[Corrections] Corrections
Pointing the way to primary prevention of dementia. Lancet Neurol 2017; 16: 677. In this Editorial, the website for World Wide FINGERS was incorrect and should have been http://wwfingers.com/. This correction has been made to the online version as of Sept 12, 2017. (Source: Lancet Neurology)
Source: Lancet Neurology - September 13, 2017 Category: Neurology Tags: Corrections Source Type: research
[Comment] A new era of multiple sclerosis rehabilitation: lessons from stroke
Just over 20 years ago, no treatments were available for multiple sclerosis, a disease characterised by two overlapping processes of nervous system injury: inflammatory destruction of myelin and neurodegeneration of grey and white matter.1 Disease-modifying drugs, particularly the new oral medications, have changed the prognosis of multiple sclerosis, contributing to increased periods of disease stability and greater potential for rehabilitative therapies to reduce impairment.2 In The Lancet Neurology, Robert Motl and colleagues3 argue that exercise can be a beneficial rehabilitation strategy for people with multiple scler...
Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: Michelle Ploughman Tags: Comment Source Type: research
[Comment] Traumatic brain injury: an enduring challenge
The outcomes of traumatic brain injury (TBI) can vary widely from no lasting effects to devastating and persistent consequences. Detailed understanding of the sequelae of TBI has been limited by the heterogeneity of this disorder and, until recently, there have been few studies of long-term outcomes in particular. However, recent progress in characterising specific consequences and the availability of longitudinal studies of outcomes are providing the basis for improved understanding of TBI sequelae, as highlighted in two Series papers on TBI in The Lancet Neurology. (Source: Lancet Neurology)
Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: Ross D Zafonte Tags: Comment Source Type: research
[Comment] Unravelling neurodegeneration in multiple sclerosis
Neurodegeneration is postulated to be a major contributor to neurological disability in multiple sclerosis and might be the dominant process underlying progressive multiple sclerosis. Whether neurodegeneration is an independent process in patients with multiple sclerosis or its occurrence is secondary to inflammation remains unknown.1 Current therapies, focused on immune modulation, are generally less effective in the progressive forms than in the relapsing remitting forms of the disease. Therefore, understanding neurodegeneration might be fundamental to determining how to prevent neurological disability in all patients wi...
Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: Robert A Bermel Tags: Comment Source Type: research
[Editorial] Treating rare disorders: time to act on unfair prices
The first disease-modifying treatment for spinal muscular atrophy (SMA), nusinersen, was approved by the US Food and Drug Administration (FDA) on Dec 23, 2016, and by the European Medicines Agency (EMA) on May 30, 2017. The approval was based on evidence of clinically meaningful improvements in motor milestones in young children with varying degrees of disease severity from two clinical trials (ENDEAR, NCT02193074, and CHERISH, NCT02292537). The regulatory approval is a historic development, but it is unlikely that the drug will be available to all patients who would benefit from treatment, unless its manufacturer offers a...
Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: The Lancet Neurology Tags: Editorial Source Type: research
[In Context] Sarah Tabrizi: timed to perfection
“Time is the scarcest resource, and unless it is managed, nothing else can be managed.” Austrian-American management consultant and author Peter Drucker may have written the above, but it was Persian-Scottish Sarah Tabrizi, Professor of Clinical Neurology at University College London (UCL, Londo n, UK), Honorary Consultant Neurologist and Neurogeneticist at the National Hospital for Neurology and Neurosurgery (London, UK), and Director of the UCL Hospital Huntington Disease Centre, who turned time management into an art. (Source: Lancet Neurology)
Source: Lancet Neurology - September 12, 2017 Category: Neurology Authors: Adrian Burton Tags: In Context Source Type: research
[Articles] Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study
TDP-43 should be considered as a potential factor related to increased rates of hippocampal atrophy in patients with Alzheimer's disease. Given the importance of hippocampal atrophy in Alzheimer's disease, it is imperative that techniques are developed for detection of TDP-43 in vivo. (Source: Lancet Neurology)
Source: Lancet Neurology - September 11, 2017 Category: Neurology Authors: Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Wh Tags: Articles Source Type: research
[Corrections] Corrections
Lai C. Flashing lights and poor funding: more than a headache. Lancet Neurol 2017; published online Aug 16. http://dx.doi.org/10.1016/S1474-4422(17)30285-5 —In this Radio review, the affiliation for Peter Goadsby should have been King's College London. This correction has been made to the online version as of Aug 23, 2017. (Source: Lancet Neurology)
Source: Lancet Neurology - August 23, 2017 Category: Neurology Tags: Corrections Source Type: research
