Mutation Research Genetic Toxicology and Environmental Mutagenesis 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Antioxidant status and cytogenetic damage in hospital workers occupationally exposed to low dose ionizing radiation
Publication date: February–March 2020Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volumes 850–851Author(s): Jianfang Gao, Xiaomei Dong, Taixiu Liu, Lilong Zhang, Lin AoAbstractThe aim of the present study was to assess the oxidative stress level and chromosomal damage induced by occupational exposure to low dose ionizing radiation (LDIR). Two hundred and eighteen hospital workers occupationally exposed to LDIR were included in this study, along with 118 healthy age- and gender-comparable controls. Occupational dosimetry records were collected over the last year and revealed that the accum...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - February 20, 2020 Category: Genetics & Stem Cells Source Type: research
Antioxidant activity and cytogenetic damage in hospital workers occupationally exposed to low dose ionizing radiation
Publication date: Available online 8 February 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Jianfang Gao, Xiaomei Dong, Taixiu Liu, Lilong Zhang, Lin AoAbstractThe aim of the present study was to assess the oxidative stress level and chromosomal damage induced by occupational exposure to low dose ionizing radiation (LDIR). Two hundred and eighteen hospital workers occupationally exposed to LDIR were included in this study, along with 118 healthy age- and gender-comparable controls. Occupational dosimetry records were collected over the last year and revealed that the accumulated a...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - February 9, 2020 Category: Genetics & Stem Cells Source Type: research
The effect of vitamin E and C on comet assay indices and apoptosis in power plant workers: A double blind randomized controlled clinical trial
In this study, the effect of using vitamin E and C supplements have been examined on employees working at a thermal power plant. In this randomized controlled, double-blind clinical trial, 81 employees from different parts of the thermal power plant were enrolled between July and November 2017, and divided into four groups: Group 1 received vitamin E (400 units/day), Group 2: vitamin C (1000 mg/day), Group 3: vitamin E + C and Group 4: placebo. DNA damage was measured in peripheral blood lymphocytes using comet assay and apoptosis, using flow cytometry. Based on the results, tail intensity and tail length in the vita...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - February 5, 2020 Category: Genetics & Stem Cells Source Type: research
Retraction notice to “Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice” [MUTGEN 747 (1) (2012) 22–28]
Publication date: Available online 29 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Amit Kumar Srivastava, Pramod Kumar Srivastava, Abdulaziz A. Al-Khedhairy, Javed Musarrat, Yogeshwer Shukla (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 30, 2020 Category: Genetics & Stem Cells Source Type: research
Biological significance of aminophenyl-β-carboline derivatives formed from co-mutagenic action of β-carbolines and aniline and o-toluidine and its effect on tumorigenesis in humans: A review
Publication date: Available online 28 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yukari Totsuka, Keiji WakabayashiAbstractNorharman exists in cigarette smoke and cooked foods and is non-mutagenic among Salmonella strains but mutagenic to S. typhimurium TA98 and YG1024 in the presence of S9 mix and aniline and o-toluidine. Co-mutagenesis of β-carbolines and aniline and o-toluidine occurs through the formation of novel mutagenic aminophenyl-β-carboline derivatives including 9-(4’-aminophenyl)-9H-pyrido[3,4-b]indole [aminophenylnorharman] (APNH)] and 9-(4’- amino-3...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 30, 2020 Category: Genetics & Stem Cells Source Type: research
50 years existence and active participation of EEMS (now EEMGS) in the scientific community: a driver of European and international scientific collaborations for the protection of the environment and human health from genome stressors
Publication date: Available online 28 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lisbeth E. Knudsen, David H. Phillips, Micheline Kirsch-VoldersAbstractEEMS and its successor Society EEMGS have provided a dynamic and successful platform to stimulate research and exchanges among the different actors involved in the protection of the environment and of human health from exposure to genome stressors. It includes basic, translational and applied research projects. This was possible due to the enthusiasm, creativity and support of scientists convinced of the importance of th...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 28, 2020 Category: Genetics & Stem Cells Source Type: research
Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays
In this study, 10 nm CdO core-PEG stabilized NPs were synthesized, characterized and used for evaluation of CdO NPs’ cytotoxicity and genotoxicity. Release of cadmium ions (Cd+2) from the CdO NPs in cell culture medium, cellular uptake of the NPs, and the endotoxin content of the particles were measured prior to the toxicity assays. Cytotoxicity was evaluated using the MTS assay, ATP content detection assay, and LDH assay. Genotoxicity was assessed using the Ames test, Comet assay, micronucleus assay, and mouse lymphoma assay. The cytotoxicity of cadmium chloride (CdCl2) was also evaluated along with that of the CdO NP...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 28, 2020 Category: Genetics & Stem Cells Source Type: research
