Induction of DNA damage as a consequence of occupational exposure to crystalline silica: a review and meta-analysis
Publication date: Available online 21 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Georg Wultsch, Tahereh Setayesh, Michael Kundi, Michael Kment, Armen Nersesyan, Michael Fenech, Siegfried Knasmüller (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 22, 2020 Category: Genetics & Stem Cells Source Type: research

Potential application of γ-H2AX as a biodosimetry tool for radiation triage
Publication date: Available online 22 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Venkateswarlu Raavi, Venkatachalam Perumal, Solomon F.D. Paul (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 22, 2020 Category: Genetics & Stem Cells Source Type: research

Micronuclei, reproduction and child health
Publication date: Available online 18 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Lisbeth E. Knudsen, Micheline Kirsch-Volders (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 18, 2020 Category: Genetics & Stem Cells Source Type: research

Micronucleus assay for predicting coronary artery disease: a systematic review and meta-analysis
Publication date: Available online 16 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Maria Grazia Andreassi, Andrea Borghini, Cecilia Vecoli (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 17, 2020 Category: Genetics & Stem Cells Source Type: research

Function and molecular mechanisms of APE2 in genome and epigenome integrity
Publication date: Available online 16 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Yunfeng Lin, Anne McMahon, Garrett Driscoll, Sharon Bullock, Jianjun Zhao, Shan Yan (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 17, 2020 Category: Genetics & Stem Cells Source Type: research

Mutagenicity monitoring in humans: Global versus specific origin of mutations
Publication date: October–December 2020Source: Mutation Research/Reviews in Mutation Research, Volume 786Author(s): Richard J. Albertini, Debra A. Kaden (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 10, 2020 Category: Genetics & Stem Cells Source Type: research

Genomic Instability in Chronic Obstructive Pulmonary Disease and Lung cancer: A Systematic Review and Meta-analysis of studies using the Micronucleus Assay
Publication date: Available online 10 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Maxim Asanov, Stefano Bonassi, Stefania Proietti, Varvara I. Minina, Carlo Tomino, Randa El-Zein (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 10, 2020 Category: Genetics & Stem Cells Source Type: research

Association of the Sp1 binding site and -1997 promoter variations in COL1A1 with osteoporosis risk: The application of meta-analysis and bioinformatics approaches offers a new perspective for future research
Publication date: October–December 2020Source: Mutation Research/Reviews in Mutation Research, Volume 786Author(s): Shirin Moradifard, Moslem Hoseinbeyki, Mohammad Mehdi Emam, Fatemehsadat Parchiniparchin, Mina Ebrahimi-Rad (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 10, 2020 Category: Genetics & Stem Cells Source Type: research

Chromosomal damage measured by the cytokinesis block micronucleus cytome assay in diabetes and obesity - A systematic review and meta-analysis
Publication date: Available online 2 November 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Bernhard Franzke, Lukas Schwingshackl, Karl-Heinz Wagner (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 3, 2020 Category: Genetics & Stem Cells Source Type: research

Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans
Publication date: Available online 28 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Michael Fenech, Siegfried Knasmueller, Claudia Bolognesi, Nina Holland, Stefano Bonassi, Micheline Kirsch-Volders (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 29, 2020 Category: Genetics & Stem Cells Source Type: research

Mutagenicity Monitoring in Humans:Global versus Specific Origin of Mutations
Publication date: Available online 18 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Richard J. Albertini, Debra A. Kaden (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 19, 2020 Category: Genetics & Stem Cells Source Type: research

Mutagenic potential of medicinal plants evaluated by the Ames Salmonella/microsome assay: A systematic review
Publication date: Available online 18 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Fabiana Gomes da Silva Dantas, Pamella Fukuda de Castilho, Adriana Araújo de Almeida-Apolonio, Renata Pires de Araújo, Kelly Mari Pires de Oliveira (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 19, 2020 Category: Genetics & Stem Cells Source Type: research

Micronucleus frequency in chronic kidney disease patients: a review
Publication date: Available online 17 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Helga Stopper, Ezgi Eyluel Bankoglu, Ricard Marcos, Susana Pastor (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 19, 2020 Category: Genetics & Stem Cells Source Type: research

Association of the Sp1 binding site and -1997 promoter variations in COLIA1 with osteoporosis risk: The application of meta-analysis and bioinformatics approaches offers a new perspective for future research
Publication date: Available online 13 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Shirin Moradifard, Moslem Hoseinbeyki, Mohammad Mehdi Emam, Fatemehsadat Parchiniparchin, Mina Ebrahimi-Rad (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 14, 2020 Category: Genetics & Stem Cells Source Type: research

Memories of a friend and colleague – Takashi Sugimura
Publication date: Available online 10 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Roderick H. Dashwood (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 11, 2020 Category: Genetics & Stem Cells Source Type: research

Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1)
Publication date: Available online 9 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Klaudia Kulczynska-Figurny, James J. Bieker, Miroslawa Siatecka (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - October 10, 2020 Category: Genetics & Stem Cells Source Type: research

Micronuclei, inflammation and auto-immune disease
Publication date: Available online 15 September 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Micheline Kirsch-Volders, Claudia Bolognesi, Marcello Ceppi, Marco Bruzzone, Michael Fenech (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - September 16, 2020 Category: Genetics & Stem Cells Source Type: research

Genetic aspects of the oxidative phosphorylation dysfunction in dilated cardiomyopathy
Publication date: Available online 25 August 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): M.Pilar Bayona-Bafaluy, Eldris Iglesias, Ester López-Gallardo, Sonia Emperador, David Pacheu-Grau, Lorenzo Labarta, Julio Montoya, Eduardo Ruiz-Pesini (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 25, 2020 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: July–September 2020Source: Mutation Research/Reviews in Mutation Research, Volume 785Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 15, 2020 Category: Genetics & Stem Cells Source Type: research

Common aspects between glaucoma and brain neurodegeneration
Publication date: Available online 13 August 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Sergio Claudio Saccà, Filippo Paluan, Stefano Gandolfi, Gianluca Manni, Carlo Alberto Cutolo, Alberto Izzotti (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 15, 2020 Category: Genetics & Stem Cells Source Type: research

Gene polymorphisms in calcium-calmodulin pathway: focus on cardiovascular disease
Publication date: Available online 31 July 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Sofia Beghi, Francesca Cavaliere, Annamaria Buschini (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 1, 2020 Category: Genetics & Stem Cells Source Type: research

Impact of genetic factors on platinum-induced gastrointestinal toxicity
Publication date: Available online 16 July 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Yi Zheng, Zheng Deng, Mimi Tang, Di Xiao, Pei Cai (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - July 18, 2020 Category: Genetics & Stem Cells Source Type: research

Oncogenic BRAF, Endoplasmic reticulum stress, and Autophagy: Crosstalk and Therapeutic Targets in Cutaneous Melanoma
Publication date: Available online 7 July 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Rather A Rafiq, Madhulika Bhagat, Shashank K Singh (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - July 8, 2020 Category: Genetics & Stem Cells Source Type: research

Effect of genetic polymorphisms on therapeutic response in multiple sclerosis relapsing-remitting patients treated with interferon-beta
Publication date: Available online 7 July 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Laura Martínez-Aguilar, Cristina Pérez-Ramírez, María del Mar Maldonado-Montoro, María Isabel Carrasco-Campos, Cristina Membrive-Jiménez, Fernando Martínez-Martínez, Carlos García-Collado, Miguel Ángel Calleja-Hernández, María Carmen Ramírez-Tortosa, Alberto Jiménez-Morales (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - July 8, 2020 Category: Genetics & Stem Cells Source Type: research

Mechanisms of oocyte aneuploidy associated with advanced maternal age
Publication date: Available online 4 July 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Myy Mikwar, Amanda J. MacFarlane, Francesco Marchetti (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - July 4, 2020 Category: Genetics & Stem Cells Source Type: research

Reprint of: Deciphering and simulating models of radiation genotoxicity with CRISPR/Cas9 systems
Publication date: July–September 2020Source: Mutation Research/Reviews in Mutation Research, Volume 785Author(s): Dusan Vukmirovic, Colin Seymour, Carmel Mothersill (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - June 28, 2020 Category: Genetics & Stem Cells Source Type: research

A comprehensive analysis of AHRR gene as a candidate for cleft lip with or without cleft palate
Publication date: Available online 5 June 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Bianca Domit Werner Linnenkamp, Salmo Raskin, Selene Elifio Esposito, Roberto Hirochi Herai (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - June 6, 2020 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: April–June 2020Source: Mutation Research/Reviews in Mutation Research, Volume 784Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - May 18, 2020 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: January–March 2020Source: Mutation Research/Reviews in Mutation Research, Volume 783Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - May 6, 2020 Category: Genetics & Stem Cells Source Type: research

The molecular biomarkers of vascular aging and atherosclerosis: telomere length and mitochondrial DNA4977 common deletion
Publication date: Available online 25 April 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Cecilia Vecoli, Andrea Borghini, Maria Grazia Andreassi (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - April 25, 2020 Category: Genetics & Stem Cells Source Type: research

Life style factors, tumor cell plasticity and cancer stem cells
Publication date: Available online 22 April 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Ilaria Chiodi, Chiara Mondello (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - April 23, 2020 Category: Genetics & Stem Cells Source Type: research

