Objective assessment of the degree of improvement or deterioration with patients by means of Ipsative Trend Analysis of resting electroencephalograms
About three decades ago we had begun to conceptualize a quantification procedure based on the Spontaneous Resting EEG (SR-EEG). The underlying idea was to objectify clinical improvement or deterioration at the single case level [1 –3,25,26]. The data were acquired from EEGs being recorded under resting conditions. The underlying idea was due to Jackson’s Global Cerebral Function (GCF) or the principle of hierarchically organized functional levels and its dynamics. The latter were calculated from spatio-temporally defined EEG-patterns according to the staging by Loomis et al. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 8, 2018 Category: Biomedical Science Authors: Gerald Ulrich, Georg Juckel, Willi Schlosser Source Type: research
It has not been proven why or that most research findings are false
The claim has been made that it can be proven that most published findings in medical, biological, and allied sciences are false and that the reason for this can be proven and explained with a mathematical model. It has not, however, been mathematically proven that most research findings are false, and this can be proven. The model used in the proof is incoherent and has been falsified. Furthermore, advice to researchers derived from the model is misleading and distracts from more important issues in experimental standards. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: John C. Ashton Source Type: research
Michelangelo Buonarroti (1475 –1564) had the deconditioning syndrome while painting the Sistine Chapel ceiling
The brilliant painter, sculptor, architect and poem writer of the Italian Renaissance, Michelangelo Buonarroti (Fig. 1) documented his own life, habits and diseases [1]. Between 1508 and 1512, he painted the vault of the Sistine Chapel and described his demanding work in a poem addressed to Giovanni da Pistoia. Lying supine all day on a high scaffold, his head was bent forwards using muscle contractions and support for hours with paint dripping on his face [1]. After two years (1510), he had trouble with his eyes. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: R. Bianucci, D. Lippi, A. Perciaccante, P. Charlier, O. Appenzeller Source Type: research
A thermodynamic approach to the problem of consciousness
This article is an attempt to provide speculative answers to these questions based on what we know about thermodynamics. The proposed answer to the first question is that qualia are self-organized structures built by exported entropy. The proposed answer to the second question is that qualia are subjective because entropy-decreasing phenomena cannot be observed physically. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: Majid Beshkar Source Type: research
The Viral Quinta Columna Strategy: a new biological hypothesis to study infections in humans
Small viral proteins with cationic domains can be involved in multiple biological processes including cell penetration or interaction with intracellular targets. Within the last two decades several reports indicated that the C-terminus of HIV-1 Vpr is a cell penetrating sequence, a PP2A-dependent death domain and also displays toxicity against Gram-negative E. coli. Interestingly, HIV-1 Vpr, as well as some cationic proteins encoded by different viruses, share similar physical properties with the unique anti-microbial human cathelicidin LL37 peptide. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: Alphonse Garcia Source Type: research
Resistance Exercise and Sports Performance: The Minority Report
Resistance exercise is typically performed to increase both muscle size and strength and is regularly incorporated into training programs for sports performance. Presumably, the exercise would be expected to increase the force producing capabilities of skeletal muscle, which may have subsequent influence on various sports related abilities. Interestingly, few studies are designed to examine sports related benefits of resistance exercise while including a proper control group to account for adaptations to simply performing the sports related task. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: Samuel L. Buckner, Matthew B. Jessee, Scott J. Dankel, Kevin T. Mattocks, Takashi Abe, Jeremy P. Loenneke Source Type: research
The aberrant urethral meatus as a possible aetiological factor of recurrent post-coital urinary infections in young women.
Recurrent urinary tract infections (rUTI) in women is a common cause of morbidity worldwide. In young women recurrent cystitis associated with sexual intercourse is quite common; however not all sexually active women will suffer a post-coital UTI episode. A variety of possible predisposing factors has been described, including behavioral risk patterns, genetic factors and increased virulence of certain subtypes of uropathogens. It has long been regarded that anatomical anomalies are rare in this setting of rUTIs. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: Kostis Gyftopoulos Source Type: research
It has not been proven why or that most research findings are false.
