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Safety profile of intravenous iron in inflammatory bowel disease: an up-to-date overview.
Authors: Spagnuolo R, Abenavoli L, Larussa T, Iannelli C, Pellicano R, Fagoonee S, Doldo P, Luzza F
Abstract
Up to 30-70% of patients may experience mild and moderate side effects during iron therapy and this is often associated with a poor adherence to therapy. Anemia is frequent in patients with active inflammatory bowel disease (IBD), due to both iron deficiency and chronic inflammation, therefore iron supplementation is frequently needed. Considering that gastrointestinal disorders are the most common side effects with oral iron, in IBD patients intravenous administration must be preferred. Although in...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Current and future perspective on targeted agents and immunotherapies in hepatocellular carcinoma.
Authors: Germani G, Battistella S, Ulinici D, Zanetto A, Shalaby S, Pellone M, Gambato M, Senzolo M, Russo FP, Burra P
PMID: 33222429 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
The role of elastography in alcoholic liver disease: fibrosis staging and confounding factors. A review of the current literature.
CONCLUSIONS: We hope that our review article may serve as a reference point in the prospect of futures guidelines.
PMID: 33222430 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Hepatocellular carcinoma risk in patients with HBV-related liver disease receiving anti-viral therapy.
Authors: Battistella S, Lynch EN, Gambato M, Zanetto A, Pellone M, Shalaby S, Sciarrone S, Ferrarese A, Germani G, Senzolo M, Burra P, Russo FP
Abstract
Hepatitis B virus is a major health problem worldwide, with approximatively 240 million people living with a chronic HBV infection. HBV chronic infection remains the major cause of hepatocellular carcinoma worldwide, with more than half of HCC patients being chronic HBV carriers, even if underlying mechanisms of tumourigenesis are not totally understood. HBV-related HCC can be prevented by reducing the exposure to HBV by vaccination or by treatment of CHB ...
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Drug induced liver injury: from pathogenesis to liver transplantation.
Authors: Germani G, Battistella S, Ulinici D, Zanetto A, Shalaby S, Pellone M, Gambato M, Senzolo M, Russo FP, Burra P
Abstract
Drug induced liver injury (DILI) is a necro-inflammatory liver disease caused by several drugs commonly used in clinical practice, herbs and dietary supplements prescribed for medical purposes. Despite its rarity, it represents the major cause of acute liver failure requiring liver transplantation in USA and its frequency is increasing in Europe too. Two types of drug induced liver injury have been recognized: intrinsic and idiosyncratic. Predisposing factors may be classified in ...
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Eosinophilic esophagitis a rising disease.
Authors: de Bortoli N, Savarino EV
PMID: 33222433 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Severe acute alcoholic hepatitis: can we offer early liver transplantation?
Authors: Burra P, Bizzaro D, Forza G, Feltrin A, Volpe B, Ronzan A, Feltrin G, Carretta G, D'Amico F, Cillo U, Germani G
Abstract
Alcohol-related liver disease is one of the most prevalent liver disease worldwide and is the second most common indication for liver transplantation. The majority of transplant programs require 6 months of abstinence prior to transplantation; commonly referred to as the "six-month rule". According to this rule, the patients admitted for severe acute alcoholic hepatitis are not eligible for liver transplantation in most transplant centers. However, there is increasing evidence t...
Source: Minerva Gastroenterologica e Dietologica - November 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Management of portal hypertension severe complications.
Authors: Zanetto A, Barbiero G, Battistel M, Sciarrone SS, Shalaby S, Pellone M, Battistella S, Gambato M, Germani G, Russo FP, Burra P, Senzolo M
Abstract
Portal hypertension is a clinical syndrome characterized by an increase in the portal pressure gradient, defined as the gradient between the portal vein at the site downstream of the site of obstruction and the inferior vena cava. The most frequent cause of portal hypertension is cirrhosis. In patients with cirrhosis, portal hypertension is the main driver of cirrhosis progression and development of hepatic decompensation (ascites, variceal hemorrhage, ...
Source: Minerva Gastroenterologica e Dietologica - November 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Gastric per-oral endoscopic myotomy for gastroparesis: a spark of hope.
Authors: Khoury T, Sbeit W, Pellicano R, Mari A
PMID: 33140624 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review.
CONCLUSIONS: CT angiography showed a good sensibility and specificity in detecting NVGIB. Therefore, it would be useful to consider CT angiography use also in the suspicion of NVGIB, especially when endoscopy is not immediately available and there are signs and symptoms of bleeding in progress.
PMID: 33103404 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Elastography: where are we now?
Authors: Giuffré M, Colecchia A, Crocé LS
PMID: 33103405 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Gastro-esophageal reflux disease: Key messages for clinicians.
Authors: Saracco M, Savarino V, Bodini G, Saracco GM, Pellicano R
Abstract
Gastroesophageal reflux disease (GERD) is a chronic common disorder for which patients often refer to specialists. In the last decades, numerous studies helped to clarify the pathophysiology and the natural history of this disease. Currently, in the clinical setting, GERD is defined by the presence of symptoms that, when endoscopic investigation is required, permit to distinguish between cases with or without associated esophageal mucosal injuries. These conditions are called erosive reflux disease and non-erosive reflux disease (NE...
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Irritable Bowel Syndrome and lactose intolerance. A challenging overlap.
Authors: Adriani A, Saracco GM, Pellicano R
PMID: 33016665 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 7, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Quercetin Phytosome ® as a potential drug for Covid-19.
Quercetin Phytosome® as a potential drug for Covid-19.
Minerva Gastroenterol Dietol. 2020 Oct 05;:
Authors: Di Pierro F, Khan A, Bertuccioli A, Maffioli P, Derosa G, Khan S, Khan BA, Nigar R, Ujjan I, Devraian BR
Abstract
When looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recently identified novel coronavirus (SARS-CoV-2), the knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent 26 RNA polymerase, and ...
Source: Minerva Gastroenterologica e Dietologica - October 7, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
The efficacy of fasting regimens on health outcomes: a systematic overview.
CONCLUSIONS: Fasting regimens showed potential beneficial effects on several health indicators in adult populations. Nevertheless, evidence on some specific health dimensions (cognitive function, well-being, quality of life) is limited. Thus, in the future, further RCTs or cohort studies with good methodological quality and larger sample sizes are warranted to better understand the underlying biological mechanism and the benefits on multidimensional aspects of health.
PMID: 32914941 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - September 13, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research