Aqueous extract of bulbus Fritillaria cirrhosa induces cytokinesis failure by blocking furrow ingression in human colon epithelial NCM460 cells
Publication date: Available online 25 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Xihan Guo, Xiayu Wu, Juan Ni, Ling Zhang, Jinglun Xue, Xu WangAbstractBulbus Fritillariacirrhosa D. Don (BFC) has been widely used as an herbal medicament for respiratory diseases in China for over 2000 years. The ethnomedicinal effects of BFC have been scientifically verified, nevertheless its toxicity has not been completely studied. Previously, we have reported that the aqueous extract of BFC induces mitotic aberrations and chromosomal instability (CIN) in human colon epithelial NCM460 c...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 27, 2020 Category: Genetics & Stem Cells Source Type: research
Guidance for publishing comet assay results
Publication date: Available online 23 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Gunnar Brunborg, Andrew Collins (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 24, 2020 Category: Genetics & Stem Cells Source Type: research
Genotoxicity and sperm defects induced by 5-FU in male mice and the possible protective role of Pentas lanceolata-iridoids
In conclusion5-FU demonstrated to be a genotoxic agent. Its genotoxicity in germ cells is serious and may lead to reproductive toxicity, infertility or heritable defects. The results also demonstrated the biosafety of IFPL and its possible protective role in combined treatment with 5-FU. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 24, 2020 Category: Genetics & Stem Cells Source Type: research
A new tool for genotoxic risk assessment: Reevaluation of the cytokinesis-block micronucleus assay using semi-automated scoring following telomere and centromere staining
ConclusionThese approaches can be potentially used to follow-up populations exposed to genotoxic agents and assess cancer risk.Graphical abstract (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 23, 2020 Category: Genetics & Stem Cells Source Type: research
Genotoxicity of the food additive E171, titanium dioxide, in the plants Lens culinaris L. and Allium cepa L
Publication date: Available online 21 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lorenza Bellani, Simonetta Muccifora, Francesco Barbieri, Eliana Tassi, Monica Ruffini Castiglione, Lucia GiorgettiAbstractE171 (titanium dioxide, TiO2), an authorized foods and beverage additive, is also used in food packaging and in pharmaceutical and cosmetic preparations. E171 is considered to be an inert and non-digestible material, not storable in animal tissues, but the possible presence of TiO2 nanoparticles (NP) may present a risk to human health and the environment. We determined ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 22, 2020 Category: Genetics & Stem Cells Source Type: research
Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms
Publication date: Available online 22 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donna Goodenow, Faith Emmanuel, Chase Berman, Mark Sahyouni, Christine RichardsonAbstractBioflavonoids have a similar chemical structure to etoposide, the well-characterized topoisomerase II (Top2) poison, and evidence shows that they also induce DNA double-strand breaks (DSBs) and promote genome rearrangements. The purpose of this study was to determine the kinetics of bioflavonoid-induced DSB appearance and repair, and their dependence on Top2. Cells were exposed to bioflavonoids individu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 22, 2020 Category: Genetics & Stem Cells Source Type: research
Premature chromosome condensation assay to study influence of high-level natural radiation on the initial DNA double strand break repair in human G0 lymphocytes
Publication date: Available online 18 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): P.R. Vivek Kumar, C.V. Karuppasamy, E.N. Ramachandran, V. Anil Kumar, G. Jaikrishan, Birajalaxmi DasAbstractThe inherent capacity of individuals to efficiently repair ionizing radiation induced DNA double strand breaks (DSBs) may be inherited, however, it is influenced by several epigenetic and environmental factors. A pilot study tested whether chronic low dose natural radiation exposure influences the rejoining of initial DNA DSBs induced by a 2 Gy γ-irradiation in 22 individuals from ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 19, 2020 Category: Genetics & Stem Cells Source Type: research
Oxidative stress-mediated genotoxicity of malathion in human lymphocytes
Publication date: Available online 17 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Olakkaran Shilpa, Kizhakke Purayil Anupama, Anet Antony, Shanthala Mallikarjunaiah, Hunasanahally Puttaswamygowda GurushankaraAbstractApplying the single-cell gel electrophoresis (comet) assay, we show that the widely used organophosphorus pesticide malathion is cytotoxic, genotoxic, and induces oxidative stress in human lymphocytes. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 18, 2020 Category: Genetics & Stem Cells Source Type: research
