[Articles] Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Bruce C V Campbell, Wim H van Zwam, Mayank Goyal, Bijoy K Menon, Diederik W J Dippel, Andrew M Demchuk, Serge Bracard, Philip White, Antoni D ávalos, Charles B L M Majoie, Aad van der Lugt, Gary A Ford, Natalia Pérez de la Ossa, Michael Kelly, Romain Bo Tags: Articles Source Type: research
[In Context] Beyond art, beyond sciences: the many faces of dementia
Beyond Memories is the fourth instalment in a series of exhibitions by the London Brain Project, a collective of scientists and artists who aim to engage and educate the public about neurological diseases though art. Beyond Memories specifically aims to illuminate lesser known aspects of dementia, and to dispel stereotypes surrounding the subject. London Brain Project co-director Georgia Pitts says, “I think it's important for people to know that ‘dementia’ itself isn't a disease. It's a word used to describe a set of symptoms caused by different neurological disorders…many people don't know that, and it's importan...
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Isabel Lokody Tags: In Context Source Type: research
[In Context] Raul Mart ínez
Raul Mart ínez is a neurologist and clinical researcher at Centro Integral en Neurociencias (CINAC), HM Puerta del Sur University Hospital (Móstoles, Madrid, Spain). After finishing his neurology training at Hospital Universitari Dr Josep Trueta (Girona, Spain), he spent 6 months in the deep brain stimulati on department of the National Hospital of Neurology and Neurosurgery (London, UK), and did a 2-year fellowship in Centre Hospitalier Universitaire de Grenoble (La Tronche, Grenoble, France). His research focuses on the study of non-motor symptoms of Parkinson's disease and on functional neurosurgery , including the ap...
Source: Lancet Neurology - December 16, 2017 Category: Neurology Tags: In Context Source Type: research
[Correspondence] Advice for those trying to find a cure for the shaking palsy
I would like to thank Ava Easton for her review of Mentored by a Madman: The William Burroughs Experiment in The Lancet Neurology.1 I believe that all neurologists, irrespective of whether they have an academic appointment, should devote a little of their working week to research. Private practice and burgeoning bureaucracy are impediments to this aspiration, but are never a valid excuse for inaction. When I speak of research, I am not talking about dedicated molecular biological investigation in a so-called wet laboratory, or crunching big numbers in front of computer screens to identify risk factors. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Andrew J Lees Tags: Correspondence Source Type: research
[Correspondence] World Wide Fingers will advance dementia prevention
Your Editorial highlighted the need of trials on dementia prevention, and welcomed the launch of World Wide Fingers WW-FINGERS),1 but did not provide details on this initiative. WW-FINGERS springs from the successful experience of the Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER),2 a landmark trial that showed that a multidomain lifestyle intervention, based on simultaneous management of several vascular and lifestyle-related risk factors for dementia and Alzheimer's disease (AD), can benefit cognition in people aged 60 –77 years with high risk of dementia. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Miia Kivipelto, Francesca Mangialasche, Tiia Ngandu, World Wide Fingers Network Tags: Correspondence Source Type: research
[Corrections] Corrections
Gilhus N E. Eculizumab: a treatment option for myasthenia gravis? Lancet Neurol 2017; 16: 947 –48—The original title of this comment was “Eculizumab: a treatment option for mysthenia gravis?”. This title has been corrected to “Eculizumab: a treatment option for myasthenia gravis?”. This correction has been made to the online version as of Dec 15, 2017. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Tags: Corrections Source Type: research
[Corrections] Corrections
van Schaik IN, Bril V, van Geloven N, et al. Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol 2018; 17: 35 –46—“J Gamez Carbonell” in the Path study group should have been listed as “J Gamez”. This correction has been made to the online version as of Dec 15, 2017, and to the printed Article. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Tags: Corrections Source Type: research
[Comment] The genetic architecture of dementia with Lewy bodies is shaping up
Genome-wide association studies (GWAS) have made substantial contributions to our understanding of complex neurodegenerative diseases. For example, the largest GWAS of Alzheimer's disease so far has identified 19 loci in addition to APOE and revealed key pathways of disease pathogenesis, including inflammation and immune response, lipid metabolism, and endocytosis.1 Similarly, two GWAS of Parkinson's disease have uncovered 41 loci and suggested a major role of autophagy and lysosomal biology in Parkinson's disease risk. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Myriam Fornage Tags: Comment Source Type: research
[Comment] HERMES: a helpful messenger in the anaesthesia for thrombectomy debate?
