Rogue versus chromothriptic cell as biomarker of cancer
Publication date: April–June 2020Source: Mutation Research/Reviews in Mutation Research, Volume 784Author(s): Aleksandra Fucic, Vladimir Druzhinin, Anna Aghajanyan, Predrag Slijepcevic, Marina Bakanova, Elizaveta Baranova, Varvara Minina, Tatiana Golovina, Kirill Kourdakov, Anna Timofeeva, Victor Titov (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - March 18, 2020 Category: Genetics & Stem Cells Source Type: research

The dark side of RNA:DNA hybrids
Publication date: Available online 29 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Alessandra Brambati, Luca Zardoni, Eleonora Nardini, Achille Pellicioli, Giordano Liberi (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 29, 2020 Category: Genetics & Stem Cells Source Type: research

Nuclear localization and actions of the insulin-like growth factor 1 (IGF-1) system components: transcriptional regulation and DNA damage response
Publication date: Available online 27 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Elzbieta Poręba, Julia Durzyńska (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 28, 2020 Category: Genetics & Stem Cells Source Type: research

Rogue versus chromothriptic cells as biomarkers cancer
Publication date: Available online 25 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Aleksandra Fucic, Vladimir Druzhinin, Anna Aghajanyan, Predrag Slijepcevic, Marina Bakanova, Elizaveta Baranova, Varvara Minina, Tatiana Golovina, Kirill Kourdakov, Anna Timofeeva, Victor Titov (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - February 26, 2020 Category: Genetics & Stem Cells Source Type: research

Deciphering and Simulating Models of Radiation Genotoxicity with CRISPR/Cas9 Systems
Publication date: Available online 3 February 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Dusan Vukmirovic, Colin Seymour, Carmel MothersillAbstractThis short review explores the utility and applications of CRISPR/Cas9 systems in experimentally simulating genotoxic effects of Ionizing Radiation (IR) to determine the contribution of DNA targets and ‘Complex Double-Stranded Breaks (complex DSBs)’ to the response. To elucidate this objective, this review considers applications of CRISPR/Cas9 to target nuclear DNA to recognize the respective ‘nucleocentric’ response as well as m...
Source: Mutation Research Reviews in Mutation Research - February 4, 2020 Category: Genetics & Stem Cells Source Type: research

Passing of the pen: Editorship of Mutation Research – Reviews in Mutation Research
Publication date: Available online 13 January 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Barbara L. Parsons, Catherine B. Klein (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Genotoxicity assessment of carbon-based nanomaterials; Have their unique physicochemical properties made them double-edged swords?
Publication date: Available online 11 January 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Hadi Samadian, Mohammad Saeid Salami, Mehdi Jaymand, Asaas Azarnezhad, Masoud Najafi, Hamed Barabadi, Amirhossein AhmadiAbstractCarbon-based nanomaterials (CNMs) have attracted a great deal of attention because of their outstanding combinations of physicochemical properties. The unique physicochemical properties of CNMs have made them promising nanomaterials (NMs) for a large number of applications. However, these size-dependent properties serve as a double-edged sword, which makes them fascinating materials w...
Source: Mutation Research Reviews in Mutation Research - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage
Publication date: Available online 26 December 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Roberto Scarpato, Serena Testi, Valentina Colosimo, Carlos Garcia Crespo, Consuelo Micheli, Alessia Azzarà, Maria Giulia Tozzi, Paolo GhirriAbstractIncreasing evidence suggests that early-life events can predispose the newborn to a variety of health issues in later life. In adverse pre- and perinatal conditions, oxidative stress appears to play an important role in the development of future pathological outcomes. From a molecular point of view, oxidative stress can result in genome damage and changes i...
Source: Mutation Research Reviews in Mutation Research - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October–December 2019Source: Mutation Research/Reviews in Mutation Research, Volume 782Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - December 17, 2019 Category: Genetics & Stem Cells Source Type: research

Application of the comet assay in human biomonitoring: an hCOMET perspective
Publication date: Available online 9 November 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Amaya Azqueta, Carina Ladeira, Lisa Giovannelli, Elisa Boutet-Robinet, Stefano Bonassi, Monica Neri, Goran Gajski, Susan Duthie, Cristian Del Bo’, Patrizia Riso, Gudrun Koppen, Nursen Basaran, Andrew Collins, Peter MøllerAbstractThe comet assay is a well-accepted biomonitoring tool to examine the effect of dietary, lifestyle, environmental and occupational exposure on levels of DNA damage in human cells. With such a wide range of determinants for DNA damage levels, it becomes challenging to deal w...
Source: Mutation Research Reviews in Mutation Research - November 10, 2019 Category: Genetics & Stem Cells Source Type: research

