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Quinones as preventive agents in Alzheimer ’s diseases: focus on NLRP3 inflammasomes
AbstractObjectivesAlzheimer ’s disease (AD) is a hidden neurological degenerative disease, which main clinical manifestations are cognitive dysfunction, memory impairment and mental disorders. Neuroinflammation is considered as a basic response of the central nervous system. NLRP3 (Nucleotide‐binding domain leucine‐rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Activation of the NLRP3 inflammasome results in the release of cytokines, pore formation and ultimately pyroptosis, which has demonstrated one of the critical roles in AD path o...
Source: Journal of Pharmacy and Pharmacology - July 14, 2020 Category: Drugs & Pharmacology Authors: Da ‐bao Chen, Hua‐wu Gao, Cheng Peng, Shao‐qiang Pei, An‐ran Dai, Xue‐ting Yu, Peng Zhou, Yan Wang, Biao Cai Tags: Review Source Type: research

Spinosin protects N2a cells from H2O2 ‐induced neurotoxicity through inactivation of p38MAPK
ConclusionsOur findings suggest that SPI protects N2a cells from H2O2‐induced oxidative damage through inactivation of p38MAPK. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 14, 2020 Category: Drugs & Pharmacology Authors: Fanxing Xu, Xiaoying Zhang, Jinyu Wang, Xu Li, Bosai He, Feng Xiao, Tingxu Yan, Bo Wu, Ying Jia, Zhenzhong Wang Tags: Research Paper Source Type: research

Concurrent administration with multivalent metal cation preparations or polycationic polymer preparations inhibits the absorption of raltegravir via its chelation
ConclusionsThe interaction of RAL with Al(OH)3, LaCO3, Bxl, or Svl can inhibit RAL absorption into the gastrointestinal tract, and thus, the multivalent metal cation and polycationic polymer are the modifying factors that can affect RAL pharmacokinetics. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 12, 2020 Category: Drugs & Pharmacology Authors: Yuki Enoki, Norihiro Suzuki, Motoyasu Ito, Eri Uchiyama, Nagomi Kishi, Chihiro Ito, Yuki Kitahiro, Kazuki Sakamoto, Kazuaki Taguchi, Yuta Yokoyama, Junko Kizu, Kazuaki Matsumoto Tags: Research Paper Source Type: research

Therapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice
ConclusionsThe results demonstrated the therapeutic effects of Qianlie Tongli decoction in CP/CPPS mice by analysing clinically relevant symptoms (urinary tract system, pelvic pain and prostate inflammation) and preliminarily explored the inflammatory ‐related treatment mechanisms by measuring TNF‐α. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 9, 2020 Category: Drugs & Pharmacology Authors: Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmad, Meng Tang, Junaid Wazir, Xiaohui Zhou, Lei Han Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 8, Page i-iv, August 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 8, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin ‐O‐glucuronide in HeLa1A1 cells
ConclusionsCYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 8, 2020 Category: Drugs & Pharmacology Authors: Yang Li, Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Synthesis, characterization, antidiabetic and antioxidative evaluation of a novel Zn(II) ‐gallic acid complex with multi‐facet activity
ConclusionsData suggest that complexation of Zn(II) with gallic acid resulted in a complex with improved and multi ‐facet antioxidative and glycaemic control properties. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 7, 2020 Category: Drugs & Pharmacology Authors: Denice M. Motloung, Samson S. Mashele, Godfrey R. Matowane, Shasank S. Swain, Susanna L. Bonnet, Anwar E.M. Noreljaleel, Sunday O. Oyedemi, Chika I. Chukwuma Tags: Research Paper Source Type: research

By reducing oxidative stress, naringenin mitigates hyperglycaemia ‐induced upregulation of hepatic nuclear factor erythroid 2‐related factor 2 protein
ConclusionsNaringenin confers hepatoprotective antioxidant effects by initially preventing upregulation of Nrf2 protein expression and its downstream antioxidant enzymes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 5, 2020 Category: Drugs & Pharmacology Authors: Lereko Kometsi, Khmera Govender, Edith P. Mofo Mato, Rajendraparsad Hurchund, Peter M. O. Owira Tags: Research Paper Source Type: research

