Editorial Board
Publication date: January 2020Source: Mechanisms of Ageing and Development, Volume 185Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - December 28, 2019 Category: Geriatrics Source Type: research

Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer’s Disease: an update
Publication date: Available online 17 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Chiara Villa, Huriye Suphesiz, Romina Combi, Enes AkyuzAbstractWith more than 80 subunits, potassium (K+) channels represent a group of ion channels showing high degree of diversity and ubiquity. They play important role in the control of membrane depolarization and cell excitability in several tissues, including the brain. Controlling the intracellular and extracellular K+ flow in cells, they also modulate the hormone and neurotransmitter release, apoptosis and cell proliferation. It is therefore not surprising that a...
Source: Mechanisms of Ageing and Development - December 18, 2019 Category: Geriatrics Source Type: research

Frailty index and phenotype frailty score: sex- and age-related differences in 5XFAD transgenic mouse model of Alzheimer’s disease
Publication date: Available online 16 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Smilja Todorovic, Natasa Loncarevic-Vasiljkovic, Milena Jovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovic DjordjevicAbstractAlzheimer’s disease patients (AD), as well as AD transgenic mice, are characterized by increased frailty. Furthermore, the assessment of frailty status represents a feasible approach for detecting individuals prone to develop more severe form of AD and for measuring the outcome of existing and putative AD therapeutics. The 5xFAD mouse is one of the widely used transgenic animal m...
Source: Mechanisms of Ageing and Development - December 18, 2019 Category: Geriatrics Source Type: research

Semi-automated quantitation of mitophagy in cells and tissues
Publication date: Available online 13 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Lambert Montava-Garriga, François Singh, Graeme Ball, Ian G. GanleyAbstractMitophagy is a natural phenomenon and entails the lysosomal degradation of mitochondria by the autophagy pathway. In recent years, the development of fluorescent pH-sensitive mitochondrial reporters has greatly facilitated the monitoring of mitophagy by distinguishing between cytosolic mitochondria or those delivered to acidic lysosomes. We recently published the mito-QC reporter, which consists of a mitochondrial outer membrane-localised...
Source: Mechanisms of Ageing and Development - December 15, 2019 Category: Geriatrics Source Type: research

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
Publication date: Available online 5 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yahyah Aman, Johannes Frank, Sofie Hindkjær Lautrup, Adrian Matysek, Zhangming Niu, Guang Yang, Liu Shi, Linda H. Bergersen, Jon Storm-Mathisen, Lene J. Rasmussen, Vilhelm A. Bohr, Hilde Nilsen, Evandro F. FangAbstractNicotinamide adenine dinucleotide (NAD+) is an important natural molecule involved in fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a co-factor for proteins promoting healthy longevity. NAD+ depletion is associated with the hallmarks of ageing and may con...
Source: Mechanisms of Ageing and Development - December 6, 2019 Category: Geriatrics Source Type: research

Revisiting the effects of menopause on the skin: functional changes, clinical studies, in vitro models and therapeutic alternatives
Publication date: Available online 4 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Thamile Luciane Reus, Carla Abdo Brohem, Desiree Cigaran Schuck, Marcio LorenciniAbstractMenopause is a stage in a woman’s life characterized by twelve months of amenorrhoea. This transition happens due to changes in ovarian follicular activity, leading to endocrine, biological and clinical modifications. The main hormones related to these changes and symptoms are oestradiol, LH, FSH, AMH, Inhibin B and GnRH. It is important to point out that the skin is very affected by all these hormone changes, leading to a dec...
Source: Mechanisms of Ageing and Development - December 6, 2019 Category: Geriatrics Source Type: research

Multi-omics approaches to human biological age estimation
Publication date: Available online 28 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Ilya Solovev, Mikhail Shaposhnikov, Alexey MoskalevAbstractMulti-omics approach nowadays increasingly applied to molecular research in many fields of life sciences. Biogerontology is not an exception; multi-omics gives possibility to evaluate complex biomarkers (or panels) which consist of quantitative as well as phenotypic ones. It is especially important because of weak understanding of the nature of aging. The difficulty now is distinguishing between causes and effects of aging. The application of the whole set of m...
Source: Mechanisms of Ageing and Development - November 29, 2019 Category: Geriatrics Source Type: research

