[Corrections] Corrections
Grisold W, Wasay M. The advocacy role of the World Federation of Neurology. Lancet Neurol 2018; 17: 204 —The name of the second author, Mohammad Wasay, was written incorrectly. This name has been corrected in the online version as of March 22, 2018. (Source: Lancet Neurology)
Source: Lancet Neurology - March 22, 2018 Category: Neurology Tags: Corrections Source Type: research
[In Context] Frederik Barkhof: building bridges between disciplines
The early academic journey of Frederik Barkhof was a winding one. As a child he was fascinated by the engineering of buildings and bridges, but then crossed over to study dentistry —“which was a mistake” (a bridge too far, presumably). He next stopped to study at the intersection between philosophy and medicine, until he landed at VU University (Amsterdam, the Netherlands) where he received his MD in 1988. Combining his love of engineering and medicine, Barkhof is now a neuroradiology professor who shares his expertise with both VU University Medical Centre and University College London (UCL, London, UK) and brings d...
Source: Lancet Neurology - March 22, 2018 Category: Neurology Authors: Jules Morgan Tags: In Context Source Type: research
[Correspondence] Accelerated long-term forgetting in asymptomatic APOE ε4 carriers
In The Lancet Neurology, Philip Weston and colleagues report that presymptomatic individuals carrying familial Alzheimer's disease gene mutations demonstrate accelerated long-term forgetting over an extended 1 week retention interval compared with gene-negative controls.1 These findings raise the question of whether accelerated long-term forgetting is also detectable in presymptomatic individuals at genetic risk of the much more common sporadic form of Alzheimer's disease. (Source: Lancet Neurology)
Source: Lancet Neurology - March 22, 2018 Category: Neurology Authors: Jacqueline F Zimmermann, Christopher R Butler Tags: Correspondence Source Type: research
[Corrections] Corrections
Grisold W, Wasay M. The advocacy role of the World Federation of Neurology. Lancet Neurol 2018; 17: 204 —The name of the second author, Mohammad Wasay, was written incorrectly. This name has been corrected in the online version as of March 22, 2018. (Source: Lancet Neurology)
Source: Lancet Neurology - March 22, 2018 Category: Neurology Tags: Corrections Source Type: research
[Articles] The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study
Common variants with small individual effects jointly modify the risk and age at onset of Alzheimer's disease and dementia, particularly in APOE ε4 carriers. These findings highlight the potential of common variants in determining Alzheimer's disease risk. (Source: Lancet Neurology)
Source: Lancet Neurology - March 16, 2018 Category: Neurology Authors: Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duijn Tags: Articles Source Type: research
[In Context] The storm and stress in the adolescent brain
Sarah-Jayne Blakemore, Professor of Cognitive Neuroscience at University College London (London, UK), is sick of hearing the same joke over and over again. When she informs people that she studies the adolescent brain, she inevitably hears a now familiar refrain: “What? Teenagers have brains?” She's right to take offence, not only on behalf of the young people she works with, but because—as her book, Inventing Ourselves: the Secret Life of the Teenage Brain demonstrates—adolescence is a fascinating and important period of neurological change. (Source: Lancet Neurology)
Source: Lancet Neurology - March 15, 2018 Category: Neurology Authors: Robert Stirrups Tags: In Context Source Type: research
[Personal View] The roles of surgery and technology in understanding focal epilepsy and its comorbidities
Intracranial electrophysiological recording in patients with refractory focal epilepsy is the gold standard for defining epileptogenic tissue. Although the concordance of intracranial electrophysiology, structural MRI, and pathology can identify brain regions for resection, complete seizure control after surgery is not achieved in all patients with focal epilepsy. Repetitive identical behavioural seizures suggest one onset area, but epileptogenesis might be distributed and connected by functional and structural brain networks outside the seizure onset area, which could explain poor postsurgical outcomes in some patients. (...
