Dosimetric comparison of linac-based modulated techniques for hippocampal sparing whole brain radiotherapy
ConclusionVMAT plans provide better target volume coverage, homogeneity, conformity, and hippocampus sparing when compared with IMRT plans. VMAT plans are also the best in terms of treatment efficiency since they require a much smaller number of MUs and thus a shorter treatment time than IMRT plans. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 6, 2020 Category: Cancer & Oncology Source Type: research
Brain metastases from small cell lung cancer: survival after whole brain radiotherapy versus stereotactic radiosurgery of recursive partitioning analysis class I –II patients
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research
Volumetric modulated craniospinal irradiation workflow optimization through quantitative analytics: a single-institution case study comparing pediatric and adult settings
ConclusionsSimple descriptive statistics and regression modeling can be used to assess workflow efficiency and estimate radiation treatment times based on patient and technique-specific factors. We modeled VMAT CSI treatment delivery times at our pediatric and adult hospitals to set time expectations for IGRT and beam delivery. Workflow analytics can identify opportunities to minimize time inefficiencies and optimize coordination of care. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 17, 2020 Category: Cancer & Oncology Source Type: research
Lymph node –directed simultaneous integrated boost in patients with clinically lymph node–positive cervical cancer treated with definitive chemoradiotherapy: clinical outcomes and toxicity
ConclusionChemoradiation with a LN-directed SIB for women with LN-positive cervical cancer is well tolerated and is associated with excellent oncologic outcomes.SummaryIn this report, we evaluated the oncologic efficacy and adverse events associated with definitive chemoradiotherapy with a simultaneous integrated boost to grossly involved lymph nodes for women with lymph node –positive cervical cancer. We have identified acceptable rates of adverse events and excellent oncologic outcomes, even in a very high risk cohort of women with cervical cancer. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 8, 2020 Category: Cancer & Oncology Source Type: research
Dosimetric correlations with urinary quality of life in patients receiving post-prostatectomy radiation therapy
ConclusionThere is an acute worsening of urinary symptoms among men receiving modern post-prostatectomy radiation. Worsening of urgency is associated with bladder dosimetry while flow, frequency, nocturia, and dysuria are not. This data can be used during treatment planning to reduce acute urinary toxicity during post-prostatectomy radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 2, 2020 Category: Cancer & Oncology Source Type: research
Capturing 3D patient features for rapid prototyping in radiotherapy prior to simulation
ConclusionWe present a new workflow that combines current known methods of both rapidly scanning a patient ’s surface and the subsequent rapid creation of bolus that then increases bolus conformity, improves comfort and the patient experience, reduces simulation time, and may decrease exposure to radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 29, 2020 Category: Cancer & Oncology Source Type: research
Radiofrequency radiation: carcinogenic and other potential risks
In conclusion, there is neither convincing evidence nor theoretic plausibility of a cause-effect relationship between RFR and cancer. Reliable evidence can be obtained by large-scale animal experiments. To make experiments less expensive, it would suffice to maintain large animal groups in equal conditions and to record the life span. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 24, 2020 Category: Cancer & Oncology Source Type: research
Biologic subtypes as a predictor of local control in patients with brain metastases from breast cancer after stereotactic radiosurgery
ConclusionThis study shows that in BC patients with BM treated with SRS, biologic subtype affects LC. Consideration of radiation treatment intensification or altered fractionation to improve LC may be indicated for the TN subtype. Further multicenter studies are necessary to corroborate our results. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 23, 2020 Category: Cancer & Oncology Source Type: research
Recommendations for radiosurgery and stereotactic ablative radiotherapy terminology to guide clinical and research practices for the medical oncologist, radiation oncologist, and surgeon
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 14, 2020 Category: Cancer & Oncology Source Type: research
A single-institution study of intraoperative radiation therapy (IORT) using electronic brachytherapy
ConclusionIORT is a convenient and well-tolerated treatment option for the appropriately selected woman undergoing partial breast irradiation. Rates of seroma formation are similar to rates reported for multiple fraction catheter-based systems. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 10, 2020 Category: Cancer & Oncology Source Type: research
Radiotherapy for maxillary sinus carcinoma: dosimetric comparison of volumetric modulated arc therapy with 0 ° and 90° collimator intensity modulated radiation therapy
ConclusionsThe VMAT has better CI of target volume and could have better OARs sparing effects for optic chiasm, ipsilateral lens and ipsilateral optic nerve compared with IMRT for MSCs. The VMAT also could use fewer MUs and has lower treatment delivery times. The nc-IMRT could have better ipsilateral lens sparing and use fewer MUs compared with zc-IMRT. Therefore we could protect the ipsilateral lens better through changing the angle of the collimator from 0 ° to 90° when the IMRT technique is used for the treatment of MSCs. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 9, 2020 Category: Cancer & Oncology Source Type: research
Safety of nivolumab in combination with prior or concurrent radiation therapy in hepatocellular carcinoma
ConclusionCombination RT and nivolumab is generally safe in the management of unresectable HCC with a low rate of serious adverse events. Prospective trials investigating the efficacy of combination nivolumab and RT are warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 8, 2020 Category: Cancer & Oncology Source Type: research
Comparison of ICRU 38 rectal reference point dose estimates with measured dose in vivo in cobalt-60 HDR brachytherapy for cervical cancer
ConclusionOverall, this study was able to provide additional evidence that in vivo dosimetry can be validly used in the clinical setting to estimate the dose to the rectum during Co-60 HDR brachytherapy. Use of this technique allows for an additional quality assurance method that can contribute to reductions of errors in dose delivery. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 7, 2020 Category: Cancer & Oncology Source Type: research
Analysis of setup uncertainties and determine the variation of the clinical target volume (CTV) to planning target volume (PTV) margin for various tumor sites treated with three-dimensional IGRT couch using KV-CBCT
ConclusionsFor adequate target coverage, van Herk-calculated CTV to PTV margin are used in our institution. To reduce the setup uncertainties and CTV to PTV margin frequently, CBCT is essential. In the yearly comparison of CTV to PTV margin, we observed that for brain and H&N cases were not in descending order due to the differently deformation of head rests which were used for molding and treatment separately. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 5, 2020 Category: Cancer & Oncology Source Type: research
Perioperative high-dose-rate brachytherapy (PoHDR) in the multidisciplinary management of adult soft tissue sarcomas: a realistic alternative for a moderate radiotherapy dose escalation
ConclusionsHDR PoBT is safe, feasible, and well tolerated and allows for a moderate radiation dose escalation with acceptable rates of tumor control. Further follow-up is necessary to confirm impact on final outcomes. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 5, 2020 Category: Cancer & Oncology Source Type: research
