Subacute sclerosing panencephalitis and immune thrombocytopenia: more than a coincidence?
Subacute sclerosing panencephalitis (SSPE) is a progressive disease caused by persistent measles virus (MV). It has an incidence of 0.4-2.0/million in Turkey. Immune thrombocytopenia (ITP) is a bleeding disorder whose estimated incidence is 4.2/100.000 person/years in the pediatric age group. We observed three cases with ITP in our cohort of 315 pediatric SSPE cases, an incidence higher than coincidentally expected in the general population. We hypothesize an association between SSPE and ITP. Our three cases had measles 1-2 years before the onset of ITP and 8-10 years before first symptoms of SSPE. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 29, 2017 Category: Biomedical Science Authors: I. Oncel, S. Saltik, B. Anlar Source Type: research
A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors
Androgenic alopecia, also known as pattern hair loss, is a chronic progressive condition that affects 80% of men and 50% of women throughout a lifetime. But despite its prevalence and extensive study, a coherent pathology model describing androgenic alopecia ’s precursors, biological step-processes, and physiological responses does not yet exist. While consensus isthat androgenic alopecia is genetic and androgen-mediated by dihydrotestosterone, questions remain regarding dihydrotestosterone's exact role in androgenic alopecia onset. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 29, 2017 Category: Biomedical Science Authors: Robert S. English Source Type: research
Subcutaneous accessory pain system (SAPS): A novel pain pathway for myofascial trigger points
Despite the accumulating neuro-physiological evidence of myofascial pain, many clinicians are skeptical about its existence as a separate disease entity. No single theory can fully explain the four cardinal features of MPS; taut bands, local tenderness, local twitching and the characteristic pattern of referred pain. Bridging the gap between basic and clinical knowledge mandates coupling the local trigger point changes with the clinically seen distant somatically innervated referred pain.The main question addressed by the present theory is why do trigger points behave differently in comparison to the surrounding muscle tis...
Source: Medical Hypotheses - December 22, 2017 Category: Biomedical Science Authors: Haytham Eloqayli Source Type: research
Subcutaneous accessory pain system (SAPS): A novel pain pathway for myofascial trigger points.
Despite the accumulating neuro-physiological evidence of myofascial pain, many clinicians are skeptical about its existence as a separate disease entity. No single theory can fully explain the four cardinal features of MPS; taut bands, local tenderness, local twitching and the characteristic pattern of referred pain. Bridging the gap between basic and clinical knowledge mandates coupling the local trigger point changes with the clinically seen distant somatically innervated referred pain.The main question addressed by the present theory is why do trigger points behave differently in comparison to the surrounding muscle tis...
Source: Medical Hypotheses - December 22, 2017 Category: Biomedical Science Authors: Haytham Eloqayli Source Type: research
The arteriolar injury in hypertension
In 1937, Drs Moritz and Oldt described arteriolar injuries in the kidneys (and other viscera) in hypertension, across the age range, in both sexes, and, in different races. This hypothesis proposes that injuries to vasomotor nerves cause the arteriolar injury in the kidney in hypertension, (as well as that in the uterus in preeclampsia). Different patterns of perivascular hyalinisation in different viscera are clues to the varying causes and consequences of arteriolar injury. In the uterus there is a symmetrical, perivascular “halo of hyalinisation” that marks the lines of extension of regenerating, injured nerves to t...
Source: Medical Hypotheses - December 21, 2017 Category: Biomedical Science Authors: Gu, Ru Qian, Yang Yang Li, Guo Rong Chen, M.J. Quinn Source Type: research
Corrigendum to “Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery” [Med. Hypotheses 104 (2017) 20–24]
The corrected author group is shown above. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 20, 2017 Category: Biomedical Science Authors: J. Sokolic, V. Sotosek Tokmadzic, D. Knezevic, I. Medved, N. Vukelic Damjani, S. Balen, M. Rakic, A. Lanca Bastiancic, G. Laskarin Tags: Corrigendum Source Type: research
Excessive fetal movements are a sign of fetal compromise which merits further examination
We present a hypothesis that a sudden episode of excessive fetal activity indicates fetal compromise relating to underlying disturbance of the in utero environment, which if it persists can lead to fetal death. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 18, 2017 Category: Biomedical Science Authors: Alexander E.P. Heazell, Tomasina Stacey, Louise M. O'Brien, Edwin A. Mitchell, Jane Warland Source Type: research
The role of antimalarial quality in the emergence and transmission of resistance
The emergence and transmission of antimalarial resistance is hampering malaria eradication efforts and is shortening the useful therapeutic life of currently available antimalarials. Drug selection pressure has been identified as a contributing factor to the emergence and transmission of resistance, especially population treatment coverage and sub-therapeutic concentrations of active pharmaceutical ingredient (API) in the bloodstream. Medicine quality can be defined as good quality or poor quality. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 14, 2017 Category: Biomedical Science Authors: Aleisha R. Brock, Joshua V. Ross, Sunil Parikh, Adrian Esterman Source Type: research
Prophylactic use of colchicine in preventing radiation induced coronary artery disease
Radiation therapy is one of the primary treatments in fighting breast cancer, one of the most common cancers in the US. One of the dose limiting factors of this therapy is radiation induced heart damage that results from mediastinal radiation. Recently statins, a medication typically used to lower cholesterol levels, have been suggested as a prophylactic treatment to potentially mitigate this process. Similarly, we hypothesized whether colchicine, an anti-inflammatory medication that is presently used in the treatment of gout and pericarditis, might be used to prevent coronary artery disease induced by radiation therapy. (...
