Physician Referral Improves Adherence to the Physical Activity Guidelines for Adults with MS: A Randomized Controlled Trial
Publication date: Available online 22 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Karissa L. Canning, Audrey L. HicksAbstractBackgroundCommitment and adherence to community-based physical activity can be a challenge for clinical populations. The aim of this study was to explore the effectiveness of physician referral on adherence to the Physical Activity Guidelines (PAGs) for adults with MS.MethodsNinety-one participants with MS (age: 47.9 ± 10.4 years, EDSS score: 3.5 ± 1.8) were randomized into a direct referral to PAGs from a physician (REF) or control (CON) group (given a print ...
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Identification of Multiple Sclerosis key genetic factors through multi-staged data mining
Publication date: Available online 22 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mohammad Navaderi, Saeideh Rajaei, Samira Rahimirad, Aysan Jafari Harandi, Zahra Ghaleh, Kowsar Falahati, Zahra Behgar, Alireza Mirzaee Sedigh, Mohammad Hossein Sanati (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

An Uncommon Neurological Manifestation of Chronic Lymphocytic Leukemia: Longitudinally Extensive Transverse Myelitis
We describe a 50-year-old male patient who was admitted to the emergency department with complaints of fever and fatigue that had suddenly started two weeks ago. In the laboratory evaluation, a white blood cell count of 131.000/mm3 was detected. The patient was hospitalized and developed fecal incontinence on the first day of hospitalization. Detailed neurological examination revealed the patient had tetraparesis. Long segment high signal intensity was observed on spinal MRI. Flow cytometry examination of the CSF and biopsy findings of the bone marrow were compatible with Chronic Lymphocytic Leukemia (CLL). The patient's M...
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

CSF β-amyloid predicts early cerebellar atrophy and is associated with a poor prognosis in multiple sclerosis
Publication date: Available online 21 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Anna M. Pietroboni, Francesca Schiano di Cola, Annalisa Colombi, Tiziana Carandini, Chiara Fenoglio, Laura Ghezzi, Milena A. De Riz, Fabio Triulzi, Elio Scarpini, Alessandro Padovani, Daniela GalimbertiAbstractBackgroundNeurodegeneration is present from the earliest stages of multiple sclerosis (MS) and is critically involved in MS related clinical disability. Aim of the present study was to assess the connection between amyloid burden and early cerebellar grey matter (GM) atrophy compared to early brain GM atrophy ...
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Independent Outdoor Mobility of Persons with Multiple Sclerosis – A systematic review
Conclusions: The reduced mobility may prevent pwMS participating in society. However, few studies investigating interventions or rehabilitation options to improve mobility were found in the existing literature, highlighting an until now under recognised unmet need. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 23, 2019 Category: Neurology Source Type: research

