The role of the long non ‐coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR‐93/RhoC pathway
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - October 1, 2017 Category: Molecular Biology Authors: Shuo Chen, Li ‐li Wang, Kai‐Xuan Sun, Yin‐ling Xiu, Zhi‐Hong Zong, Xi Chen, Yang Zhao Tags: RESEARCH ARTICLE Source Type: research
miR ‐200c‐3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - October 1, 2017 Category: Molecular Biology Authors: Tomoyo Kawakubo ‐Yasukochi, Masahiko Morioka, Mai Hazekawa, Atsushi Yasukochi, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima Tags: BRIEF COMMUNICATION Source Type: research
The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - October 1, 2017 Category: Molecular Biology Authors: Shasha Tao, Montserrat Rojo de la Vega, Eli Chapman, Aikseng Ooi, Donna D. Zhang Tags: RESEARCH ARTICLE Source Type: research
Gain of function in the mouse model of a recurrent mutation p53N236S promotes the formation of double minute chromosomes and the oncogenic potential of p19ARF
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 26, 2017 Category: Molecular Biology Authors: Lanjun Zhao, Boyuan Wang, Xilong Zhao, Xiaoming Wu, Qiushi Zhang, Chuanyu Wei, Minling Shi, Yunlong Li, Wenru Tang, Jihong Zhang, Julun Yang, Sanjay Kumar Singh, Shuting Jia, Ying Luo Tags: RESEARCH ARTICLE Source Type: research
Procyanidin B2 3,3 ″‐di‐O‐gallate induces oxidative stress‐mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK
Neoplastic cells exhibit higher oxidative stress compared to normal cells; however, antioxidants based clinical trials have mostly failed. Another attractive therapeutic approach is to further increase the oxidative stress in cancer cells leading to cell death. Herein, we show that Procyanidin B2 3,3″‐di‐O‐gallate (B2G2), the most active constituent of grape seed extract, treatment causes cell death in human prostate cancer (PCa) cells (LNCaP and 22Rv1) via increasing the reactive oxygen species (ROS) generation. Mechanistically, B2G2 treatment decreased the mitochondrial electron transport chain complex III activi...
Source: Molecular Carcinogenesis - September 22, 2017 Category: Molecular Biology Authors: Rahul Kumar, Gagan Deep, Michael F. Wempe, Joseph Surek, Amit Kumar, Rajesh Agarwal, Chapla Agarwal Tags: RESEARCH ARTICLE Source Type: research
ITIH5 induces a shift in TGF ‐β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 21, 2017 Category: Molecular Biology Authors: Michael Rose, Steffen K. Meurer, Vera Kloten, Ralf Weiskirchen, Bernd Denecke, Wiebke Antonopoulos, Martina Deckert, Ruth Kn üchel, Edgar Dahl Tags: RESEARCH ARTICLE Source Type: research
MiR ‐182 inhibits the epithelial to mesenchymal transition and metastasis of lung cancer cells by targeting the Met gene
Conclusions: miR‐182 might suppress the EMT and metastasis via inactivation of Met/AKT/Snail in non‐small cell lung cancer (NSCLC) cells, which implicates miR‐182 may be useful as a new therapeutic target in NSCLC. This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 21, 2017 Category: Molecular Biology Authors: Yongwen Li, Hongbin zhang, Ying Li, Chenlong Zhao, Yaguang Fan, Jinghao Liu, Xin Li, Hongyu Liu, Jun Chen Tags: RESEARCH ARTICLE Source Type: research
Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma
Conclusion: HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma. This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 19, 2017 Category: Molecular Biology Authors: Jie Shen, Tiffany R Hodges, Renduo Song, Ye Gong, George A Calin, Amy B Heimberger, Hua Zhao Tags: BRIEF COMMUNICATION Source Type: research
TNFAIP8 regulates Hippo pathway through interacting with LATS1 to promote cell proliferation and invasion in lung cancer
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 19, 2017 Category: Molecular Biology Authors: Yong Han, ZhongPing Tang, Yue Zhao, Qingchang Li, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research
