Interpretation of clinical endpoints in trials of acute myeloid leukemia
(Source: Leukemia Research)
Source: Leukemia Research - February 7, 2018 Category: Hematology Authors: Bruno C. Medeiros Source Type: research
Targeting histone demethylases KDM5A and KDM5B in AML cancer cells: A comparative view
(Source: Leukemia Research)
Source: Leukemia Research - February 7, 2018 Category: Hematology Authors: Gelareh Shokri, Shaghayegh Doudi, Mehrnoosh Fathi-Roudsari, Fatemeh Kouhkan, Mohammad-Hossein Sanati Tags: Research paper Source Type: research
Association of red cell distribution width with clinical outcomes in myelodysplastic syndrome
(Source: Leukemia Research)
Source: Leukemia Research - February 7, 2018 Category: Hematology Authors: Yuta Baba, Bungo Saito, Shotaro Shimada, Yohei Sasaki, So Murai, Maasa Abe, Shun Fujiwara, Nana Arai, Yukiko Kawaguchi, Nobuyuki Kabasawa, Hiroyuki Tsukamoto, Yui Uto, Hirotsugu Ariizumi, Kouji Yanagisawa, Norimichi Hattori, Hiroshi Harada, Tsuyoshi Nakam Tags: Research paper Source Type: research
Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia
(Source: Leukemia Research)
Source: Leukemia Research - February 6, 2018 Category: Hematology Authors: Natasa Tosic, Isidora Petrovic, Natasa Kovacevic Grujicic, Slobodan Davidovic, Marijana Virijevic, Nada Suvajdzic Vukovic, Sonja Pavlovic, Milena Stevanovic Tags: Research paper Source Type: research
Prognostic impact of a suboptimal number of analyzed metaphases in normal karyotype lower-risk MDS
(Source: Leukemia Research)
Source: Leukemia Research - February 4, 2018 Category: Hematology Authors: Louise de Swart, Alex Smith, Detlef Haase, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Guillermo Sanz, Reinhard Stauder, Moshe Mittelman, Eva Hellstr öm-Lindberg, Luca Malcovati, Saskia Langemeijer, Mette Skov Holm, Krzysztof Mądry, Ulrich Germi Tags: Research paper Source Type: research
Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation
Although the treatment of acute leukemia using a combination of chemotherapeutic agents showed an improved clinical outcome in the past decades, multidrug resistance (MDR) remains a major obstacle to chemotherapy, as one of the key etiologies for relapse or treatment failure. The mechanism of MDR in leukemia is complex, and involves multiple pathways. One of the best characterized mechanisms involves the efflux function of the P-glycoprotein (P-gp), an ATP-binding cassette transporter localized to the cell membrane and encoded by the human multidrug resistance 1 (MDR1, or ABCB1) gene [1 –3]. (Source: Leukemia Research)
Source: Leukemia Research - February 3, 2018 Category: Hematology Authors: Yan-Hua Wang, Yoichi Imai, Masayuki Shiseki, Junji Tanaka, Toshiko Motoji Tags: Research paper Source Type: research
Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug-resistant leukemic cells and inhibits leukemic cell proliferation
(Source: Leukemia Research)
Source: Leukemia Research - February 3, 2018 Category: Hematology Authors: Yan-Hua Wang, Yoichi Imai, Masayuki Shiseki, Junji Tanaka, Toshiko Motoji Tags: Research paper Source Type: research
PD-1 /PD-L1 checkpoint in hematological malignancies
(Source: Leukemia Research)
Source: Leukemia Research - February 3, 2018 Category: Hematology Authors: O. Annibali, A. Crescenzi, V. Tomarchio, A. Pagano, A. Bianchi, A. Grifoni, G. Avvisati Source Type: research
Report of the Relapsed/Refractory Cohort of SWOG S0919: A Phase 2 Study of Idarubicin and Cytarabine in Combination with Pravastatin for Acute Myelogenous Leukemia (AML)
(Source: Leukemia Research)
Source: Leukemia Research - February 3, 2018 Category: Hematology Authors: Anjali S. Advani, Hongli Li, Laura C. Michaelis, Bruno C. Medeiros, Michaela Liedtke, Alan F. List, Kristen O ’Dwyer, Megan Othus, Harry P. Erba, Frederick R. Appelbaum Tags: Research paper Source Type: research
