Morphological transformation of hBMSC from 2D monolayer to 3D microtissue on low ‐crystallinity SF‐PCL patch with promotion of cardiomyogenesis
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 12, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 12, 2017 Category: Biotechnology Source Type: research

Design and biological functionality of a novel hybrid Ti ‐6Al‐4V/hydrogel system for reconstruction of bone defects
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 10, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 10, 2017 Category: Biotechnology Source Type: research

Design and biological functionality of a novel hybrid Ti ‐6Al‐4V/hydrogel system for reconstruction of bone defects
In conclusion, we underscore that the 3D‐printed Ti‐6Al‐4V scaffold‐loaded with bioactive hydrogel to treat the bone defects significantly impacted cellular functions and cell‐material interaction. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 10, 2017 Category: Biotechnology Authors: Alok Kumar, K.C. Nune, R.D.K. Misra Tags: RESEARCH ARTICLE Source Type: research

Low ‐melt Bioactive Glass‐reinforced 3D Printing Akermanite Porous Cages with Highly Improved Mechanical Properties for Lumbar Spinal Fusion
Abstract Although great strides have been made in medical technology, low back/neck pain and intervertebral disc degeneration initiated from disc degenerative disease remains a clinical challenge. Within the field of regenerative medicine therapy, we have sought to improve the biomechanical transformation of spinal fusion procedures conducted using biodegradable porous implants. Specifically, we have focused on developing mechanically strong bioceramic cages for spinal fusion and functional recovery. Herein we fabricated the akermanite (AKE) ceramic‐based porous cages using low‐melting bioactive glass (BG) and 3D print...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 9, 2017 Category: Biotechnology Authors: Xiurong Ke, Lei Zhang, Xianyan Yang, Juncheng Wang, Chen Zhuang, Zhouwen Jin, An Liu, Tengfei Zhao, Sanzhong Xu, Changyou Gao, Zhongru Gou, Guojing Yang Tags: RESEARCH ARTICLE Source Type: research

Evaluation of an ovary ‐on‐a‐chip in large mammalian models: Species specificity and influence of follicle isolation status
In this study, we utilized an innovative microfluidic dynamic system to support the in vitro survival of domestic cat and dog follicles enclosed within the ovarian cortex or isolated from ovarian cortex. Results indicate both species and tissue type‐specific differences in response to microfluidic culture. Domestic cat but not dog ovarian cortical tissue maintained viability under flow similar to conventional agarose gel controls. Preantral stage isolated follicles from both species grew most favorably in conventional alginate bead culture, but overall there was no influence of culture system on expression of follicle de...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 8, 2017 Category: Biotechnology Authors: J. Nagashima, R. El Assal, N. Songsasen, U. Demirci Tags: RESEARCH ARTICLE Source Type: research

Bone marrow transplantation improves motor activity in a mouse model of ataxia
Abstract Ataxias are locomotor disorders that can have an origin both neural and muscular, although both impairments are related. Unfortunately, ataxia has no cure and the current therapies are aimed at motor re‐education or muscular reinforcement. Nevertheless, cell therapy is becoming a promising approach to deal with incurable neural diseases, including neuro‐muscular ataxias. Here we have used a model of ataxia, the PCD mutant mouse, to study the effect of healthy (wild‐type) bone marrow transplantation on the restoration of defective mobility. Bone marrow transplants (from both mutant and healthy donors) were pe...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 8, 2017 Category: Biotechnology Authors: David D íaz, Marina Piquer‐Gil, Javier Sánchez Recio, María Magdalena Martínez‐Losa, José Ramón Alonso, Eduardo Weruaga, Manuel Álvarez‐Dolado Tags: RESEARCH ARTICLE Source Type: research

Decellularized Human Liver Extracellular Matrix (hDLM) Mediated Hepatic Differentiation of Human Induced Pluripotent Stem Cells (hIPSc)
Abstract Liver tissue engineering has emerged as a promising approach in organ transplantation, but has been hampered by the lack of a reliable and readily available cell source. Induced pluripotent cells (hiPSC) have been highlighted a desirable source, due to their differentiation potential, ability to self‐renew and the possibility of making patient specific cells. We developed a decellularization protocol that efficiently removes cellular material, while retaining extracellular matrix components. Subsequently, hiPSC were differentiated on the decellularized human liver matrix (hDLM) scaffolds using an established hep...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 8, 2017 Category: Biotechnology Authors: Maria Jaramillo, Heidi Yeh, Martin L. Yarmush, Basak E. Uygun Tags: RESEARCH ARTICLE Source Type: research

Cell ‐laden composite suture threads for repairing damaged tendons
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 6, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 6, 2017 Category: Biotechnology Source Type: research

Mesenchymal stem cells seeded on a human amniotic membrane improve liver regeneration and mouse survival after extended hepatectomy
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 5, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 5, 2017 Category: Biotechnology Source Type: research

3D matrix ‐embedding inhibits cycloheximide‐mediated sensitization to TNF‐alpha‐induced apoptosis of human endothelial cells
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 3, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 3, 2017 Category: Biotechnology Source Type: research