Early genetic aberrations in patients with sporadic colorectal cancer
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 19, 2017 Category: Molecular Biology Authors: Brooke R. Druliner, Xiaoyang Ruan, Hugues Sicotte, Daniel O'Brien, Hongfang Liu, Jean ‐Pierre A. Kocher, Lisa Boardman Tags: RESEARCH ARTICLE Source Type: research
Cten promotes epithelial ‐mesenchymal transition through the post‐transcriptional stabilization of Snail
In conclusion, we have described a novel Cten‐Snail signaling pathway that contributes to cell motility in CRC, mediated by the stabilization of Snail protein. This finding potentially furthers the understanding of EMT regulatory networks in cancer metastasis. (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 18, 2017 Category: Molecular Biology Authors: Hannah Thorpe, Abdulaziz Asiri, Maham Akhlaq, Mohammad Ilyas Tags: RESEARCH ARTICLE Source Type: research
RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells
Phosphorylation of Pyruvate Kinase M2 (PKM2) on Tyr105 by fibroblast growth factor receptor 1 (FGFR1) has been shown to promote its nuclear localization as well as cell growth in lung cancer. Better understanding the regulation of this process would benefit the clinical treatment for lung cancer. Here, it has been found that the adaptor protein receptor for activated PKC kinase (RACK1) formed a complex with FGFR1 and PKM2, and activated the FGFR1/PKM2 signaling. Knocking down the expression of RACK1 impaired the phosphorylation on Tyr105 of PKM2 and inhibited the growth and migration of lung cancer cells, while over‐expr...
Source: Molecular Carcinogenesis - September 15, 2017 Category: Molecular Biology Authors: Chengzhi Zhou, Tao Chen, Zhanhong Xie, Yinyin Qin, Yangming Ou, Jiexia Zhang, Shiyue Li, Rongchang Chen, Nanshan Zhong Tags: RESEARCH ARTICLE Source Type: research
p0071 interacts with E ‐cadherin in the cytoplasm so as to promote the invasion and metastasis of non‐small cell lung cancer
This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 12, 2017 Category: Molecular Biology Authors: Huanyu Zhao, Di Zhang, Lianhe Yang, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research
Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo
Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced disease stages by the time it is diagnosed, high recurrence rates and metastasis. In the present study, we investigated the effects of metformin (a safe anti‐diabetic drug) and curcumin (a turmeric polyphenol extracted from rhizome of Curcuma longa Linn.) on proliferation, apoptosis, invasion, metastasis, and angiogenesis of HCC in vitro and in vivo. It was found that co‐treatment of metformin and curcumin could not only induce tumor cells into apoptosis through activating the mitochondria pathways, but also suppress the invasion, metastasis of HCC c...
Source: Molecular Carcinogenesis - September 12, 2017 Category: Molecular Biology Authors: Hui ‐Hui Zhang, Ying Zhang, Yan‐Na Cheng, Fu‐Lian Gong, Zhan‐Qi Cao, Lu‐Gang Yu, Xiu‐Li Guo Tags: RESEARCH ARTICLE Source Type: research
Two BRM Promoter Polymorphisms Predict Poor Survival in Patients with Hepatocellular Carcinoma
CONCLUSION: Two BRM promoter polymorphisms were strongly associated with HCC prognosis but were not associated with increased HCC susceptibility. The association was strongest in double homozygotes for the allele variants. This article is protected by copyright. All rights reserved (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - September 11, 2017 Category: Molecular Biology Authors: Ivan Pasic, Kit Man Wong, Jonghun John Lee, Osvaldo Espin ‐Garcia, Yonathan Brhane, Dangxiao Cheng, Zhuo Chen, Devalben Patel, Catherine Brown, Roxana Bucur, David Reisman, Jennifer J Knox, Wei Xu, Rayjean J Hung, Geoffrey Guo, Sean P Cleary Tags: RESEARCH ARTICLE Source Type: research