The effectiveness of endovascular treatment in patients with anterior circulation ischaemic stroke due to large artery occlusion is firmly established, although optimal anaesthesia for the procedure remains contentious. Studies have suggested that endovascular treatment under general anaesthesia (GA) is associated with a worse outcome than when treatment is done without GA. However, because patients with more severe stroke and comorbidities are more likely to receive GA, there is potential for confounding by indication. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Judith Dinsmore Tags: Comment Source Type: research
[2017 Round-up] Research advances in neurological infections in 2017
Viruses are the most commonly identified causes of meningitis and encephalitis, but in as many as half of patients, particularly those with encephalitis, the cause is not identified. Hasbun and colleagues1 examined the epidemiology of meningitis and encephalitis in 26 429 adults in the USA between 2011 and 2014. The most common causes were enterovirus (52%), unknown causes (21%), bacterial meningitis (14%), herpes viruses (8%), non-infectious causes (4%), fungi (3%), arboviruses (1%), and other viruses (1%). (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Christina M Marra Tags: 2017 Round-up Source Type: research
[2017 Round-up] Health implications of sleep and circadian rhythm research in 2017
This has been a great year for the field of sleep and circadian rhythm research. Notably, the 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey Hall, Michael Rosbash, and Michael Young for their discovery of the genetic mechanisms that generate circadian rhythms. The subsequent discoveries of the ubiquity of these molecular circadian clocks in the body, and of their fundamental role in the regulation of cellular function have, over the past decade, fuelled an explosion of research on the central role of sleep and circadian rhythms in health. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Sabra M Abbott, Kristen L Knutson, Phyllis C Zee Tags: 2017 Round-up Source Type: research
[2017 Round-up] Pain medicine gets personal
The opioid crisis has attracted increasing commentary during 2017. A recent study has shown that after surgery, in the USA, one in 16 patients will become a chronic opioid user.1 This number does not differ when comparing minor versus major surgery and largely represents inappropriate use of opioid analgesics triggered by overprescribing. This problem emphasises the need to optimise health-care delivery and to develop new, effective, and non-addictive drugs for the treatment of chronic pain. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: David Bennett Tags: 2017 Round-up Source Type: research
[2017 Round-up] Traumatic brain injury in 2017: exploring the secrets of concussion
The US Centers for Disease Control and Prevention estimates of mild traumatic brain injury —also referred to as concussion—range from 1·6 million to 3·8 million affected individuals annually in the USA, with one in five aged younger than 19 years and treated for sports-related or recreation-related injuries. Although our awareness of concussion has increased, our understanding of th e nuances of this injury remains a work in progress. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Marc Maegele Tags: 2017 Round-up Source Type: research
[2017 Round-up] Neuromuscular disorders: 2017, a year to remember
2017 will be remembered for the substantial progress related to therapeutic approaches in the neuromuscular field. Selecting just a few studies to highlight is quite challenging because many has been reported, from observations of innovative therapeutic approaches in animal studies to the results of successful clinical trials. Perhaps the most exciting of these advances have been in Duchenne muscular dystrophy and spinal muscular atrophy. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Eugenio Mercuri Tags: 2017 Round-up Source Type: research
[2017 Round-up] Advances in multiple sclerosis: from reduced relapses to remedies
Progress in multiple sclerosis research continues at an impressive pace, with contributions from basic science, translational research, and experimental therapeutics. Several publications in the past year have had a major impact on both our understanding of the disease and our ability to treat it. (Source: Lancet Neurology)
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Peter A Calabresi Tags: 2017 Round-up Source Type: research
