Prioritized Brain Selenium Retention and Selenoprotein Expression: Nutritional Insights into Parkinson’s Disease
Publication date: Available online 15 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Xiong Zhang, Rong-Pei Liu, Wen-Hsing Cheng, Jian-Hong ZhuAbstractSelenium (Se), an essential trace mineral, confers its physiological functions mainly through selenoproteins, most of which are oxidoreductases. Results from animal, epidemiological, and human genetic studies link Parkinson’s disease to Se and certain selenoproteins. Parkinson’s disease is characterized by multiple motor and non-motor symptoms that are difficult to diagnose at early stages of the pathogenesis. While irreversible, degenerative and...
Source: Mechanisms of Ageing and Development - April 17, 2019 Category: Geriatrics Source Type: research

Modulation of frailty syndrome by diet: a review of evidence from mouse studies
Publication date: Available online 10 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Sarah J. Mitchell, Gareth J. Mitchell, James R. MitchellAbstractFrailty is a progressive, aging-related syndrome of unknown etiology characterized by increased susceptibility and decreased resilience to external stressors. Understanding underlying mechanisms and identifying interventions to improve resilience are major challenges in biogerontology. Adequate nutrition is central to organismal health and wellbeing and can be modulated to improve longevity. While there are clear associations between poor nutrition (excess or...
Source: Mechanisms of Ageing and Development - April 11, 2019 Category: Geriatrics Source Type: research

Astragaloside IV and Ferulic Acid Synergistically Promote Neurite Outgrowth through Nrf2 Activation
Publication date: Available online 10 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yini Liang, Yu Zou, Chengu Niu, Yingcai NiuAbstractRecently, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) have nuclear localization and nuclear exclusion signals and shuttle between the cytoplasm and the nucleus. Thus, we hypothesised that astragaloside IV (AS-IV) induction nuclear import of Nrf2 and ferulic acid (FA) inhibition nuclear export of Nrf2 contribute to synergistic antioxidant effects of combination of FA and AS-IV (FA/AS-IV). Here, we have demonstrated that FA/AS-IV enhances neurite outgrowth of PC12 ce...
Source: Mechanisms of Ageing and Development - April 11, 2019 Category: Geriatrics Source Type: research

Sublethal whole-body irradiation causes progressive premature frailty in mice
Publication date: Available online 4 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Edward Fielder, Melanie Weigand, Julien Agneessens, Brigid Griffin, Craig Parker, Satomi Miwa, Thomas von ZglinickiAbstractThere is an unmet need to develop and validate therapies that can treat or at least prevent premature therapy-induced frailty, multi-morbidity and mortality in long-term tumour survivors. In an approach to develop a first mouse model for therapy-induced long-term frailty, we irradiated male C57Bl/6 mice at 5 to 6 months of age sub-lethally with 3 x 3 Gy (whole body) and assessed su...
Source: Mechanisms of Ageing and Development - April 6, 2019 Category: Geriatrics Source Type: research

High intensity interval training improves physical performance in aged female mice: a comparison of mouse frailty assessment tools
Publication date: Available online 2 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Kenneth Ladd Seldeen, Yonas Z. Redae, Ramkumar Thiyagarajan, Reem Nagi Berman, Merced Marie Leiker, Bruce Robert TroenAbstractFrailty syndrome increases the risk for disability and mortality, and is a major health concern amidst the geriatric shift in the population. High intensity interval training (HIIT), which couples bursts of vigorous activity interspersed with active recovery intervals, shows promise for the treatment of frailty. Here we compare and contrast five Fried physical phenotype and one deficit accumulation ...
Source: Mechanisms of Ageing and Development - April 3, 2019 Category: Geriatrics Source Type: research