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Dennis D Spencer, Jason L Gerrard, Hitten P Zaveri Tags: Personal View Source Type: research
[Articles] Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study
Our study provides quantitative data on the survival of patients with the most common spinocerebellar ataxias, based on a long follow-up period. These results have implications for the design of future interventional studies of spinocerebellar ataxias; for example, the prognostic survival nomogram could be useful for selection and stratification of patients. Our findings need validation in an external population before they can be used to counsel patients and their families. (Source: Lancet Neurology)
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Alhassane Diallo, Heike Jacobi, Arron Cook, Robyn Labrum, Alexandra Durr, Alexis Brice, Perrine Charles, Cecilia Marelli, Caterina Mariotti, Lorenzo Nanetti, Marta Panzeri, Maria Rakowicz, Anna Sobanska, Anna Sulek, Tanja Schmitz-H übsch, Ludger Schöls, Tags: Articles Source Type: research
[In Context] Yogeshwar Kalkonde
Yogeshwar Kalkonde is a neurologist and a public health researcher working at the Society for Education, Action and Research in Community Health in Gadchiroli, India. His research focuses on stroke as a public health problem in rural India, and he is currently investigating community-based interventions to reduce stroke mortality. (Source: Lancet Neurology)
Source: Lancet Neurology - March 14, 2018 Category: Neurology Tags: In Context Source Type: research
[In Context] Hemiplegic migraine and stroke in Mary Shelley
Mary Wollstonecraft Godwin Shelley (1797 –1851) was the author of Frankenstein; or, the Modern Prometheus. In 1839, she had recurrent, severe headaches whose severity, location, and duration were variable.1 These headaches were associated with dizziness; pain in the legs, right hand, and right eye; and episodes of transient partial paral ysis of the right leg and hand, with tremors, convulsive seizures, and severe pain on the top of the head.2 She was diagnosed with psychosomatic illness in 1842, “functional derangement in the nerves or brain” in 1845, and back pain and “neuralgia of the heart” in 1846. (Source: Lancet Neurology)
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Philippe Charlier, Otto Appenzeller, Saudamini Deo, Antonio Perciaccante, Raffaella Bianucci Tags: In Context Source Type: research
[Correspondence] MPTP-induced parkinsonism: an historical case series
In 1982, seven young adults developed severe and irreversible parkinsonism shortly after they injected themselves with a new synthetic heroin.1 Sample analyses revealed that this synthetic heroin consisted of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),2 a potent neurotoxin targeting neurons within the substantia nigra.3 (Source: Lancet Neurology)
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Jorik Nonnekes, Bart Post, James W Tetrud, J William Langston, Bastiaan R Bloem Tags: Correspondence Source Type: research
[Correspondence] Outcome assessment after traumatic brain injury – Authors' reply
We thank Thomas McMillan and colleagues for their thoughtful comments on assessment of outcomes, with many of which we fully agree. As with many outcome assessments in traumatic brain injury (TBI), the Glasgow Outcome Scale (GOS) is open to a wide variety of influences other than brain injury: factors related to acute TBI appear to explain at best 35% of the variance.1 The predictors, moderators, and mediators of outcome after TBI are incompletely understood. There is thus much progress to be made in identifying confounding covariates for the effects of interventions. (Source: Lancet Neurology)
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Lindsay Wilson, Nicole von Steinbuechel, David K Menon, Andrew I R Maas Tags: Correspondence Source Type: research
[Correspondence] Outcome assessment after traumatic brain injury
In their wide ranging and impressive Commission of traumatic brain injury (TBI), Andrew Maas and colleagues1 recommend the development and validation of multidimensional outcome constructs that quantify overall burden of disability from TBI. Their observation that there are already nearly 1000 assessment instruments to consider is one of many challenges that need to be overcome to achieve this aim. (Source: Lancet Neurology)
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Thomas McMillan, Erin D Bigler, Graham Teasdale, Jennie Ponsford, Gordon D Murray Tags: Correspondence Source Type: research
