Bifidobacteria: a probable missing puzzle piece in the pathogenesis of multiple sclerosis
Publication date: Available online 28 August 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mehdi Toghi, Sara Bitarafan, Hosein Delavar Kasmaei, Soudeh Ghafouri-FardAbstractMultiple sclerosis (MS) is an autoimmune disorder in which the immunopathogenesis is not fully understood. In the recent years, the role of gut microbiome in the pathogenesis of this disorder has been highlighted. Bifidobacteria as a component of gut microbiome might also be involved in MS pathogenesis. Being emerged in early days after birth, bifidobacteria have a prominent role in immune system maturation and function. Some factors lik...
Source: Multiple Sclerosis and Related Disorders - August 29, 2019 Category: Neurology Source Type: research

Pediatric Multiple Sclerosis and its familial recurrence: A population based study (1999-2017)
ConclusionIn comparison to other large studies, the prevalence of POMS was high in the data collected from Tehran. POMS risk is higher among females and the sex ratio increases after puberty. We found a significant association between POMS risk and familial history in maternal second degree relatives. Further studies of POMS epidemiology might yield greater understanding of the natural history of this disease. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 29, 2019 Category: Neurology Source Type: research

Non-invasive Brain Stimulation for Fatigue in Multiple Sclerosis Patients: A Systematic Review and Meta-analysis
ConclusionstDCS is a safe and effective treatment for fatigue in MS patients. However, further studies are required to confirm our results in a large-scale population and to investigate the effectiveness of other NIBS subtypes. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 29, 2019 Category: Neurology Source Type: research

Comparative analysis of fingolimod versus teriflunomide in relapsing–remitting multiple sclerosis
The objective of this study was to compare the efficacy of fingolimod and teriflunomide in reducing disease activity in RRMS.MethodsThis multicenter, retrospective observational study was carried out with prospectively collected data from 15 centers. All consecutive RRMS patients treated with teriflunomide or fingolimod were included. Data for relapses, Expanded Disability Status Scale (EDSS) scores and brain magnetic resonance imaging (MRI) scans were collected. Patients were matched using propensity scores.Annualized relapse rates (ARR), disability accumulation, percentage of patients with active MRI and treatment discon...
Source: Multiple Sclerosis and Related Disorders - August 27, 2019 Category: Neurology Source Type: research

Progressive Multifocal Myelopathy or Multiple Sclerosis?
Publication date: Available online 15 August 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Simona Lattanzi, Francesco Logullo, Claudia Cagnetti, Paolo Di Bella, Mauro Silvestrini (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 17, 2019 Category: Neurology Source Type: research

The long-term effects of disease modifying therapies on disability in people living with multiple sclerosis: a systematic review and meta-analysis
ConclusionThere is some evidence that long-term treatment with interferon beta reduces the risk of EDSS 6.0 and SPMS compared to no treatment or placebo. More work is needed on the effect of second generation DMT and the relative effect of DMT on health outcomes. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 17, 2019 Category: Neurology Source Type: research

MicroRNA-29b variants and MxA expression change during interferon beta therapy in patients with relapsing-remitting multiple sclerosis
ConclusionsOur results might provide fundamentals for the development of new markers of the biological effects of IFN-β therapy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 15, 2019 Category: Neurology Source Type: research

Vitamin D and MRI Measures in Progressive Multiple Sclerosis
Conclusions25(OH)D3 levels were not associated with brain volume or lesional measures in progressive MS contrary to what has been described in relapsing remitting MS. An association between WB-MTR and NAGM-MTR suggest higher vitamin D levels may exert a protective role on myelin content in progressive MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 15, 2019 Category: Neurology Source Type: research

Circulating mesenchymal stem cells, stromal derived factor (SDF)-1 and IP-10 levels increased in clinically active Multiple Sclerosis patients but not in clinically stable patients treated with beta Interferon
ConclusionCirculating MSCs, IP-10 and SDF-1α levels, increased in RRMS patients with clinically active not on DMT and IFN-β therapy reduced circulating MSCs and SDF-1α levels. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 12, 2019 Category: Neurology Source Type: research

