Optimise the microbial flora with milk and yoghurt to prevent disease
Pathogenic bacteria, which are temporary or permanent members of our microbial flora, cause or contribute to a wide range of human disease at all ages. Conditions include Alzheimer ’s disease, atherosclerosis, diabetes mellitus, obesity, cancer, autoimmunity and psychosis, amongst others. The mechanism of damage is inflammation which can be chronic or acute. An optimal microbial flora includes a wide range of pathogenic bacteria in low dose. This allows specific immunity to be developed and maintained with minimal inflammatory damage. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 26, 2018 Category: Biomedical Science Authors: James A. Morris Source Type: research
The presence of tumor extrachomosomal circular DNA (ecDNA) as a component of liquid biopsy in blood
In molecular biology covalently closed circular DNAsare able to passthrough double layer of eukaryotic cellular membrane. Very recently the presence of circular extra chromosomal DNA (ecDNA) has been shown which are different in seventeen different types of cancers. In fact, ecDNA are the tricky way of oncogenes to increase their copy number. We hypothesis the presence of ecDNA in the blood of cancer patients as a subpopulation of liquid biopsy. On the occasion of their presence in blood they will be very beneficial to cover the small amount of cell frees DNA (cfDNA). (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 26, 2018 Category: Biomedical Science Authors: Fatemeh Khatami, Bagher Larijani, Seyed Mohammad Tavangar Source Type: research
Role of Apolipoprotein E in the tangled mystery of pain
Pain is one of the common and debilitating manifestations associated with the majority of diseased conditions, making it a serious health concern worldwide. While trying to decipher the cryptic mechanism of pain in hope to provide better gene-based therapeutics, researchers have concluded pain to be of multigenic origin.Apolipoprotein E is a protein coded by APOE gene containing 4 exons, located on chromosome 19q13.2. It is among the key regulators of various crucial body functions such as lipid transport, apoptosis, vitamin k pathway, and cognition, hence, it is highly suspected to play a pivotal role in the nociception p...
Source: Medical Hypotheses - February 26, 2018 Category: Biomedical Science Authors: Harjot Dhillon, Sargun Singh Source Type: research
The possible role of stress induced hormonal disbalance in the patophysiology of insulin resistane in lean individuals
Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore, the mechanism of its development is in the center of scientific and professional interest. Established or acquired factors, or combinations thereof, which disturb any step of the physiological insulin action mechanism: its binding to the cellular receptor, through the complex cascade of intracellular signali...
Source: Medical Hypotheses - February 26, 2018 Category: Biomedical Science Authors: K. Blaslov, I. Kruljac, G. Miro šević, Lora S. Kirigin Biloš, M. Vrkljan Source Type: research
Seminal cell-free DNA molecular profile as a tool to discover novel diagnostic and prognostic prostate cancer biomarkers.
Cell-free DNA (cfDNA) include circulating DNA fragments in human bloodstream originated from apoptotic and/or necrotic cells [1] or actively secreted by cancer cells [2]. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 26, 2018 Category: Biomedical Science Authors: G. Ponti, M. Maccaferri, M. Manfredini, M. Cotugno, G. Pellacani, A. Conti, S. Micali, M. Mandrioli, A. Tomasi Source Type: research
Optimise the microbial flora with milk and yoghurt to prevent disease.
Pathogenic bacteria, which are temporary or permanent members of our microbial flora, cause or contribute to a wide range of human disease at all ages. Conditions include Alzheimer ’s disease, atherosclerosis, diabetes mellitus, obesity, cancer, autoimmunity and psychosis, amongst others. The mechanism of damage is inflammation which can be chronic or acute. An optimal microbial flora includes a wide range of pathogenic bacteria in low dose. This allows specific immunity to be developed and maintained with minimal inflammatory damage. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 26, 2018 Category: Biomedical Science Authors: James A Morris Source Type: research
Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma?
Cholesteatoma is an ear disease based on a locally destructive noncancerous conglomerate of epidermis and keratin debris. Abnormal growth of stratified keratinized squamous epithelium in the temporal bone causes destruction of the outer and middle ear, potentially leading to hearing impairment, facial palsy, vertigo, lateral sinus thrombosis, and intracranial complications. Although cholesteatoma is effectively treated by surgical resection (mastoidectomy), the lack of effective and nonsurgical therapies potentially results in fatal consequences, establishing the need for a comprehensive investigation of cholesteatoma path...
Source: Medical Hypotheses - February 24, 2018 Category: Biomedical Science Authors: Hiroshi Nakagawa, Yu Toyoda, Tobias Albrecht, Megumi Tsukamoto, Mark Praetorius, Toshihisa Ishikawa, Kazusaku Kamiya, Takeshi Kusunoki, Katsuhisa Ikeda, Serkan Sertel Source Type: research
Application of 3D Printing Technology in RGPCL Simulation Fitting
The rigid gas permeable contact lens (RGPCL) is an ideal choice to improve the corrective vision of patients with a high degree of refractive error, keratoconus and corneal transplantation. However, RGPCL fitting is not an easy work for those patients with extremely irregular corneal surface. Technicians or doctors often need to try many times to determine the relatively satisfied lens customization parameters. This repeated try-on process not only increases discomfort of patients, but also will increase the risks of corneal epithelial shedding or corneal infection. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 24, 2018 Category: Biomedical Science Authors: Feng Zhao, Guiyang Zhao, Fan Weijie, Lixun Chen Source Type: research
Categorising bone defect hematomas – Enhance early bone healing
Fracture hematoma formation describes a transitional phase that involves a dynamic and tightly choreographed interaction between the fibrin matrix, cells, and cytokines that guides the ensuing bone repair. Here we propose a novel hypothesis to explain why hematomas in conjunction with critical sized bone defects are prone to differentiate into fibrous tissues, which eventually results in non-unions of the bone. We postulate that certain hematoma qualities are triggers that influence cell biological behaviours and that the release of certain growth factors determines what pattern of remodelling will prevail: intramembranous...