Frailty index as a biomarker of lifespan and healthspan: focus on pharmacological interventions
Publication date: Available online 26 March 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Dushani L. Palliyaguru, Jacqueline M. Moats, Clara di Germanio, Michel Bernier, Rafael de CaboAbstractAlthough survival has been the focus of aging research for many years, the field is rapidly evolving towards incorporating healthspan and health indices in studies that explore aging-related outcomes. Frailty is one such measure that is tightly correlated with human aging. Several frailty measures have been developed that focus on phenotypes of aging, including physical, cognitive and metabolic health that define healthsp...
Source: Mechanisms of Ageing and Development - March 27, 2019 Category: Geriatrics Source Type: research

The Impact of Physical Activity and Sedentary Behaviors on Frailty Levels
Publication date: Available online 26 March 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Dustin Scott Kehler, Olga TheouAbstractHeterogeneity in aging can be explained by frailty. Lifestyle behaviors such as physical activity can help manage frailty levels. Conversely, sedentary behaviours are associated with frailty independently of physical activity. Here, we summarize epidemiological and clinical trial evidence concerning the impact of physical activity and sedentary behaviors on frailty levels. We also analysed the National Health and Nutrition Examination Survey (NHANES) data to describe physical activit...
Source: Mechanisms of Ageing and Development - March 27, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: April 2019Source: Mechanisms of Ageing and Development, Volume 179Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - March 25, 2019 Category: Geriatrics Source Type: research

Age and Frailty as Risk Factors for the Development of Osteoarthritis
Publication date: Available online 18 March 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Melissa S. O’Brien, Jason J. McDougallAbstractOsteoarthritis (OA) is a degenerative joint disease that increases in prevalence with advanced age. While a multitude of factors contribute to the development of OA, ageing has been implicated as a major driving force leading to an inability of the joint to repair itself and maintain normal health. In aged individuals, changes in joint cellular composition and signalling mechanisms have been observed which could lead to the development of degenerative joint disease. Sene...
Source: Mechanisms of Ageing and Development - March 19, 2019 Category: Geriatrics Source Type: research

Geroprotectors: a role in the treatment of frailty
Publication date: Available online 15 March 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): AU Trendelenburg, AC Scheuren, P Potter, R Müller, I BellantuonoAbstractThe proportion of the population over the age of 65 is growing the most rapidly due to the longevity revolution. Frailty is prevalent in this age group and strongly associated with disability and hospitalization, having a significant impact on the costs of health and social care. New effective interventions to delay or reverse frailty are urgently required. Geroprotectors are a new class of drugs, which target fundamental mechanisms of ageing and...
Source: Mechanisms of Ageing and Development - March 16, 2019 Category: Geriatrics Source Type: research

Circulating miR-146a in Healthy Aging and Type 2 Diabetes: Age- and Gender-Specific Trajectories
Publication date: Available online 14 March 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Emanuela Mensà, Angelica Giuliani, Giulia Matacchione, Felicia Gurău, Anna Rita Bonfigli, Fabio Romagnoli, Maria De Luca, Jacopo Sabbatinelli, Fabiola OlivieriAbstractTo evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR‐146a levels, 188 healthy subjects (CTR) aged 20-104 years and 144 type-2 diabetic patients (T2DM), aged 40‐80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran...
Source: Mechanisms of Ageing and Development - March 16, 2019 Category: Geriatrics Source Type: research

Do sex differences in chronic disease underpin the sex-frailty paradox?
Publication date: Available online 27 February 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): EH Gordon, RE HubbardAbstractThe ‘male-female health-survival paradox’ is a well-described clinical phenomenon. More recently, it has been conceptualized as a ‘sex-frailty paradox’: females may be considered to be more frail (because they have poorer health status) but also less frail (because they are less vulnerable to death) than males of the same age. Here, we review potential biological, behavioral and social mechanisms underpinning sex differences in morbidity, mortality and frailty before...
Source: Mechanisms of Ageing and Development - February 27, 2019 Category: Geriatrics Source Type: research

