Mutation Research Genetic Toxicology and Environmental Mutagenesis 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Assessment of oxidative damage induced by iron oxide nanoparticles on different nervous system cells
Publication date: Available online 30 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Natalia Fernández-Bertólez, Carla Costa, Maria João Bessa, Margriet Park, Marie Carriere, Fanny Dussert, João Paulo Teixeira, Eduardo Pásaro, Blanca Laffon, Vanessa ValdiglesiasAbstractIron oxide nanoparticles (ION) have received much attention for their utility in biomedical applications, such as magnetic resonance imaging, drug delivery and hyperthermia, but concerns regarding their potential harmful effects are also growing. Even though ION may induce different toxic effects in a w...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 1, 2018 Category: Genetics & Stem Cells Source Type: research
Comet assay in neural cells as a tool to monitor DNA damage induced by chemical or physical factors relevant to environmental and occupational exposure
Publication date: Available online 30 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Marcin Kruszewski, Katarzyna Sikorska, Sylwia Meczynska-Wielgosz, Agnieszka Grzelak, Monika Sramkova, Alena Gabelova, Lucyna Kapka-SkrzypczakAbstractBiomonitoring of the effects of environmental and occupational exposure relevant chemical or physical factors on central nervous system is difficult due to the problems with sampling of biological material. Thus, surrogate systems allowing for the estimation of effect intensity are necessary to evaluate a potential risk of exposure. Cancerous ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 1, 2018 Category: Genetics & Stem Cells Source Type: research
Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test
Publication date: Available online 1 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Xiuming Du, Shunxiang Gao, Liling Hong, Xin Zheng, Qingyun Zhou, Jihong WuAbstractTitanium dioxide nanoparticles (TiO2-NPs) are widely used in the cosmetics, health, and food industries, but their safety and genotoxicity remain a matter of debate. We investigated whether TiO2-NPs could induce gene mutations in mouse lymphoma L5178Y cells and Salmonella typhimurium strains TA97a, TA98, TA100, TA102, and TA1535. Following preliminary tests, 2 mg/mL for the mouse lymphoma gene mutation assay...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 1, 2018 Category: Genetics & Stem Cells Source Type: research
Genotoxic and oxidative damage in the freshwater teleost Prochilodus lineatus exposed to the insecticides lambda-cyhalothrin and imidacloprid alone and in combination
The objective of this study was to evaluate genotoxic and oxidative effects of LC and IMI, isolated and in binary mixture, on the neotropical freshwater teleost curimba (Prochilodus lineatus). Juveniles of P. lineatus were exposed to LC (0.15 μg L-1), IMI (100 μg L-1), LC + IMI or only to water (CTR) for 48, 96, 144 and 192 h. The occurrence of DNA damage (comet assay), was evaluated in erythrocytes, gills, liver and brain cells, the frequency of micronucleus (MN) and nuclear abnormalities (ENA) was measured in erythrocytes and protein carbonylation (PCC) and lipid peroxidation (LPO) were determined in gill...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 29, 2018 Category: Genetics & Stem Cells Source Type: research
Effect of age and sex on the level of DNA strand breaks and oxidatively damaged DNA in human blood cells
Publication date: Available online 27 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Peter MøllerAbstractDNA damage measured by the comet assay is a well-established biomarker in studies on environmental and occupational exposures, dietary factors and clinical outcomes. Age and sex are typically regarded as confounding factors that are controlled by either selective inclusion criteria of subjects or adjustment in the statistical analysis. This review assesses the influence of age and sex on levels of DNA damage in leukocytes in study populations of healthy subjects. Analy...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 28, 2018 Category: Genetics & Stem Cells Source Type: research
Cytotoxic and genotoxic effects of environmental relevant concentrations of bisphenol A and interactions with doxorubicin
This study is intended to assess potential cytotoxic and genotoxic effects of BPA, as well as its interactions with DOX, in Human epithelial type 2 cells (Hep-2) originated from a human laryngeal carcinoma and in a DNA damage responsive cell line, the human lung fibroblasts (MRC-5). Cell viability was analyzed through the resazurin assay. The G protein-coupled estrogen receptor 1 (GPER) expression was visualized by immunodetection. Genotoxicity, namely DNA damage and oxidative DNA damage, were assessed by comet assay and micronuclei induction, and mitotic disruption was evaluated cytologically by fluorescent microscopy wit...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 28, 2018 Category: Genetics & Stem Cells Source Type: research
Evaluation of 12 mouse marker genes in rat toxicogenomics public data, Open TG-GATEs: discrimination of genotoxic from non-genotoxic hepatocarcinogens
Publication date: Available online 23 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Chie Furihata, Takayoshi SuzukiAbstractPreviously, we proposed 12 marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2 and Tubb4b) to discriminate mouse genotoxic hepatocarcinogens (GTHC) from non-genotoxic hepatocarcinogens (NGTHC). This was determined by qPCR and principal component analysis (PCA), as the aim of an in vivo short-term screening for genotoxic hepatocarcinogens. For this paper, we conducted an application study of the 12 mouse marker genes to r...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 24, 2018 Category: Genetics & Stem Cells Source Type: research
