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Intestinal ultrasonography in adults with Crohn's disease: a 2020 update.
Authors: Sarno A, Varello S, Debani P, Bonenti G, Robotti D Abstract In the last years intestinal ultrasonography (IUS) has increased its role in the management of inflammatory bowel diseases (IBD), that include Crohn's disease (CD) and ulcerative colitis. This is due to the fact that IUS is a non-invasive, inexpensive, and well-tolerated examination technique. Furthermore, it allows a real-time diagnosis with no radiation exposure. Usually, convex and linear probes with frequency between 3.5 and 12 MHz are used, also with the Color- Power Doppler. Focusing on CD, the IUS images of clinical interest are: b...
Source: Minerva Gastroenterologica e Dietologica - November 27, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Magnetic resonance enterography: a narrative review.
Authors: Gatti M, Allois L, Carisio A, Dianzani C, Garcia Martinez M, Ruggirello I, Varello S, Darvizeh F, Faletti R Abstract Crohn's disease (CD) is a condition of chronic inflammation that may involve any part of the gastrointestinal tract, although it more frequently affects the terminal ileum. Longstanding inflammation may lead to several bowel complications including obstruction, stricture, fistula and abscesses which often necessitate surgery. Cross-sectional imaging methods such as computed tomography (CT) and magnetic resonance imaging (MRI) are being utilized more frequently to assess mural and ex...
Source: Minerva Gastroenterologica e Dietologica - November 27, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Non alcoholic fatty liver disease: a survey of involvement of primary care physician.
CONCLUSIONS: FPs are more likely to neglect proper treatment for NAFLD/NASH due to lack of proper knowledge and are more likely neglect referring patients to specialist. Patients with significant obesity and obesity related conditions are more likely to have proactive treatment plans by their FPs. PMID: 31646850 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 26, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Evaluation of cytokines levels as putative biomarkers to predict the pharmacological response to biologic therapy in inflammatory bowel diseases.
Authors: Bertani L, Antonioli L, Fornai M, Tapete G, Baiano Svizzero G, Marchi S, Blandizzi C, Costa F Abstract Cytokines play a central role in the pathogenesis of inflammatory bowel diseases. For this reason, the vast majority of biological therapies are aimed to block pro-inflammatory cytokines or their receptors. Although these drugs have modified the course of the disease due to their efficacy, a high rate of non- response or loss of response over time is still an important issue for clinicians. In this perspective, many studies have been conducted in recent years to individuate a reliable biomarker o...
Source: Minerva Gastroenterologica e Dietologica - October 26, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Effects of rifaximin-resistant Bifidobacterium longum W11 in subjects with symptomatic uncomplicated diverticular disease treated with rifaximin.
CONCLUSIONS: Despite the many biases that our retrospective analysis presents, we believe that a probiotic strain demonstrating a strong non-transferable resistance to a particular antibiotic should be used along with that specific antibiotic, at least in cases of SUDD diagnosis. PMID: 31646852 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 26, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Therapeutic drug monitoring for Vedolizumab.
Authors: Pugliese D, Privitera G, Pizzolante F, Gasbarrini A, Guidi L, Armuzzi A Abstract Therapeutic drug monitoring (TDM) is a useful tool for decision-making process in patients with Inflammatory Bowel Disease (IBD) treated with anti TNF-α drugs, especially when experiencing loss of response. Growing evidences support the existence of exposure-response relationship with Vedolizumab, but the utility and the appropriate use of TDM in clinical practice is still under debate. In this review, we summarize all evidences supporting a TDM-guided approach for patients treated with Vedolizumab, suggesting three ...
Source: Minerva Gastroenterologica e Dietologica - October 26, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Why candidates for liver transplantation should be considered as frail patients.
Authors: Moscara M, Mattei G, Ferrari S, Galeazzi GM Abstract PMID: 31646854 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 26, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Endoscopic therapy compared to surgical repair for the treatment of acute esophageal perforations.
CONCLUSIONS: Technical and clinical success for acute esophageal perforation therapy were similar among patients who underwent placement of stents as compared to surgery. Surgery was associated with a higher mortality, longer hospital stay and a markedly higher rate of procedural adverse events. Esophageal stents may be considered as the initial mode of therapy of a patient with acute esophageal perforation. PMID: 31617695 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 18, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Trimebutine: a state-of-the-art review.
This article provides an overview of the current knowledge on the pharmacological mechanisms of trimebutine and its clinical applications in gastrointestinal disorders. Its biochemical properties and the complex mechanisms of action, along with a well-studied pharmacological safety, make this compound still actual and valuable. PMID: 31617696 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 18, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Assessing urban minority attitudes for colorectal cancer screening using financial incentives.
Authors: Ramai D, Shahnazarian V, Etienne D, Ayide G, Reddy M Abstract PMID: 31617697 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 18, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Healthcare professionals' attitudes towards PEG tube feeding in advanced dementia: time to engage with a wide clinical audience?
Authors: Adu-Tei S, Penny HA, El-Fekhi M, Ruse C, Sanders DS Abstract PMID: 31617698 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 18, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Endoscopic biliary sphincterotomy on thienopyridine therapy compared to low dose aspirin alone has similar outcomes.
Authors: Krill TS, Chatila A, Marcondes F, Samuel R, Guturu P, Parupudi S Abstract PMID: 31617699 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 18, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Which role for blue light emitting diodes for the treatment of Helicobacter pylori?
Authors: Pellicano R Abstract PMID: 31602968 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 12, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Human microbiota and inflammatory bowel diseases: new pieces of an intricate puzzle.
Authors: Pellicano R Abstract PMID: 31602969 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 12, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Anti-TNF Combination Therapy in Inflammatory Bowel Disease: de novo or selective?
Authors: Macaluso FS, Orlando A Abstract Anti-TNFs still remain the backbone of advanced therapies in inflammatory bowel diseases, but their efficacy is not universal and tends to diminish over time. As a consequence, there is the need for optimization of these treatments, and the use of combination therapy - i.e. an anti-TNF plus an immunosuppressant - is one of the main strategies. The rationale for this approach lies in the evidence that the immunosuppressant reduces the formation of antibodies directed against the anti-TNF, thus avoiding the reduction or elimination of circulating drug levels, and in t...
Source: Minerva Gastroenterologica e Dietologica - October 12, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research