Neuromyelitis optica spectrum disorders in Arabian Gulf (NMOAG); establishment and initial characterization of a patient registry
Publication date: Available online 19 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Eslam Shosha, Abdulla Al Asmi, Eman Nasim, Jihad Inshasi, Fatima Abdulla, Yaser Al Malik, Ahmed Althobaiti, Mohamed Alzawahmah, Hind A Alnajashi, Mohamed Binfalah, Awad AlHarbi, Ibtisam A. Thubaiti, Samar F Ahmed, Jasem Al-Hashel, Mortada Elyas, Ramachandiran Nandhagopal, Arunodaya Gujjar, Talal Al Harbi, Ghadah Al Towaijri, Isa A AlsharooqiAbstractObjectiveTo describe the clinical and radiological characteristics of neuromyelitis optica spectrum disorders (NMOSD) patients from the Arabian Gulf relative to anti-aqua...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Efficacy of tocilizumab for fulminant multiple sclerosis with a tumefactive cervical lesion: A 12-year-old boy
Publication date: Available online 19 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Hiroki Hoshino, Yoko Shirai, Hiroe Konishi, Takashi Yamamura, Norikazu ShimizuAbstractFulminant demyelinating disease including acute disseminating encephalitis, multiple sclerosis (MS) variants, and neuromyelitis optica spectrum disorder (NMOSD) are often managed with similar acute treatment such as intravenous methylprednisolone and plasma exchange. On the other hand, long-term management varies. The choice of the drug is based on several factors including the activity and severity of the disease course. Tocilizum...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Consensus Recommendations for the Diagnosis and Treatment of Multiple Sclerosis: 2019 revisions to The MENACTRIMS Guidelines
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): B. Yamout, M. Sahraian, S. Bohlega, M. Al-Jumah, R. Goueider, M. Dahdaleh, J. Inshasi, S. Hashem, I. Alsharoqi, S. Khoury, M Alkhawajah, Riyadh S. Koussa, J. Al Khaburi, A. Almahdawi, T. Alsaadi, E. Slassi, S Daodi, M. Zakaria, R. AlroughaniAbstractWith evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS, most current diagnostic and treatment algorithms need revision and updating. The diagnosis of MS relies on incorporating clinical and paraclinical findings to prove dissemination...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS): A Danish validation study of sensitivity in early stages of MS
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Lisbet Marstrand, Ole Østerberg, Trine Walsted, Amalie C. Skov, Karen I. Schreiber, Finn SellebjergAbstractBackgroundCognitive impairment is highly prevalent in multiple sclerosis (MS). Due to the lack of specialized neuropsychological resources in many MS clinics, a brief cognitive monitoring tool that can be administered by other MS clinic staff is needed. BICAMS (Brief International Cognitive As-sessment for Multiple Sclerosis) has been developed and recommended by MS experts to monitor MS-related cognitiv...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Clinical and radiological findings of facial paralysis in multiple sclerosis: a case series.
ConclusionsFP clinically classified as peripheral may be caused by central lesions in the cortex or pons and not only by peripheral facial nerve damage. In MS patients, FP may appear at the onset of the disease and be misdiagnosed as Bell ’s palsy. Clinicians should carefully approach FP diagnosis and perform a brain as well as temporal bone MRI before pursuing pharmacological treatment.Graphical Abstract (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Acute effects of whole-body vibration training on neuromuscular performance and mobility in hypoxia and normoxia in persons with Multiple Sclerosis: A crossover study
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Luis Andreu, Domingo J. Ramos-Campo, Vicente Ávila-Gandía, Tomas Freitas, Linda H. Chung, Jacobo Á. Rubio-AriasAbstractBackgroundWhole-body vibration training (WBVT) has been used in people with relapsing-remitting multiple sclerosis (pwMS), showing improvements in different neuromuscular and mobility variables. However, the acute effects of this training are still unknown. The acute effects of WBVT on neuromuscular performance, mobility and rating of perceived exertion (RPE) were evaluated in 1...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Extensive linear scleroderma en coup de sabre with exertion-induced hemiplegic migraine
We report the case of a 9-year-old girl with linear scleroderma en coup de sabre (LSCS) who developed progressive white matter involvement, presenting as intractable hemiplegic migraine-like attacks induced by exercise. After a period of severely aggressive course, clinical and radiological stabilization was achieved under immunosuppressant treatment. Intrathecal synthesis of IgG and lymphocytic pleocytosis provided indirect evidence of a chronic inflammatory process of the central nervous system. We discuss the possible immunopathogenic mechanisms responsible for the neurocutaneous involvement in LSCS, favouring the hypot...
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Characteristics and treatment of Multiple Sclerosis – related trigeminal neuralgia: an Italian multi-centre study
ConclusionMS patients with a higher disability at TN onset and with a longer interval between MS and TN onset had differing clinical features and outcomes: pain was more frequently bilateral, surgery was more frequent and anticipated, and preventive medication discontinuation due to pain remission was less common. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 20, 2019 Category: Neurology Source Type: research