[In Context] Flashing lights and poor funding: more than a headache
For many migraineurs, daily life can be a carefully choreographed routine of avoiding triggers. So to intentionally induce a migraine seems not only ill-advised, but also foolish. Yet, that is precisely what author A L Kennedy did for the BBC Radio 4 production AL Kennedy's Migraine. At the start of the programme, Kennedy thoughtfully advises listeners for whom simply hearing about symptoms of migraines might trigger an attack, “Please, don't soldier on, the way we sometimes do, switch this off. (Source: Lancet Neurology)
Source: Lancet Neurology - August 16, 2017 Category: Neurology Authors: Cheryl Lai Tags: In Context Source Type: research
[In Context] Communication at the borders of consciousness
Consciousness and concepts of the mind have long been central to medical, scientific, and philosophical debate. Yet it is only with recent advances in technology that we have been able even to capture functional processes in the brain, let alone make the leap from observing certain neural activity patterns to trying to define consciousness. A significant contributor to field is the lab led by Adrian Owen, who in his decades-long research into brain injury has pioneered breakthrough techniques in imaging and communicating with patients in persistent vegetative states. (Source: Lancet Neurology)
Source: Lancet Neurology - August 11, 2017 Category: Neurology Authors: Anna Kennedy Tags: In Context Source Type: research
[Comment] T cells and Parkinson's disease
Although effector and regulatory T-cell populations can promote either neurotoxic or neuroprotective effects in the control of the brain's microenvironment, how these cells are induced during Parkinson's disease is not known.1,2 David Sulzer and colleagues3 have reported a functional role of α-synuclein in immune tolerance. The authors posit that lymphocyte populations emerge from α-synuclein induction of autoreactive CD4+ and CD8+ T cells. (Source: Lancet Neurology)
Source: Lancet Neurology - August 11, 2017 Category: Neurology Authors: R Lee Mosley, Howard E Gendelman Tags: Comment Source Type: research
[Personal View] B vitamins in stroke prevention: time to reconsider
B vitamin therapy lowers plasma total homocysteine concentrations, and might be a beneficial intervention for stroke prevention; however, cyanocobalamin (a form of vitamin B12) can accelerate decline in renal function and increase the risk of cardiovascular events in patients with impaired renal function. Although early trials did not show benefit in reduction of stroke, these results might have been due to harm in participants with impaired renal function. In patients with diabetic nephropathy, cyanocobalamin is harmful, whereas B vitamins appear to reduce cardiovascular events in study participants with normal renal func...
Source: Lancet Neurology - August 9, 2017 Category: Neurology Authors: J David Spence, Qilong Yi, Graeme J Hankey Tags: Personal View Source Type: research
[Review] Clinical presentation and management of dyskinetic cerebral palsy
Cerebral palsy is the most frequent cause of severe physical disability in childhood. Dyskinetic cerebral palsy (DCP) is the second most common type of cerebral palsy after spastic forms. DCP is typically caused by non-progressive lesions to the basal ganglia or thalamus, or both, and is characterised by abnormal postures or movements associated with impaired tone regulation or movement coordination. In DCP, two major movement disorders, dystonia and choreoathetosis, are present together most of the time. (Source: Lancet Neurology)
Source: Lancet Neurology - August 9, 2017 Category: Neurology Authors: Elegast Monbaliu, Kate Himmelmann, Jean-Pierre Lin, Els Ortibus, Laura Bonouvri é, Hilde Feys, R Jeroen Vermeulen, Bernard Dan Tags: Review Source Type: research
[Series] Paroxysmal sympathetic hyperactivity: the storm after acute brain injury
A substantial minority of patients who survive an acquired brain injury develop a state of sympathetic hyperactivity that can persist for weeks or months, consisting of periodic episodes of increased heart rate and blood pressure, sweating, hyperthermia, and motor posturing, often in response to external stimuli. The unifying term for the syndrome —paroxysmal sympathetic hyperactivity (PSH)—and clear diagnostic criteria defined by expert consensus were only recently established. PSH has predominantly been described after traumatic brain injury (TBI), in which it is associated with worse outcomes. (Source: Lancet Neurology)
Source: Lancet Neurology - August 9, 2017 Category: Neurology Authors: Geert Meyfroidt, Ian J Baguley, David K Menon Tags: Series Source Type: research
[In Context] Seth Oliveria
Seth Oliveria is a clinical lecturer at the University of Florida, Department of Neurosurgery (Gainesville, FL, USA). He earned his MD and PhD from the University of Colorado (Denver, CO, USA), where his research focused on neuronal L-type calcium channel regulation and nuclear signaling. He completed his neurosurgical training at the University of Florida, including a fellowship in stereotactic and functional neurosurgery. He is particularly interested in deep brain stimulation and the surgical treatment of epilepsy. (Source: Lancet Neurology)
Source: Lancet Neurology - August 9, 2017 Category: Neurology Tags: In Context Source Type: research
