Compared to an active control condition, in persons with multiple sclerosis two different types of exercise training improved sleep and depression, but not fatigue, paresthesia, and intolerance of uncertainty
ConclusionsBoth endurance and coordinative exercising had the potential to favorably impact on some aspects of cognitive-emotional processing, while also an active control condition appeared to have a positive impact. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 30, 2019 Category: Neurology Source Type: research

The predictive value of CSF multiple assay in Multiple Sclerosis: a single center experience
Publication date: Available online 28 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): C. De Fino, M. Lucchini, D. Lucchetti, V. Nociti, F.A. Losavio, A. Bianco, F. Colella, C. Ricciardi-Tenore, A. Sgambato, M. MirabellaAbstractBackgroundMultiple sclerosis (MS) is a chronic, immune-mediated, inflammatory, neurodegenerative disorder. Many studies are investigating the potential role of body fluid biomarkers as prognostic factors for early identification of patients presenting with clinical isolated syndrome (CIS) at high risk for conversion to MS or to recognize RRMS patients at high risk for progression....
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Depression, fatigue and disability are independently associated with Quality of Life in Patients with Multiple Sclerosis: Results of a Cross-Sectional Study
ConclusionsDepression, fatigue, family status, physical activity, and occupational status were closely associated with QoL in MS patients. Potential measures to improve QoL include assessment and treatment of depression, physical exercise, and maintaining patients employed in accordance with their physical and mental disabilities. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Minimally important difference of the Fatigue Severity Scale and Modified Fatigue Impact Scale in people with Multiple Sclerosis
Conclusions: MID estimates derived from this study indicate that a difference of at least 0.45 points on the FSS or 4 points on the MFIS constitutes a clinically significant difference in fatigue. Therefore, these estimates represent a threshold value which can be used to interpret changes in the FSS and MFIS over time or in response to an intervention. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Cognitive and Brain Reserve in Multiple Sclerosis. A Cross-Sectional Study
Publication date: Available online 29 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Parthenopi Ifantopoulou, Artemios K. Artemiadis, Christos Bakirtzis, Katerina Zekiou, Timotheos-Stefanos Papadopoulos, Ioannis Diakogiannis, Georgios Hadjigeorgiou, Nikolaos Grigoriadis, Anastasios OrologasAbstractBackgroundCognitive impairment (CI) is detected in 40-70% of multiple sclerosis (MS) patients, but only 33-50% of the CI variance is explained by the disease burden assessed by MRI. The cognitive reserve (CR) hypothesis has been postulated to account for this discrepancy. So far, most previous studies have co...
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Validation of the 2015 diagnostic criteria for neuromyelitis optica spectrum disorders in a cohort of South Indian patients
Publication date: Available online 29 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Meena A Kanikannan, Praveen Kumar Arepareddy, Neeharika L Mathukumalli, Sireesha Y, Rukmini Mridula Kandadai, Afshan S Jabeen, Suryaprabha T, Rupam BorgohainAbstractBackgroundNeuromyelitis Optica spectrum disorders are one of the most common CNS demyelinating disorders as they will present with disabling recurrent demyelinating attacks. Hence, it is of paramount importance to diagnose early, and early diagnoses and intervention will prevent further relapses associated with NMOSD. New international consensus criteria ha...
Source: Multiple Sclerosis and Related Disorders - July 29, 2019 Category: Neurology Source Type: research