Functional Genomics of Dietary Restriction and Longevity in Yeast
Publication date: Available online 18 February 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Sergio E. Campos, Alexander DeLunaAbstractDietary restriction-limitation of calories or other specific nutrients in the diet-is the sole non-genetic intervention known to extend the lifespan of a wide range of model organisms from yeast to mammals. Cell biology studies on the responses to dietary restriction have provided important clues about the mechanisms of longevity; however, a comprehensive genome-wide description of lifespan by dietary restriction has been mostly absent. Large-scale genetic analysis in the buddi...
Source: Mechanisms of Ageing and Development - February 19, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: March 2019Source: Mechanisms of Ageing and Development, Volume 178Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 12, 2019 Category: Geriatrics Source Type: research

Retraction notice to "Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing" [YNBDI 178 (2019) 1 - 8]
Publication date: March 2019Source: Mechanisms of Ageing and Development, Volume 178Author(s): Qi Zhu, Linsheng Huang, Jian Zhu, Jianquan Lu, Huanlong Qin (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 12, 2019 Category: Geriatrics Source Type: research

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations
Publication date: Available online 6 February 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Ngangyola Tuikhar, Santosh Keisam, Rajendra Kumar Labala, Imrat, Padma Ramakrishnan, Moirangthem Cha Arunkumar, Giasuddin Ahmed, Elena Biagi, Kumaraswamy JeyaramAbstractGut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut microbiota composition and fecal metabolit...
Source: Mechanisms of Ageing and Development - February 7, 2019 Category: Geriatrics Source Type: research

RETRACTED: Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing
Publication date: March 2019Source: Mechanisms of Ageing and Development, Volume 178Author(s): Qi Zhu, Linsheng Huang, Jian Zhu, Jianquan Lu, Huanlong QinAbstractPromoting the health span and lifespan of humans is the ultimate proposition of medical science. Several lifespan-reducing chronic diseases are associated with alterations in the gut microbiota (GM) composition. We aimed to identify the particular age-related GM trajectory in older Chinese adults and investigated the characteristic gut bacterial taxa of long-lived Chinese individuals. Faecal samples from 375 older adults (centenarians or adults nearly 100 years ol...
Source: Mechanisms of Ageing and Development - February 5, 2019 Category: Geriatrics Source Type: research

Cell cycle arrest in replicative senescence is not an immediate consequence of telomere dysfunction
Publication date: Available online 30 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): M. Shamim Nassrally, Ashley Lau, Katherine Wise, Noah John, Sanjeev Kotecha, Kar Lai Lee, Robert F. BrooksAbstractIn replicative senescence, cells with critically-short telomeres activate a DNA-damage response leading to cell-cycle arrest, while those without telomere dysfunction would be expected to cycle normally. However, population growth declines more gradually than such a simple binary switch between cycling and non-cycling states would predict. We show here that late-passage cultures of human fibroblasts are not ...
Source: Mechanisms of Ageing and Development - January 31, 2019 Category: Geriatrics Source Type: research

Rodent models of frailty and their application in preclinical research
Publication date: Available online 28 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Shubham Banga, Stefan D. Heinze-Milne, Susan E. HowlettAbstractIn clinical medicine, the concept of frailty is viewed as a state of high vulnerability to adverse health outcomes in people of the same age. Frailty is an important challenge because the loss of physiological reserve means that even minor stressors can lead to disability and death in those who are frail. Even so, the biology of frailty is not well understood. Rodent models of frailty are stimulating research into the biology of frailty. These pre-clinical m...
Source: Mechanisms of Ageing and Development - January 29, 2019 Category: Geriatrics Source Type: research