Catalytic Antibody (Catabody) Platform for Age-Associated Amyloid Disease: From Heisenberg’s Uncertainty Principle to the Verge of Medical Interventions
Publication date: Available online 26 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Stephanie A. Planque, Richard J. Massey, Sudhir PaulAbstractQuantum mechanics-based design of useful catalytic antibodies (catabodies) failed because of the uncertain structure of the dynamic catalyst-substrate complex. The Catabody Platform emerged from discovery of beneficial germline gene catabodies that hydrolyzed self-proteins by transient covalent pairing of the strong catabody nucleophile with a weak target protein electrophile. Catabodies have evolved by Darwinian natural selection for protection against misfol...
Source: Mechanisms of Ageing and Development - November 26, 2019 Category: Geriatrics Source Type: research

Increased Oxidative Stress, Inflammation, and Glutamate: Potential Preventive and Therapeutic Targets for Hearing Disorders
Publication date: Available online 22 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Kadar N. Prasad, Stephen C. BondyAbstractHearing disorders constitute one of the major health concerns in the USA. Decades of basic and clinical studies have identified numerous ototoxic agents and investigated their modes of action on the inner ear, utilizing tissue culture as well as animal and human models. Current preventive and therapeutic approaches are considered unsatisfactory. Therefore, additional modalities should be developed. Many studies suggest that increased levels of oxidative stress, chronic inflammat...
Source: Mechanisms of Ageing and Development - November 23, 2019 Category: Geriatrics Source Type: research

Telomere length analysis on leukocytes derived from patients with Huntington Disease
This study contributes with current evidence suggesting a potential role of telomere shortening as HD biomarker. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - November 23, 2019 Category: Geriatrics Source Type: research

Endurance training improves plasma superoxide dismutase activity in healthy elderly
Publication date: Available online 22 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Roberta Ceci, Guglielmo Duranti, Ester Sara Di Filippo, Danilo Bondi, Vittore Verratti, Christian Doria, Daniela Caporossi, Stefania Sabatini, Ivan Dimauro, Tiziana PietrangeloAbstractWe aimed to characterize the plasma redox homeostasis as underlying physiological mechanisms of specific training on healthy elderly. 51 healthy volunteers were trained to endurance, resistance, Neuro-Muscular Electrical Stimulation for 12 weeks, 3 sessions/w, all applied to lower limbs. We assessed ex-post quadriceps’ maximal volun...
Source: Mechanisms of Ageing and Development - November 23, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: December 2019Source: Mechanisms of Ageing and Development, Volume 184Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - November 16, 2019 Category: Geriatrics Source Type: research

Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways
Publication date: Available online 9 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Saara Marttila, Kasit Chatsirisupachai, Daniel Palmer, João Pedro de MagalhãesAbstractAgeing-associated changes in the protein coding transcriptome have been extensively characterised, but less attention has been paid to the non-coding portion of the human genome, especially to long non-coding RNAs (lncRNAs). Only a minority of known lncRNAs have been functionally characterised; however, a handful of these lncRNAs have already been linked to ageing-associated processes. To gain more information on the effe...
Source: Mechanisms of Ageing and Development - November 10, 2019 Category: Geriatrics Source Type: research

Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients
Publication date: Available online 2 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Moisés Garcés, M. Isabel Guijarro, Antonia Vargas, Juan J. Badiola, Marta MonzónAbstractNeurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are considered prion-like disorders because they are all proteinopathies in which aberrant proteins spread throughout the brain during disease progression. The overall aim of this study is to determine how glial cells are commonly involved in the neurodegeneration progress observed in all these pathologies. The suggestion that they are c...
Source: Mechanisms of Ageing and Development - November 4, 2019 Category: Geriatrics Source Type: research

Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease
Publication date: Available online 1 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Tao-Ran Li, Xiao-Ni Wang, Can Sheng, Yu-Xia Li, Frederic Zhen-Tao Li, Yu Sun, Ying HanAbstractAlzheimer’s disease (AD) is characterized by a series of interacting pathophysiological cascades, including the aggregation of β-amyloid plaques and the formation of neurofibrillary tangles derived from hyperphosphorylated tau proteins. AD is the cause of approximately 70% of dementia, an irreversible and untreatable syndrome at its late stage. Hence, more efforts should be devoted to identifying at-risk or preclinic...
Source: Mechanisms of Ageing and Development - November 2, 2019 Category: Geriatrics Source Type: research

Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells
In this study, we explored the role of Dsg3 on dome formation, reactive oxygen species (ROS) production and transepithelial electrical resistance (TER) in MDCK cells, a kidney epithelial cell model widely used to study cell differentiation and tight junction formation and integrity. We show that overexpression of Dsg3 constrained nuclear ROS production and cellular doming in confluent cell cultures and these features coincided with augmented TER and enhanced tight junction integrity. Conversely, cells expressing dominant-negative Dsg3ΔC mutants exhibited heightened ROS production and accelerated doming, accompanied b...
Source: Mechanisms of Ageing and Development - November 1, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: October 2019Source: Mechanisms of Ageing and Development, Volume 183Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - October 26, 2019 Category: Geriatrics Source Type: research

Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice
Publication date: Available online 21 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Francesco Piccirillo, Myriam Carpenito, Giuseppe Verolino, Camilla Chello, Annunziata Nusca, Mario Lusini, Cristiano Spadaccio, Francesco Nappi, Germano Di Sciascio, Antonio NennaAbstractAging results in functional and structural changes in the cardiovascular system, translating into a progressive increase of mechanical vessel stiffness, due to a combination of changes in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell migration and proliferation. The two pivotal mechanisms of aging-...
Source: Mechanisms of Ageing and Development - October 23, 2019 Category: Geriatrics Source Type: research

NF-κB signaling in skin aging
Publication date: Available online 18 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yujia Wang, Lian Wang, Xiang Wen, Dan Hao, Nan Zhang, Gu He, Xian JiangAbstractSkin is the largest organ of the body, and is prone to be affected by external environmental factors. Skin aging is caused by both genetic and environmental factors. Furthermore, aging skin tissue is known to create a permissive tissue microenvironment that promotes the initiation, progression and resistance of cancer cells by promoting the senescence-associated secretory phenotype (SASP). Therefore, more attention should be paid to skin agin...
Source: Mechanisms of Ageing and Development - October 20, 2019 Category: Geriatrics Source Type: research

Glycoanalysis of the placental membrane glycoproteins throughout placental development
Publication date: Available online 4 October 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Dragana Robajac, Romana Masnikosa, Marek Nemčovič, Martina Križáková, Ľudmila Belická Kluková, Peter Baráth, Jaroslav Katrlík, Olgica NedićAbstractStructural changes of glycans are observed in different (patho)physiological conditions. Human placental membrane (glyco)proteins were isolated from the first and third trimester placentas of mothers at different ages. By using lectin microarray, we demonstrated that the placental membrane N-glycome contains several N-glycan group...
Source: Mechanisms of Ageing and Development - October 5, 2019 Category: Geriatrics Source Type: research

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories
Publication date: Available online 28 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Jaana Van Gastel, Huan Cai, Wei-Na Cong, Wayne Chadwick, Caitlin Daimon, Hanne Leysen, Jhana O. Hendrickx, Robin De Schepper, Laura Vangenechten, Jens Van Turnhout, Jasper Verswyvel, Kevin G. Becker, Yongqing Zhang, Elin Lehrmann, William H. Wood, Bronwen Martin, Stuart MaudsleyAbstractIn most species, females live longer than males. An understanding of this female longevity advantage will likely uncover novel anti-aging therapeutic targets. Here we investigated the transcriptomic responses in the hypothalamus –...
Source: Mechanisms of Ageing and Development - September 29, 2019 Category: Geriatrics Source Type: research

Replicative senescence is distinguishable from DNA damage-induced senescence by increased methylation of promoter of rDNA and reduced expression of rRNA
Publication date: Available online 27 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Reiko Sanokawa-Akakura, Shin Akakura, Elena A. Ostrakhovitch, Siamak TabibzadehAbstractHuman fibroblasts become senescent after a limited number of replications or by diverse stresses, such as DNA damage. However, replicative and damage induced senescence are indistinguishable in respect to proliferation cessation and expression of senescence markers, senescence-associated β-galactosidase, p16 and p21. Here, we show that senescence types can be distinguished by reduced levels of 18S, 5.8S and 28S rRNA, in replica...
Source: Mechanisms of Ageing and Development - September 28, 2019 Category: Geriatrics Source Type: research

Interferons: a molecular switch between damage and repair in ageing and Alzheimer’s disease
Publication date: Available online 18 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): N. Gorlé, R.E. VandenbrouckeAbstractAlzheimer’s disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer’s disease. Th...
Source: Mechanisms of Ageing and Development - September 20, 2019 Category: Geriatrics Source Type: research