Gender identity and sexual orientation affect health care satisfaction, but not utilization, in persons with Multiple Sclerosis
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R. Cutter, Robert J. Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on health care utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexual ori...
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

Dimethyl fumarate therapy reduces memory T cells and the CNS migration potential in patients with multiple sclerosis
ConclusionDMF influences the balance between proinflammatory and regulatory T cells, presumably favoring a less proinflammatory environment. DMF also reduces the CNS migratory potential of CD4+ T cells whereas CD8+ T cells are less affected. Altogether, our study suggests an anti-inflammatory effect of DMF mainly on the CD4+ T cell compartment. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

MSDo people with multiple sclerosis want to discuss their long-term prognosis? A nationwide study in Argentina
Publication date: Available online 16 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Edgar Carnero C, Pablo A. López, Juan Pablo Pettinicchi, Ricardo Alonso, Santiago Tizio, Verónica Tkachuk, Alejandro Caride, Ian GaleaAbstractBackgroundDemographics, clinical and imaging prognostic factors have been reported in large series of people with multiple sclerosis (PwMS). However, personalized long-term prognosis (LTP) is varied and uncertain in each particular case. Currently, there is limited evidence on how PwMS feel about prognosis communication and their coping strategies. Therefore, we ...
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

Silent symptoms of multiple sclerosis
Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy, Christopher Hawkes (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 18, 2019 Category: Neurology Source Type: research

Alemtuzumab-induced lung injury in multiple sclerosis: learning from adversity in three patients
ConclusionsClinicians should be aware to early recognize acute and subacute respiratory adverse events for a promptly management. In these patients re-treatment is challenging. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 17, 2019 Category: Neurology Source Type: research

Differential diagnosis of multiple sclerosis and other inflammatory CNS diseases
Publication date: Available online 15 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Paula Wildner, Mariusz Stasiołek, Mariola MatysiakAbstractMultiple sclerosis (MS) is the most common acquired demyelinating disorder of the central nervous system (CNS). Diagnosing MS can be very challenging owing to its variable clinical features and lack of specific tests. Magnetic resonance imaging (MRI) is a key measure in this process. Although white matter lesions on brain MRI are regarded as a hallmark of MS, they are a common radiological finding and their pattern may overlap in particular CNS inflammatory ...
Source: Multiple Sclerosis and Related Disorders - October 17, 2019 Category: Neurology Source Type: research

Effects of aging on finger movements in multiple sclerosis
ConclusionFinger motor performance assessment provides important hints about upper limb disability, which should be evaluated in relation to age, disease duration and EDSS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Neuromyelitis Optica Spectrum Disorder after treatment with pembrolizumab
Publication date: Available online 14 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tomoyo Shimada, Yasunobu Hoshino, Taiji Tsunemi, Anri Hattori, Emi Nakagawa, Kazumasa Yokoyama, Nobutaka HattoriAbstractWhile immune checkpoint inhibitors (ICIs) have contributed to the development of therapeutic treatments for previously incurable advanced malignancies, they may induce immune-related adverse events (irAEs) in many organs including the CNS [1]. Because immune checkpoint molecules are predominantly expressed on T cells, irAEs are largely not B cell-mediated. Here, we report a patient who was treated ...
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Optic perineuritis with anti-myelin oligodendrocyte glycoprotein antibody
Publication date: Available online 14 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): M. Yanagidaira, T. Hattori, H. Emoto, M. Kiyosawa, T. YokotaAbstractA 25-year-old male presented with blurred peripheral vision and movement pain in his right eye. Fundus examination revealed unilateral disc swelling in his right eye with normal intracranial pressure. MRI showed remarkably high intensity in the optic nerve sheath and slightly high intensity in the optic nerve, indicating optic perineuritis (OPN). Anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive in both serum and cerebrospinal flu...
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Impairments of humour comprehension in multiple sclerosis
ConclusionThese preliminary results suggest that a high proportion of relapsing-remitting multiple sclerosis patients may be impaired in humour comprehension, some as a primary deficit and others as a secondary deficit to more general comprehension difficulties. On a theoretical level, the dissociations obtained between verbal and visual material do not support an amodal humour comprehension model. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Initiation of rituximab therapy for new onset neuromyelitis optica spectrum disorder during pregnancy
ConclusionThis case demonstrated a favorable outcome in administering rituximab for NMOSD with disease onset during pregnancy. This description of therapy for disease onset during pregnancy is novel, and adds to the few existing case reports of administering rituximab during pregnancy. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 15, 2019 Category: Neurology Source Type: research