Tauopathy: A common mechanism for neurodegeneration and Brain Aging
Publication date: Available online 19 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Pampa Saha, Nilkantha SenAbstractTau, a microtubule-associated protein promotes assembly and stability of microtubules which is related to axoplasmic flow and critical neuronal activities upon physiological conditions. Under neurodegenerative condition such as in Alzheimer’s Disease (AD), tau-microtubule binding dynamics and equilibrium are severely affected due to its aberrant post-translational modifications including acetylation and hyperphosphorylation. This event results in its conformational changes to form ...
Source: Mechanisms of Ageing and Development - January 20, 2019 Category: Geriatrics Source Type: research

Glycation interferes with natural killer cell function
Publication date: Available online 16 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Philip Rosenstock, Veronika Bezold, Kaya Bork, Jonas Scheffler, Rüdiger HorstkorteAbstractOne hallmark of molecular aging is glycation, better known as formation of so-called advanced glycation end products (AGEs), where reactive carbonyls react with amino-groups of proteins. AGEs accumulate over time and are responsible for various age-dependent diseases and impairments. Two very potent dicarbonyls to generate AGEs are glyoxal (GO) and methylglyoxal (MGO). The plasma level of such dicarbonyls is higher in aging an...
Source: Mechanisms of Ageing and Development - January 17, 2019 Category: Geriatrics Source Type: research

Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat
Publication date: Available online 16 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Emmanuel Moyse, Madeleine Arsenault, Pierrette Gaudreau, Guylaine Ferland, Charles RamassamyAbstractCaloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad ...
Source: Mechanisms of Ageing and Development - January 17, 2019 Category: Geriatrics Source Type: research

Apolipoprotein E gene in physiological and pathological aging
ConclusionsOur study indicates that ε4 allele is strongly associated with AD. APOE significantly affects AD risk, but apparently not longevity. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - January 16, 2019 Category: Geriatrics Source Type: research

Resistin: a reappraisal
Publication date: Available online 14 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): E. Acquarone, F. Monacelli, R. Borghi, A. Nencioni, P. OdettiAbstractFrom a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging.Resistin is a small s...
Source: Mechanisms of Ageing and Development - January 15, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: January 2019Source: Mechanisms of Ageing and Development, Volume 177Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - January 12, 2019 Category: Geriatrics Source Type: research

Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the ‘tissue skeleton’ gene network as a component of skin chrono-ageing
Publication date: Available online 11 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Valérie Haydont, Véronique Neiveyans, Nicolas O. Fortunel, Daniel AsselineauAbstractInteractions between extracellular matrix (ECM) and fibroblasts are essential for maintaining dermis integrity, and are subject to ageing. The ‘tissue skeleton’ network connects ECM to the nucleus and DNA, impacting nuclear shape and gene expression. In a previous Mech Ageing Dev publication, we have presented a transcriptomic study of papillary (Fp) and reticular (Fr) fibroblasts, with a main focus on Fp ageing...
Source: Mechanisms of Ageing and Development - January 12, 2019 Category: Geriatrics Source Type: research

Klotho gene polymorphisms are associated with healthy aging and longevity: evidence from a meta-analysis
In conclusion, Klotho G-395 A polymorphisms were associated with urolithiasis and cardiovascular disease but not with cognitive impairment. Additionally, Klotho F352 V polymorphisms were associated with cancers and longevity. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - January 11, 2019 Category: Geriatrics Source Type: research

Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells
Publication date: Available online 4 January 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Rumi Arai, Atsuki En, Yuki Takauji, Keisuke Maki, Kensuke Miki, Michihiko Fujii, Dai AyusawaAbstractCellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin proteins in cellular senescence. Here we analysed the role of lamin B receptor (LBR), a nuclear envelope protein ...
Source: Mechanisms of Ageing and Development - January 5, 2019 Category: Geriatrics Source Type: research

Where ageing goes nowadays: mechanisms, pathways, biomarkers and anti-ageing strategies
Publication date: Available online 18 December 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Efstathios S. Gonos, Niki Chondrogianni, Aleksandra Mladenovic Djordjevic (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - December 18, 2018 Category: Geriatrics Source Type: research