Source: Medical Hypotheses - December 14, 2017 Category: Biomedical Science Authors: T. O'Herron, J. Lafferty Source Type: research
Understanding pluripotency under Folic acid deficiency using embryonic stem cells as an in vitro model
Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst them, the one which is gaining importance in the recent past is the metabolism of stem cells, especially One carbon metabolism. Being associated directly or indirectly, with DNA and Histone methylation, One carbon metabolism has an important role to play as far as epigenetic regulation of stemness is concerned. Folic acid being a methyl donor forms an important component of One Carbon metabolism, and thus its availability has a significant effect on the methylation ...
Source: Medical Hypotheses - December 14, 2017 Category: Biomedical Science Authors: Sowmya kasulanati, Vijayalakshmi venkatesan Source Type: research
Breast milk is conditionally perfect
Breast milk is the universal preferred nutrition for the newborn human infant. New mother have been encouraged to exclusively breastfeed by health care professionals and consumer-advocacy forums for years, citing “breast milk is the perfect food”. The benefits are numerous and include psychological, convenience, economical, ecological and nutritionally superior.Human milk is a composite of nutritional choices of the mother, commencing in the pre-conceptual era. Events influencing the eventual nutritional profile of breast milk for the neonate start with pre-conceptual dietary habits through pregnancy and finally to pos...
Source: Medical Hypotheses - December 14, 2017 Category: Biomedical Science Authors: Miriam Erick Source Type: research
Dry eye disease in strabismus patients: does eye deviation harm ocular surface?
Dry eye disease is a multifactorial disease which affects the ocular surface system, and determines ocular discomfort symptoms and visual disturbance. Various types of ocular surgery, including strabismus one, represents a recognized cause for iatrogenic dry eye. However, it is not uncommon that strabismus patients, even not undergone to surgery, report symptoms of ocular discomfort and dryness.HypothesisWe hypothesize that two possible mechanisms may determine dry eye in strabismus patients by setting up a specific vicious circle: firstly, the increased exposure of the area of the bulbar conjunctiva located on the opposit...
Source: Medical Hypotheses - December 14, 2017 Category: Biomedical Science Authors: Giuseppe Giannaccare, Piera Versura, Stefano Sebastiani, Chiara Fariselli, Marco Pellegrini, Emilio Campos Source Type: research
The role of antimalarial quality in the emergence and transmission of resistance.
The emergence and transmission of antimalarial resistance is hampering malaria eradication efforts and is shortening the useful therapeutic life of currently available antimalarials. Drug selection pressure has been identified as a contributing factor to the emergence and transmission of resistance, especially population treatment coverage and sub-therapeutic concentrations of active pharmaceutical ingredient (API) in the bloodstream. Medicine quality can be defined as good quality or poor quality. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 14, 2017 Category: Biomedical Science Authors: Aleisha.R. Brock, Joshua.V. Ross, Sunil Parikh, Adrian Esterman Source Type: research
Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment.
Chronic kidney disease (CKD) is an increasing global health burden. Disturbance in purine metabolism pathway and a higher level of serum uric acid, called hyperuricemia, is a risk factor of CKD, and it has been linked to increased prevalence and progression of the disease. In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 13, 2017 Category: Biomedical Science Authors: Muhammed Khairujjaman Mazumder, Banashree Chetia Phukan, Aradhana Bhattacharjee, Anupom Borah Source Type: research
A new etiologic model for Alzheimers Disease
This etiologic model proposes that Alzheimers Disease (AD) arises when an unusually rapid increase in ventricle volume triggers axon stretch that culminates in the physical separation of trans-synaptic proteins. As a result, these proteins, such as neurexin, neuroligin, N-Cadherin and Amyloid Precursor Protein (APP), experience a change in the configuration of their cytoplasmic tail, so that instead of transmitting signals to create and maintain synaptic structure they activate enzymes, and generate molecules, that stimulate neurite growth; for example, the transformation of the N-Cadherin tail dissolves its complex with p...
Source: Medical Hypotheses - December 13, 2017 Category: Biomedical Science Authors: Kathryn A. Schiel Source Type: research
