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Agreement between chest ultrasonography and chest X-ray in patients who have undergone thoracic surgery: preliminary results
ConclusionAnalysis of agreement between chest X-ray and chest US showed that ultrasonography is able to detect important findings for surgeons. Limitations and advantages have been found for both chest X-ray and chest US. Knowing the limits of each one is important to really justify and optimize the use of ionizing radiations. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - March 3, 2019 Category: Respiratory Medicine Source Type: research

Obstructive sleep apnea and comorbidities: a dangerous liaison
AbstractObstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported. A high comorbidity burden worsens prognosis, but some data suggest that CPAP might be protective especially in patients with comorbidities. Aim of this narrative review is to provide an update on recent studies, with special attention to cardiovascular and cerebrovascular comorbidities, the metabolic syndrome and type 2 diabetes, asthma, COPD and ...
Source: Multidisciplinary Respiratory Medicine - February 14, 2019 Category: Respiratory Medicine Source Type: research

Idiopathic pulmonary fibrosis: prognostic impact of histologic honeycombing in transbronchial lung cryobiopsy
ConclusionsThe same pathologic criteria that have been used to define the UIP pattern in surgical biopsies (with honeycombing changes considered as non-mandatory for the definition of the pattern itself) can be applied to cryobiopsy samples, as the presence of these changes do not define different clinical or radiological phenotypes of patients with IPF. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 8, 2019 Category: Respiratory Medicine Source Type: research

The Proceedings of the 16th Italian Convention of Investigators in Cystic Fibrosis
(Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 6, 2019 Category: Respiratory Medicine Source Type: research

Predictive factors for exacerbation and re-exacerbation in chronic obstructive pulmonary disease: an extension of the Cox model to analyze data from the Swiss COPD cohort
ConclusionOur data confirmed well-established risk factors for exacerbations whilst analyzing their predictive association with exacerbation and re-exacerbation. This study confirmed the importance of spirometry in primary care, not only for diagnosis but also as a risk evaluation for possible future exacerbations.Trial registrationOur study got approval by local ethical committee in 2006 (EK Nr. 170/06) and was registered retrospectively on ClinicalTrials.gov (NCT02065921, 19th of February 2014). (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 5, 2019 Category: Respiratory Medicine Source Type: research

Comparison of different conditions for DNA extraction in sputum - a pilot study
ConclusionsNone of the conditions emerged to be superior to the others even if enzyme-based kits seem to be needed in order to have a higher extraction yield. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - January 31, 2019 Category: Respiratory Medicine Source Type: research

Efficacy of new intermittent abdominal pressure ventilator for post-ischemic cervical myelopathy ventilatory insufficiency
AbstractNon-invasive ventilation (NIV) is the treatment of choice for patients symptomatic for respiratory muscle dysfunction. It can normalize gas exchange and provide up to continuous non-invasive ventilator support (CNVS) as an alternative to intubation and tracheotomy. It is usually provided via non-invasive facial interfaces or mouthpieces, but these can be uncomfortable and uncosmetic. The intermittent abdominal pressure ventilator (IAPV) has been used for diurnal ventilatory support since 1938 but has been off the market since about 1990. Now, however, with greater emphasis on non-invasive management, a new IAPV is ...
Source: Multidisciplinary Respiratory Medicine - January 28, 2019 Category: Respiratory Medicine Source Type: research

Indoor bacterial load and its correlation to physical indoor air quality parameters in public primary schools
ConclusionsHigh bacterial load was found in public primary schools in the Gondar city as compared to different indoor air biological standards. Temperature, relative humidity and particulate matter concentration (PM2.5 and PM10) were associated with the indoor bacterial load.Staphylococcus aureus, Coagulase-negative Staphylococcus species andBacillus species were among isolated bacterial species. Attention should be given to control those physical factors which favour the growth and multiplication of bacteria in the indoor environment of classrooms to safeguard the health of students and teachers in school. (Source: Multid...
Source: Multidisciplinary Respiratory Medicine - January 22, 2019 Category: Respiratory Medicine Source Type: research

Ultrasound evaluation of diaphragmatic mobility in patients with idiopathic lung fibrosis: a pilot study
ConclusionsDiaphragmatic mobility is lower in IPF patients than in healthy controls, especially during deep inspiration. The correlation between reduced FVC and diaphragmatic excursion values in IPF patients can be of interest, since it could represent an index of functional respiratory function performed by a non-invasive, low-cost, simple and reliable imaging technique, such as LUS. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - December 14, 2018 Category: Respiratory Medicine Source Type: research

Utility of the six-minute walk test in patients with idiopathic pulmonary fibrosis
AbstractThe six-minute walk test (6MWT) is a simple test that is widely used to assess functional exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Patients with IPF have reduced exercise capacity due to a number of factors, such as impaired respiratory mechanics and circulatory problems. As a self-paced and usually submaximal exercise test, the 6MWT reflects the exercise level of everyday activities. Variables measured during the 6MWT, such as six-minute walk distance (6MWD) and desaturation, are strong predictors of mortality in patients with IPF. However, the results of a 6MWT are affected by numer...
Source: Multidisciplinary Respiratory Medicine - December 13, 2018 Category: Respiratory Medicine Source Type: research

From CPAP to tailored therapy for obstructive sleep Apnoea
AbstractObstructive Sleep Apnoea (OSA) is a common sleep disorder that is associated with daytime symptoms and a range of comorbidity and mortality. Continuous Positive Airway Pressure (CPAP) therapy is highly efficacious at preventing OSA when in use and has long been the standard treatment for newly diagnosed patients. However, CPAP therapy has well recognised limitations in real world effectiveness due to issues with patient acceptance and suboptimal usage. There is a clear need to enhance OSA treatment strategies and options. Although there are a range of alternative treatments (e.g. weight loss, oral appliances, posit...
Source: Multidisciplinary Respiratory Medicine - December 3, 2018 Category: Respiratory Medicine Source Type: research

OSAS: its burden increases, not enough the awareness
(Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - December 3, 2018 Category: Respiratory Medicine Source Type: research

Assessment of survival in patients with idiopathic pulmonary fibrosis using quantitative HRCT indexes
ConclusionsCT-histogram derived indexes may provide an accurate estimation of survival in IPF patients. They demonstrate a correlation with PFTs, highlighting their possible use in clinical practice. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - December 1, 2018 Category: Respiratory Medicine Source Type: research

Implementing TB control in a rural, resource-limited setting: the stop-TB Italia project in Senegal
ConclusionThe implementation of diagnostic procedures, if integrated in a socio-economical intervention, impacts favourably on TB retention in care and treatment outcomes. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - November 9, 2018 Category: Respiratory Medicine Source Type: research

Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults
AbstractFifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (Streptococcus pneumoniae,Streptococcus pyogenes,Haemophilus influenzae andMoraxella catarrhalis). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of theftsI gene amongH. influenzae isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed. Based on published data, an overall analysis is pe...
Source: Multidisciplinary Respiratory Medicine - November 2, 2018 Category: Respiratory Medicine Source Type: research