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Modulation of NADPH oxidase and Nrf2/HO ‐1 pathway by vanillin in cisplatin‐induced nephrotoxicity in rats
ConclusionsThe antioxidant mechanism by which vanillin protected against CP ‐induced nephrotoxicity involved the inhibition ofNOX ‐4 along with the stimulation of Nrf2/HO ‐1 signalling pathway. These in turn inhibited inflammation and apoptosis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 2, 2020 Category: Drugs & Pharmacology Authors: Nahla N. Younis, Nehal M Elsherbiny, Mohamed A. Shaheen, Mohamed M. Elseweidy Tags: Research Paper Source Type: research

Efficiency comparison of apigenin ‐7‐O‐glucoside and trolox in antioxidative stress and anti‐inflammatory properties
ConclusionsThese results suggest the potential of AG as a pharmaceutical drug for anti ‐oxidation and anti‐inflammation, and the combined usage of AG and trolox might promote its efficacy. Our findings will provide new insights into the development of new drugs with antioxidative and anti‐inflammatory functions. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 1, 2020 Category: Drugs & Pharmacology Authors: Wei Wang, Ru ‐Feng Yue, Zhen Jin, Li‐Min He, Rong Shen, Dan Du, You‐Zhi Tang Tags: Research Paper Source Type: research

e5NT inhibitor protects acute restraint stress ‐induced depression by regulating nucleoside release in mice
ConclusionsThese data suggest that acute restraint stress may alter extracellular adenosine and uridine levels content in the hippocampus of mice via e5NT, and thus, the inhibition of e5NT may improve the anxiety behaviour in mice. Therefore, e5NT may therefore be a potential therapeutic target for the treatment of anxiety in mice. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 1, 2020 Category: Drugs & Pharmacology Authors: Ping Liu, Lei Zhu, Limei Zhou, Xinyu Bai Tags: Research Paper Source Type: research

Xanthone ‐enriched fraction of Garcinia mangostana and α‐mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats
ConclusionsHowever, α‐MG (50 mg/kg) and XEFGM (100 mg/kg) reversed the cognitive impairment induced by CCH in MWM test. α‐MG (50 mg/kg) was further tested upon sub‐acute 14‐day treatment in CCH rats. Cognitive improvement was shown in MWM test but not in long‐term potentiation (LTP). BDNF but not CaMKII was found to be down‐regulated in CCH rats; however, both parameters were not affected by α‐MG. In conclusion, α‐MG ameliorated learning and memory deficits in both acute and sub‐acute treatments in CCH rats by improving the spatial learning but not hippocampal LTP. Hence, α‐MG may be a promising...
Source: Journal of Pharmacy and Pharmacology - August 1, 2020 Category: Drugs & Pharmacology Authors: Ning Tiang, Mohamad Anuar Ahad, Vikneswaran Murugaiyah, Zurina Hassan Tags: Research Paper Source Type: research

A comprehensive review of therapeutic approaches available for the treatment of cholera
ConclusionsKnowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 30, 2020 Category: Drugs & Pharmacology Authors: Francisca B. M. Sousa, Isabela R. S. G. Nol êto, Leticia S. Chaves, Gabriella Pacheco, Ana P. Oliveira, Mikhail M. V. Fonseca, Jand V. R. Medeiros Tags: Review Source Type: research

Pharmacogenetic impact of UGT1A1 polymorphisms on pulmonary neuroendocrine tumours treated with metronomic irinotecan ‐based chemotherapy in Chinese populations
ConclusionsThe impact of UGT1A1 polymorphisms varies in different irinotecan ‐based chemotherapies.UGT1A1*6 andUGTA1A*28 were useful for the prediction of irinotecan ‐related severe toxicity in Chinese PNT patients treated with metronomic IBC. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 30, 2020 Category: Drugs & Pharmacology Authors: Xu Ma, Sen Han, Ying Liu, Jing ‐Tao Liu, Jian Fang, Yan‐Hua Zhang Tags: Research Paper Source Type: research

HWL ‐088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis
ConclusionsThese positive results indicated that PPAR δ/FFA1 dual agonist HWL‐088 might be a potential candidate to improve multiple pathogenesis of NASH. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 30, 2020 Category: Drugs & Pharmacology Authors: Lijun Hu, Zongtao Zhou, Liming Deng, Qiang Ren, Zongyu Cai, Bin Wang, Zheng Li, Guangji Wang Tags: Research Paper Source Type: research

