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Ultra ‐high‐frequency deep brain stimulation at 10,000 Hz improves motor function
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Irene E. Harmsen, Darrin J. Lee, Robert F. Dallapiazza, Philippe De Vloo, Robert Chen, Alfonso Fasano, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano Tags: Letters: New Observations Source Type: research

Parkinsonism due to A53E α‐synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features
Conclusions: A53E as a cause of parkinsonism is not restricted to Finnish individuals. DNA methylation may contribute to disease age at onset. A53E enriches α‐synuclein oligomers and fibrils dependent on the phosphorylation state. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Marina Picillo, Karlo J. Lizarraga, Erik L. Friesen, Hien Chau, Ming Zhang, Christine Sato, Grace Rooke, Renato P. Munhoz, Ekaterina Rogaeva, Paul E. Fraser, Suneil K. Kalia, Lorraine V. Kalia Tags: Brief Report Source Type: research

Prodromal features of Parkinson's disease: Self ‐reported symptoms versus clinically assessed signs
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Anja Friederich, Aminah Flinspach, Ulrike Suenkel, Gerhard W. Eschweiler, Katharina Greulich, the TREND study team, Walter Maetzler, Daniela Berg, Sebastian Heinzel Tags: Letters: New Observations Source Type: research

Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study
Conclusion: Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short ‐ to mid‐term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Manuel Delgado ‐Alvarado, Rosalía Dacosta‐Aguayo, Irene Navalpotro‐Gómez, Belén Gago, Ana Gorostidi, Haritz Jiménez‐Urbieta, Ana Quiroga‐Varela, Javier Ruiz‐Martínez, Alberto Bergareche, María C. Rodríguez‐Oroz Tags: Brief Report Source Type: research

Anodal tDCS over prefrontal cortex improves dual ‐task walking in Parkinsonian patients with freezing
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Martina Putzolu, Elisa Pelosin, Carla Ogliastro, Giovanna Lagravinese, Gaia Bonassi, Andrea Ravaschio, Giovanni Abbruzzese, Laura Avanzino Tags: Letters: Published Article Source Type: research

Life span pigmentation changes of the substantia nigra detected by neuromelanin ‐sensitive MRI
Conclusions: Using optimized neuromelanin MRI in a life span sample, we demonstrate a strong age effect with inverted U ‐shaped SNpc pigmentation‐related contrast from childhood to old age. This age trajectory of physiological SNpc pigmentation needs to be taken into account for diagnostic applications of depigmentation. The study also paves the way for systematic investigations of the mechanisms of neuromelanin in healthy and pathological brain development and aging. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Yue Xing, Abdul Sapuan, Rob A. Dineen, Dorothee P. Auer Tags: Research Article Source Type: research

Sensing α‐Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration
AbstractParkinson's disease and other synucleinopathies are characterized by the accumulation of aggregated α‐synuclein in intracellular proteinaceous inclusions. The progressive nature of synucleinopathies seems to be related to the cell‐to‐cell spreading of α‐synuclein pathology, and several possible mechanisms have been put forward to explain this phenomenon. In our recent study, we found tha t α‐synuclein oligomers interact with cellular prion protein in glutamatergic synapses. This interaction triggered a signaling cascade involving phosphorylation of Fyn kinase and activation of the N‐methyl‐d‐aspa...
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: In ês Caldeira Brás, Luísa V. Lopes, Tiago Fleming Outeiro Tags: Scientific Perspectives Source Type: research

Abnormal sensory gating in patients with different types of focal dystonias
Conclusions: Somatosensory temporal discrimination threshold changes induced by movement execution are abnormal in focal dystonias. This abnormality is related to the type of dystonia. Abnormal gating of sensory information is likely involved in movement ‐induced triggering or worsening of different forms focal dystonia. (Source: Movement Disorders)
Source: Movement Disorders - November 7, 2018 Category: Neurology Authors: Antonella Conte, Daniele Belvisi, Maria Ilenia Bartolo, Nicoletta Manzo, Francesca Natalia Cortese, Matteo Tartaglia, Gina Ferrazzano, Giovanni Fabbrini, Alfredo Berardelli Tags: Research Article Source Type: research

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Roger L. Albin, D. James Surmeier, Cecilia Tubert, Martin Sarter, Martijn L.T.M. M üller, Nicolaas I. Bohnen, William T. Dauer Tags: Viewpoint Source Type: research