Prognostic significance of The Wilms ’ Tumor-1 (WT1) rs16754 polymorphism in acute myeloid leukemia
Acute myeloid leukemia is a genetically heterogeneous disease characterized by the accumulation of mutations in hematopoietic progenitor cells [1]. AML is the most common acute leukemia affecting adults and its incidence increases with age [2]. AML is divided in to several cytogenetic risk groups and treatment and prognosis vary among this subtypes [3]. For a therapy decision, it is very important to determine the individual patient's risk and chances of success of a treatment. Prognostic factors are associated with outcome parameters, they can be incorporated into scoring systems and influence therapeutic choice [4]. (Sou...
Source: Leukemia Research - January 29, 2018 Category: Hematology Authors: Jessica Petiti, Valentina Rosso, Marco Lo Iacono, Chiara Calabrese, Elisabetta Signorino, Valentina Gaidano, Massimo Berger, Giuseppe Saglio, Daniela Cilloni Tags: Research paper Source Type: research
Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
Philadelphia chromosome negative myeloproliferative neoplasms (Ph- MPNs) [1] are malignant diseases developing from clonally transformed hematopoietic stem cell [2]. They have classically been divided into primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocytosis (ET). A majority of Ph- MPN patients bear a mutation in either of Janus-kinase-2 (JAK2), Calreticulin (CALR) or Myeloproliferative-leukemia-virus-oncogene (MPL) genes [3] resulting in constitutive activation of JAK/signal-transducer-and-activator-of-transcription (STAT) signaling pathway, strong myeloproliferation and high inflammatory atmos...
Source: Leukemia Research - January 29, 2018 Category: Hematology Authors: Marko Lucijanic, Zeljko Prka, Vlatko Pejsa, Tajana Stoos-Veic, Jelena Lucijanic, Rajko Kusec Tags: Research paper Source Type: research
Comparison of induction therapy in non-high risk acute promyelocytic leukemia with arsenic trioxide or in combination with ATRA
Acute promyelocytic leukemia (APL) is a lethal but potentially curable form of Acute myeloid leukemia (AML), and it responds better to chemotherapy than other forms of AML [1]. APL has a distinct genetic morphology compared with other acute leukemia. Specific chromosomal marker for APL is t(15; 17), with promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) oncogene activation. All-trans-retinoic acid (ATRA) in conjunction with an attenuated dose of chemotherapy (anthracyclines alone or in combination with other drugs) is the conventional and standard therapy for APL during remission induction and maintenance phas...
Source: Leukemia Research - January 29, 2018 Category: Hematology Authors: Ardeshir Ghavamzadeh, Mahdi Jalili, Sharbanoo Rostami, Marjan Yaghmaie, Leyla Sharifi Aliabadi, Seyed Asadollah Mousavi, Mohammad Vaezi, Hossein Kamranzadeh Fumani, Mohammad Jahani, Kamran Alimoghaddam Tags: Research paper Source Type: research
Allogeneic Hematopoietic Cell Transplantation in T-Cell Prolymphocytic Leukemia: A Single-Center Experience
(Source: Leukemia Research)
Source: Leukemia Research - January 21, 2018 Category: Hematology Authors: Bhagirathbhai R. Dholaria, Ernesto Ayala, Lubomir Sokol, Taiga Nishihori, Julio C. Chavez, Mohammad Hussaini, Ambuj Kumar, Mohamed A. Kharfan-Dabaja Tags: Research paper Source Type: research
Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response —The final results of the D-first study
(Source: Leukemia Research)
Source: Leukemia Research - January 19, 2018 Category: Hematology Authors: Yuho Najima, Chikashi Yoshida, Noriyoshi Iriyama, Shin Fujisawa, Hisashi Wakita, Shigeru Chiba, Shinichiro Okamoto, Kimihiro Kawakami, Naoki Takezako, Takashi Kumagai, Kazuma Ohyashiki, Jun Taguchi, Shingo Yano, Tadahiko Igarashi, Yasuji Kouzai, Satoshi M Tags: Research paper Source Type: research
New synergistic combinations of differentiation-inducing agents in the treatment of acute promyelocytic leukemia cells
Acute myeloid leukemia (AML) is a heterogeneous neoplasm characterized by the accumulation of leukemia blasts arrested at various stages of granulocytic and monocytic differentiation [1]. As conventional chemotherapy does not seem to be effective to cure most AML patients, there has been an effort to find new drugs that possess differentiative and apoptotic potentials. Several compounds capable of inducing the differentiation of leukemia cells or cell lines to mature cells in vitro, however, only a few compounds have therapeutic value for leukemia because of their severe side effects or unusually high concentration require...
