Editorial Board
(Source: Medical Hypotheses)
Source: Medical Hypotheses - May 30, 2018 Category: Biomedical Science Source Type: research
“Autologous White Blood Cell Infusion for Trauma, Brain Trauma, Stroke and select Immune Dysfunction Co-morbidities : A Promising and Timely Proposal ?”
All traumas suppress the immune system, resulting in higher morbidity and mortality. Infections, poor nutritional status, chronic illness, fatigue, therapies or procedures performed during and after transport also negatively affect the immune system. Large populations are impacted by trauma worldwide and suffer enormous costs in both direct and indirect expenditures from physical, psychological and functional losses. Most therapies and studies of trauma, brain trauma, stroke, immune suppression and their co-morbidities do not address nor discuss methods that promote immune system resuscitation or efficacy to support its ro...
Source: Medical Hypotheses - May 26, 2018 Category: Biomedical Science Authors: Gerald Dieter Griffin, Dominique Charron, Reem Al-Daccak Source Type: research
miR-146a Induces Apoptosis in Neuroblastoma Cells by Targeting BCL11A
In this study, targeted genes were predicted by bioinformatic analysis and confirmed by dual-Luciferase reporter assay. The expression level of miR-146a in the human neuroblastoma SK-N-SH cell line was detected by quantitative RT-PCR. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 26, 2018 Category: Biomedical Science Authors: Sheng-Hua Li, Jin-Pin Li, Lan Chen, Jing-Li Liu Source Type: research
A Bi-Directional Model of Exercise and Episodic Memory Function
Recent empirical work suggests that acute exercise engagement may help to subserve episodic memory function. In this paper, we discuss this these effects as well as introduce a hypothesized model suggesting a potential bi-directional relationship between exercise and memory. We provide empirical support for each of the pathways delineated within this model. Future research is needed to empirically evaluate the totality of this model. If such work demonstrates utility and predictive validity, then this model will have important implications not only for clinicians, but for the exercise neurobiology field as well. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 26, 2018 Category: Biomedical Science Authors: Pamela Ponce, Paul D. Loprinzi Source Type: research
Art is long, life is short. Francisco Jos é de Goya y Lucientes (1746–1828), the suffering artist
Francisco Jos é de Goya y Lucientes is one of the major figures of European art. From royal portraits to bizarre, grotesque illustrations, his legacy demonstrates a tortured genius, generating some of the most compelling art ever produced. His story is also the story of Spain during one of the most tumultuous pa ssages of its history. In the winter of 1792–3, Goya experienced a mysterious illness resulting in lifelong deafness. After that, his work became more negative, with thick, bold strokes of dark colour. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 25, 2018 Category: Biomedical Science Authors: Gabriele Cipriani, Luca Cipriani, Lucia Picchi, Mario Di Fiorino Source Type: research
Hypothesizing the potential complications of using DNA mismatch repair gene inhibition in cancer therapy
Recent studies have shown that inactivation of (DNA mismatch repair gene) MMR could be exploited as a potential therapeutic tool in cancer therapy [1 –3]. MMR inactivation has shown to increase the mutational load of the cancer cells which in turn causes a sustained antigenic response against the neoantigens (additional mutations) leading to tumor inhibition. Although in-vitro and animal based in-vivo studies have shown the effectiveness of MMR inhibition (flow chart 1) [3] on halting the tumor progression, there are potential complications which could arise due to MMR inactivation. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 24, 2018 Category: Biomedical Science Authors: A. Thirumal Raj, Shankargouda Patil Source Type: research
Tizanidine is not effective treating EPMS
Extrapyramidal motoric symptoms (EPMS) are common adverse side effects of conventional antipsychotics [1], which can be reduced by Biperiden, an anticholinergic acting drug. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 19, 2018 Category: Biomedical Science Authors: Helmut Niederhofer Source Type: research
Tizanidine is not effective in treating EPMS
Extrapyramidal motoric symptoms (EPMS) are common adverse side effects of conventional antipsychotics (Greil et al., 2013), which can be reduced by Biperiden, an anticholinergic acting drug. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 19, 2018 Category: Biomedical Science Authors: Helmut Niederhofer Source Type: research
Transposable elements, placental development, and oocyte activation: Cellular stress and AMPK links jumping genes with the creation of human life
Transposable elements (TEs), also known as “jumping genes”, are DNA sequences first described by Nobel laureate Barbara McClintock that comprise nearly half of the human genome and are able to transpose or move from one genomic location to another. As McClintock also noted that a genome “shock” or stress may induce TE activation and transposition, accumulating evidence suggests that cellular stress (e.g. mediated by increases in intracellular reactive oxygen species [ROS] and calcium [Ca2+], etc.) induces TE mobilization in several model organisms and L1s (a member of the retrotransposon class of TEs) are active an...