Response to: Transorbital ultrasonography in acute optic neuritis: Can it be a supportive diagnostic tool?
Publication date: Available online 27 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Aristeidis H. Katsanos, Christoph Schroeder, Georgios Tsivgoulis, Christos Krogias (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Cerebrospinal fluid neurofilament light chain predicts disease activity after the first demyelinating event suggestive of multiple sclerosis
ConclusionOur results confirm that CSF NfL is a prognostic marker in the very early phases of MS. The validation of a cut-off value of 500 pg/mL could provide clinicians with a dichotomous variable that can simplify the prognostic assessment of patients at the first demyelinating event. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Lymphocytes B population profile in a case of multiple sclerosis presenting with sudden sensorineural hearing loss caused by a demyelinating pontine lesion
Publication date: Available online 28 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Adriana Octaviana Dulamea, Gabriela Cornelia Musat, Ioana Gabriela Lupescu, Codruta Delia PopaAbstractSudden sensorineural hearing loss (SSHL) is a rare manifestation of multiple sclerosis, typically appearing in the early stages of the disease, especially in female subjects. SSHL is produced by the involvement of auditory tract, vestibulocochlear nerve and possibly cochlear structures and rarely due to a single lesion. The authors report the case of a young woman in which the onset of multiple sclerosis presented with...
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Neuropsychological Characteristics of Benign Multiple Sclerosis Patients: a Two-year Matched Cohort Study
Conclusion: The results of our study confirm that cognitive functions and mood can be affected in MS independent of disease course and disease modifying treatment. The “benign” label should be treated as only a reference to physical status and non-motor symptoms should be routinely monitored. Without receiving therapy it is an existing entity with longstanding minimal disability. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Continuous 12 min walking to music, metronomes and in silence: Auditory-motor coupling and its effects on perceived fatigue, motivation and gait in persons with multiple sclerosis
Conclusion12 min of uninterrupted walking was possible in PwMS in all conditions, while better synchronization, low perception of cognitive fatigue and high motivation occurred with music compared to other conditions. Coupling walking to music could offer novel paradigms for motor task-oriented training in PwMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 28, 2019 Category: Neurology Source Type: research

Discontinuation of disease-modifying therapy for patients with relapsing-remitting multiple sclerosis: effect on clinical and MRI outcomes
ConclusionsThis study found that patients who discontinued treatment after a period of disease inactivity had a similar time to next event compared to subjects who remained on first-generation DMTs. In our cohort, we found that discontinuation after age 45 was associated with a stable disease course, while patients younger than age 45 who discontinued treatment were more likely to experience a new clinical relapse or MRI event. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 26, 2019 Category: Neurology Source Type: research

Response to Correspondence: Testing for Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) in typical MS
Publication date: Available online 24 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Marianthi Breza, Georgios Koutsis, John S. Tzartos, Georgios Velonakis, Maria Eleftheria Evangelopoulos, Dimitrios Tzanetakos, Katerina Karagiorgou, Georgia Angelopoulou, Dimitrios Kasselimis, Constantin Potagas, Maria Anagnostouli, Leonidas Stefanis, Constantinos Kilidireas (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 25, 2019 Category: Neurology Source Type: research

[11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive multiple sclerosis
Publication date: Available online 24 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Robert H.F. Carvalho, Caroline C. Real, Simone Cinini, Alexandre T. Garcez, Fabio L.S. Duran, Fabio L.N. Marques, Luiz Eugênio Mello, Geraldo Busatto Filho, Erik F.J. de Vries, Luiz R.G. de Britto, Carlos A. Buchpiguel, Daniele de Paula FariaAbstractBackgroundMultiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system. Its diagnosis is clinical, often confirmed by magnetic resonance imaging. This image modality, however, is not ideal for discrimination of demyelination in gre...
Source: Multiple Sclerosis and Related Disorders - July 25, 2019 Category: Neurology Source Type: research

Adaptation to repeated gait-slip perturbations among individuals with multiple sclerosis
This study explored whether people with multiple sclerosis can adapt to large-scale repeated gait-slips.MethodsThirteen individuals with multiple sclerosis (the mean ± standard deviation of the Patient Determined Disability Steps: 2.27 ± 1.42) were exposed unexpectedly to a block of five repeated standard slips while walking on a treadmill. The outcome (fall or recovery) for each slip, as our primary outcome measure, was determined. A battery of secondary variables, including dynamic gait stability and gait parameters, were also calculated. Both primary and secondary variables were compared across trials.Resu...
Source: Multiple Sclerosis and Related Disorders - July 25, 2019 Category: Neurology Source Type: research

A special association between Charcot-Marie-Tooth Type 1A disease and Relapsing Remitting Multiple Sclerosis
ConclusionPMP22, the target protein in CMT1A, shares partial homology with other CNS proteins. PMP22 gene might be relevant to a common pathway of the demyelinating process. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 23, 2019 Category: Neurology Source Type: research