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview
Publication date: Available online 7 December 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Babatunde Fariyike, Quante Singleton, Monte Hunter, William D. Hill, Carlos M. Isales, Mark W. Hamrick, Sadanand FulzeleAbstractMicroRNA’s are small non-coding RNAs that regulate the expression of genes by targeting the 3’ UTR’s of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathologic...
Source: Mechanisms of Ageing and Development - December 7, 2018 Category: Geriatrics Source Type: research

Circular RNA involvement in aging: An emerging player with great potential
Publication date: Available online 1 December 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Hongcai Cai, Yamin Li, Jean Damascene Niringiyumukiza, Ping Su, Wenpei XiangAbstractCircular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting as a special covalent loop without a 5’ cap or 3’ tail. Multiple biological properties of circRNA have been revealed during the past decades, such as widespread expression, high conservation, cell-specificity, tissue-specificity and developmental stage-specific expression patterns, as well as resistance to RNase R digestion. CircRNA also e...
Source: Mechanisms of Ageing and Development - December 1, 2018 Category: Geriatrics Source Type: research

Editorial Board
Publication date: December 2018Source: Mechanisms of Ageing and Development, Volume 176Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - November 24, 2018 Category: Geriatrics Source Type: research

Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing
Publication date: Available online 22 November 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Qi Zhu, Linsheng Huang, Jian Zhu, Jianquan Lu, Huanlong QinAbstractPromoting the health span and lifespan of humans is the ultimate proposition of medical science. Several lifespan-reducing chronic diseases are associated with alterations in the gut microbiota (GM) composition. We aimed to identify the particular age-related GM trajectory in older Chinese adults and investigated the characteristic gut bacterial taxa of long-lived Chinese individuals. Faecal samples from 375 older adults (centenarians or adults nearly 1...
Source: Mechanisms of Ageing and Development - November 23, 2018 Category: Geriatrics Source Type: research

Caloric restriction and cellular senescence
Publication date: Available online 3 November 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Luigi Fontana, Jamil Nehme, Marco DemariaAbstractCellular senescence is a state of irreversible growth arrest characterized by hypertrophy and secretion of various bioactive molecules, a phenomenon defined the Senescence-Associated Secretory Phenotype (SASP). Senescent cells are implicated in a number of biological functions, from embryogenesis to aging. Significantly, excessive accumulation of senescent cells is associated to a decline of regenerative capacity and chronic inflammation. In accordance, the removal of sen...
Source: Mechanisms of Ageing and Development - November 3, 2018 Category: Geriatrics Source Type: research

Methionine restriction leads to hyperhomocysteinemia and alters hepatic H2S production capacity in Fischer-344 rats
Publication date: Available online 25 October 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Nahid Tamanna, Shyamchand Mayengbam, James D. House, Jason R. TrebergAbstractDietary methionine restriction (MR) increases lifespan in several animal models. Despite low dietary intake of sulphur amino acids, rodents on MR develop hyperhomocysteinemia. On the contrary, MR has been reported to increase H2S production in mice. Enzymes involved in homocysteine metabolism also take part in H2S production and hence, in this study, the impact of MR on hyperhomocysteinemia and H2S production capacity were investigated using Fi...
Source: Mechanisms of Ageing and Development - October 26, 2018 Category: Geriatrics Source Type: research

Dietary Fibers and Their Fermented Short-Chain Fatty Acids in Prevention of Human Diseases
Publication date: Available online 15 October 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Kedar N Prasad, Stephen C BondyAbstractMany studies show that daily consumption of high-fiber diet is associated with a reduced risk of developing kidney stones, inflammatory disease, colon cancer and other malignancies, obesity, type II diabetes, and cardiovascular disease. Dietary fibers are non-digestible polysaccharides that are composed of complex carbohydrates. Based on their relative solubility in water, dietary fibers can be divided into insoluble and soluble forms. An important property of insoluble fibers is t...
Source: Mechanisms of Ageing and Development - October 16, 2018 Category: Geriatrics Source Type: research