Carissa carandas L. – phyto‐pharmacological review
ConclusionsThis current review offers primary data for further research work. The in ‐vitro evaluations as well as in‐vivo models/experiments have provided a biosynthetic observation for its various ethno‐pharmacological uses and even pharmacological properties. This review would provide all valuable information which will be beneficiary to conduct some important pharmacokinet ic and toxicological research works on human models with respect to ensure the effects of active ingredients in the body and even to validate its safety issues in clinical aspects. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 28, 2020 Category: Drugs & Pharmacology Authors: Sonia Singh, Meenakshi Bajpai, Pradeep Mishra Tags: Review Source Type: research

Pharmacological postconditioning: a molecular aspect in ischemic injury
AbstractObjectiveIschaemia/reperfusion (I/R) injury is defined as the damage to the tissue which is caused when blood supply returns to tissue after ischaemia. To protect the ischaemic tissue from irreversible injury, various protective agents have been studied but the benefits have not been clinically applicable due to monotargeting, low potency, late delivery or poor tolerability.Key FindingsStrategies involving preconditioning or postconditioning can address the issues related to the failure of protective therapies. In principle, postconditioning (PoCo) is clinically more applicable in the conditions in which there is u...
Source: Journal of Pharmacy and Pharmacology - July 27, 2020 Category: Drugs & Pharmacology Authors: Heena Khan, Ankita Kashyap, Amarjot Kaur, Thakur Gurjeet Singh Tags: Review Source Type: research

Cytotoxic activity of dimeric acridone alkaloids derived from Citrus plants towards human leukaemia HL ‐60 cells
ConclusionsCitbismine ‐E is a powerful cytotoxic agent against HL‐60 cells that acts by inducing mitochondrial dysfunction‐mediated apoptosis through ROS‐dependent JNK activation. Citbismine‐E also induced oxidative stress damage via ROS‐mediated lipid peroxidation and DNA damage in HL‐60 cells. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 26, 2020 Category: Drugs & Pharmacology Authors: Tomiyasu Murata, Susumu Kohno, Kazuma Ogawa, Chihiro Ito, Masataka Itoigawa, Masafumi Ito, Kiyomi Hikita, Norio Kaneda Tags: Research Paper Source Type: research

Modulation of non ‐steroidal anti‐inflammatory drug‐induced, ER stress‐mediated apoptosis in Caco‐2 cells by different polyphenolic antioxidants: a mechanistic study
ConclusionEpigallocatechin gallate, phyllanthin and hypophyllanthin displayed different effects in the ER stress ‐mediated apoptosis, depending upon their interaction with the specific unfolded protein response signalling. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 26, 2020 Category: Drugs & Pharmacology Authors: Cherdsak Boonyong, Nontima Vardhanabhuti, Suree Jianmongkol Tags: Research Paper Source Type: research

Benzothiazoles as potential antiviral agents
AbstractObjectivesThe recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic.Key findingsBenzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight i...
Source: Journal of Pharmacy and Pharmacology - July 23, 2020 Category: Drugs & Pharmacology Authors: Yahya I. Asiri, Abdulrhman Alsayari, Abdullatif B. Muhsinah, Yahia N. Mabkhot, Mohd. Z. Hassan Tags: Review Source Type: research

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems
AbstractObjectivesTetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising anticancer activities on diverse tumours. This review provides systematically organized information on cancers of tetrandrinein vivo andin vitro, discuss the related molecular mechanisms and put forward some new insights for the future investigations.Key findingsAnticancer activities of tetrandrine have been reported comprehensively, including lung cancer, colon cancer, bladder cancer, prostate cancer, ovarian cancer, gastric cancer, breast cancer, pancreatic cancer, cervical cancer and liver cancer. The potential molecular mechani...
Source: Journal of Pharmacy and Pharmacology - July 21, 2020 Category: Drugs & Pharmacology Authors: Fei Luan, Xirui He, Nan Zeng Tags: Review Source Type: research

Scalable solvent ‐free production of liposomes
ConclusionsWe apply a simple and scalable solvent ‐free method for the production of both aqueous core or bilayer drug‐loaded liposomes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 15, 2020 Category: Drugs & Pharmacology Authors: Swapnil Khadke, Carla B. Roces, Rachel Donaghey, Valeria Giacobbo, Yang Su, Yvonne Perrie Tags: Research Paper Source Type: research

Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
ConclusionsThese findings suggest that combining cisplatin with agents that target the RSK mediated cell survival pathway, may potentiate the cisplatin effect in lung adenocarcinoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 14, 2020 Category: Drugs & Pharmacology Authors: Nabeel Abdulrahman, Kodappully Sivaraman Siveen, Jensa Mariam Joseph, Aisha Osman, Huseyin C. Yalcin, Anwarul Hasan, Shahab Uddin, Fatima Mraiche Tags: Research Paper Source Type: research