Source: Medical Hypotheses - February 24, 2018 Category: Biomedical Science Authors: Xin Wang, Yi Zhang, Wenjun Ji, Jun Ao Source Type: research
SGLT2 inhibitor-induced euglycaemic diabetic ketoacidosis may be due to abrupt, severe and transient impaired glucose sensing in susceptible individuals with a hitherto unrecognised beta cell SGLT variant
Euglycaemic diabetic ketoacidosis (EDKA) is a rare complication of treatment with SGLT2 inhibitors in patients with type 2 diabetes. Uncertainty remains about its precise mechanistic basis, but the physiological derangement is acute and profound, yet reversible with cessation of the drug. It is reminiscent of other “non type 1” presentations with DKA such as ketosis prone diabetes, except that glucose levels are usually normal. Impaired beta cell glucose sensing that mimicked a state of hypoglycaemia could theoretically lead to abrupt and transient cessation of insulin secretion. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 23, 2018 Category: Biomedical Science Authors: F.M. Finucane Source Type: research
Clinical manifestations of pachychoroid may be secondary to pachysclera and increased scleral rigidity
Current imaging advancements have led to emergence of pachychoroid as an association of important vision threatening diseases like chronic serous chorioretinopathy and polypoidal choroidal vasculopathy. While the precise relation between thick choroid and such disorder is being investigated, the etiology behind pachychoroid remains elusive. We hypothesize pachychoroid to be a resultant of impeded vascular outflow due to thick sclera and increased scleral rigidity. We discuss our hypothesis in the perspective of other choroidal manifestations of anomalously thick scleral structure. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 23, 2018 Category: Biomedical Science Authors: Pradeep Venkatesh, Brijesh Takkar, Shreyas Temkar Source Type: research
PVDF piezoelectric neural conduit incorporated pre-differentiated adipose-derived stem cells may accelerate the repair of peripheral nerve injury
Peripheral nerve injury is a common trauma disease which often results in sensory and motor dysfunction. However, the surgical repair for peripheral nerve injury, especially for large segmental defects, is not satisfactory. Growing evidences suggest that artificial neural conduit combined with stem cells is potential tissue engineering remediation method for peripheral nerve injury. But, selections of biomaterials and stem cells are still being debated. Based on the findings from previous studies, we hypothesize that PVDF piezoelectric neural conduit incorporated Schwann-like cells which pre-differentiated from adipose-der...
Source: Medical Hypotheses - February 23, 2018 Category: Biomedical Science Authors: Li Ming, Zhang Peixun, Zhang Dianying Source Type: research
SGLT2 Inhibitor- Induced Euglycaemic Diabetic Ketoacidosis May be due to Abrupt, Severe and Transient Impaired Glucose Sensing in Susceptible Individuals with a Hitherto Unrecognised Beta Cell SGLT Variant
Euglycaemic diabetic ketoacidosis (EDKA) is a rare complication of treatment with SGLT2 inhibitors in patients with type 2 diabetes. Uncertainty remains about its precise mechanistic basis, but the physiological derangement is acute and profound, yet reversible with cessation of the drug. It is reminiscent of other “non type 1” presentations with DKA such as ketosis prone diabetes, except that glucose levels are usually normal. Impaired beta cell glucose sensing that mimicked a state of hypoglycaemia could theoretically lead to abrupt and transient cessation of insulin secretion. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 23, 2018 Category: Biomedical Science Authors: F.M. Finucane Source Type: research
Dissecting Spontaneous Cerebrospinal Fluid Collection
We report from the analysis of 2 cases the existence of a new complication of pediatric hydrocephalus. Naming this entity “dissecting intraparenchymal cerebrospinal fluid collection”, we advance a hypothesis regarding its pathophysiology and discuss its clinical implications and management. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 23, 2018 Category: Biomedical Science Authors: Pierre-Olivier Champagne, Jean-Claude Decarie, Louis Crevier, Alexander G Weil Source Type: research
Sleep and gravity
What is known about sleep results from years of observation at the surface of the Earth. Since a few decade man has been able to reach space, escape from the earth attraction and spend days and nights in a weightless condition. Some major physiological changes have been observed during long stays and in particular the sleep duration in space is shorter than on ground.This paper reviews a novel hypothesis proposing that sleep is partly due to gravity. Gravity is a fundamental part of our environment, but is elusive and difficult to apprehend. (Source: Medical Hypotheses)
Source: Medical Hypotheses - February 22, 2018 Category: Biomedical Science Authors: Alain A Gonfalone Source Type: research