Retrospective biodosimetry techniques: Focus on cytogenetics assays for individuals exposed to ionizing radiation
Publication date: Available online 8 November 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): C. Herate, L. SabatierAbstractIn the absence of physical data, biodosimetry tools are required for fast dose and risk assessment in the event of radiological or nuclear mass accidents or attacks to triage exposed humans and take immediate medical countermeasures. Biodosimetry tools have mostly been developed for retrospective dose assessment and the follow-up of victims of irradiation. Among them, cytogenetics analyses, to reveal chromosome damage, are the most developed and allow the determination of doses fr...
Source: Mutation Research Reviews in Mutation Research - November 9, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: July–September 2019Source: Mutation Research/Reviews in Mutation Research, Volume 781Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 14, 2019 Category: Genetics & Stem Cells Source Type: research

The characteristics and biological significance of NPC2: Mutation and disease
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Xu Yanan, Qian Zhang, Liang Tan, Xubiao Xie, Yong ZhaoAbstractNiemann–Pick C disease (NPC) is a rare autosomal recessive disorder characterized by severe neurodegeneration of central nervous system. Linkage studies in multiplex NPC families and genetic complementation research revealed two disease genes, NPC1 and NPC2, both of which are important transporters for cholesterol trafficking. NPC2 executes cholesterol-transport function through protein-protein interaction with NPC1 as well as through protein-memb...
Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research

Roles of microRNAs and prospective view of competing endogenous RNAs in mycotoxicosis
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Yuxiao Liao, Zhao Peng, Liangkai Chen, Liegang Liu, Qinghua Wu, Wei YangAbstractMycotoxins, produced by fungi, are secondary metabolites causing adverse, toxic and pathological effects on human and animals. Studies about the association between mycotoxins and microRNAs (miRNAs) were developed since miRNAs have been demonstrated to play a critical role in many developmental processes for regulating messenger RNA (mRNA). As published studies showed, dozens of miRNAs were influenced by mycotoxins, indicating that miR...
Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research

XPC beyond nucleotide excision repair and skin cancers
Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Abir Zebian, Abdullah Shaito, Frédéric Mazurier, Hamid Reza Rezvani, Kazem ZibaraAbstractXeroderma pigmentosum group C (XPC) has been known as a DNA damage recognition factor of bulky adducts and as an initiator of global genome nucleotide excision repair (GG-NER). XP-C patients have been shown to have a predisposition to develop skin and certain internal cancers. Recent studies have shown that XPC presents several functional and molecular interactions with fundamental players in several other DNA re...
Source: Mutation Research Reviews in Mutation Research - July 9, 2019 Category: Genetics & Stem Cells Source Type: research

Trapping of dna radicals with the nitrone spin trap 5,5-dimethyl-1-pyrroline n-oxide and genotoxic damage: recent advances using immuno-spin trapping technology
Publication date: Available online 5 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Sandra E. Gomez-Mejiba, Dario C. RamirezAbstractImmuno-spin trapping detection of DNA radicals with the nitrone spin trap 5,5-dimethyl-1-pyrrloine N-oxide (DMPO) has made important contributions towards the understanding of DNA radicalization and genotoxicity at sites of inflammation. At sites of inflammation, one-electron oxidants and chloramines decay induce oxidation of genomic DNA, genotoxicity and cell transformation. Radicalization of DNA can result in either single- or double-strand breaks, or end-oxidation...
Source: Mutation Research Reviews in Mutation Research - July 6, 2019 Category: Genetics & Stem Cells Source Type: research

Emerging confluences of epigenetics and DNA repair in cancer and disease
Publication date: Available online 13 June 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Catherine B. Klein (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - June 13, 2019 Category: Genetics & Stem Cells Source Type: research

Tobacco carcinogens and the methionine metabolism in human bladder cancer
Publication date: Available online 4 June 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): A. Wojtczyk-Miaskowska, B SchlichtholzAbstractCigarette smoking is a strong risk factor for bladder cancer. It has been shown that the duration of smoking is associated with a poor prognosis and a higher risk of recurrence. This is due to tobacco carcinogens forming adducts with DNA and proteins that participate in the DNA repair mechanisms. Additionally, polymorphisms of genes responsible for methyl group transfer in the methionine cycle and dosages of vitamins (from diet and supplements) can cause an increased r...
Source: Mutation Research Reviews in Mutation Research - June 6, 2019 Category: Genetics & Stem Cells Source Type: research