Rogue versus chromothriptic cell as biomarker of cancer
Publication date: April–June 2020Source: Mutation Research/Reviews in Mutation Research, Volume 784Author(s): Aleksandra Fucic, Vladimir Druzhinin, Anna Aghajanyan, Predrag Slijepcevic, Marina Bakanova, Elizaveta Baranova, Varvara Minina, Tatiana Golovina, Kirill Kourdakov, Anna Timofeeva, Victor Titov (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - March 18, 2020 Category: Genetics & Stem Cells Source Type: research

The dark side of RNA:DNA hybrids
Publication date: Available online 29 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Alessandra Brambati, Luca Zardoni, Eleonora Nardini, Achille Pellicioli, Giordano Liberi (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 29, 2020 Category: Genetics & Stem Cells Source Type: research

Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: transcriptional regulation and DNA damage response
Publication date: Available online 27 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Elzbieta Poręba, Julia Durzyńska (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 28, 2020 Category: Genetics & Stem Cells Source Type: research

Rogue versus chromothriptic cells as biomarkers cancer
Publication date: Available online 25 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Aleksandra Fucic, Vladimir Druzhinin, Anna Aghajanyan, Predrag Slijepcevic, Marina Bakanova, Elizaveta Baranova, Varvara Minina, Tatiana Golovina, Kirill Kourdakov, Anna Timofeeva, Victor Titov (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 26, 2020 Category: Genetics & Stem Cells Source Type: research

Deciphering and Simulating Models of Radiation Genotoxicity with CRISPR/Cas9 Systems
Publication date: Available online 3 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Dusan Vukmirovic, Colin Seymour, Carmel MothersillAbstractThis short review explores the utility and applications of CRISPR/Cas9 systems in experimentally simulating genotoxic effects of Ionizing Radiation (IR) to determine the contribution of DNA targets and ‘Complex Double-Stranded Breaks (complex DSBs)’ to the response. To elucidate this objective, this review considers applications of CRISPR/Cas9 to target nuclear DNA to recognize the respective ‘nucleocentric’ response as well as m...
Source: Mutation Research Reviews in Mutation Research - February 4, 2020 Category: Genetics & Stem Cells Source Type: research

Passing of the pen: Editorship of Mutation Research – Reviews in Mutation Research
Publication date: Available online 13 January 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Barbara L. Parsons, Catherine B. Klein (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Genotoxicity assessment of carbon-based nanomaterials; Have their unique physicochemical properties made them double-edged swords?
Publication date: Available online 11 January 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Hadi Samadian, Mohammad Saeid Salami, Mehdi Jaymand, Asaas Azarnezhad, Masoud Najafi, Hamed Barabadi, Amirhossein AhmadiAbstractCarbon-based nanomaterials (CNMs) have attracted a great deal of attention because of their outstanding combinations of physicochemical properties. The unique physicochemical properties of CNMs have made them promising nanomaterials (NMs) for a large number of applications. However, these size-dependent properties serve as a double-edged sword, which makes them fascinating materials w...
Source: Mutation Research Reviews in Mutation Research - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage
Publication date: Available online 26 December 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Roberto Scarpato, Serena Testi, Valentina Colosimo, Carlos Garcia Crespo, Consuelo Micheli, Alessia Azzarà, Maria Giulia Tozzi, Paolo GhirriAbstractIncreasing evidence suggests that early-life events can predispose the newborn to a variety of health issues in later life. In adverse pre- and perinatal conditions, oxidative stress appears to play an important role in the development of future pathological outcomes. From a molecular point of view, oxidative stress can result in genome damage and changes i...
Source: Mutation Research Reviews in Mutation Research - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October–December 2019Source: Mutation Research/Reviews in Mutation Research, Volume 782Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - December 17, 2019 Category: Genetics & Stem Cells Source Type: research

Application of the comet assay in human biomonitoring: an hCOMET perspective
Publication date: Available online 9 November 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Amaya Azqueta, Carina Ladeira, Lisa Giovannelli, Elisa Boutet-Robinet, Stefano Bonassi, Monica Neri, Goran Gajski, Susan Duthie, Cristian Del Bo’, Patrizia Riso, Gudrun Koppen, Nursen Basaran, Andrew Collins, Peter MøllerAbstractThe comet assay is a well-accepted biomonitoring tool to examine the effect of dietary, lifestyle, environmental and occupational exposure on levels of DNA damage in human cells. With such a wide range of determinants for DNA damage levels, it becomes challenging to deal w...
Source: Mutation Research Reviews in Mutation Research - November 10, 2019 Category: Genetics & Stem Cells Source Type: research

