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Comparing DNA Damage Induced by Mobile Telephony and Other Types of Man-Made Electromagnetic Fields
Publication date: Available online 11 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Dimitris J. PanagopoulosAbstractThe number of studies showing adverse effects on living organisms induced by different types of man-made Electromagnetic Fields (EMFs) has increased tremendously. Hundreds of peer reviewed published studies show a variety of effects, the most important being DNA damage which is linked to cancer, neurodegenerative diseases, reproductive declines etc. Those studies that are far more effective in showing effects employ real-life Mobile Telephony (MT) exposures emitted by commercially...
Source: Mutation Research Reviews in Mutation Research - March 12, 2019 Category: Genetics & Stem Cells Source Type: research

Biological monitoring of workers exposed to carcinogens using the buccal micronucleus approach: A systematic review and meta-analysis
Publication date: Available online 8 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Nancy B. Hopf, Claudia Bolognesi, Brigitta Danuser, Pascal WildAbstractA biomarker-based approach using micronucleus (MN) (extranuclear DNA-containing bodies) frequencies in buccal cells has been proposed to monitor workers exposed to aero-digestive carcinogens for early detection of occupational cancer. To assess this non-invasive MN approach, we sought to understand: A) What is the extent of MN frequency increase in occupationally exposed over non-exposed populations across studies published in the scientific l...
Source: Mutation Research Reviews in Mutation Research - March 8, 2019 Category: Genetics & Stem Cells Source Type: research

Genetic predisposition for malignant mesothelioma: a concise review
Publication date: Available online 6 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Marta Betti, Anna Aspesi, Marika Sculco, Giuseppe Matullo, Corrado Magnani, Irma DianzaniAbstractMalignant mesothelioma (MM) is an aggressive cancer associated with asbestos exposure. Studies of familial malignant pleural mesothelioma (MPM) have suggested the existence of a genetic predisposition. Information on the role of genetic risk factors in the development of MM has been growing in the last years, and both low- and high-risk genetic factors have been identified, but genetic factors alone (without any expos...
Source: Mutation Research Reviews in Mutation Research - March 7, 2019 Category: Genetics & Stem Cells Source Type: research

DNA repair as a human biomonitoring tool; comet assay approaches
In conclusion, although comet assay based approaches to measure BER/NER phenotypes are feasible and promising; more work is needed to further optimize their application in human biomonitoring and intervention studies. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - March 7, 2019 Category: Genetics & Stem Cells Source Type: research

Free-access copy-number variant detection tools for targeted next-generation sequencing data
Publication date: Available online 23 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Iria Roca, Lorena González-Castro, Helena Fernández, Mª Luz Couce, Ana Fernández-MarmiesseAbstractCopy number variants (CNVs) are intermediate-scale structural variants containing copy number changes involving DNA fragments of between 1 kb and 5 Mb. Although known to account for a significant proportion of the genetic burden in human disease, the role of CNVs (especially small CNVs) is often underestimated, as they are undetectable by traditional Sanger sequencing. Since the development of next-generati...
Source: Mutation Research Reviews in Mutation Research - February 25, 2019 Category: Genetics & Stem Cells Source Type: research

The comet assay in animal models: From bugs to whales – (Part 1 Invertebrates)
Publication date: Available online 16 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Goran Gajski, Bojana Žegura, Carina Ladeira, Bertrand Pourrut, Cristian Del Bo’, Matjaž Novak, Monika Sramkova, Mirta Milić, Kristine Bjerve Gutzkow, Solange Costa, Maria Dusinska, Gunnar Brunborg, Andrew CollinsAbstractThe comet assay, also called single cell gel electrophoresis, is a sensitive, rapid and low-cost technique for quantifying and analysing DNA damage and repair at the level of individual cells. The assay itself can be applied on virtually any cell type derived from different organs and tis...
Source: Mutation Research Reviews in Mutation Research - February 17, 2019 Category: Genetics & Stem Cells Source Type: research

Cataractogenic load – a concept to study the contribution of ionizing radiation to accelerated aging in the eye lens
Publication date: Available online 15 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Alice Uwineza, Alexia A. Kalligeraki, Nobuyuki Hamada, Miguel Jarrin, Roy A. QuinlanAbstractIonizing radiation (IR) damages DNA and other macromolecules, including proteins and lipids. Most cell types can repair DNA damage and cycle continuously their macromolecules as a mechanism to remove defective proteins and lipids. In those cells that lack nuclei and other organelles, such as lens fiber cells and mammalian erythrocytes, IR-induced damage to macromolecules is retained because they cannot be easily replen...
Source: Mutation Research Reviews in Mutation Research - February 16, 2019 Category: Genetics & Stem Cells Source Type: research

Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting Evidence
Publication date: Available online 10 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Luoping Zhang, Iemaan Rana, Emanuela Taioli, Rachel M. Shaffer, Lianne SheppardAbstractGlyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of glyphosate’s carcinogenic potential by various regional, national and international agencies have engendered controversy. We independently investigate whether there is an association between high cumulative exposures to glyphosate and increased risk of non-Hodgkin lymphoma (NHL) in humans and conduct a new meta-analysi...
Source: Mutation Research Reviews in Mutation Research - February 11, 2019 Category: Genetics & Stem Cells Source Type: research

Micronucleus Assay for Monitoring the Genotoxic Effects of Arsenic: A Systematic Review
Publication date: Available online 6 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Ju Dong, Jun-qin Wang, Qin Qian, Guo-chun Li, Dong-qin Yang, Chao JiangAbstractThe micronucleus (MN) assay has been used to determine the potential genotoxic effects and cancer risk in human populations exposed to arsenic. Some of these studies have found an increase in MN frequencies among exposed individuals, but different results have also been found by others. Thus, the main purpose of this study is to investigate whether MN can be used as an effective biomarker for the arsenic exposure, as well as which k...
Source: Mutation Research Reviews in Mutation Research - February 7, 2019 Category: Genetics & Stem Cells Source Type: research

Associations between single nucleotide polymorphisms and erythrocyte parameters in humans: a systematic literature review
Publication date: Available online 2 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Tiffany C. Timmer, Michael W.T. Tanck, Elisabeth M.J. Huis in’ t Veld, Barbera Veldhuisen, Joost G. Daams, Wim L.A.M. de Kort, C. Ellen van der Schoot, Katja van den HurkAbstractIndividual variations in erythrocyte parameters are influenced by factors like sex, age, diet and season. Genetic variations have also been associated with erythrocyte parameters. The aim of this systematic review is to provide an overview of associations between single nucleotide polymorphisms (SNPs) and erythrocyte parameters in hu...
Source: Mutation Research Reviews in Mutation Research - February 3, 2019 Category: Genetics & Stem Cells Source Type: research

A systematic review and quantitative assessment of methylation biomarkers in fecal DNA and colorectal cancer and its precursor, colorectal adenoma
Publication date: Available online 16 January 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Rongbin Liu, Xuan Su, Yakang Long, Dalei Zhou, Xiao Zhang, Zulu Ye, Jiangjun Ma, Tao Tang, Fang Wang, Caiyun HeAbstractColorectal cancer (CRC) arises from accumulated genetic and epigenetic alterations, which provide the possibility to identify tumor-specific biomarkers by analyzing fecal DNA. Methylation status in human genes from tumor tissue is highlighted as promising biomarker in the early detection of CRC. A number of studies have documented altered methylation levels in DNA extracted from stool samples,...
Source: Mutation Research Reviews in Mutation Research - January 17, 2019 Category: Genetics & Stem Cells Source Type: research

Glaucomagenesis following ionizing radiation exposure
Publication date: Available online 8 January 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Nobuyuki Hamada, Tamara V. Azizova, Mark P. LittleAbstractGlaucoma is a group of optic neuropathies causing optic nerve damage and visual field defects, and is one of the leading causes of blindness. Nearly a century has passed since the first report of glaucoma manifested following ionizing radiation therapy of cancers. Nevertheless, associations between glaucoma and radiation exposures, a dose response relationship, and the mechanistic underpinnings remain incompletely understood. Here we review the current k...
Source: Mutation Research Reviews in Mutation Research - January 9, 2019 Category: Genetics & Stem Cells Source Type: research

Risks of aneuploidy induction from chemical exposure: twenty years of collaborative research in Europe from basic science to regulatory implications
Publication date: Available online 27 December 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): M. Kirsch-Volders, F. Pacchierotti, E.M. Parry, A. Russo, U. Eichenlaub-Ritter, I.-D. AdlerAbstractAlthough Theodor Boveri linked abnormal chromosome numbers and disease more than a century ago, an in-depth understanding of the impact of mitotic and meiotic chromosome segregation errors on cell proliferation and diseases is still lacking. This review reflects on the efforts and results of a large European research network that, from the 1980's until 2004, focused on protection against aneuploidy-inducing fact...
Source: Mutation Research Reviews in Mutation Research - December 27, 2018 Category: Genetics & Stem Cells Source Type: research

The Molecular Origins and Pathophysiological Consequences of Micronuclei: New Insights into an Age-old Problem
Publication date: Available online 23 November 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Xihan Guo, Juan Ni, Ziqing Liang, Jinglun Xue, Michael F. Fenech, Xu WangABSTRACTMicronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can exist in cells with numerical and/or structural chromosomal aberrations in apparently normal tissues and more so in tumors in humans. While MN have been observed for over 100 years, they were merely and constantly considered as passive indicators of chromosome instability (CIN) for a long time. Relatively little is known about the molecular or...
Source: Mutation Research Reviews in Mutation Research - November 24, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October–December 2018Source: Mutation Research/Reviews in Mutation Research, Volume 778Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 18, 2018 Category: Genetics & Stem Cells Source Type: research