Source: Medical Hypotheses - May 18, 2018 Category: Biomedical Science Authors: Jahahreeh Finley Source Type: research
A synthetic mitochondrial-based vector for therapeutic purposes
Delivery of large DNA constructs is necessary for combinatorial, anti-aging gene therapy. However, this is hindered by the lack of a non-inflammatory vector with sufficient packaging space and the ability to effectively spread through tissue. It is possible that a mitochondrion, altered to be able to secrete therapeutic proteins, could serve as an ideal gene delivery vector in this regard (for post-mitotic cells at least). Initial transfection of mitochondria with a therapeutic gene vector could be undertaken by MITO-Porter, i.e., a dual-layered fusogenic liposomal-based delivery system. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 18, 2018 Category: Biomedical Science Authors: Michael Renteln Source Type: research
The potential for disease initiation by inhaled beta-emitting nuclear particles
There were many anecdotal reports of injuries to humans, animals and plants following the Three Mile Island, Chernobyl and Fukushima accidents that were indicative of radiation exposures that delivered a dose of at least 0.5 Sieverts, but studies that attempted to relate observed increases of cancer rates and other injuries with exposure to the radioactive releases from these accidents have failed to find an association.To resolve this dissonance, it was assumed that an analysis of knowledge about accident releases a nd health effects gathered from one of these accidents could lead to the identification of an unrecogniz...
Source: Medical Hypotheses - May 17, 2018 Category: Biomedical Science Authors: Norman O. Aamodt Source Type: research
The potential for disease initiation: by inhaled beta-emitting nuclear particles
There were many anecdotal reports of injuries to humans, animals and plants following the Three Mile Island, Chernobyl and Fukushima accidents that were indicative of radiation exposures that delivered a dose of at least 0.5 Sieverts, but studies that attempted to relate observed increases of cancer rates and other injuries with exposure to the radioactive releases from these accidents have failed to find an association.To resolve this dissonance, it was assumed that an analysis of knowledge about accident releases and health effects gathered from one of these accidents could lead to the identification of an unrecognized e...
Source: Medical Hypotheses - May 17, 2018 Category: Biomedical Science Authors: Norman O. Aamodt Source Type: research
Resolution of chronic nasal Staphylococcus aureus infection in a non-smoker who started to use glycerine based e-cigarettes: Antibacterial effects of vaping?
Smokers who switch to vaping report a decrease in respiratory infections. A previous case report of a non-smoker who started to vape and experienced a resolution of chronic tonsillitis proposed that this could be due to bactericidal effects of propylene glycol. Here were report a similar case where a resolution of chronic nasal infection was associated with using glycerol-based nicotine vaporiser. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 15, 2018 Category: Biomedical Science Authors: Joanna Astrid Miler, Peter Hajek Source Type: research
Resolution of chronic rhinitis tostaphylococcus aureus in a non-smoker who started to use glycerine based e-cigarettes: Antibacterial effects of vaping?
Smokers who switch to vaping report a decrease in respiratory infections. A previous case report of a non-smoker who started to vape and experienced a resolution of chronic tonsillitis proposed that this could be due to bactericidal effects of propylene glycol. Here were report a similar case where a resolution of chronic nasal infection was associated with using glycerol-based nicotine vaporiser. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 15, 2018 Category: Biomedical Science Authors: Joanna Astrid Miler, Peter Hajek Source Type: research
Hypothesis: persistently normal tsh levels may be used to recognize patients with transient forms of hypothyroidism and to suggest tratment withdrawal.
There are no text-book recommendations on when or if treatment should or could be stopped in patients with a diagnosis of hypothyroidism, and these patients usually receive lifelong thyroxine therapy (despite the fact that some of them may have forms of transient hypothyroidism that will later recover function). Since TSH fluctuations during thyroxine treatment are common and a lack of this fluctuation might be used to identify patients who no longer need thyroxine treatment, we hypothesize that by offering patients with persistently controlled TSH levels a withdrawal trial of thyroxine treatment we may identify those who ...
Source: Medical Hypotheses - May 15, 2018 Category: Biomedical Science Authors: H. Tandeter, M. Fraenkel Source Type: research