Validation of the Guy's Neurological Disability Scale as a screening tool for cognitive impairment in multiple sclerosis
ConclusionThe GNDS-J is a valid tool to perform in outpatient clinics, which could provide a comprehensive scale for evaluating symptoms of MS, thus the disease activity by repeated measure. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 12, 2019 Category: Neurology Source Type: research

Ultrasonographic evaluation of the diaphragm thickness in patients with multiple sclerosis
ConclusionAlthough the diaphragm thickness of MS patients seems to be similar to those of healthy subjects, the change level and TR of MS patients seem to be lower. Furthermore, the change level and TR were found to be associated with EDSS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 12, 2019 Category: Neurology Source Type: research

Fatigue and depression predict health-related quality of life in patients with pediatric-onset multiple sclerosis
This study aims to evaluate depression, fatigue and HRQoL and its relationship in a cohort of patients with POMS and matched healthy controls (HCs).MethodsIn a multicenter cross-sectional study, Beck Depression Inventory II, Depressionstest für Kinder, the Pediatric Quality of Life Inventory (PedsQLTM) 4.0 Generic Core Scale and the PedsQLTM Multidimensional Fatique Scale were performed.ResultsIn a cohort of 106 patients with POMS and 210 matched HCs, patients were significantly more often depressed (21.7% vs. 11.4%, p=0.014) experienced greater fatigue (40.6 % vs. 17.3%, p
Source: Multiple Sclerosis and Related Disorders - August 10, 2019 Category: Neurology Source Type: research

Effectiveness and tolerability of immunosuppressants and monoclonal antibodies in preventive treatment of neuromyelitis optica spectrum disorders: a systematic review and network meta-analysis
ConclusionRTX and MMF may be recommended as optimal treatments to prevent relapse in NMOSD. Low-dose cyclosporine A could be a promising alternative therapy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 10, 2019 Category: Neurology Source Type: research

Construct validity and test–retest reliability of the Swedish version of the Acceptance of Chronic Health Conditions Scale
Publication date: October 2019Source: Multiple Sclerosis and Related Disorders, Volume 35Author(s): Andreas Wallin, Mia Forslin, Sverker Johansson, Marie KierkegaardAbstractThe Acceptance of Chronic Health Conditions Scale was developed to measure acceptance in chronic health conditions like multiple sclerosis (MS) and has been translated into Swedish (The Swedish Acceptance of Chronic Health Conditions Scale). The purpose of the present study was to evaluate construct validity and test–retest reliability of the Swedish Acceptance of Chronic Health Conditions Scale in a sample of 138 people with MS. Predefined hypoth...
Source: Multiple Sclerosis and Related Disorders - August 8, 2019 Category: Neurology Source Type: research

Cytomegalovirus primary infection in a patient with multiple sclerosis treated with alemtuzumab
We report one patient with MS who develops cytomegalovirus (CMV) primary infection after a third cycle of alemtuzumab, with spontaneous recovery associated with rapid lymphocyte reconstitution. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

Secukinumab may be a valid treatment option in patients with CNS demyelination and concurrent ankylosing spondylitis: Report of two clinical cases
We report the clinical cases of two patients affected by a CNS demyelinating disease and ankylosing spondylitis who were successfully treated with secukinumab, providing additional evidence of the feasibility of this therapeutic option when the use of TNF inhibitors is discouraged by challenging comorbidities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

Rash Developing after Cessation of Daclizumab for Relapsing Remitting MS; A Case Series
We present three patients who developed urticarial papulovesicular rashes at a median of 3 months after discontinuation of Daclizumab. We propose an unexpected T cell mediated immune reaction as the cause (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

“Secukinumab may be a valid treatment option in patients with CNS demyelination and concurrent ankylosing spondylitis: report of two clinical cases”
We report the clinical cases of two patients affected by a CNS demyelinating disease and ankylosing spondylitis who were successfully treated with secukinumab, providing additional evidence of the feasibility of this therapeutic option when the use of TNF inhibitors is discouraged by challenging comorbidities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

Changing patterns of multiple sclerosis in Korea: toward a more baseline MRI lesions and intrathecal B cell responses
ConclusionsIn Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal B cell responses, and also higher female ratio. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