Twenty Years of Reflections in Mutation Research
Publication date: Available online 23 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): George R. HoffmannAbstractReflections is a component of Mutation Research Reviews devoted to historical and philosophical themes pertaining to the subject of mutation. Reflections was initiated in 1999 and has included a broad array of topics centered on mutation research, but overlapping other scientific fields and touching upon history, sociology, politics, philosophy and ethics. This commentary offers an editor's reflections on the 44 papers in the Reflections series, including the people who contributed to the...
Source: Mutation Research Reviews in Mutation Research - May 24, 2019 Category: Genetics & Stem Cells Source Type: research

The role of miRNAs as biomarkers in prostate cancer
Publication date: Available online 22 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): J.M. Cozar, I. Robles-Fernandez, A. Rodriguez-Martinez, I. Puche-Sanz, F. Vazquez-Alonso, J.A. Lorente, L.J. Martinez-Gonzalez, M.J. Alvarez-CuberoAbstractThere is an urged need of non-invasive biomarkers for the implementation of precision medicine. These biomarkers are required to these days for improving prostate cancer (PCa) screening, treatment or stratification in current clinical strategies. There are several commercial kits (Oncotype DX genomic prostate score®, Prolaris®, among others) that use gen...
Source: Mutation Research Reviews in Mutation Research - May 24, 2019 Category: Genetics & Stem Cells Source Type: research

Diagnostic and prognostic impact of cell-free DNA in human cancers: systematic review
Publication date: Available online 11 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Klara Cervena, Pavel Vodicka, Veronika VymetalkovaAbstractThe development of minimally invasive and low-cost assay enabling early diagnosis, treatment response and prognosis in cancer patients may provide a promising alternative to tumor biopsy. Circulating cell-free DNA (cfDNA) is probably the most promising tool among all components of liquid biopsy. This review includes studies exploring cfDNA as the diagnostic, prognostic or predictive biomarker for all types of cancer. In this article, we systematically revie...
Source: Mutation Research Reviews in Mutation Research - May 13, 2019 Category: Genetics & Stem Cells Source Type: research

The significance of gene mutations across eight major cancer types
Publication date: Available online 4 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Prosenjit Paul, Arup Kumar Malakar, Supriyo ChakrabortyAbstractMutations occur spontaneously, which can be induced by either chemicals (e.g. benzene) or biological factors (e.g. virus). Not all mutations cause noticeable changes in cellular functions. However, mutation in key cellular genes leads to developmental disorders. It is one of the main ways in which proto-oncogenes can be changed into their oncogenic state. The progressive accumulation of multiple mutations throughout life leads to cancer. In the past few...
Source: Mutation Research Reviews in Mutation Research - May 5, 2019 Category: Genetics & Stem Cells Source Type: research

The role of bracken fern illudanes in bracken fern-induced toxicities
Publication date: Available online 4 May 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): P.J. O’Connor, M.E. Alonso-Amelot, S.A. Roberts, A.C. PoveyAbstractBracken fern is carcinogenic when fed to domestic and laboratory animals inducing bladder and ileal tumours and is currently classified as a possible human carcinogen by IARC. The carcinogenic illudane, ptaquiloside (PTQ) was isolated from bracken fern and is widely assumed to be the major bracken carcinogen. However, several other structurally similar illudanes are found in bracken fern, in some cases at higher levels than PTQ and so may cont...
Source: Mutation Research Reviews in Mutation Research - May 4, 2019 Category: Genetics & Stem Cells Source Type: research

DNA repair as a human biomonitoring tool: Comet assay approaches
In conclusion, although comet assay based approaches to measure BER/NER phenotypes are feasible and promising, more work is needed to further optimize their application in human biomonitoring and intervention studies. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - May 1, 2019 Category: Genetics & Stem Cells Source Type: research

Functional genomics applications and therapeutic implications in sarcopenia
Publication date: Available online 20 April 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-AmandAbstractIt is well known that the human genome contains around 100,000 genes coding for 30,000 proteins. Some proteins represent therapeutic targets for human diseases. RNA and protein expression profiling tools allow the study of the molecular basis of aging and drug discovery validation. Age-related physiological and disease-related muscle decline progressively throughout the life. Sarcopenia is defined as a loss of muscle mass and a decrease in...
Source: Mutation Research Reviews in Mutation Research - April 22, 2019 Category: Genetics & Stem Cells Source Type: research