The mediating effect of health-related hardiness on the degree of physical disability and perceived stress in Chinese female patients with neuromyelitis optica spectrum disorder
The objective of this study was to evaluate the mediating role of health-related hardiness on physical disability and perceived stress in Chinese NMOSD female patients.MethodsParticipants were 68 female patients with NMOSD treated at the Department of Neurology, Huashan Hospital, Fudan University, China, between March and September 2018. Patients were evaluated for their degree of physical disability, perceived stress, and health-related hardiness. Measures included the Expanded Disability Status Scale (EDSS), Perceived Stress Scale (PSS), and Health-related Hardiness Scale (HRHS). Pearson's correlation analyses and stepwi...
Source: Multiple Sclerosis and Related Disorders - July 23, 2019 Category: Neurology Source Type: research

Continuous 12 minute walking to music, metronomes and in silence: auditory-motor coupling and its effects on perceived fatigue, motivation and gait in persons with multiple sclerosis
Conclusion12 minutes of uninterrupted walking was possible in PwMS in all conditions, while better synchronization, low perception of cognitive fatigue and high motivation occurred with music compared to other conditions. Coupling walking to music could offer novel paradigms for motor task-oriented training in PwMS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

B cell Depletion Therapy Resulting in Sustained Remission of Severe Autoimmune Complications Following Alemtuzumab Treatment of Multiple Sclerosis.
Publication date: Available online 20 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jennifer Massey, Yael Barnett, Jennifer Curnow, Ian SuttonAbstractSecondary autoimmune disorders (AID) are a recognised complication of alemtuzumab treatment for multiple sclerosis. We have previously reported two female multiple sclerosis patients treated with alemtuzumab who developed rare but severe secondary AID; acquired haemophilia A and autoimmune encephalitis with seizures. Both cases proved to be refractory to treatment with conventional immuno-therapy. However, treatment of the patients with anti-CD20 therapy...
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

AQP4-IgG-seropositive neuromyelitis optica spectrum disorder (NMOSD) coexisting with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis: A case report and literature review
ConclusionsThis case provides further evidence for the occurrence of NMOSD with AQP4-IgG-seropositive overlapping anti-NMDAR encephalitis in a Chinese patient. The mechanisms underlying the occurrence of double positive antibodies remains elusive. When NMOSD patients show unusual symptoms (abnormal behavior, prominent psychiatric manifestations, cognitive dysfunction, autonomic dysfunction), or atypical supratentorial lesions, the coexistence of anti-NMDAR encephalitis should be considered. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

Unilateral arm rehabilitation for persons with Multiple Sclerosis using Serious games in a virtual reality approach: Bilateral treatment effect?
In this study we verified the feasibility and efficacy of a serious games approach to supervised upper limb rehabilitation of the more affected arm in persons with MS and the cross-over effect to the nontreated arm.MethodsEighteen persons with moderate to severe MS symptoms participated (mean age 56.1 (range 28-73) years; mean disease duration 17.6 (4-35) years). Each participant received 12 supervised sessions of serious games (45 min, 12 sessions) aimed at improving the most affected upper limb. Primary outcomes were the Nine Hole Peg Test (9HPT) and the Box and Blocks Test (BBT). Perceived health was evaluated pre and p...
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

A unique case of multiphasic ADEM or what else?
ConclusionsTo the best of our knowledge, this is the first case of MDEM in which the two episodes of ADEM occurred 8 years apart. Although this case fulfills the diagnostic criteria for MDEM, the time elapsed between the two episodes is very long. Therefore, we cannot exclude that this disease might be a new nosological entity that could be included in the expanding range of demyelinating diseases. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

Early switch to fingolimod reduces rates of severe relapses over the long term: Post hoc analysis from the FREEDOMS, FREEDOMS II, and TRANSFORMS studies
The objective of this study was to report the effect of fingolimod on relapse severity and associated healthcare utilization in patients with RRMS.Methods: This is a post hoc descriptive analysis of data from the pooled placebo-controlled FREEDOMS/FREEDOMS II studies and from the active-comparator TRANSFORMS study. Patients were analyzed under 2 groups: those initially randomized to receive fingolimod0.5 mg and who continued fingolimod throughout the core and extension study (continuous group), and those who initially received placebo or IFN β-1a during the core phase and switched to fingolimod during the extension ph...
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

