Can cerebrospinal fluid diversion be beneficial in the treatment of chronic fatigue syndrome?
Dear Editor, (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 24, 2018 Category: Biomedical Science Authors: Peter Wostyn, Peter Paul De Deyn Source Type: research
Vitamin D supplementation may improve symptoms in Meniere ́s disease
In the last 4 years the authors observed a trend that correcting vitamin D deficiency in newly diagnosed cases of Meniere ́s disease decreased the necessity of the ablative therapy with intratympanic gentamicin. According to their hypothesis, vitamin D supplementation may indeed have a beneficial effect in Menierés disease if the symptoms are caused by a local postviral autoimmune reaction. Vitamin D has a strong im munomodulatory role, one of which is the regulation of the expression of pro-inflammatory mediators. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 24, 2018 Category: Biomedical Science Authors: Bela B üki, Heinz Jünger, Yunxia Wang Lundberg Source Type: research
Can cerebrospinal fluid diversion be beneficial in the treatment of chronic fatigue syndrome?
Dear Editor, (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 24, 2018 Category: Biomedical Science Authors: Peter Wostyn, Peter Paul De Deyn Source Type: research
Vitamin D supplementation may improve symptoms in Meniere ́s disease
In the last 4 years the authors observed a trend that correcting vitamin D deficiency in newly diagnosed cases of Meniere ́s disease decreased the necessity of the ablative therapy with intratympanic gentamicin. According to their hypothesis, vitamin D supplementation may indeed have a beneficial effect in Menierés disease if the symptoms are caused by a local postviral autoimmune reaction. Vitamin D has a strong im munomodulatory role, one of which is the regulation of the expression of pro-inflammatory mediators. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 24, 2018 Category: Biomedical Science Authors: Bela B üki, Heinz Jünger, Yunxia Wang Lundberg Source Type: research
Editorial Board
(Source: Medical Hypotheses)
Source: Medical Hypotheses - April 21, 2018 Category: Biomedical Science Source Type: research
Facilitation of hippocampal long-term potentiation and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking learning, memory, and the potential eradication of HIV-1
Learning and memory is generally considered the behavioral correlate of long-term potentiation (LTP), a form of synaptic plasticity associated with a persistent and long-lasting increase in synaptic strength. Repetitive stimulation of excitatory synapses in the hippocampal CA1 region leads to release and binding of glutamate to the glutamate receptors AMPAR and NMDAR located on pyramidal neurons. Activation of AMPARs facilitates Na+ influx, postsynaptic depolarization, NMDAR-mediated Ca2+ influx, and activation of several intracellular mechanisms that characterize LTP, including increased AMPAR synthesis, ROS production, a...
Source: Medical Hypotheses - April 21, 2018 Category: Biomedical Science Authors: Jahahreeh Finley Source Type: research
Literature contradictions about the prevalence of diabetes mellitus and the existence of “diabetes paradox”in patients with takotsubo syndrome
A recent paper reported on the prevalence of diabetes mellitus (DM) (21.1%, and “slightly higher than the expected sex and age-adjusted rates in the general population of the participating countries, Italy and Germany”) in patients with takotsubo syndrome (TTS), based on 826 patients from the International Multicenter GEIST Registry’s database [1]. This finding stands in stark contrast to the 10.2% prevalence of DM found among 1,085 patients from the international literature of individually reported patients with TTS of a mean age of 61.7 years old [2] (younger than the authors’ cohort with a mean age of 72 years o...
Source: Medical Hypotheses - April 21, 2018 Category: Biomedical Science Authors: John E. Madias Source Type: research
Facilitation of hippocampal long-term potentiation and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking learning, memory, and the potential eradication of HIV-1
Learning and memory is generally considered the behavioral correlate of long-term potentiation (LTP), a form of synaptic plasticity associated with a persistent and long-lasting increase in synaptic strength. Repetitive stimulation of excitatory synapses in the hippocampal CA1 region leads to release and binding of glutamate to the glutamate receptors AMPAR and NMDAR located on pyramidal neurons. Activation of AMPARs facilitates Na+ influx, postsynaptic depolarization, NMDAR-mediated Ca2+ influx, and activation of several intracellular mechanisms that characterize LTP, including increased AMPAR synthesis, ROS production, a...