The comet assay in animal models: From bugs to whales – (Part 2 Vertebrates)
Publication date: Available online 20 April 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Goran Gajski, Bojana Žegura, Carina Ladeira, Matjaž Novak, Monika Sramkova, Bertrand Pourrut, Cristian Del Bo’, Mirta Milić, Kristine Bjerve Gutzkow, Solange Costa, Maria Dusinska, Gunnar Brunborg, Andrew CollinsAbstractThe comet assay has become one of the methods of choice for the evaluation and measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for the evaluation of DNA damage and repair at the level of individual cells. The comet assay can be applied to virtually ...
Source: Mutation Research Reviews in Mutation Research - April 20, 2019 Category: Genetics & Stem Cells Source Type: research

Impact of single nucleotide polymorphisms on the efficacy and toxicity of egfr tyrosine kinase inhibitors in advanced non-small cell lung cancer patients
Publication date: Available online 9 April 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Miguel Ángel Molina, José Cabeza Barrera, María José Faus-DáderABSTRACTEGFR tyrosine kinase inhibitors (EGFR-TKIs) are the treatment of choice for advanced-stage (IIIB-IV) NSCLC patients with mutations in EGFR. However, EGFR-TKIs clinical outcomes vary from person to person and these inter-individual differences may be due to genetic factors such as single nucleotide polymorphisms (SNPs). SNPs in genes involved i...
Source: Mutation Research Reviews in Mutation Research - April 10, 2019 Category: Genetics & Stem Cells Source Type: research

The worldwide mutational landscape of Berardinelli-Seip congenital lipodystrophy
Publication date: Available online 23 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Aquiles Sales Craveiro Sarmento, Leonardo Capistrano Ferreira, Josivan Gomes de Lima, Lázaro Batista de Azevedo Medeiros, Patrícia Tainá Barbosa Cunha, Lucymara Fassarella Agnez-Lima, Marcela Abbott Galvão Ururahy, Julliane Tamara Araújo de Melo CamposAbstractBerardinelli-Seip congenital lipodystrophy (BSCL) is a rare disease characterized by the near total absence of body fat at birth. BSCL etiology involves genetic variations in four different genes: AGPAT2, BSCL2, CAV1, and ...
Source: Mutation Research Reviews in Mutation Research - March 24, 2019 Category: Genetics & Stem Cells Source Type: research

Micronucleus assay for monitoring the genotoxic effects of arsenic in human populations: A systematic review of the literature and meta-analysis
Publication date: April–June 2019Source: Mutation Research/Reviews in Mutation Research, Volume 780Author(s): Ju Dong, Jun-qin Wang, Qin Qian, Guo-chun Li, Dong-qin Yang, Chao JiangAbstractThe micronucleus (MN) assay has been used to determine the potential genotoxic effects in human populations exposed to arsenic. Some of these studies found an increase in MN frequency among exposed individuals, but others found no increase or inconclusive results. Thus, the main purpose of this current study was to investigate whether MN can be used as a biomarker for the arsenic exposure, as well as whether or not the different ce...
Source: Mutation Research Reviews in Mutation Research - March 15, 2019 Category: Genetics & Stem Cells Source Type: research

Comparing DNA Damage Induced by Mobile Telephony and Other Types of Man-Made Electromagnetic Fields
Publication date: Available online 11 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Dimitris J. PanagopoulosAbstractThe number of studies showing adverse effects on living organisms induced by different types of man-made Electromagnetic Fields (EMFs) has increased tremendously. Hundreds of peer reviewed published studies show a variety of effects, the most important being DNA damage which is linked to cancer, neurodegenerative diseases, reproductive declines etc. Those studies that are far more effective in showing effects employ real-life Mobile Telephony (MT) exposures emitted by commercially...
Source: Mutation Research Reviews in Mutation Research - March 12, 2019 Category: Genetics & Stem Cells Source Type: research