The clinical spectrum and prognosis of idiopathic acute optic neuritis: A longitudinal study in Southern Finland
Publication date: Available online 5 August 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mika Siuko, Tero T. Kivelä, Kirsi Setälä, Pentti J. TienariAbstractBackgroundTo analyse in a population-based setting the clinical features, prognostic factors, and seasonality of patients diagnosed with acute idiopathic optic neuritis (ON).MethodsRetrospective analysis of ophthalmological records, laboratory parameters, and magnetic resonance imaging (MRI) of patients with symptoms suggestive of ON referred to the Helsinki University Hospital (serving a population of 1.53 million in Southern Finland) w...
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

Risk of cancer among Finnish multiple sclerosis patients
ConclusionsOverall risk of cancer in our MS cohort did not significantly differ from the controls. However, the age at diagnosis of breast cancer was statistically significantly higher among the MS patients in comparison with a control population from the same patient pool. Further population-based larger studies spanning longer follow-up periods and longer exposure to emerging MS therapies are needed to evaluate cancer risk related to MS treatments and breast cancer risk in particular. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

Repeated anti-N-methyl-D-aspartate receptor encephalitis coexisting with anti-myelin oligodendrocyte glycoprotein antibody-associated diseases: A case report
We report the case of a 36-year-old woman who presented with repeated typical anti-NMDAR encephalitis coexisting with unusual symptoms not consistent with anti-NMDAR encephalitis. Apart from the anti-NMDAR encephalitis, her first episode was characterized by balance disability with bilateral medial frontal cortical lesions, suggesting the involvement of the cortico-reticular projections and the basal ganglia-brainstem projections. The second episode presented with Broca's aphasia caused by involvement of the Broca's area and lower part of the precentral gyrus. The detection of MOG-Ab in both episodes suggested the coexiste...
Source: Multiple Sclerosis and Related Disorders - August 7, 2019 Category: Neurology Source Type: research

Repeated anti-༮-methyl-D-aspartate receptor encephalitis coexisting with anti-myelin oligodendrocyte glycoprotein antibody-associated diseases: A case report
We report the case of a 36-year-old woman who presented with repeated typical anti-NMDAR encephalitis coexisting with unusual symptoms not consistent with anti-NMDAR encephalitis. Apart from the anti-NMDAR encephalitis, her first episode was characterized by balance disability with bilateral medial frontal cortical lesions, suggesting the involvement of the cortico-reticular projections and the basal ganglia-brainstem projections. The second episode presented with Broca's aphasia caused by involvement of the Broca's area and lower part of the precentral gyrus. The detection of MOG-Ab in both episodes suggested the coexiste...
Source: Multiple Sclerosis and Related Disorders - August 4, 2019 Category: Neurology Source Type: research

Initiation of first disease-modifying treatment for multiple sclerosis patients in the Czech Republic from 2013–2016: data from the national registry ReMuS
Conclusion: Data from the ReMuS registry highlights improvements made in the management of MS in the Czech Republic. However, a relatively low percentage of patients started treatment using second-line drugs, in contrast to trends in other countries. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 4, 2019 Category: Neurology Source Type: research

Multiple Sclerosis and Migration Revisited
Publication date: Available online 1 August 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): C.H. Hawkes, G. Giovannoni, J. Lechner-Scott, M. Levy, E. Waubant (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 2, 2019 Category: Neurology Source Type: research

Construct validity and test-retest reliability of the Swedish version of the Acceptance of Chronic Health Conditions Scale
Publication date: Available online 31 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Andreas Wallin, Mia Forslin, Sverker Johansson, Marie KierkegaardAbstractThe Acceptance of Chronic Health Conditions Scale was developed to measure acceptance in chronic health conditions like multiple sclerosis (MS) and has been translated into Swedish (The Swedish Acceptance of Chronic Health Conditions Scale). The purpose of the present study was to evaluate construct validity and test-retest reliability of the Swedish Acceptance of Chronic Health Conditions Scale in a sample of 138 people with MS. Predefined hypoth...
Source: Multiple Sclerosis and Related Disorders - August 1, 2019 Category: Neurology Source Type: research

miR-29b variants and MxA expression change during interferon beta therapy in patients with relapsing-remitting multiple sclerosis
ConclusionsOur results might provide fundamentals for the development of new markers of the biological effects of IFN-β therapy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - August 1, 2019 Category: Neurology Source Type: research