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Amir Amanzadeh, Vahid Molla-kazemiha, Saeed Samani, Mahdi Habibi-Anbouhi, Kayhan Azadmanesh, Mohsen Abolhassani, Mohammad Ali Shokrgozar Tags: Research paper Source Type: research
Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study
Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease [1,2]. Therefore, the evaluation of the prognostic risk is clinically important for AML patients to determine the appropriate therapeutic strategy. The Medical Research Council (MRC) developed the cytogenetic classification system in 1998, and it was refined by considering the clinical characteristics and prognostic relevance of rare cytogenetic abnormalities [3,4]. The refined MRC system, in which three cytogenetic risk groups are distinguished, is widely used for cytogenetic risk stratification of younger adults with AML. (Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Yasuhiko Harada, Yasunobu Nagata, Rika Kihara, Yuichi Ishikawa, Norio Asou, Shigeki Ohtake, Shuichi Miyawaki, Toru Sakura, Yukiyasu Ozawa, Noriko Usui, Heiwa Kanamori, Yoshikazu Ito, Kiyotoshi Imai, Youko Suehiro, Shinichi Kobayashi, Kunio Kitamura, Emiko Tags: Research paper Source Type: research
Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study
(Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Yasuhiko Harada, Yasunobu Nagata, Rika Kihara, Yuichi Ishikawa, Norio Asou, Shigeki Ohtake, Shuichi Miyawaki, Toru Sakura, Yukiyasu Ozawa, Noriko Usui, Heiwa Kanamori, Yoshikazu Ito, Kiyotoshi Imai, Youko Suehiro, Shinichi Kobayashi, Kunio Kitamura, Emiko Tags: Research paper Source Type: research
Targeting the IL-17/IL-6 axis can alter growth of Chronic Lymphocytic Leukemia in vivo/in vitro
(Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Fang Zhu, Lindsay McCaw, David E. Spaner, Reginald M. Gorczynski Tags: Research paper Source Type: research
New synergistic combinations of differentiation-inducing agents in the treatment of acute promyelocytic leukemia cells
(Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Amir Amanzadeh, Vahid Molla-kazemiha, Saeed Samani, Mahdi Habibi-Anbouhi, Kayhan Azadmanesh, Mohsen Abolhassani, Mohammad Ali Shokrgozar Tags: Research paper Source Type: research
Expression of autophagy related genes in chronic lymphocytic leukemia is associated with disease course
Chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world, accounts for ∼40% of all adult leukemia. Though the pathogenesis of CLL is not entirely clear, accumulation of monoclonal CD5+/CD19+/CD23+ B lymphocytes is indicated mainly resulted from failure to undergo apoptosis rather than excessive proliferation [1]. There are a considerable number of patients with CLL w ho do not need treatment until treatment indications are present, while a proportion of patients have aggressive disease progression, which fully reflects the high degree of prognosis heterogeneity of CLL. (Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Yi-Lin Kong, Ying Huang, Jia-Zhu Wu, Xin Cao, Jin-Hua Liang, Yi Xia, Wei Wu, Lei Cao, Hua-Yuan Zhu, Li Wang, Lei Fan, Jian-Yong Li, Wei Xu Tags: Research paper Source Type: research
Pegaspargase-related high-grade hepatotoxicity in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not predict recurrent hepatotoxicity with subsequent doses
(Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Patrick W. Burke, Ibrahim Aldoss, Matthew A. Lunning, Sean M. Devlin, Martin S. Tallman, Vinod Pullarkat, Ann M. Mohrbacher, Dan Douer Tags: Research paper Source Type: research
NM23 downregulation and lysophosphatidic acid receptor EDG2/lpa1 upregulation during myeloid differentiation of human leukemia cells
A common mechanism for inhibition of leukemia cell myeloid differentiation and breast cancer cell motility involving NM23 and EDG2. (Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Junko Okabe-Kado, Yuki Hagiwara-Watanabe, Nozomi Niitsu, Takashi Kasukabe, Yasuhiko Kaneko Tags: Research paper Source Type: research
Therapeutic effects of tyrosine kinase inhibitors and subtypes of BCR-ABL1 transcripts in Japanese chronic myeloid leukemia patients with three-way chromosomal translocations
(Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Koiti Inokuchi, Kazutaka Nakayama, Tetsuzo Tauchi, Tomoiku Takaku, Norio Yokose, Hiroki Yamaguchi, Takashi Kumagai, Norio Komatsu, Kazuma Ohyashiki Tags: Research paper Source Type: research
Quantitative assessment of jak2 v617f and calr mutations in philadelphia negative myeloproliferative neoplasms
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Ambrus G ángó, Réka Mózes, Zsófia Boha, Béla Kajtár, Botond Timár, Péter Attila Király, Richárd Kiss, Viktória Fésüs, Noémi Nagy, Judit Demeter, Gábor Körösmezey, Zita Borbényi, Imelda Marton, Anita Szőke, Tamás Masszi, Péter Farkas, Tags: Research paper Source Type: research