Biological monitoring of workers exposed to carcinogens using the buccal micronucleus approach: A systematic review and meta-analysis
Publication date: Available online 8 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Nancy B. Hopf, Claudia Bolognesi, Brigitta Danuser, Pascal WildAbstractA biomarker-based approach using micronucleus (MN) (extranuclear DNA-containing bodies) frequencies in buccal cells has been proposed to monitor workers exposed to aero-digestive carcinogens for early detection of occupational cancer. To assess this non-invasive MN approach, we sought to understand: A) What is the extent of MN frequency increase in occupationally exposed over non-exposed populations across studies published in the scientific l...
Source: Mutation Research Reviews in Mutation Research - March 8, 2019 Category: Genetics & Stem Cells Source Type: research

Genetic predisposition for malignant mesothelioma: a concise review
Publication date: Available online 6 March 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Marta Betti, Anna Aspesi, Marika Sculco, Giuseppe Matullo, Corrado Magnani, Irma DianzaniAbstractMalignant mesothelioma (MM) is an aggressive cancer associated with asbestos exposure. Studies of familial malignant pleural mesothelioma (MPM) have suggested the existence of a genetic predisposition. Information on the role of genetic risk factors in the development of MM has been growing in the last years, and both low- and high-risk genetic factors have been identified, but genetic factors alone (without any expos...
Source: Mutation Research Reviews in Mutation Research - March 7, 2019 Category: Genetics & Stem Cells Source Type: research

DNA repair as a human biomonitoring tool; comet assay approaches
In conclusion, although comet assay based approaches to measure BER/NER phenotypes are feasible and promising; more work is needed to further optimize their application in human biomonitoring and intervention studies. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - March 7, 2019 Category: Genetics & Stem Cells Source Type: research

Free-access copy-number variant detection tools for targeted next-generation sequencing data
Publication date: Available online 23 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Iria Roca, Lorena González-Castro, Helena Fernández, Mª Luz Couce, Ana Fernández-MarmiesseAbstractCopy number variants (CNVs) are intermediate-scale structural variants containing copy number changes involving DNA fragments of between 1 kb and 5 Mb. Although known to account for a significant proportion of the genetic burden in human disease, the role of CNVs (especially small CNVs) is often underestimated, as they are undetectable by traditional Sanger sequencing. Since the d...
Source: Mutation Research Reviews in Mutation Research - February 25, 2019 Category: Genetics & Stem Cells Source Type: research

The comet assay in animal models: From bugs to whales – (Part 1 Invertebrates)
Publication date: Available online 16 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Goran Gajski, Bojana Žegura, Carina Ladeira, Bertrand Pourrut, Cristian Del Bo’, Matjaž Novak, Monika Sramkova, Mirta Milić, Kristine Bjerve Gutzkow, Solange Costa, Maria Dusinska, Gunnar Brunborg, Andrew CollinsAbstractThe comet assay, also called single cell gel electrophoresis, is a sensitive, rapid and low-cost technique for quantifying and analysing DNA damage and repair at the level of individual cells. The assay itself can be applied on virtually any cell type derived from different organs and...
Source: Mutation Research Reviews in Mutation Research - February 17, 2019 Category: Genetics & Stem Cells Source Type: research

Cataractogenic load – a concept to study the contribution of ionizing radiation to accelerated aging in the eye lens
Publication date: Available online 15 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Alice Uwineza, Alexia A. Kalligeraki, Nobuyuki Hamada, Miguel Jarrin, Roy A. QuinlanAbstractIonizing radiation (IR) damages DNA and other macromolecules, including proteins and lipids. Most cell types can repair DNA damage and cycle continuously their macromolecules as a mechanism to remove defective proteins and lipids. In those cells that lack nuclei and other organelles, such as lens fiber cells and mammalian erythrocytes, IR-induced damage to macromolecules is retained because they cannot be easily replen...
Source: Mutation Research Reviews in Mutation Research - February 16, 2019 Category: Genetics & Stem Cells Source Type: research

Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting Evidence
Publication date: Available online 10 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Luoping Zhang, Iemaan Rana, Emanuela Taioli, Rachel M. Shaffer, Lianne SheppardAbstractGlyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of glyphosate’s carcinogenic potential by various regional, national and international agencies have engendered controversy. We independently investigate whether there is an association between high cumulative exposures to glyphosate and increased risk of non-Hodgkin lymphoma (NHL) in humans and conduct a new meta-ana...
Source: Mutation Research Reviews in Mutation Research - February 11, 2019 Category: Genetics & Stem Cells Source Type: research