Investigation of Tumefactive Demyelination is Associated with Higher Economic Burden and More Adverse Events Compared with Conventional Multiple Sclerosis
Publication date: Available online 20 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Dr. Matthew SilsbyAbstractBackgroundTumefactive demyelinating lesions occur as part of the spectrum of multiple sclerosis (MS), but can be difficult to distinguish from other large cerebral lesions such as neoplasm or abscess.ObjectivesTo estimate the cost associated with diagnostic investigation of patients with tumefactive demyelination (TD), including associated morbidity, and compare this to more typical relapsing-remitting MS.MethodsRetrospective review of medical records of patients seen between 2013 and 2018 in ...
Source: Multiple Sclerosis and Related Disorders - July 22, 2019 Category: Neurology Source Type: research

Observational Designs in Clinical Multiple Sclerosis Research: Particulars, Practices and Potentialities
Publication date: Available online 20 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Peter Joseph JongenAbstractObservational studies investigate a wide range of topics in multiple sclerosis research. This paper presents an overview of the various observational designs and their applications in clinical studies. Observational studies are well suited for making discoveries and assessing new explanations of phenomena, but less so for establishing causal relationships, due to confounding by indication (selection bias), co-morbidity, socio-economic or other factors. Whether observational findings are demon...
Source: Multiple Sclerosis and Related Disorders - July 20, 2019 Category: Neurology Source Type: research

Accessing Palliative Care for Multiple Sclerosis: A Qualitative Study of a Neglected Neurological Disease
Conclusions: MS patients in Malaysia face several barriers in accessing palliative care. Overcoming these barriers will require improving the shared understanding of palliative care and its role in MS. The existing care pathway also needs to be reformed to ensure that it improves access to palliative care for MS patients. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2019 Category: Neurology Source Type: research

TREM2 R47H (rs75932628) variant is unlikely to contribute to Multiple Sclerosis susceptibility and severity in a large Greek MS cohort.
ConclusionThis variant does not seem to play a determining role in the pathogenesis of MS, although further studies examining the presence of TREM2 mutations in other, phylogenetically different populations and the epigenetic regulation of this gene are needed in order to thoroughly investigate its role in MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 20, 2019 Category: Neurology Source Type: research

Testing for Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) in typical MS
Publication date: October 2019Source: Multiple Sclerosis and Related Disorders, Volume 35Author(s): Sebastian Lopez-Chiriboga, Sean J. Pittock, Brian G. Weinshenker, John J. Chen, Eoin Flanagan (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2019 Category: Neurology Source Type: research

A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children
ConclusionsPLEX is an overall well-tolerated second-line treatment option for pediatric patients with severe acute CNS demyelinating events with limited response to PS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2019 Category: Neurology Source Type: research

Patients’ Preferences and Willingness-to-Pay for Disease-Modifying Therapies
ConclusionsPatients with MS considered relapse rate, disability progression, severe adverse events, route of administration, frequency of administration, and out-of-pocket cost, when they chose DMTs. Their WTPs for DMTs varied widely. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 10, 2019 Category: Neurology Source Type: research

Editorial on: Eculizumab in aquaporin-4-positive neuromyelitis optica spectrum disorder
Publication date: Available online 2 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Santiago Pardo, Gavin Giovannoni, Christopher Hawkes, Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2019 Category: Neurology Source Type: research

Physical Activity and Walking Performance across the Lifespan among Adults with Multiple Sclerosis
Conclusion: Interventions targeting MVPA may be an appropriate approach for managing walking impairment, particularly in older adults with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 5, 2019 Category: Neurology Source Type: research

Higher health care use before a clinically isolated syndrome with or without subsequent MS
ConclusionHealth care use was higher in individuals with a CIS than without a CIS in the five years before an incident demyelinating event, regardless of whether they were subsequently diagnosed with MS. This suggests that there is a prodromal period before CIS which is not unique to MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 4, 2019 Category: Neurology Source Type: research

The prevalence and utility of screening for urinary tract infection at the time of presumed multiple sclerosis relapse
ConclusionUTIs at the time of a suspected MS relapse are relatively uncommon. Female sex is a strong risk factor for UTI in people with MS; foul-smelling urine is a potential predictor of UTI in people with MS. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 2, 2019 Category: Neurology Source Type: research

