Particle radiation-induced dysregulation of protein homeostasis in primary human and mouse neuronal cells
In this study, we employed a quantitative proteomics method to evaluate the impact of particle-radiation induced alterations in three major pUb-linked chains at lysine residues Lys-48 (K-48), Lys-63 (K-63) and Lys-11 (K-11), and probed for global proteomic changes in mouse and human neural cells that were irradiated with low doses of 250 MeV proton, 260 MeV/u silicon or 1 GeV/u iron ions. We found significant accumulation in K-48 linkage after 1 Gy protons and K-63 linkage after 0.5 Gy iron ions in human neural cells. Cells derived from different regions of the mouse brain (cortex, striatum and mesencephalon) showed differ...
Source: Life Sciences in Space Research - February 21, 2020 Category: Biology Source Type: research
Pattern of the variation of the TEC extracted from the GPS, IRI 2016, IRI-Plas 2017 and NeQuick 2 over polar region, Antarctica
Publication date: Available online 21 February 2020Source: Life Sciences in Space ResearchAuthor(s): Yekoye Asmare TarikuAbstractAs a result of the complex and typical behavior of the earth's magnetic field, the high latitude ionospheric parameters (such as the Vertical Total Electron Content, VTEC) are very dynamic. Thus, this study mainly focuses on the pattern of variation of the VTEC inferred from the GPS, IRI 2016, IRI-Plas 2017 and NeQuick 2 with different height over Antarctica during 2011-2017. It has been shown that the GPS-derived (GPS VTEC) and modelled (IRI 2016, IRI-Plas 2017 and NeQuick 2) VTEC do not show si...
Source: Life Sciences in Space Research - February 21, 2020 Category: Biology Source Type: research
The associations of geomagnetic storms, fast solar wind, and stream interaction regions with cardiovascular characteristic in patients with acute coronary syndrome
Publication date: Available online 25 January 2020Source: Life Sciences in Space ResearchAuthor(s): Deivydas Kiznys, Jone Vencloviene, Irena MilvidaitėAbstractIt is shown the statistical associations between space weather pattern and humans’ cardiovascular system. We investigated the association between space weather events and cardiovascular characteristics of 4076 randomly selected patients with acute coronary syndrome (ACS) who were admitted for inpatient treatment in Kaunas city, Lithuania during 2000–2005. We hypothesized that days of the space weather events, 1–3 days after, and the period between two events, ...
Source: Life Sciences in Space Research - January 26, 2020 Category: Biology Source Type: research
IFC - Editorial Board
Publication date: February 2020Source: Life Sciences in Space Research, Volume 24Author(s): (Source: Life Sciences in Space Research)
Source: Life Sciences in Space Research - January 24, 2020 Category: Biology Source Type: research
Mars Terraforming: A Geographic Information Systems Framework
This study has developed a GIS framework that uses spatial environmental and climate data to better understand areas on Earth that share the most environmental similarities to Mars. The purpose of developing this framework is to determine which vegetation is most likely to survive in closed bioregenerative life support systems on Mars, using as many in-situ materials and environmental elements as possible. Using remotely sensed climate data, digital elevation models, and vegetation occurrence data sourced from the Global Biodiversity Information Facility, 2018, Global Biodiversity Information Facility, 2018, Global Biodive...
Source: Life Sciences in Space Research - January 17, 2020 Category: Biology Source Type: research
Simulating galactic cosmic ray effects: synergy modeling of murine tumor prevalence after exposure to two one-ion beams in rapid sequence
Publication date: Available online 7 January 2020Source: Life Sciences in Space ResearchAuthor(s): Edward Greg Huang, Ren-Yi Wang, Liyang Xie, Polly Chang, Gracie Yao, Borong Zhang, Dae WoongHam, Yimin Lin, Eleanor Blakely, Rainer SachsABSTRACTHealth risks from galactic cosmic rays (GCR) in space travel above low earth orbit remain a concern. For many years accelerator experiments investigating space radiation induced prevalence of murine Harderian gland (HG) tumorigenesis have been performed to help estimate GCR risks. Most studies used acute, relatively low fluence, exposures. Results on a broad spectrum of individual io...
Source: Life Sciences in Space Research - January 8, 2020 Category: Biology Source Type: research
A commentary on the impact of modelling results to inform mission planning and shield design
Publication date: Available online 16 November 2019Source: Life Sciences in Space ResearchAuthor(s): Samy El-Jaby, Brent J. Lewis, Leena TomiAbstractA correspondence has been received in reference to a recently published article titled “On the decision making criteria for cis-lunar reference scenarios”. The intent of the paper was to demonstrate: (i) a novel methodology for calculating the dose from solar particle events (SPEs), and (ii) the impact of the SPE parametric model, shield thickness, dose metric, and radiation transport code on choosing a worst-case scenario. This effort assumed a spherical, aluminum spacecr...