Altered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster
Publication date: Available online 10 October 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Nithya Mary Joseph, Nateshwar Yogindra Elphick, Sasha Mohammad, Johannes H. BauerAbstractMany insect behaviors, including foraging, aggression, mating or group behavior, are tightly regulated by pheromones. Recently, it has been shown that pheromones may influence extreme longevity in the honeybee Apis mellifera, while changes in pheromone profile have been observed during ageing in Drosophila melanogaster. These data suggest a potential link between the pheromone system, behavior and longevity in insects.Here, we inves...
Source: Mechanisms of Ageing and Development - October 11, 2018 Category: Geriatrics Source Type: research

Replicative aging as a source of cell heterogeneity in budding yeast
Publication date: Available online 4 October 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Dmitry A. Knorre, Aglaia V. Azbarova, Kseniia V. Galkina, Boris A. Feniouk, Fedor F. SeverinAbstractWhile deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious factors and, at late stages, the death of old pole (mother) cells. This phenomenon is known as replicative agi...
Source: Mechanisms of Ageing and Development - October 5, 2018 Category: Geriatrics Source Type: research

Modelling physical resilience in ageing mice
Publication date: Available online 2 October 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Markus Schosserer, Gareth Banks, Soner Dogan, Peter Dungel, Adelaide Fernandes, Darja Marolt Presen, Ander Matheu, Marcin Osuchowski, Paul Potter, Coral Sanfeliu, Bilge Guvenc Tuna, Isabel Varela-Nieto, Ilaria BellantuonoAbstractGeroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, intervent...
Source: Mechanisms of Ageing and Development - October 5, 2018 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2018Source: Mechanisms of Ageing and Development, Volume 175Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - September 5, 2018 Category: Geriatrics Source Type: research

Emerging Topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics
Publication date: Available online 19 August 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Martin S. Denzel, Louis R. Lapierre, Hildegard I.D. MackAbstractKey discoveries in aging research have been made possible with the use of model organisms. Caenorhabditis elegans is a short-lived nematode that has become a well-established system to study aging. The practicality and powerful genetic manipulations associated with this metazoan have revolutionized our ability to understand how organisms age. 25 years after the publication of the discovery of the daf-2 gene as a genetic modifier of lifespan, C. elegans remai...
Source: Mechanisms of Ageing and Development - August 19, 2018 Category: Geriatrics Source Type: research

Clinical and laboratory skin biomarkers of organ-specific diseases
Publication date: Available online 15 August 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Christos C. Zouboulis, Eugenia MakrantonakiAbstractIntense research during the last few years has elucidated a number of mechanisms of the complex human aging procedure. Among the body organs, skin has a distinguished role in aging perceptance both because it constitutes the organ on which the first signs of aging are mostly visible and because skin is recognized as an indicator of human health. Analogous to all other organs, skin undergoes multiple morphological and functional changes with age affected by extrinsic and ...
Source: Mechanisms of Ageing and Development - August 16, 2018 Category: Geriatrics Source Type: research

Cellular senescence in osteoarthritis and anti-aging strategies
Publication date: Available online 11 August 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Angyang Hou, Peng Chen, He Tang, Haoye Meng, Xiaoqing Cheng, Yu Wang, Yuming Zhang, Jiang PengAbstractIn older adults, the prevalence of osteoarthritis (OA) increases directly with age and is the most common cause of chronic disability. It is necessary to recognize that OA is a degenerative disease that strongly correlates with age, and often promotes elevated levels of cartilage injury. Chondrocytes undergo an age-dependent decline in proliferative and synthetic capacity. It is thought that cellular senescence may play ...
Source: Mechanisms of Ageing and Development - August 12, 2018 Category: Geriatrics Source Type: research