The claim has been made that it can be proven that most published findings in medical, biological, and allied sciences are false and that the reason for this can be proven and explained with a mathematical model. It has not, however, been mathematically proven that most research findings are false, and this can be proven. The model used in the proof is incoherent and has been falsified. Furthermore, advice to researchers derived from the model is misleading and distracts from more important issues in experimental standards. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: John C. Ashton Source Type: research
Michelangelo Buonarroti (1475-1564) had the deconditioning syndrome while painting the Sistine Chapel ceiling
To the Editor, (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 7, 2018 Category: Biomedical Science Authors: R. Bianucci, D. Lippi, A. Perciaccante, P. Charlier, O. Appenzeller Source Type: research
Pathogenesis of Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or ‘Idiopathic retinal arteriolar aneurysms (IRAA)’ with macular star
I read with interest the interesting hypothesis regarding the pathogenesis of the so-called ‘idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN).[1] The authors suggest that in IRVAN, there is no true inflammation of retinal arteries. They propose that ‘a developmental or congenital presence of saccular macroaneurysms’ leads to ‘vascular flow abnormalities’ result ing in retinal capillary nonperfusion (CNP) and generation of vascular endothelial growth factor (VEGF). The angiographical paravscular staining has been hypothesized by the authors to be ‘a result of the VEGF produced by the adjacent ...
Source: Medical Hypotheses - February 3, 2018 Category: Biomedical Science Authors: Koushik Tripathy Source Type: research
Eliminated respiration-coupled oscillations in the brain as a possible link between adenotonsillar hypertrophy and cognitive impairment
Adenotonsillar hypertrophy is a common disorder in early childhood [1]. It can cause some problems in normal breathing such as difficult nasal breathing, and in higher stages, sleep apnea necessitate oral breathing [1]. There is a relationship between breathing disorder in adenotonsillar hypertrophy and cognitive and behavioral problems (such as attention, learning and memory), which could be resolved after surgical treatment (adenotonsillectomy) [2]. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 1, 2018 Category: Biomedical Science Authors: Farhad Tabasi, Mohammad Reza Raoufy Source Type: research
The relationship between plasma vascular endothelial growth factor and erythrocyte 2,3-bisphosphoglycerate: The putative role of chronic hypoxia
The non-invasive assessment of chronic tissue hypoxia is difficult. Pulse oximetry only allows the peripheral oxygen saturation to be measured, while the detection of hyperlactataemia needs to take into account the fact that the accumulation of lactic acid may result from several causes other than prolonged tissue hypoxia. Arterial blood oxygen measurement is invasive and often does not give a good indication of the level of tissue hypoxia. Other suggested methods include the use of positron emission tomography, magnetic resonance T2 ∗ relaxation time measurement, photoacoustics and high-frequency ultrasound. (Source: Medical Hypotheses)
Source: Medical Hypotheses - January 29, 2018 Category: Biomedical Science Authors: B.K. Puri, J.A. Monro Source Type: research
Editorial Board
(Source: Medical Hypotheses)
Source: Medical Hypotheses - January 26, 2018 Category: Biomedical Science Source Type: research
Ultrasound-Guided Percutaneous Electrolysis: A New Therapeutic Option For Mammary Fistulas
Mammary fistula (MF) is a recurrent condition characterised by the draining of abscesses around the areola. The best management for MF remains challenging. Moreover, the main problem is the high recurrence rate of this disease. MF is considered a chronic process. The percutaneous electrolysis (PE) technique involves the application of a galvanic current with an ultrasound-guided needle to induce ablation and repair of the affected tissue. Good results have been obtained with PE in chronic tendinopathies. (Source: Medical Hypotheses)
Source: Medical Hypotheses - January 21, 2018 Category: Biomedical Science Authors: Juan D. Bern á-Serna, José A. García-Vidal, Escolar-Reina Pilar, Juan D. Berná-Mestre Source Type: research
Inducing hypertrophic effects of type I skeletal muscle fibers: A hypothetical role of time under load in resistance training aimed at muscular hypertrophy
An emerging body of evidence is starting to suggest that the hypertrophy of skeletal muscle fibers might be load specific. In other words, it may be that resistance training with high loads (i.e., ≥60% of 1 repetition maximum [RM]) emphasizes a greater growth of type II muscle fibers, while resistance training with low loads (i.e., (Source: Medical Hypotheses)
Source: Medical Hypotheses - January 19, 2018 Category: Biomedical Science Authors: Jozo Grgic, Jan Homolak, Pavle Mikulic, Javier Botella, Brad J. Schoenfeld Source Type: research