Gender Identity and Sexual Orientation Affect Healthcare Satisfaction, but not Utilization, in Persons with Multiple Sclerosis
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R Cutter, Robert J Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on healthcare-related utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexua...
Source: Multiple Sclerosis and Related Disorders - October 13, 2019 Category: Neurology Source Type: research

The effect of galanin gene polymorphism rs948854 on the severity of multiple sclerosis: a significant association with the age of onset.
Conclusion: Collectively, our data support the contribution of galanin gene polymorphism rs948854 to the mechanisms of adverse course of the disease in the late onset MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 11, 2019 Category: Neurology Source Type: research

IRAK1 polymorphisms are associated with susceptibility to neuromyelitis optica spectrum disorder
ConclusionsThis study is first to demonstrate that X-chromosome-linked IRAK1 polymorphisms are associated with the risk of NMOSD and provide novel insights into the underlying mechanisms of this disease. Further studies are needed to elucidate the function of IRAK1 variants in the pathogenesis of NMOSD and the underlying molecular mechanisms. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 11, 2019 Category: Neurology Source Type: research

Progressive sensorineural hearing loss many years preceding completion of Susac's syndrome triad: A case report
We report a 7-year-old girl who presented with chronic, progressive sensorineural hearing loss, who, years later, presented with encephalopathy and vision loss. Such prolonged period between symptoms is unusual and to our knowledge, this is the longest interval between onset of hearing loss and completion of the full triad in SuS. In addition, she had a protracted disease course, requiring multiple immune therapies for disease control. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 9, 2019 Category: Neurology Source Type: research

Skin Warts during Fingolimod Treatment in Patients with Multiple Sclerosis
Conclusions: In conclusion, we report five patients who developed skin warts during fingolimod therapy, especially HPV-related, for an overall incidence of 2.2%. Larger cohorts are needed to confirm this proposed higher susceptibility of fingolimod-treated patients to HPV infections. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 9, 2019 Category: Neurology Source Type: research

Clinical characteristics and use of disease modifying therapy in the nationwide Danish cohort of paediatric onset multiple sclerosis
Publication date: Available online 8 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Julie Laub Erdal, Tine Iskov Kopp, Morten Blinkenberg, Thor Petersen, Per Soelberg Sørensen, Melinda MagyariAbstractBackgroundSeveral disease-modifying therapies (DMT) are used in paediatric patients with multiple sclerosis (MS) despite the limited number of randomised controlled clinical trials leading to approved indication in children.ObjectivesThe aim of this study was to describe clinical characteristics of the Danish population of paediatric onset MS, and the patterns of DMT utilisation in patients who s...
Source: Multiple Sclerosis and Related Disorders - October 9, 2019 Category: Neurology Source Type: research

Spinal cord infarction in a patient with multiple sclerosis
We describe a 49 year old woman with relapsing-remitting multiple sclerosis (MS) with a suspected severe recurrent attack of myelitis that was ultimately diagnosed as a spinal cord infarction (SCI). This case of SCI in a patient with an established diagnosis of MS highlights the clinical, laboratory, and radiographic characteristics that help distinguish SCI from inflammatory myelitis due to MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 8, 2019 Category: Neurology Source Type: research