Cognitive and brain reserve in multiple sclerosis––A cross-sectional study
Publication date: October 2019Source: Multiple Sclerosis and Related Disorders, Volume 35Author(s): Parthena Ifantopoulou, Artemios K. Artemiadis, Christos Bakirtzis, Katerina Zekiou, Timotheos-Stefanos Papadopoulos, Ioannis Diakogiannis, Georgios Hadjigeorgiou, Nikolaos Grigoriadis, Anastasios OrologasAbstractBackgroundCognitive impairment (CI) is detected in 40–70% of multiple sclerosis (MS) patients, but only 33–50% of the CI variance is explained by the disease burden assessed by MRI. The cognitive reserve (CR) hypothesis has been postulated to account for this discrepancy. So far, most previous studies hav...
Source: Multiple Sclerosis and Related Disorders - August 1, 2019 Category: Neurology Source Type: research

Compared to an active control condition, in persons with multiple sclerosis two different types of exercise training improved sleep and depression, but not fatigue, paresthesia, and intolerance of uncertainty
ConclusionsBoth endurance and coordinative exercising had the potential to favorably impact on some aspects of cognitive-emotional processing, while also an active control condition appeared to have a positive impact. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 30, 2019 Category: Neurology Source Type: research

The predictive value of CSF multiple assay in Multiple Sclerosis: a single center experience
Publication date: Available online 28 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): C. De Fino, M. Lucchini, D. Lucchetti, V. Nociti, F.A. Losavio, A. Bianco, F. Colella, C. Ricciardi-Tenore, A. Sgambato, M. MirabellaAbstractBackgroundMultiple sclerosis (MS) is a chronic, immune-mediated, inflammatory, neurodegenerative disorder. Many studies are investigating the potential role of body fluid biomarkers as prognostic factors for early identification of patients presenting with clinical isolated syndrome (CIS) at high risk for conversion to MS or to recognize RRMS patients at high risk for progression....
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Depression, fatigue and disability are independently associated with Quality of Life in Patients with Multiple Sclerosis: Results of a Cross-Sectional Study
ConclusionsDepression, fatigue, family status, physical activity, and occupational status were closely associated with QoL in MS patients. Potential measures to improve QoL include assessment and treatment of depression, physical exercise, and maintaining patients employed in accordance with their physical and mental disabilities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Minimally important difference of the Fatigue Severity Scale and Modified Fatigue Impact Scale in people with Multiple Sclerosis
Conclusions: MID estimates derived from this study indicate that a difference of at least 0.45 points on the FSS or 4 points on the MFIS constitutes a clinically significant difference in fatigue. Therefore, these estimates represent a threshold value which can be used to interpret changes in the FSS and MFIS over time or in response to an intervention. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Cognitive and Brain Reserve in Multiple Sclerosis. A Cross-Sectional Study
Publication date: Available online 29 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Parthenopi Ifantopoulou, Artemios K. Artemiadis, Christos Bakirtzis, Katerina Zekiou, Timotheos-Stefanos Papadopoulos, Ioannis Diakogiannis, Georgios Hadjigeorgiou, Nikolaos Grigoriadis, Anastasios OrologasAbstractBackgroundCognitive impairment (CI) is detected in 40-70% of multiple sclerosis (MS) patients, but only 33-50% of the CI variance is explained by the disease burden assessed by MRI. The cognitive reserve (CR) hypothesis has been postulated to account for this discrepancy. So far, most previous studies have co...
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Validation of the 2015 diagnostic criteria for neuromyelitis optica spectrum disorders in a cohort of South Indian patients
Publication date: Available online 29 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Meena A Kanikannan, Praveen Kumar Arepareddy, Neeharika L Mathukumalli, Sireesha Y, Rukmini Mridula Kandadai, Afshan S Jabeen, Suryaprabha T, Rupam BorgohainAbstractBackgroundNeuromyelitis Optica spectrum disorders are one of the most common CNS demyelinating disorders as they will present with disabling recurrent demyelinating attacks. Hence, it is of paramount importance to diagnose early, and early diagnoses and intervention will prevent further relapses associated with NMOSD. New international consensus criteria ha...
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Response to: Transorbital ultrasonography in acute optic neuritis: Can it be a supportive diagnostic tool?
Publication date: Available online 27 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Aristeidis H. Katsanos, Christoph Schroeder, Georgios Tsivgoulis, Christos Krogias (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Cerebrospinal fluid neurofilament light chain predicts disease activity after the first demyelinating event suggestive of multiple sclerosis
ConclusionOur results confirm that CSF NfL is a prognostic marker in the very early phases of MS. The validation of a cut-off value of 500 pg/mL could provide clinicians with a dichotomous variable that can simplify the prognostic assessment of patients at the first demyelinating event. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Lymphocytes B population profile in a case of multiple sclerosis presenting with sudden sensorineural hearing loss caused by a demyelinating pontine lesion
Publication date: Available online 28 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Adriana Octaviana Dulamea, Gabriela Cornelia Musat, Ioana Gabriela Lupescu, Codruta Delia PopaAbstractSudden sensorineural hearing loss (SSHL) is a rare manifestation of multiple sclerosis, typically appearing in the early stages of the disease, especially in female subjects. SSHL is produced by the involvement of auditory tract, vestibulocochlear nerve and possibly cochlear structures and rarely due to a single lesion. The authors report the case of a young woman in which the onset of multiple sclerosis presented with...
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Neuropsychological Characteristics of Benign Multiple Sclerosis Patients: a Two-year Matched Cohort Study
Conclusion: The results of our study confirm that cognitive functions and mood can be affected in MS independent of disease course and disease modifying treatment. The “benign” label should be treated as only a reference to physical status and non-motor symptoms should be routinely monitored. Without receiving therapy it is an existing entity with longstanding minimal disability. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Continuous 12 min walking to music, metronomes and in silence: Auditory-motor coupling and its effects on perceived fatigue, motivation and gait in persons with multiple sclerosis
Conclusion12 min of uninterrupted walking was possible in PwMS in all conditions, while better synchronization, low perception of cognitive fatigue and high motivation occurred with music compared to other conditions. Coupling walking to music could offer novel paradigms for motor task-oriented training in PwMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Discontinuation of disease-modifying therapy for patients with relapsing-remitting multiple sclerosis: effect on clinical and MRI outcomes
ConclusionsThis study found that patients who discontinued treatment after a period of disease inactivity had a similar time to next event compared to subjects who remained on first-generation DMTs. In our cohort, we found that discontinuation after age 45 was associated with a stable disease course, while patients younger than age 45 who discontinued treatment were more likely to experience a new clinical relapse or MRI event. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 26, 2019 Category: Neurology Source Type: research