Editorial on: Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder
Publication date: Available online 2 July 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Santiago Pardo, Gavin Giovannoni, Christopher Hawkes, Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 2, 2019 Category: Neurology Source Type: research

Pulmonary embolism during the third cycle of alemtuzumab in a patient with relapsing multiple sclerosis
Publication date: Available online 29 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mario Habek, Berislav Ruška, Tin Pavičić, Ana Marija Alduk, Tereza Gabelić, Ivan AdamecAbstractAlemtuzumab is one of immunomodulatory drugs used for treatment of multiple sclerosis (MS). Although it is very effective it carries significant risk for various side effects. This paper reports a case of young patient who developed pulmonary embolism during the third cycle of alemtuzumab. It is suggested that awareness about possible vascular toxicity of this drug should be raised. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 1, 2019 Category: Neurology Source Type: research

Laboratory testing for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders (MOGAD)
Publication date: Available online 29 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Sebastian Lopez-Chiriboga, Sean J. Pittock, Brian G. Weinshenker, John J. Chen, Eoin Flanagan (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - July 1, 2019 Category: Neurology Source Type: research

Three-week inpatient energy management education (IEME) for persons with multiple sclerosis-related fatigue: feasibility of a randomized clinical trial.
Publication date: Available online 29 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ruth Hersche, Andrea Weise, Gisela Michel, Jürg Kesselring, Sara Della Bella, Marco Barbero, Jan KoolAbstractBackground: Multiple sclerosis (MS)-related fatigue limits participation in everyday activities and has a considerable impact on quality of life (QoL), thereby affecting productivity and employment. Outpatient education interventions involving energy conservation strategies and cognitive behavioral therapy techniques are helpful. However, no inpatient program is currently available. The inpatient energy man...
Source: Multiple Sclerosis and Related Disorders - July 1, 2019 Category: Neurology Source Type: research

Safety outcomes of disease-modifying therapies for relapsing–remitting multiple sclerosis: a network meta-analysis
ConclusionSafety outcomes are poorly reported in primary studies of DMTs in RRMS, precluding the conduction of robust meta-analyses. Therefore, the current available data on safety of these drugs is not contributing to regulatory and clinical decision making, with adverse event reports underbalanced compared to efficacy outcomes. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

The clinical value of complement proteins in differentiating AQP4-IgG-positive from MOG-IgG-positive neuromyelitis optica spectrum disorders
ConclusionThe combination of C3 and C4 could assist in the differential diagnosis of AQP4-IgG-positive NMOSD from MOG-IgG-positive NMOSD. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: a case report
We report a patient with neuromyelitis optica spectrum disorders (NMOSD) with anti-aquaporin 4 (AQP4) antibodies, who developed intractable axonal neuropathy presenting with multifocal peripheral nerve swelling by magnetic resonance (MR) neurography. A 52-year-old woman with a 12-year history of polymyositis and rheumatoid arthritis had been treated with prednisolone, tacrolimus, and abatacept (CTLA-4-Ig). She developed progressive numbness and tingling sensations in the distal parts of all limbs at the age of 50 years, followed by weakness of both upper limbs 6 months later. Neurological examination revealed severe muscle...
Source: Multiple Sclerosis and Related Disorders - June 29, 2019 Category: Neurology Source Type: research

Co-occurrence of Multiple Sclerosis and Myasthenia Gravis: A case report and review of immunological theories
Publication date: Available online 26 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Sara Dehbashi, Diaa Hamouda, Elena ShaninaAbstractAutoimmune mechanisms are implicated in both Myasthenia Gravis (MG) and Multiple Sclerosis (MS), and hypothesis of a common immunological mechanism of pathogenesis is supported by the fact that this rare combination of the two diseases occurs more frequently than expected by random association. Although MS is primarily mediated by T lymphocytes and MG primarily involves the destruction of the neuromuscular junction by antibodies, there are evidences that support both ce...
Source: Multiple Sclerosis and Related Disorders - June 28, 2019 Category: Neurology Source Type: research