Subcortical Structural Abnormalities in Female Neuromyelitis Optica Patients with Neuropathic Pain
Publication date: Available online 5 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ting Wang, Zhiyun Lian, Xi Wu, Yazhuo Kong, Dr Hongyu Zhou, Min WeiAbstractNeuromyelitis optica (NMO) is a disease characterised by severe relapses of optic neuritis and longitudinally extensive transverse myelitis and it has a strong female predilection. Pain is one of the most typical symptom in NMO. However, few studies have been conducted to examine the neuropathic pain mechanism of NMO patients or gender-specific effects using magnetic resonance imaging technique. A total of 38 female patients with NMO, 28 with ...
Source: Multiple Sclerosis and Related Disorders - October 6, 2019 Category: Neurology Source Type: research

The Relation between Memory and Decision-Making in Multiple Sclerosis Patients
Conclusions. Taken together, our study suggests that the memory problems, frequently reported in MS patients, may reach out to higher-order cognitive functions, such as decision making skills. Supporting shared decision-making and patient autonomy within MS thus requires to take memory impairments into account and to match the information provided to the patient’s memory abilities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 6, 2019 Category: Neurology Source Type: research

A-scan ultrasonography as a supportive diagnostic tool in case of acute optic neuritis
Publication date: Available online 5 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Maddalena De Bernardo, Livio Vitiello, Nicola Rosa (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 6, 2019 Category: Neurology Source Type: research

Efficacy of different rituximab therapeutic strategies in patients with neuromyelitis optica spectrum disorders
Publication date: Available online 4 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Giovanni Novi, Francesca Bovis, Marco Capobianco, Jessica Frau, Giorgia Mataluni, Erica Curti, Luigi Zuliani, Paola Cavalla, Laura Brambilla, Pietro Annovazzi, Anna Maria Repice, Roberta Lanzillo, Sabrina Esposito, Luana Benedetti, Ilaria Maietta, Francesco Sica, Fabio Buttari, Simona Malucchi, Giuseppe Fenu, Doriana LandiAbstractObjectiveTo evaluate disease activity according to rituximab (RTX) induction and maintenance regimens in a multicenter real-life dataset of NMOSD patients.Methodsthis is an observational-ret...
Source: Multiple Sclerosis and Related Disorders - October 5, 2019 Category: Neurology Source Type: research

School performance and psychiatric morbidity 6 years after pediatric acute disseminated encephalomyelitis: A nationwide population-based cohort study
Publication date: Available online 3 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Magnus Spangsberg Boesen, Annika Langkilde, Alfred Peter Born, Melinda Magyari, Morten Blinkenberg, Tanuja Chitnis, Lau Caspar Thygesen, Frank ErikssonAbstractBackgroundAcute disseminated encephalomyelitis (ADEM) can cause cognitive impairment in children. However, long-term consequences for school performance and psychiatric morbidity have never been characterized. Our aim was to investigate long-term school performance and psychiatric morbidity after pediatric ADEM (
Source: Multiple Sclerosis and Related Disorders - October 4, 2019 Category: Neurology Source Type: research

Rituximab Associated Necrosis: A Case Report
ConclusionThe present case raises the possibility of anti-CD20 antibody contributing to the development of palatal mucosal necrosis in some patients. Given the increasing administration of rituximab as a result of its efficacy against several diseases, a report on the potential iatrogenic effects of this drug is essential. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 3, 2019 Category: Neurology Source Type: research

The Multiple Sclerosis Gut Microbiota: A Systematic Review
Conclusion: Gut microbiota diversity did not differ between MS cases and controls in the majority of studies. However, taxonomic differences were found, with consistent patterns emerging across studies. Longitudinal studies are warranted to elucidate the relationship between IMD exposure and differences in the gut microbiota composition. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 3, 2019 Category: Neurology Source Type: research