Protective effects of Sosihotang extract against ultraviolet B ‐induced skin photoageing in hairless mice
ConclusionsThese results indicate that SSH extract can be used therapeutically for the treatment of UVB ‐induced skin damage and photoageing. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 1, 2020 Category: Drugs & Pharmacology Authors: A ‐Rang Im, Kon‐Young Ji, Kung‐Woo Nam, Sungwook Chae Tags: Research Paper Source Type: research

The effect of apatinib on pharmacokinetic profile of buspirone both in vivo and in vitro
ConclusionsApatinib suppresses the CYP450 based metabolism of buspirone in a mixed mechanism and boosted the blood exposure of prototype drug and 6 ‐OH buspirone dramatically. Therefore, extra caution should be taken when combining apatinib with buspirone in clinic. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 29, 2020 Category: Drugs & Pharmacology Authors: Xiao ‐dan Zhang, Ying‐hui Li, Dao‐xing Chen, Wei‐wei You, Xiao‐xia Hu, Bing‐bing Chen, Guo‐xin Hu, Jian‐chang Qian Tags: Research Paper Source Type: research

Dual effects of S ‐adenosyl‐methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+
Conclusions(1) SAM might induce neurotoxic or neuroprotective effects on PC12 cells, depending on the exposure conditions; (2) DNMT inhibitors might attenuate the MPP+ exacerbation toxicity induced by SAM; (3) DNA methylation might be involved in the observed effects of SAM (needs further investigation). (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Rebeca Araujo Cantelmo, Neife Aparecida G. Santos, Antonio Cardozo Santos, S âmia Regiane Lourenço Joca Tags: Research Paper Source Type: research

1 ‐(4‐((5‐chloro‐4‐((2‐(isopropylsulfonyl)phenyl)amino)pyrimidin‐2‐yl)amino)‐3‐methoxyphenyl)‐3‐(2‐(dimethylamino)ethyl)imidazolidin‐2‐one (ZX‐42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells
ConclusionsIn summary, ZX ‐42 is a novel ALK inhibitor that significantly inhibits the cell viability of H2228 cells and ultimately induces apoptosis through the mitochondrial pathway, in which autophagy plays a protective role. Therefore, inhibition of autophagy might enhance the anti‐cancer effect of ZX‐42. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 27, 2020 Category: Drugs & Pharmacology Authors: Lijing Wang, Xiaobo Xu, Tong Liu, Junfang Wang, Jiwei Shen, Ming Guo, Yingliang Wu, Xin Zhai, Daiying Zuo Tags: Research Paper Source Type: research

A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine
Conclusions(34Pro,35Phe)CGRP27 –37 is a potent CGRP receptor antagonist bothin vitro andin vivo, and it can be formulated as a dry powder with no loss of activity indicating its potential as a nasally formulated anti ‐migraine medicine. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 24, 2020 Category: Drugs & Pharmacology Authors: Bengt Mentzer, Andrew F. Russo, Zhang Zhongming, Adisa Kuburas, Patrick M. Killoran, Vera D ’Aloisio, Laura Nizic, Vicky Capel, David A. Kendall, Christopher R. Coxon, Gillian A. Hutcheon Tags: Research Paper Source Type: research

Nose ‐to‐brain delivery of sumatriptan‐loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation
ConclusionsNeuropharmacokinetic evaluation of intranasal NLC dispersion represents a suitable brain delivery system. The DTP of NLC formulation suggests the desirable entrance of sumatriptan into the brain. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 23, 2020 Category: Drugs & Pharmacology Authors: Moein Masjedi, Amir Azadi, Reza Heidari, Soliman Mohammadi ‐Samani Tags: Research Paper Source Type: research

In vitro metabolic characterization of orbitazine, a novel derivative of the PAC ‐1 anticancer agent
ConclusionsThisin vitro data on the metabolism of orbitazine may provide valuable information to support further clinical progression as a potential therapeutic molecule. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 23, 2020 Category: Drugs & Pharmacology Authors: Fang Li, Xuhua Han, Yanfen Chen, Shanshan Wang, Zeneng Cheng, Gaoyun Hu, Wenjie Liu, Qubo Zhu Tags: Research Paper Source Type: research