Response to Correspondence: Testing for Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) in typical MS
Publication date: Available online 24 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Marianthi Breza, Georgios Koutsis, John S. Tzartos, Georgios Velonakis, Maria Eleftheria Evangelopoulos, Dimitrios Tzanetakos, Katerina Karagiorgou, Georgia Angelopoulou, Dimitrios Kasselimis, Constantin Potagas, Maria Anagnostouli, Leonidas Stefanis, Constantinos Kilidireas (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 25, 2019 Category: Neurology Source Type: research

[11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive multiple sclerosis
Publication date: Available online 24 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Robert H.F. Carvalho, Caroline C. Real, Simone Cinini, Alexandre T. Garcez, Fabio L.S. Duran, Fabio L.N. Marques, Luiz Eugênio Mello, Geraldo Busatto Filho, Erik F.J. de Vries, Luiz R.G. de Britto, Carlos A. Buchpiguel, Daniele de Paula FariaAbstractBackgroundMultiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system. Its diagnosis is clinical, often confirmed by magnetic resonance imaging. This image modality, however, is not ideal for discrimination of demyelination in gre...
Source: Multiple Sclerosis and Related Disorders - July 25, 2019 Category: Neurology Source Type: research

Adaptation to repeated gait-slip perturbations among individuals with multiple sclerosis
This study explored whether people with multiple sclerosis can adapt to large-scale repeated gait-slips.MethodsThirteen individuals with multiple sclerosis (the mean ± standard deviation of the Patient Determined Disability Steps: 2.27 ± 1.42) were exposed unexpectedly to a block of five repeated standard slips while walking on a treadmill. The outcome (fall or recovery) for each slip, as our primary outcome measure, was determined. A battery of secondary variables, including dynamic gait stability and gait parameters, were also calculated. Both primary and secondary variables were compared across trials.Resu...
Source: Multiple Sclerosis and Related Disorders - July 25, 2019 Category: Neurology Source Type: research