Micronucleus Assay for Monitoring the Genotoxic Effects of Arsenic: A Systematic Review
Publication date: Available online 6 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Ju Dong, Jun-qin Wang, Qin Qian, Guo-chun Li, Dong-qin Yang, Chao JiangAbstractThe micronucleus (MN) assay has been used to determine the potential genotoxic effects and cancer risk in human populations exposed to arsenic. Some of these studies have found an increase in MN frequencies among exposed individuals, but different results have also been found by others. Thus, the main purpose of this study is to investigate whether MN can be used as an effective biomarker for the arsenic exposure, as well as which k...
Source: Mutation Research Reviews in Mutation Research - February 7, 2019 Category: Genetics & Stem Cells Source Type: research

Associations between single nucleotide polymorphisms and erythrocyte parameters in humans: a systematic literature review
Publication date: Available online 2 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Tiffany C. Timmer, Michael W.T. Tanck, Elisabeth M.J. Huis in’ t Veld, Barbera Veldhuisen, Joost G. Daams, Wim L.A.M. de Kort, C. Ellen van der Schoot, Katja van den HurkAbstractIndividual variations in erythrocyte parameters are influenced by factors like sex, age, diet and season. Genetic variations have also been associated with erythrocyte parameters. The aim of this systematic review is to provide an overview of associations between single nucleotide polymorphisms (SNPs) and erythrocyte parameters i...
Source: Mutation Research Reviews in Mutation Research - February 3, 2019 Category: Genetics & Stem Cells Source Type: research

A systematic review and quantitative assessment of methylation biomarkers in fecal DNA and colorectal cancer and its precursor, colorectal adenoma
Publication date: Available online 16 January 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Rongbin Liu, Xuan Su, Yakang Long, Dalei Zhou, Xiao Zhang, Zulu Ye, Jiangjun Ma, Tao Tang, Fang Wang, Caiyun HeAbstractColorectal cancer (CRC) arises from accumulated genetic and epigenetic alterations, which provide the possibility to identify tumor-specific biomarkers by analyzing fecal DNA. Methylation status in human genes from tumor tissue is highlighted as promising biomarker in the early detection of CRC. A number of studies have documented altered methylation levels in DNA extracted from stool samples,...
Source: Mutation Research Reviews in Mutation Research - January 17, 2019 Category: Genetics & Stem Cells Source Type: research

Glaucomagenesis following ionizing radiation exposure
Publication date: Available online 8 January 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Nobuyuki Hamada, Tamara V. Azizova, Mark P. LittleAbstractGlaucoma is a group of optic neuropathies causing optic nerve damage and visual field defects, and is one of the leading causes of blindness. Nearly a century has passed since the first report of glaucoma manifested following ionizing radiation therapy of cancers. Nevertheless, associations between glaucoma and radiation exposures, a dose response relationship, and the mechanistic underpinnings remain incompletely understood. Here we review the current k...
Source: Mutation Research Reviews in Mutation Research - January 9, 2019 Category: Genetics & Stem Cells Source Type: research

Risks of aneuploidy induction from chemical exposure: twenty years of collaborative research in Europe from basic science to regulatory implications
Publication date: Available online 27 December 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): M. Kirsch-Volders, F. Pacchierotti, E.M. Parry, A. Russo, U. Eichenlaub-Ritter, I.-D. AdlerAbstractAlthough Theodor Boveri linked abnormal chromosome numbers and disease more than a century ago, an in-depth understanding of the impact of mitotic and meiotic chromosome segregation errors on cell proliferation and diseases is still lacking. This review reflects on the efforts and results of a large European research network that, from the 1980's until 2004, focused on protection against aneuploidy-inducing fact...
Source: Mutation Research Reviews in Mutation Research - December 27, 2018 Category: Genetics & Stem Cells Source Type: research

The Molecular Origins and Pathophysiological Consequences of Micronuclei: New Insights into an Age-old Problem
Publication date: Available online 23 November 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Xihan Guo, Juan Ni, Ziqing Liang, Jinglun Xue, Michael F. Fenech, Xu WangABSTRACTMicronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can exist in cells with numerical and/or structural chromosomal aberrations in apparently normal tissues and more so in tumors in humans. While MN have been observed for over 100 years, they were merely and constantly considered as passive indicators of chromosome instability (CIN) for a long time. Relatively little is known about the molecular or...
Source: Mutation Research Reviews in Mutation Research - November 24, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: October–December 2018Source: Mutation Research/Reviews in Mutation Research, Volume 778Author(s): (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - November 18, 2018 Category: Genetics & Stem Cells Source Type: research

