Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Long-term Cognitive Trajectories and Mortality in Older Women
Conclusions: Our study suggests that greater decline in general cognition or executive function is associated with higher rates of mortality in oldest-old women. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Yaffe, K., Peltz, C. B., Ewing, S. K., McCulloch, C. E., Cummings, S. R., Cauley, J. A., Hillier, T. A., Ensrud, K. E. Tags: Research Article Source Type: research

Meta-analysis of Telomere Length in Alzheimers Disease
Conclusions: Our results show a consistent evidence of shorter telomeres in AD patients and highlight the importance of the analysis of epigenomic markers associated with neurodegeneration and with the risk for common and severe neurological diseases, such as AD. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Forero, D. A., Gonzalez-Giraldo, Y., Lopez-Quintero, C., Castro-Vega, L. J., Barreto, G. E., Perry, G. Tags: Research Article Source Type: research

Alcohol Consumption and Longitudinal Trajectories of Physical Functioning in Central and Eastern Europe: A 10-Year Follow-up of HAPIEE Study
Conclusions: This large longitudinal study in Central and Eastern European populations with relatively high alcohol intake does not strongly support the existence of a protective effect of alcohol on PF trajectories; if anything, it suggests that alcohol consumption is associated with greater deterioration in PF over time. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Hu, Y., Pikhart, H., Kubinova, R., Malyutina, S., Pajak, A., Besala, A., Bell, S., Peasey, A., Marmot, M., Bobak, M. Tags: Research Article Source Type: research

Sex Differences in Concomitant Trajectories of Self-Reported Disability and Measured Physical Capacity in Older Adults
Conclusions: Despite the female disadvantage in self-reported disability, older women preserve measured physical capacity better than men over time. Self-reported and measured indicators should be viewed as complementary rather than interchangeable assessments of functional status for both clinical and research purposes, especially for sex-specific comparisons. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Botoseneanu, A., Allore, H. G., Mendes de Leon, C. F., Gahbauer, E. A., Gill, T. M. Tags: Research Article Source Type: research

Abdominal Obesity and Low Skeletal Muscle Mass Jointly Predict Total Mortality and Cardiovascular Mortality in an Elderly Asian Population
Conclusions: Elderly individuals with abdominal obesity and low skeletal muscle mass have higher all-cause and cardiovascular mortality risk. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Chuang, S.-Y., Hsu, Y.-Y., Chen, R. C.-Y., Liu, W.-L., Pan, W.-H. Tags: Research Article Source Type: research

Assessing Daily Physical Activity in Older Adults: Unraveling the Complexity of Monitors, Measures, and Methods
At the 67th Gerontological Society of America Annual Meeting, a preconference workshop was convened to discuss the challenges of accurately assessing physical activity in older populations. The advent of wearable technology (eg, accelerometers) to monitor physical activity has created unprecedented opportunities to observe, quantify, and define physical activity in the real-world setting. These devices enable researchers to better understand the associations of physical activity with aging, and subsequent health outcomes. However, a consensus on proper methodological use of these devices in older populations has not been e...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Schrack, J. A., Cooper, R., Koster, A., Shiroma, E. J., Murabito, J. M., Rejeski, W. J., Ferrucci, L., Harris, T. B. Tags: Review Source Type: research

Change in Epigenome-Wide DNA Methylation Over 9 Years and Subsequent Mortality: Results From the InCHIANTI Study
Patterns of DNA methylation (DNAm) that track with aging have been identified. However, the relevance of these patterns for aging outcomes remains unclear. Longitudinal epigenome-wide DNAm information was obtained from the InCHIANTI study, a large representative European population. DNAm was evaluated using the Illumina HumanMethylation450 array on blood samples collected at baseline and 9-year follow-up: observations from 499 participants with paired longitudinal blood sample and information on differential blood count were included in analyses. A total of 56,579 markers were significantly associated with age in cross-sec...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Moore, A. Z., Hernandez, D. G., Tanaka, T., Pilling, L. C., Nalls, M. A., Bandinelli, S., Singleton, A. B., Ferrucci, L. Tags: Original Article Source Type: research

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age
In conclusion, p16INK4a positive cell numbers in sun-protected human arm skin are indicative of both local elastic fiber morphology and the extent of aging visible in the face. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Waaijer, M. E. C., Gunn, D. A., Adams, P. D., Pawlikowski, J. S., Griffiths, C. E. M., van Heemst, D., Slagboom, P. E., Westendorp, R. G. J., Maier, A. B. Tags: Original Article Source Type: research

Estimating the Upper Limit of Lifetime Probability Distribution, Based on Data of Japanese Centenarians
In modern biology, theories of aging fall mainly into two groups: damage theories and programed theories. If programed theories are true, the probability that human beings live beyond a specific age will be zero. In contrast, if damage theories are true, such an age does not exist, and a longevity record will be eventually destroyed. In this article, for examining real state, a special type of binomial model based on the generalized Pareto distribution has been applied to data of Japanese centenarians. From the results, it is concluded that the upper limit of lifetime probability distribution in the Japanese population has...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Hanayama, N., Sibuya, M. Tags: Original Article Source Type: research

Interactions of Short-Term and Chronic Treadmill Training With Aging of the Left Ventricle of the Heart
With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies suggest that lifelong exercise can potentially reduce age-associated changes in the heart. Although exercise itself is associated with changes in cardiac function, little is known about the interactions of aging and exercise with respect to myocyte calcium regulation. To investigate this, adult (12 months) and old (24 months) C57/Bl6 mice were trained using moderate-intensity tread...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., Lancaster, M. K. Tags: Original Article Source Type: research

Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice
In conclusion, sex and age influence pro-inflammatory cell recruitment, muscle regeneration, and adipocyte area following skeletal muscle injury. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Fearing, C. M., Melton, D. W., Lei, X., Hancock, H., Wang, H., Sarwar, Z. U., Porter, L., McHale, M., McManus, L. M., Shireman, P. K. Tags: Original Article Source Type: research

Impaired Immune Response in Old Mice Suffering from Obesity and Premature Immunosenescence in Adulthood
In conclusion, these results demonstrate that a high fat intake during adolescence can produce an obesity state in adult age associated with a premature immunosenescence, which is aggravated through aging. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Hunsche, C., Hernandez, O., De la Fuente, M. Tags: Original Article Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research