High frequency of intermediate and poor risk copy number abnormalities in pediatric cohort of B-ALL correlate with high MRD post induction
B-cell precursor acute lymphoblastic leukemia (B-ALL) comprises 80 –85% of all acute lymphoblastic leukemia and is the most common type of childhood leukemia. Age, white blood cell (WBC) count at presentation, minimal residual disease (MRD) post induction and chromosomal translocations are well known prognostic and risk stratification markers in B-ALL. Most devel oped countries show event free survival (EFS) from 74% to 87% and overall survival (OS) from 85% to 90% [1], while a recently published study from our country shows EFS and OS to be only 66% and 74%, respectively [2]. (Source: Leukemia Research)
Source: Leukemia Research - February 2, 2018 Category: Hematology Authors: Minu Singh, Prateek Bhatia, Amita Trehan, Neelam Varma, Manupdesh Singh Sachdeva, Deepak Bansal, Richa Jain, Shano Naseem Tags: Research paper Source Type: research
8q24/MYC rearrangement is a recurrent cytogenetic abnormality in blastic plasmacytoid dendritic cell neoplasms
MYC encodes a transcription factor that plays a crucial rule in multiple cellular processes of cellular growth, proliferation and metabolism. This proto-oncogene is involved in transformation and cell proliferation via activation of the cyclin D2 promoter [1], but also induces apoptosis through the nuclear respiratory factor (NRF-1) [2] and the Arf-p53 pathway [3]. MYC is frequently dysregulated in multiple hematologic and non-hematologic malignancies. Chromosome 8q24/MYC translocation represents a prototype for oncogene activation. (Source: Leukemia Research)
Source: Leukemia Research - February 2, 2018 Category: Hematology Authors: Prajwal C. Boddu, Sa A. Wang, Naveen Pemmaraju, Zhenya Tang, Shimin Hu, Shaoying Li, Jie Xu, L. Jeffrey Medeiros, Guilin Tang Tags: Research paper Source Type: research
The combination of TRAIL and MG-132 induces apoptosis in both TRAIL-sensitive and TRAIL-resistant human follicular lymphoma cells
Apoptosis is a type of programmed cell death that plays an essential role in the development and homeostasis of normal tissues. The two main apoptotic pathways are the death receptor pathway (extrinsic pathway) and the mitochondrial pathway (intrinsic pathway). These pathways are executed by caspases which eventually lead to the demise of a cell [1]. (Source: Leukemia Research)
Source: Leukemia Research - February 2, 2018 Category: Hematology Authors: Jemal Adem, Mine Eray, Jonna Eeva, Ulla Nuutinen, Jukka Pelkonen Tags: Research paper Source Type: research
Identification of chronic myeloid leukemia patients treated with imatinib who are potentially eligible for treatment discontinuation by assessing real-life molecular responses on the international scale in a EUTOS-certified lab
(Source: Leukemia Research)
Source: Leukemia Research - February 2, 2018 Category: Hematology Authors: Am élie Heinrichs, Barbara Dessars, Hakim El Housni, Wim Pluymers, Karen Peeters, Fleur S. Benghiat, Pierre Heimann Tags: Research paper Source Type: research
Pulmonary Langerhans Cell Histiocytosis, Acute Myeloid Leukemia, and Myelofibrosis in a Large Family and Review of the Literature
This is the first report of familial LCH, AML, and MF in one family. The pedigree suggests a common basis for these entities, which is further suggested by the presence of anticipation in the pedigree. (Source: Leukemia Research)
Source: Leukemia Research - February 1, 2018 Category: Hematology Authors: Matthew P. Blakley, Janice P. Dutcher, Peter H. Wiernik Tags: Research paper Source Type: research
Editorial Board
(Source: Leukemia Research)
Source: Leukemia Research - January 31, 2018 Category: Hematology Source Type: research