Source: Life Sciences in Space Research - January 2, 2020 Category: Biology Source Type: research
Data Analysis for Optimization of Mars Terraforming: A GIS Framework
This study has developed a GIS framework that uses spatial environmental and climate data to better understand areas on Earth that share the most environmental similarities to Mars. The purpose of developing this framework is to determine which vegetation is most likely to survive in closed bioregenerative life support systems on Mars, using as many in-situ materials and environmental elements as possible. Using remotely sensed climate data, digital elevation models, and vegetation occurrence data sourced from the Global Biodiversity Information Facility, three Mars-like study areas on Earth were analysed (the Antarctic Pe...
Source: Life Sciences in Space Research - December 27, 2019 Category: Biology Source Type: research
A commentary on the of the impact of modeling results to inform mission planning and shield design
Publication date: Available online 16 November 2019Source: Life Sciences in Space ResearchAuthor(s): Samy El-Jaby, Brent J. Lewis, Leena TomiAbstractA correspondence has been received in reference to a recently published article titled “On the decision making criteria for cis-lunar reference scenarios”. The intent of the paper was to demonstrate: (i) a novel methodology for calculating the dose from solar particle events (SPEs), and (ii) the impact of the SPE parametric model, shield thickness, dose metric, and radiation transport code on choosing a worst-case scenario. This effort assumed a spherical, aluminum spacecr...
Source: Life Sciences in Space Research - December 24, 2019 Category: Biology Source Type: research
Synergistic effects of edible plants with light environment on the emotion and sleep of humans in long-duration isolated environment
Publication date: Available online 16 December 2019Source: Life Sciences in Space ResearchAuthor(s): Wenzhu Zhang, Hui Liu, Zhaoming Li, Hong LiuAbstractThe emotion and sleep-related problems of humans who are on mission of deep-space and deep-sea exploration are topics of special interest because of the isolated environment. Effective regulatory approaches should be developed to manage the positive emotions and sleep quality in a long-duration isolated environment. The results reported that emotion and sleep were closely linked to each other because plants could significantly regulate humans’ emotion and sleep through t...
Source: Life Sciences in Space Research - December 16, 2019 Category: Biology Source Type: research
William (Bill) Atwell (1939-2019)
Publication date: November 2019Source: Life Sciences in Space Research, Volume 23Author(s): (Source: Life Sciences in Space Research)
Source: Life Sciences in Space Research - November 30, 2019 Category: Biology Source Type: research
IFC - Editorial Board
Publication date: November 2019Source: Life Sciences in Space Research, Volume 23Author(s): (Source: Life Sciences in Space Research)
Source: Life Sciences in Space Research - November 30, 2019 Category: Biology Source Type: research
Altered rodent gait characteristics after ~35 days in orbit aboard the International Space Station
Publication date: February 2020Source: Life Sciences in Space Research, Volume 24Author(s): Andy Kwok, Samuel Rosas, Ted A. Bateman, Eric Livingston, Thomas L Smith, Joseph Moore, David C. Zawieja, Tom Hampton, Xiao W. Mao, Michael D. Delp, Jeffrey S. WilleyAbstractThe long-term adaptations to microgravity and other spaceflight challenges within the confines of a spacecraft, and readaptations to weight-bearing upon reaching a destination, are unclear. While post-flight gait change in astronauts have been well documented and reflect multi-system deficits, no data from rodents have been collected. Thus, the purpose of this s...
Source: Life Sciences in Space Research - November 18, 2019 Category: Biology Source Type: research
Correct modeling results are needed to inform mission planning and shield design
Publication date: Available online 16 November 2019Source: Life Sciences in Space ResearchAuthor(s): Tony C. Slaba, Robert C. SingleterryAbstractThere are a large number of modeling results in the literature focused on astronaut protection from solar particle events (SPE) over a broad range of mission architectures. These studies form the basis for shield design and mission planning strategies currently used by NASA. To optimize SPE protection or affect decision making criteria for these missions, one must have an accurate assessment of exposure levels at one or more locations within a vehicle or habitat concept. Such asse...
Source: Life Sciences in Space Research - November 16, 2019 Category: Biology Source Type: research
A commentary on the of the impact of modelling results to inform mission planning and shield design
Publication date: Available online 16 November 2019Source: Life Sciences in Space ResearchAuthor(s): Samy El-Jaby, Brent J. Lewis, Leena TomiAbstractA correspondence has been received in reference to a recently published article titled “On the decision making criteria for cis-lunar reference scenarios”. The intent of the paper was to demonstrate: (i) a novel methodology for calculating the dose from solar particle events (SPEs), and (ii) the impact of the SPE parametric model, shield thickness, dose metric, and radiation transport code on choosing a worst-case scenario. This effort assumed a spherical, aluminum spacecr...
Source: Life Sciences in Space Research - November 16, 2019 Category: Biology Source Type: research