Retrospective biodosimetry techniques: Focus on cytogenetics assays for individuals exposed to ionizing radiation
Publication date: Available online 8 November 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): C. Herate, L. SabatierAbstractIn the absence of physical data, biodosimetry tools are required for fast dose and risk assessment in the event of radiological or nuclear mass accidents or attacks to triage exposed humans and take immediate medical countermeasures. Biodosimetry tools have mostly been developed for retrospective dose assessment and the follow-up of victims of irradiation. Among them, cytogenetics analyses, to reveal chromosome damage, are the most developed and allow the determination of doses fr...
Source: Mutation Research Reviews in Mutation Research - November 9, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: July–September 2019Source: Mutation Research/Reviews in Mutation Research, Volume 781Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 14, 2019 Category: Genetics & Stem Cells Source Type: research

The characteristics and biological significance of NPC2: Mutation and disease
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Xu Yanan, Qian Zhang, Liang Tan, Xubiao Xie, Yong ZhaoAbstractNiemann–Pick C disease (NPC) is a rare autosomal recessive disorder characterized by severe neurodegeneration of central nervous system. Linkage studies in multiplex NPC families and genetic complementation research revealed two disease genes, NPC1 and NPC2, both of which are important transporters for cholesterol trafficking. NPC2 executes cholesterol-transport function through protein-protein interaction with NPC1 as well as through protein-memb...
Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research

Roles of microRNAs and prospective view of competing endogenous RNAs in mycotoxicosis
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Yuxiao Liao, Zhao Peng, Liangkai Chen, Liegang Liu, Qinghua Wu, Wei YangAbstractMycotoxins, produced by fungi, are secondary metabolites causing adverse, toxic and pathological effects on human and animals. Studies about the association between mycotoxins and microRNAs (miRNAs) were developed since miRNAs have been demonstrated to play a critical role in many developmental processes for regulating messenger RNA (mRNA). As published studies showed, dozens of miRNAs were influenced by mycotoxins, indicating that miR...
Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research

XPC beyond nucleotide excision repair and skin cancers
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Abir Zebian, Abdullah Shaito, Frédéric Mazurier, Hamid Reza Rezvani, Kazem ZibaraAbstractXeroderma pigmentosum group C (XPC) has been known as a DNA damage recognition factor of bulky adducts and as an initiator of global genome nucleotide excision repair (GG-NER). XP-C patients have been shown to have a predisposition to develop skin and certain internal cancers. Recent studies have shown that XPC presents several functional and molecular interactions with fundamental players in several other DNA re...
Source: Mutation Research Reviews in Mutation Research - July 8, 2019 Category: Genetics & Stem Cells Source Type: research

Trapping of dna radicals with the nitrone spin trap 5,5-dimethyl-1-pyrroline n-oxide and genotoxic damage: recent advances using immuno-spin trapping technology
Publication date: Available online 5 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Sandra E. Gomez-Mejiba, Dario C. RamirezAbstractImmuno-spin trapping detection of DNA radicals with the nitrone spin trap 5,5-dimethyl-1-pyrrloine N-oxide (DMPO) has made important contributions towards the understanding of DNA radicalization and genotoxicity at sites of inflammation. At sites of inflammation, one-electron oxidants and chloramines decay induce oxidation of genomic DNA, genotoxicity and cell transformation. Radicalization of DNA can result in either single- or double-strand breaks, or end-oxidation...
Source: Mutation Research Reviews in Mutation Research - July 6, 2019 Category: Genetics & Stem Cells Source Type: research

Emerging confluences of epigenetics and DNA repair in cancer and disease
Publication date: Available online 13 June 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Catherine B. Klein (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - June 13, 2019 Category: Genetics & Stem Cells Source Type: research

Tobacco carcinogens and the methionine metabolism in human bladder cancer
Publication date: Available online 4 June 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): A. Wojtczyk-Miaskowska, B SchlichtholzAbstractCigarette smoking is a strong risk factor for bladder cancer. It has been shown that the duration of smoking is associated with a poor prognosis and a higher risk of recurrence. This is due to tobacco carcinogens forming adducts with DNA and proteins that participate in the DNA repair mechanisms. Additionally, polymorphisms of genes responsible for methyl group transfer in the methionine cycle and dosages of vitamins (from diet and supplements) can cause an increased r...
Source: Mutation Research Reviews in Mutation Research - June 6, 2019 Category: Genetics & Stem Cells Source Type: research

Twenty Years of Reflections in Mutation Research
Publication date: Available online 23 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): George R. HoffmannAbstractReflections is a component of Mutation Research Reviews devoted to historical and philosophical themes pertaining to the subject of mutation. Reflections was initiated in 1999 and has included a broad array of topics centered on mutation research, but overlapping other scientific fields and touching upon history, sociology, politics, philosophy and ethics. This commentary offers an editor's reflections on the 44 papers in the Reflections series, including the people who contributed to the...
Source: Mutation Research Reviews in Mutation Research - May 24, 2019 Category: Genetics & Stem Cells Source Type: research