian Bock Catherine Cloix Kai Cao Alba Roca Jonathan Lopez Gabriel Ichim Emma Pro ï cs Camila Rubio-Pati ñ o Loic Fort Nader Yatim Emma Woodham Susana Orozco Lucia Taraborrelli Nieves Peltzer Dani Tags: Article Source Type: research
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors
Nature Cell Biology 19, 1037 (2017).
doi:10.1038/ncb3598
Authors: Maria Skamagki, Cristina Correia, Percy Yeung, Timour Baslan, Samuel Beck, Cheng Zhang, Christian A. Ross, Lam Dang, Zhong Liu, Simona Giunta, Tzu-Pei Chang, Joye Wang, Aparna Ananthanarayanan, Martina Bohndorf, Benedikt Bosbach, James Adjaye, Hironori Funabiki, Jonghwan Kim, Scott Lowe, James J. Collins, Chi-Wei Lu, Hu Li, Rui Zhao & Kitai Kim (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 28, 2017 Category: Cytology Authors: Maria Skamagki Cristina Correia Percy Yeung Timour Baslan Samuel Beck Cheng Zhang Christian  A. Ross Lam Dang Zhong Liu Simona Giunta Tzu-Pei Chang Joye Wang Aparna Ananthanarayanan Martina Bohndorf Benedikt Bosbach James Adjaye Hironori Funabiki Jonghw Tags: Article Source Type: research
A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression
Nature Cell Biology 19, 1105 (2017).
doi:10.1038/ncb3595
Authors: Simon Grelet, Laura A. Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy, Vamsi K. Gangaraju, J. Alan Diehl & Philip H. Howe (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Simon Grelet Laura A. Link Breege Howley Cl é mence Obellianne Viswanathan Palanisamy Vamsi K. Gangaraju J. Alan Diehl Philip H. Howe Tags: Article Source Type: research
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
Nature Cell Biology 19, 1093 (2017).
doi:10.1038/ncb3597
Authors: Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G. Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q. Du, David J. Adams & Brian J. P. Huntly (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Sarah J. Horton George Giotopoulos Haiyang Yun Shabana Vohra Olivia Sheppard Rachael Bashford-Rogers Mamunur Rashid Alexandra Clipson Wai-In Chan Daniel Sasca Loukia Yiangou Hikari Osaki Faisal Basheer Paolo Gallipoli Natalie Burrows Ay ş eg ü l Erdem A Tags: Article Source Type: research
SMC complexes differentially compact mitotic chromosomes according to genomic context
Nature Cell Biology 19, 1071 (2017).
doi:10.1038/ncb3594
Authors: Stephanie Andrea Schalbetter, Anton Goloborodko, Geoffrey Fudenberg, Jon-Matthew Belton, Catrina Miles, Miao Yu, Job Dekker, Leonid Mirny & Jonathan Baxter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Stephanie Andrea Schalbetter Anton Goloborodko Geoffrey Fudenberg Jon-Matthew Belton Catrina Miles Miao Yu Job Dekker Leonid Mirny Jonathan Baxter Tags: Article Source Type: research
An apical MRCK-driven morphogenetic pathway controls epithelial polarity
Nature Cell Biology 19, 1049 (2017).
doi:10.1038/ncb3592
Authors: Ceniz Zihni, Evi Vlassaks, Stephen Terry, Jeremy Carlton, Thomas King Chor Leung, Michael Olson, Franck Pichaud, Maria Susana Balda & Karl Matter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 21, 2017 Category: Cytology Authors: Ceniz Zihni Evi Vlassaks Stephen Terry Jeremy Carlton Thomas King Chor Leung Michael Olson Franck Pichaud Maria Susana Balda Karl Matter Tags: Article Source Type: research
NFIA co-localizes with PPAR γ and transcriptionally controls the brown fat gene program
Nature Cell Biology 19, 1081 (2017).
doi:10.1038/ncb3590
Authors: Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake, Gaku Nagano, Ryo Nakaki, Ken Suzuki, Hirofumi Kobayashi, Shogo Yamamoto, Wei Sun, Tomohisa Aoyama, Yusuke Hirota, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Andrew P. White, Yu-Hua Tseng, Aaron M. Cypess, Therese J. Larsen, Naja Z. Jespersen, Camilla Scheele, Shuichi Tsutsumi, Hiroyuki Aburatani, Toshimasa Yamauchi & Takashi Kadowaki (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2017 Category: Cytology Authors: Yuta Hiraike Hironori Waki Jing Yu Masahiro Nakamura Kana Miyake Gaku Nagano Ryo Nakaki Ken Suzuki Hirofumi Kobayashi Shogo Yamamoto Wei Sun Tomohisa Aoyama Yusuke Hirota Haruya Ohno Kenji Oki Masayasu Yoneda Andrew P. White Yu-Hua Tseng Aaron M. Cypess T Tags: Article Source Type: research
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
Nature Cell Biology 19, 1027 (2017).
doi:10.1038/ncb3593
Authors: John C. Schell, Dona R. Wisidagama, Claire Bensard, Helong Zhao, Peng Wei, Jason Tanner, Aimee Flores, Jeffrey Mohlman, Lise K. Sorensen, Christian S. Earl, Kristofor A. Olson, Ren Miao, T. Cameron Waller, Don Delker, Priyanka Kanth, Lei Jiang, Ralph J. DeBerardinis, Mary P. Bronner, Dean Y. Li, James E. Cox, Heather R. Christofk, William E. Lowry, Carl S. Thummel & Jared Rutter (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2017 Category: Cytology Authors: John C. Schell Dona R. Wisidagama Claire Bensard Helong Zhao Peng Wei Jason Tanner Aimee Flores Jeffrey Mohlman Lise K. Sorensen Christian S. Earl Kristofor A. Olson Ren Miao T. Cameron Waller Don Delker Priyanka Kanth Lei Jiang Ralph J. DeBerardinis Mary Tags: Article Source Type: research
Lactate dehydrogenase activity drives hair follicle stem cell activation
Nature Cell Biology 19, 1017 (2017).
doi:10.1038/ncb3575
Authors: Aimee Flores, John Schell, Abigail S. Krall, David Jelinek, Matilde Miranda, Melina Grigorian, Daniel Braas, Andrew C. White, Jessica L. Zhou, Nicholas A. Graham, Thomas Graeber, Pankaj Seth, Denis Evseenko, Hilary A. Coller, Jared Rutter, Heather R. Christofk & William E. Lowry (Source: Nature Cell Biology)
Source: Nature Cell Biology - August 14, 2017 Category: Cytology Authors: Aimee Flores John Schell Abigail S. Krall David Jelinek Matilde Miranda Melina Grigorian Daniel Braas Andrew C. White Jessica L. Zhou Nicholas A. Graham Thomas Graeber Pankaj Seth Denis Evseenko Hilary A. Coller Jared Rutter Heather R. Christofk William  Tags: Article Source Type: research