Vascular malformations masquerading as demyelinating disease
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Gabriel Lupu (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Incident cardiovascular disease in patients diagnosed with multiple sclerosis: a multi-database study
ConclusionMS patients in the UK and the US have increased risk of venous thromboembolism and peripheral vascular disease. The risk of myocardial infarction is increased among female MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Correlation between EDSS scores and cervical spinal cord atrophy at 3T MRI in multiple sclerosis: A systematic review and meta-analysis
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Xiaodong Song, Dawei Li, Zhandong Qiu, Shengyao Su, Yan Wu, Jingsi Wang, Zheng Liu, Huiqing DongAbstractBackgroundCervical spinal cord atrophy (CSCA), which partly reflects the axonal loss in the spinal cord, is increasingly recognized as a valuable predictor of disease outcome. However, inconsistent results have been reported regarding the correlation of CSCA and clinical disability in multiple sclerosis (MS). The aim of this meta-analysis was to synthesize the available data obtained from 3.0-Tesla (3T) MRI scanner...
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Fatigue scores correlate with other self-assessment data, but not with clinical and biomarker parameters, in CIS and RRMS
ConclusionsIn this cohort of patients with newly diagnosed CIS and RRMS, fatigue scores were associated with mood, disease impact on daily life and quality of life as well as with alterations of attentive functions. Study results indicate that subjective fatigue scores are not well reflected by some commonly used and objectively measurable disease parameters like EDSS, T2 lesions and NFL levels. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

Grassroot efforts towards diversity in MS care and research: win-win for patients and science
Publication date: Available online 2 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Emmanuelle Waubant, Michael Levy, Jeannette Lechner-Scott, Gavin Giovannoni, Christopher Hawkes (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 2, 2019 Category: Neurology Source Type: research

TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis
Publication date: Available online 30 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Panagiotis Ntellas, Efthimios Dardiotis, Eirini Sevdali, Vasileios Siokas, Athina-Maria Aloizou, Gerasimina Tsinti, Anastasios E. Germenis, Georgios M Hadjigeorgiou, Hermann Eibel, Matthaios SpeletasABSTRACTRecent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently been analyzed in MS patients. BAFF mediates its function through binding to three receptors; ...
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Psoriasis in family members of patients with multiple sclerosis
ConclusionFamily members of those with MS may be at greater risk of developing psoriasis. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Commentary re: Multiple sclerosis and psychosis: A case report. Cheema J, Huyh AC, Prat SS. 2019 Jun 3;34:158–161
Publication date: November 2019Source: Multiple Sclerosis and Related Disorders, Volume 36Author(s): Rosalie Greenberg (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - October 1, 2019 Category: Neurology Source Type: research

Clinical observation during alemtuzumab administration
Publication date: Available online 25 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Christopher M Allen, Jenny J Feng, Mark D Willis, Marisa McGinley, Daniel Ontaneda, Emma C Tallantyre, Nikos Evangelou (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 29, 2019 Category: Neurology Source Type: research

Evaluating the Efficacy and Safety of ZytuxTM (Rituximab, AryoGen Pharmed) in Iranian Multiple Sclerosis Patients: An observational Study
Conclusion: The observed results revealed that the ZytuxTM could have a positive and significant effect on all types of MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Long-term outcome and prognosis in patients with neuromyelitis optica spectrum disorder from serbia
ConclusionOur results support the benefits of early diagnosis and treatment of NMOSD, especially in persons with severe optic and spinal disability at onset. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research

Transient MOG antibody seroconversion associated with immunomodulating therapy
We present the case of a 35-year-old patient who was seronegative for MOG-IgG (as confirmed by means of three independent immunoassays) during two corticosteroid-responsive attacks of brainstem encephalitis and optic neuritis, respectively, but turned positive for MOG-IgG under treatment with interferon-beta (IFN-beta), which was commenced 6 months after onset of the first attack. MOG-IgG serum levels declined after therapy was switched to glatiramer acetate. The fact that seroconversion was first observed under treatment with IFN-beta is in accordance with previous evidence suggesting a role of IFN-beta in disease exacerb...
Source: Multiple Sclerosis and Related Disorders - September 28, 2019 Category: Neurology Source Type: research