A special association between Charcot-Marie-Tooth Type 1A disease and Relapsing Remitting Multiple Sclerosis
ConclusionPMP22, the target protein in CMT1A, shares partial homology with other CNS proteins. PMP22 gene might be relevant to a common pathway of the demyelinating process. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 23, 2019 Category: Neurology Source Type: research

The mediating effect of health-related hardiness on the degree of physical disability and perceived stress in Chinese female patients with neuromyelitis optica spectrum disorder
The objective of this study was to evaluate the mediating role of health-related hardiness on physical disability and perceived stress in Chinese NMOSD female patients.MethodsParticipants were 68 female patients with NMOSD treated at the Department of Neurology, Huashan Hospital, Fudan University, China, between March and September 2018. Patients were evaluated for their degree of physical disability, perceived stress, and health-related hardiness. Measures included the Expanded Disability Status Scale (EDSS), Perceived Stress Scale (PSS), and Health-related Hardiness Scale (HRHS). Pearson's correlation analyses and stepwi...
Source: Multiple Sclerosis and Related Disorders - July 23, 2019 Category: Neurology Source Type: research

Continuous 12 minute walking to music, metronomes and in silence: auditory-motor coupling and its effects on perceived fatigue, motivation and gait in persons with multiple sclerosis
Conclusion12 minutes of uninterrupted walking was possible in PwMS in all conditions, while better synchronization, low perception of cognitive fatigue and high motivation occurred with music compared to other conditions. Coupling walking to music could offer novel paradigms for motor task-oriented training in PwMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

B cell Depletion Therapy Resulting in Sustained Remission of Severe Autoimmune Complications Following Alemtuzumab Treatment of Multiple Sclerosis.
Publication date: Available online 20 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jennifer Massey, Yael Barnett, Jennifer Curnow, Ian SuttonAbstractSecondary autoimmune disorders (AID) are a recognised complication of alemtuzumab treatment for multiple sclerosis. We have previously reported two female multiple sclerosis patients treated with alemtuzumab who developed rare but severe secondary AID; acquired haemophilia A and autoimmune encephalitis with seizures. Both cases proved to be refractory to treatment with conventional immuno-therapy. However, treatment of the patients with anti-CD20 therapy...
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

AQP4-IgG-seropositive neuromyelitis optica spectrum disorder (NMOSD) coexisting with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis: A case report and literature review
ConclusionsThis case provides further evidence for the occurrence of NMOSD with AQP4-IgG-seropositive overlapping anti-NMDAR encephalitis in a Chinese patient. The mechanisms underlying the occurrence of double positive antibodies remains elusive. When NMOSD patients show unusual symptoms (abnormal behavior, prominent psychiatric manifestations, cognitive dysfunction, autonomic dysfunction), or atypical supratentorial lesions, the coexistence of anti-NMDAR encephalitis should be considered. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

Unilateral arm rehabilitation for persons with Multiple Sclerosis using Serious games in a virtual reality approach: Bilateral treatment effect?
In this study we verified the feasibility and efficacy of a serious games approach to supervised upper limb rehabilitation of the more affected arm in persons with MS and the cross-over effect to the nontreated arm.MethodsEighteen persons with moderate to severe MS symptoms participated (mean age 56.1 (range 28-73) years; mean disease duration 17.6 (4-35) years). Each participant received 12 supervised sessions of serious games (45 min, 12 sessions) aimed at improving the most affected upper limb. Primary outcomes were the Nine Hole Peg Test (9HPT) and the Box and Blocks Test (BBT). Perceived health was evaluated pre and p...
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

A unique case of multiphasic ADEM or what else?
ConclusionsTo the best of our knowledge, this is the first case of MDEM in which the two episodes of ADEM occurred 8 years apart. Although this case fulfills the diagnostic criteria for MDEM, the time elapsed between the two episodes is very long. Therefore, we cannot exclude that this disease might be a new nosological entity that could be included in the expanding range of demyelinating diseases. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research