Pediatric Acquired Demyelinating Syndrome (ADS) in Inpatient Hospital Settings: the hospitalization rate, costs, and outcomes in the US.
ConclusionHospital utilization by pediatric patients with ADS increased during the period 2003 through 2012. The cross-sectional analysis for the year 2016 indicated that the trend could be ongoing, although the direct comparison was not feasible due to the changes in the coding system of the dataset from ICD9-CM to ICD10-CM. Although relatively rare, pediatric ADS warrant long-term follow-ups and hospitalizations, impacting the developmental trajectory of the affected children and the lives of their family members. Th potentially increasing trend of pediatric ADS hospital utilization should be acknowledged when allocating...
Source: Multiple Sclerosis and Related Disorders - June 28, 2019 Category: Neurology Source Type: research

Plasma Cell And B Cell-Targeted Treatments For Use In Advanced Multiple Sclerosis
Publication date: Available online 26 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): David Baker, Benjamin M. Jacobs, Sharmilee Gnanapavan, Klaus Schmierer, Gavin GiovannoniABSTRACTThere is increasing evidence that agents that target peripheral B cells and in some instances plasma cells can exhibit marked effects on relapsing multiple sclerosis. In addition, B cells, including plasma cells, within the central nervous system compartment are likely to play an important role in disease progression in both relapsing and progressive MS. However, current B cell-targeting antibodies may not inhibit these, bec...
Source: Multiple Sclerosis and Related Disorders - June 26, 2019 Category: Neurology Source Type: research

Fulminant and fatal onset of pan-aquaporinopathy
We report the case of a first devastating NMOSD attack leading to death despite optimal treatment. While receiving steroids during a bilateral blinding optic neuritis, this female patient suffered a severe attack involving the spinal cord and circumventricular organs (CVOs), including the pineal gland. Early adjunctive daily PE failed to prevent sudden death. AQP4-antibodies were strongly positive.To our knowledge, this is the first case of exceptionally severe monophasic NMOSD leading to full-blown lesions in all AQP4-expressing sites. Lesions of the periventricular ependyma and CVOs are highly exceptional and the involve...
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Differences in age of diagnosis in familial multiple sclerosis
Publication date: September 2019Source: Multiple Sclerosis and Related Disorders, Volume 34Author(s): Vanesa Pytel, Jordi A. Matias-Guiu, Laura Torre-Fuentes, Paloma Montero-Escribano, Jorge Matias-Guiu (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Descriptive Analysis of Free-Text Comments on Healthcare Priorities and Experiences in a National Sample of People with Multiple Sclerosis
Conclusion: PwMS prioritize accessibility, affordability, insurance coverage, and comprehensiveness in MS healthcare services. (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Response Heterogeneity to Home-Based Restorative Cognitive Rehabilitation in Multiple Sclerosis: An Exploratory Study
Publication date: Available online 22 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tom A. Fuchs, Stefano Ziccardi, Michael G. Dwyer, Leigh E. Charvet, Alexander Bartnik, Rebecca Campbell, Jose Escobar, David Hojnacki, Chana Kolb, Devon Oship, Jeta Pol, Michael T. Shaw, Curtis Wojcik, Faizan Yasin, Bianca Weinstock-Guttman, Robert Zivadinov, Ralph H.B. BenedictAbstractBackgroundGrowing evidence supports the efficacy of restorative cognitive training in people with multiple sclerosis (PwMS), but the effects vary across individuals. Differences in treatment efficacy may be related to baseline individual...
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Concurrent aquaporin-4-positive NMOSD and neurosyphilis: a case report
In this report we describe a rare case of concurrent AQP4-positive NMOSD and neurosyphilis. A 60-year-old man was admitted to our hospital with a complaint of progressive weakness in his legs for one month. T2-weighted magnetic resonance images of the spinal cord showed longitudinal extensive lesions at C7–T7. The rapid plasma reagin test and T. pallidum particle agglutination assay performed using patient serum and cerebrospinal fluid (CSF) were positive. Additionally, the AQP4-immunoglobulin (Ig) G was detected in the serum and CSF. The patient's symptom gradually improved after penicillin and methylprednisolo...
Source: Multiple Sclerosis and Related Disorders - June 25, 2019 Category: Neurology Source Type: research

Reply to Letter to the Editor
Publication date: Available online 20 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Kassandra L. Munger, Hilda Dejong, Feng Zhu, Helen Tremlett, Alberto Ascherio (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - June 22, 2019 Category: Neurology Source Type: research