Blood levels of nitric oxide and dna breaks assayed in whole blood and isolated peripheral blood mononucleated cells in patients with multiple sclerosis
Publication date: Available online 23 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Vitālijs Borisovs, Elīna Ļeonova, Larisa Baumane, Jolanta Kalniņa, Natalja Mjagkova, Nikolajs SjaksteAbstractOxidative stress, especially overproduction of nitric oxide (NO), is considered to be one of the crucial factors in the pathogenesis of multifactorial multiple sclerosis (MS). DNA breaks could be one of the consequences of oxidative stress; however, data on DNA breakage in MS are very few and contradictory. There are no data on direct measurements of NO production in the blood o...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 23, 2018 Category: Genetics & Stem Cells Source Type: research
The enzyme-modified comet assay: enzyme incubation step in 2 vs 12-gels/slide systems
Publication date: Available online 22 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Damian Muruzabal, Sabine Langie, Bertrand Pourrut, Amaya AzquetaAbstractThe enzyme-modified comet assay is a commonly used method to detect specific DNA lesions. However, still a lot of errors are made by many users, leading to dubious results and even misinterpretations. This technical note describes some critical points in the use of the enzyme-modified comet assay, such as the enzyme concentration, the time of incubation, the format used and the equipment. To illustrate the importance o...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 22, 2018 Category: Genetics & Stem Cells Source Type: research
Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells
Publication date: Available online 22 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Marie Dorier, Céline Tisseyre, Fanny Dussert, David Béal, Marie-Edith Arnal, Thierry Douki, Vanessa Valdiglesias, Blanca Laffon, Sónia Fraga, Fátima Brandão, Nathalie Herlin-Boime, Frédérick Barreau, Thierry Rabilloud, Marie CarriereAbstractTiO2 particles are widely used in products for everyday consumption, such as cosmetics and food; their possible adverse effects on human health must therefore be investigated. The aim of this study was to document in vitro impact of the food addi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 22, 2018 Category: Genetics & Stem Cells Source Type: research
Assessment of dna damage in welders using comet and micronucleus assays
Publication date: Available online 19 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): İldeniz Aksu, Hatice Gül Anlar, Gökçe Taner, Merve Bacanlı, Servet İritaş, Engin Tutkun, Nursen BasaranAbstractWelding technology is widely used in pressurized containers, thermal power plants, refineries, chemical facilities and steel structures. Welders are exposed to a number of hazardous compounds such as ultraviolet (UV) radiation, electromagnetic fields, toxic metals and polycyclic aromatic hydrocarbons (PAHs). In the present study, 48 welders and an equal number of control su...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 21, 2018 Category: Genetics & Stem Cells Source Type: research
Fish and salad consumption are inversely associated with levels of oxidatively damaged DNA in a Danish adult cohort
This study investigated associations between levels of oxidatively damaged DNA, measured by the formamidopyrimidine DNA glycosylase (Fpg)-modified comet assay and intake of fish, salad, fruits, vegetables, wholegrain items, and potatoes in a cross-sectional study of 382 men and 591 women between 18 and 93 years. Intake of dietary items was obtained from questionnaires, and stratified into less than once per week, weekly or daily consumption. Intake of fish as main course was inversely associated with levels of Fpg-sensitive sites in peripheral blood mononuclear cells (PBMCs) in especially women (P < 0.001 multivari...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 21, 2018 Category: Genetics & Stem Cells Source Type: research
Markedly enhanced micronucleus induction by 1,2-dimethylhydrazine dihydrochloride in colonic cells of rats with bacterial colonization in the intestine
Publication date: Available online 20 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Wakako OhyamaAbstractTo investigate how intestinal bacteria affect host cytogenetic alterations in the early initiation step of colon carcinogenesis, we conducted a comet assay and micronucleus (MN) test using germ-free (GF) and conventionalized (Cvd) rats after a single subcutaneous injection of the carcinogen, 1,2-dimethylhydrazine dihydrochloride (DMH). DNA damage was also determined in the liver in comet assays, as DMH is metabolized and activated in this organ. The time-response patte...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 21, 2018 Category: Genetics & Stem Cells Source Type: research
Risk Is In The Air”: Polycyclic Aromatic Hydrocarbons, Metals And Mutagenicity Of Atmospheric Particulate Matter In A Town Of Northern Italy (Respira Study)
Publication date: Available online 16 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donatella Feretti, Roberta Pedrazzani, Elisabetta Ceretti, Mario Dal Grande, Ilaria Zerbini, Gaia Claudia Viviana Viola, Umberto Gelatti, Francesco Donato, Claudia ZaniAbstractAir pollution has well-known harmful effects on human beings, causing both acute and chronic diseases. Some data suggest that genetic damage occurring early in life may influence the risk of having cancer and other chronic diseases in adulthood. Therefore, there is a growing interest in studying the genotoxic activit...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 17, 2018 Category: Genetics & Stem Cells Source Type: research
Editorial Board
Publication date: December 2018Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 836, Part BAuthor(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 14, 2018 Category: Genetics & Stem Cells Source Type: research