Telomere length and physical performance among older people—The Helsinki Birth Cohort Study
Publication date: October 2019Source: Mechanisms of Ageing and Development, Volume 183Author(s): Max J. Åström, Mikaela B. von Bonsdorff, Mia-Maria Perälä, Minna K. Salonen, Taina Rantanen, Eero Kajantie, Mika Simonen, Pertti Pohjolainen, Markus J. Haapanen, Maria A. Guzzardi, Patricia Iozzo, Hannu Kautiainen, Johan G. ErikssonAbstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and...
Source: Mechanisms of Ageing and Development - September 16, 2019 Category: Geriatrics Source Type: research

Classical Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide Stimulation
In conclusion, aged classical monocytes maintain effector and metabolic functions during glucose deprivation, at least in an ex vivo context. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

Ischemic Stroke In Neonatal And Adult Astrocytes
The objective of this paper is to review current information regarding astrocytes function after a stroke in neonatal and adult brain. Based on the current literature, there are some molecular differences related to blood brain barrier (BBB) homeostasis disruption, inflammation and reactive oxygen species (ROS) mediated injury between the immature and mature brain after an ischemic event. In particular, astrocytes, the main glial cells in brain, play a different role in neonatal and adult brain after stroke, as time course of glial activation is strongly age dependent. Moreover, the present review provides further insight ...
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

Telomere length and physical performance among older people – the Helsinki Birth Cohort Study
Publication date: Available online 3 September 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Max J. Åström, Mikaela B. von Bonsdorff, Mia-Maria Perälä, Minna K. Salonen, Taina Rantanen, Eero Kajantie, Mika Simonen, Pertti Pohjolainen, Markus J. Haapanen, Maria A. Guzzardi, Patricia Iozzo, Hannu Kautiainen, Johan G. ErikssonAbstractTelomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 ...
Source: Mechanisms of Ageing and Development - September 4, 2019 Category: Geriatrics Source Type: research

Regulation of cellular senescence by retinoid X receptors and their partners
Publication date: Available online 30 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Nadine Martin, Xingjie Ma, David BernardABSTRACTCellular senescence is a response characterized by a stable cell proliferation arrest and a senescence-associated secretory phenotype (SASP) which can be induced by many stresses, including telomere shortening and oncogene activation. Senescence is crucially involved in a variety of physiopathological contexts, such as cancer and aging. Given the fundamental role of this process, senescence needs to be tightly regulated. In the last decade, the key implication of nuclear re...
Source: Mechanisms of Ageing and Development - August 31, 2019 Category: Geriatrics Source Type: research

Feed-forward Loop between Body Composition, Strength and Performance in Older Adults
We present evidence of a feed-forward loop relationship between certain components of the frailty syndrome: body composition, strength and physical performance level.The evidence has been found by performing statistical analysis on measures from 878 females and 588 males aged 60-97, participating in the Rancho Bernardo Study, followed for at least three visits over 12 years. In the analysis, we have used fat mass and lean mass (measured by whole body DXA scans), grip strength (measured by dynamometer) and time to get up and walk a certain distance. The results provide evidence of a feed-forward loop between these variables...
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research

Publisher's Note
Publication date: September 2019Source: Mechanisms of Ageing and Development, Volume 182Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: September 2019Source: Mechanisms of Ageing and Development, Volume 182Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - August 30, 2019 Category: Geriatrics Source Type: research

Prognostic networks for unraveling the biological mechanisms of Sarcopenia
Publication date: Available online 21 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Ana Cernea, Juan Luis Fernández-Martínez, Enrique Juan de Andrés-Galiana, Zulima Fernández-Muñiz, Juan Carlos Bermejo-Millo, Laura González-Blanco, Juan José Solano, Pedro Abizanda, Ana Coto-Montes, Beatriz CaballeroAbstractSarcopenia is an age-related multifactorial process that involved several biological mechanisms, whose specific contribution and interplay is still unknown. The present study proposes prognostic networks based on machine learning approaches to unravel t...
Source: Mechanisms of Ageing and Development - August 23, 2019 Category: Geriatrics Source Type: research

Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats
Publication date: Available online 9 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Leonardo D. Diene, Zaquer S.M. Costa-Ferro, Silvia Barbosa, Bruna Bueno Milanesi, Gabriele Zenato Lazzari, Laura Tartari Neves, Lisiê Valéria Paz, Paula Fernanda Ribas Neves, Vanessa Battisti, Lucas A. Martins, Gunther Gehlen, Régis Gemerasca Mestriner, Jaderson C. Da Costa, Léder L. XavierAbstractNormal ageing results in brain selective neuronal and glial losses. In the present study we analyze neuronal and glial changes in Wistar rats at two different ages, 45 days (young) and 420 days (mature...
Source: Mechanisms of Ageing and Development - August 11, 2019 Category: Geriatrics Source Type: research