Source: Medical Hypotheses - April 21, 2018 Category: Biomedical Science Authors: Jahahreeh Finley Source Type: research
Literature contradictions about the prevalence of diabetes mellitus and the existence of “diabetes paradox”in patients with takotsubo syndrome
A recent paper reported on the prevalence of diabetes mellitus (DM) (21.1%, and “slightly higher than the expected sex and age-adjusted rates in the general population of the participating countries, Italy and Germany”) in patients with takotsubo syndrome (TTS), based on 826 patients from the International Multicenter GEIST Registry’s database [1]. This finding stands in stark contrast to the 10.2% prevalence of DM found among 1,085 patients from the international literature of individually reported patients with TTS of a mean age of 61.7 years old [2] (younger than the authors’ cohort with a mean age of 72 years o...
Source: Medical Hypotheses - April 21, 2018 Category: Biomedical Science Authors: John E. Madias Source Type: research
An allometric approach of tumor-angiogenesis
The objective of this study is to examine the effect of angiogenesis with an allometric approach applied to angiogenesis and the regulating factors. The results show that allometry has the potential to describe this aspect, including the sigmoid-like transport function. There are particular conditions under which the complex control maximizes the relative tumor mass. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 20, 2018 Category: Biomedical Science Authors: Oliver Szasz, Gyula Vincze, Gyula Peter Szigeti, Zoltan Benyo, Andras Szasz Source Type: research
Vitamin D deficiency may stimulate fibroblasts in Dupuytren ’s disease via mitochondrial increased reactive oxygen species through upregulating transforming growth factor-β1
Dupuytren ’s disease, a benign fibroproliferative disorder of the palmar fascia, represents an ideal model to study tissue fibrosis. Transforming growth factor-β1 (TGF-β1) and its downstream Smad signaling system is well established as a keyplayer during fibrogenesis. Vitamin D has been extensively studie d as an anti-fibrotic agent in malignant chronic diseases. A number of studies have shown that myofibroblasts are main target cells of 1,25(OH)2D3 inhibitory action. The myofibroblast in the palmar aponeurosis of patients in different stages of Dupuytren’s disease was found by electron microscopy to contain a large ...
Source: Medical Hypotheses - April 17, 2018 Category: Biomedical Science Authors: Harun Seyhan, Jan-Phillip Stromps, Erhan Demir, Paul C. Fuchs, J ürgen Kopp Source Type: research
The electronics in fluorescent bulbs and light emitting diodes (LED), rather than ultraviolet radiation, cause increased malignant melanoma incidence in indoor office workers and tanning bed users
The epidemiology of cutaneous malignant melanoma (CMM) has a number of facets that do not fit with sunlight and ultraviolet light as the primary etiologic agents. Indoor workers have higher incidence and mortality rates of CMM than outdoor workers; CMM occurs in body locations never exposed to sunlight; CMM incidence is increasing in spite of use of UV blocking agents and small changes in solar radiation.Installation of two new fluorescent lights in the milking parlor holding area of a Minnesota dairy farm in 2015 caused an immediate drop in milk production. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 17, 2018 Category: Biomedical Science Authors: Samuel Milham, Dave Stetzer Source Type: research
Neuromuscular taping reduces blood pressure in systemic arterial hypertension
Systemic arterial hypertension, a well-known cause of morbidity, is associated with dysfunction of the autonomic nervous system. Neuromuscular taping (also known as kinesio taping, medical taping and Vendje neuromuscular) allows movement and muscle activity to treat pain, muscle disorders and lymphoedema, in which its mode of action may involve muscular stimulation leading to increased local blood circulation or stimulating dermatological, muscular and fascial structures with a form of passive massage. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 17, 2018 Category: Biomedical Science Authors: M. Shah, P.O.O. Julu, J.A. Monro, J. Coutinho, C. Ijeh, B.K. Puri Source Type: research
Telomere length, thyroid dysfunction/autoimmunity and parity
There may exist an association between thyroid dysfunction/autoimmunity and parity. Autoimmune thyroiditis shows some degree of telomere shortening. Parity was recently found to be associated with telomere shortening. We hypothesize that among the factors affecting the tentative association between parity and thyroid dysfunction/autoimmunity shortened telomeres' may also be implicated. This could also be another facet of the processes leading to autoimmune thyroiditis. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 17, 2018 Category: Biomedical Science Authors: Ioannis Ilias, Maria Alexiou, George Mastorakos Source Type: research