Aflatoxin B1 metabolism: regulation by phase I and II metabolizing enzymes and chemoprotective agents
Publication date: Available online 29 October 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Jiang Deng, Zhao Ling, Zhang Ni-Ya, Niel Alexander Karrow, Steven Krumm Christopher, Qi De-Sheng, Sun Lv-HuiAbstractAflatoxin B1 (AFB1) widely contaminates staple food and feed crops and is well-known as the most potent natural hepatocarcinogen in humans and domesticated animals. This review highlights significant advances in our understanding of the pivotal role of phase I and II metabolizing enzymes in the bioactivation and detoxification of AFB1 and its metabolites across species. In humans, cytochrome P450...
Source: Mutation Research Reviews in Mutation Research - October 30, 2018 Category: Genetics & Stem Cells Source Type: research

Pathophysiological Mechanisms Linking F-box only Protein 7 (FBXO7) and Parkinson’s disease (PD)
Publication date: Available online 17 October 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Zhi Dong Zhou, Ji Chao Tristan Lee, Eng King TanAbstractMutations of F-box only protein 7 (FBXO7) gene are associated with a severe form of autosomal recessive juvenile Parkinson's disease (PD) (PARK15) with clinical features of Parkinsonian-Pyramidal syndrome (PPS). FBXO7 is an adaptor protein in SCFFBXO7 ubiquitin E3 ligase complex that recognizes and mediates degradative or non-degradative ubiquitination of substrates. The FBXO7 protein can regulate cell cycle, proliferation, mitochondrial and proteasome fu...
Source: Mutation Research Reviews in Mutation Research - October 18, 2018 Category: Genetics & Stem Cells Source Type: research

Line-1: implications in the etiology of cancer, clinical applications, and pharmacologic targets
Publication date: Available online 19 September 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): M Khalid, P Bojang, KS RamosAbstractLong interspersed nuclear elements-1 (Line-1 or L1) accounts for approximately 17% of the human genome. The majority of L1s are inactive, but ~100 remain retrotransposon competent (RC-L1) and able to retrotranspose through RNA intermediates to different locations of the genome. L1 is involved in both disease initiation and progression via retrotransposition dependent and independent mechanisms. Retrotransposed L1 sequences disrupt genetic loci at sites of insertion, while ...
Source: Mutation Research Reviews in Mutation Research - September 21, 2018 Category: Genetics & Stem Cells Source Type: research

Molecular genetics of the POMT1-related muscular dystrophy-dystroglycanopathies
Publication date: Available online 12 September 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Pengzhi Hu, Lamei Yuan, Hao DengABSTRACTProtein O-mannosyltransferase 1 (POMT1) is a critical enzyme participating in the first step of protein O-mannosylation. Mutations in the coding gene, POMT1, have been described to be related to a series of autosomal recessive disorders associated with defective alpha-dystroglycan glycosylation, later termed muscular dystrophy-dystroglycanopathies (MDDGs). MDDGs are characterized by a broad phenotypic spectrum of congenital muscular dystrophy or later-onset limb-girdle...
Source: Mutation Research Reviews in Mutation Research - September 13, 2018 Category: Genetics & Stem Cells Source Type: research

Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance
Publication date: Available online 7 September 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Benazir Siddeek, Claire Mauduit, Umberto Simeoni, Mohamed BenahmedAbstractPaternal exposure to environmental challenges plays a critical role in the offspring's future health and the transmission of acquired traits through generations. This review summarizes our current knowledge in the new field of epigenomic paternal transmission of health and disease. Epidemiological studies identified that paternal ageing or challenges (imbalanced diets, stress, toxicants, cigarette smoke, alcohol) increased the risk of o...
Source: Mutation Research Reviews in Mutation Research - September 7, 2018 Category: Genetics & Stem Cells Source Type: research

Genetic landscape of Gallbladder Cancer: Global overview
This article is the first one to provide insights into the genetic heterogeneity of GBC along with somatic mutational data from Catalogue of Somatic Mutations in Cancer (COSMIC) database. In addition, this article throws light on the management of tumor heterogeneity as a therapeutic challenge. Furthermore, future prospects involve implications of liquid biopsy based research in clinical management. (Source: Mutation Research Reviews in Mutation Research)
Source: Mutation Research Reviews in Mutation Research - August 24, 2018 Category: Genetics & Stem Cells Source Type: research