Inflamm-aging micrornas may integrate signals from food and gut microbiota by modulating common signalling pathways
Publication date: Available online 8 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Laura Teodori, Ilaria Petrignani, Angelica Giuliani, Francesco Prattichizzo, Felicia Gurău, Giulia Matacchione, Fabiola Olivieri, Sofia Coppari, Maria Cristina AlbertiniAbstractHuman gut microbiota, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, may be associated with inflammation and age-related chronic health conditions. However, the mechanism underlying this association is only recently beginning to emerge. Transfer and modulation of gene expression by die...
Source: Mechanisms of Ageing and Development - August 9, 2019 Category: Geriatrics Source Type: research

When will my mouse die? Life span prediction based on immune function, redox and behavioural parameters in female mice at the adult age
Publication date: Available online 2 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Irene Martínez de Toda, Carmen Vida, Luis Sanz San Miguel, Mónica De la FuenteAbstractThe identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N = 38). Mice were monitored individually until they died and individual life spans were regist...
Source: Mechanisms of Ageing and Development - August 4, 2019 Category: Geriatrics Source Type: research

Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice
Publication date: Available online 2 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Allen Herbst, Austin N. Hoang, Wendy Woo, Debbie McKenzie, Judd M. Aiken, Richard A. Miller, David B. Allison, Nianjun Liu, Jonathan WanagatAbstractThe age-induced, exponential accumulation of mitochondrial DNA (mtDNA) deletion mutations contributes to muscle fiber loss. The causes of these mutations are not known. Systemic inflammation is associated with decreased muscle mass in older adults and is implicated in the formation of sporadic mtDNA deletions. Macrophage migration inhibitory factor knockout (MIF-KO) mice are l...
Source: Mechanisms of Ageing and Development - August 4, 2019 Category: Geriatrics Source Type: research

The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53
Publication date: Available online 1 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Deping Xu, Fanjun Zeng, Linzi Han, Jun Wang, Zongzhi Yin, Liying Lv, Liyu Guo, Deguang Wang, Yuanhong Xu, Haisheng ZhouAbstractCardiovascular calcification is associated with cardiovascular morbidity and mortality of patients with end-stage renal diseases (ESRD). Hyperphosphatemia and many of the inflammatory markers and mediators, including interleukin-6 (IL-6), are considered as the major risk factors of cardiovascular calcification. Although cellular senescence may be involved in cardiovascular calcification caused by ...
Source: Mechanisms of Ageing and Development - August 1, 2019 Category: Geriatrics Source Type: research

Spelunking the biology of frailty
Publication date: Available online 10 July 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Alice E. Kane, Susan E. Howlett (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - July 19, 2019 Category: Geriatrics Source Type: research

EditorialSpelunking the Biology of Frailty
Publication date: Available online 10 July 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Alice E Kane, Susan E Howlett (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - July 11, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: July 2019Source: Mechanisms of Ageing and Development, Volume 181Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - June 26, 2019 Category: Geriatrics Source Type: research

Attenuation of frailty in older adults with mesenchymal stem cells
Publication date: Available online 7 June 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Victoria Florea, Luiza Bagno, Angela C. Rieger, Joshua HareAbstractAging frailty is a syndrome characterized by a progressive decline in health and clinical symptoms of exhaustion, weight loss, a feeling of slowing down, and a decrease in functional capacity. The biological substrate for frailty is sarcopenia, which is potentiated by chronic inflammation and depletion or impairment of endogenous precursor and stem cells. Current interventions focus on interdisciplinary approaches which include nutritional supplementation, p...
Source: Mechanisms of Ageing and Development - June 8, 2019 Category: Geriatrics Source Type: research

Role of frailty in the assessment of cognitive functioning
Publication date: Available online 3 June 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Marco Canevelli, Matteo Cesari, Riccardo Raganato, Federica Trentin, Martina Valletta, Emanuela Salati, Giuseppe BrunoAbstractNeuropsychological tests, besides reflecting the cognitive reserves and deficits of the tested individual, might also be differently affected by his/her underlying biological asset. In this context, the construct of frailty may offer an opportunity for better weighting the results of traditional tests. We evaluated the relationships between a set neuropsychological measures and a 35-item Frailty Inde...
Source: Mechanisms of Ageing and Development - June 4, 2019 Category: Geriatrics Source Type: research