Oxaloacetate decarboxylase FAHD1 – a new regulator of mitochondrial function and senescence
Publication date: Available online 25 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Solmaz Etemad, Michèle Petit, Alexander K.H. Weiss, Andre Schrattenholz, Giorgia Baraldo, Pidder Jansen-DürrAbstractFAHD1, a member of the FAH superfamily of enzymes, was identified in a proteomic screen for mitochondrial proteins with differential expression in young versus senescent human endothelial cells. FAHD1 acts as oxaloacetate decarboxylase, and recent observations suggest that FAHD1 plays an important role in regulating mitochondrial function. Thus, mutation of the nematode homolog, fahd-1, impairs mi...
Source: Mechanisms of Ageing and Development - August 10, 2018 Category: Geriatrics Source Type: research

Editorial Board
Publication date: September 2018Source: Mechanisms of Ageing and Development, Volume 174Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - August 2, 2018 Category: Geriatrics Source Type: research

HIV Antiretroviral Therapy Drugs Induce Premature Senescence and altered Physiology in HUVECs
Publication date: Available online 25 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Justin Cohen, Luca D’Agostino, Ferit Tuzer, Claudio TorresAbstractDevelopments in medicine have led to a significant increase in the average human lifespan. This increase in aging is most readily apparent in the case of HIV where antiretroviral therapy has shifted infection from a terminal to a chronic but manageable disease. Despite this advance, patients suffer from co-morbidities best described as an accelerated aging phenotype. A potential contributor is cellular senescence, an aging-associated growth arrest, whi...
Source: Mechanisms of Ageing and Development - July 26, 2018 Category: Geriatrics Source Type: research

Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence
Publication date: Available online 25 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Solmaz Etemad, Michèle Petit, Alexander K.H. Weiss, Andre Schrattenholz, Giorgia Baraldo, Pidder Jansen-DürrAbstractFAHD1, a member of the FAH superfamily of enzymes, was identified in a proteomic screen for mitochondrial proteins with differential expression in young versus senescent human endothelial cells. FAHD1 acts as oxaloacetate decarboxylase, and recent observations suggest that FAHD1 plays an important role in regulating mitochondrial function. Thus, mutation of the nematode homolog, fahd-1, impairs mi...
Source: Mechanisms of Ageing and Development - July 26, 2018 Category: Geriatrics Source Type: research

Regulation of metabolic health by essential dietary amino acids
Publication date: Available online 22 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Cara L. Green, Dudley W. LammingAbstractAlthough the beneficial effects of calorie restriction (CR) on health and aging were first observed a century ago, the specific macronutrients and molecular processes that mediate the effect of CR have been heavily debated. Recently, it has become clear that dietary protein plays a key role in regulating both metabolic health and longevity, and that both the quantity and quality - the specific amino acid composition - of dietary protein mediates metabolic health. Here, we discuss rec...
Source: Mechanisms of Ageing and Development - July 23, 2018 Category: Geriatrics Source Type: research

Iron status in the elderly: a review of recent evidence
Publication date: Available online 21 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Anna A. Wawer, Amy Jennings, Susan J. Fairweather-TaitAbstractA comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 papers were retrieved that described research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (...
Source: Mechanisms of Ageing and Development - July 21, 2018 Category: Geriatrics Source Type: research

Proinflammatory cytokines and ageing of the cardiovascular-renal system
Publication date: Available online 19 July 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Paweł Smykiewicz, Agnieszka Segiet, Michelle Keag, Tymoteusz ŻeraAbstractCardiovascular health deteriorates with age, and age is one of the strongest risk factors for cardiovascular complications including myocardial infarction, heart failure, cardiac arrhythmias, and death related to heart diseases. In this review, we show that expression of proinflammatory cytokines (PICs) increases throughout the human lifespan, and this increase is correlated with cardiovascular health, morbidity, and mortality. We argue that increas...
Source: Mechanisms of Ageing and Development - July 20, 2018 Category: Geriatrics Source Type: research