Knockdown of the neuronal gene Lim3 at the early stages of development affects mitochondrial function and lifespan in Drosophila
Publication date: Available online 31 May 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Olga Y. Rybina, Mikhail I. Schelkunov, Ekaterina R. Veselkina, Svetlana V. Sarantseva, Anna V. Krementsova, Mikhail Y. Vysokikh, Pavel A. Melentev, Maria A. Volodina, Elena G. PasyukovaAbstractUnderstanding the molecular mechanisms underlying variation in lifespan is central to ensure long life. Lim3 encoding a homolog of the vertebrate Lhx3/4 transcription factors plays a key role in Drosophila neuron development. Here, we demonstrated that Lim3 knockdown early in life decreased survival of adult flies. To study the mechan...
Source: Mechanisms of Ageing and Development - June 1, 2019 Category: Geriatrics Source Type: research

Biology of frailty: implications for clinical pharmacology and drug therapy in frail older people
Publication date: Available online 22 May 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Sarah N. Hilmer, Harry Wu, Meggie ZhangAbstractPolypharmacy is very common in frail older people, although medications are rarely evaluated in this population. We conducted a narrative review of the effects of the biology of frailty on clinical pharmacology to inform the extrapolation of the results from clinical trials in robust people to the treatment of frail older people. Biological changes of frailty, such as changes in body composition, organ function and vulnerability to external stressors, are likely to impact on th...
Source: Mechanisms of Ageing and Development - May 22, 2019 Category: Geriatrics Source Type: research

Editorial Board
Publication date: June 2019Source: Mechanisms of Ageing and Development, Volume 180Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - May 16, 2019 Category: Geriatrics Source Type: research

Chromosomal instability and pro-inflammatory response in aging
Publication date: Available online 15 May 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Monika Barroso-Vilares, Elsa LogarinhoAbstractAging refers to the progressive deterioration of tissue and organ function over time. Increasing evidence points to the accumulation of highly damaged cell cycle-arrested cells with age (cellular senescence) as major reason for the development of certain aging-associated diseases. Recent studies have independently shown that aneuploidy, an abnormal chromosome set, occurs in senescent cells, and that the accumulation of cytoplasmic DNA driven by faulty chromosome segregation duri...
Source: Mechanisms of Ageing and Development - May 15, 2019 Category: Geriatrics Source Type: research

Crucial players in Alzheimer’s disease and Diabetes Mellitus: Friends or Foes?
Publication date: Available online 11 May 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): AM. Kubis-Kubiak, A. Rorbach-Dolata, A. PiwowarAbstractAlzheimer's disease (AD) and diabetes mellitus, especially type 2 (T2DM), are very common and widespread diseases in contemporary societies, and their incidence is steadily on the increase. T2DM is a multiple metabolic disorder, with several mechanisms including hyperglycaemia, insulin resistance, insulin receptor and insulin growth factor disturbances, glucose toxicity, formation of advanced glycation end products (AGEs) and the activity of their receptors. AD is the m...
Source: Mechanisms of Ageing and Development - May 12, 2019 Category: Geriatrics Source Type: research

Emerging senolytic agents derived from natural products
Publication date: Available online 8 May 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Wen Li, Lin Qin, Rennan Feng, Guangrong Hu, Hui Sun, Yonghan He, Rongping ZhangAbstractCellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. During the aging process, senescent cells (SCs) increasingly accumulate in tissues, causing a loss of tissue-repair capacity because of cell cycle arrest in progenitor cells and produce proinflammatory and matrix-degrading molecules which are known as the senescence-associated secretory phenotype (SASP), and thereby contri...
Source: Mechanisms of Ageing and Development - May 9, 2019 Category: Geriatrics Source Type: research

Age-related deficit accumulation and the diseases of ageing
Publication date: Available online 16 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Kenneth Rockwood, Susan E HowlettAbstractWith ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. The many effects of age-related changes can be demonstrated epidemiologically, and in preclinical models, using a frailty index to disting...
Source: Mechanisms of Ageing and Development - April 17, 2019 Category: Geriatrics Source Type: research

Frailty biomarkers in humans and rodents: current approaches and future advances
Publication date: Available online 17 April 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Alice E. Kane, David A. SinclairAbstractEven though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are l...
Source: Mechanisms of Ageing and Development - April 17, 2019 Category: Geriatrics Source Type: research