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Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
ConclusionsThe study expands the understanding of the pharmacological properties of Berberine and its applicability as a radiosensitizer towards treating liver cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 19, 2020 Category: Drugs & Pharmacology Authors: Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva Tags: Research Paper Source Type: research

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis
AbstractObjectivesRheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self ‐neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self‐epitopes as biomarkers in RA provides a better understanding of pathogenesis of disease and has led to the development of novel the rapeutic approaches acting as potent inhibitors of these cells.Key findingsThe current review retrieved the various medicinal plant...
Source: Journal of Pharmacy and Pharmacology - August 17, 2020 Category: Drugs & Pharmacology Authors: Shareen Singh, Thakur Gurjeet Singh, Kriti Mahajan, Sonia Dhiman Tags: Review Source Type: research

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage
AbstractObjectivesThe myoblast cell line, C2C12, has been utilised extensively in vitro as an examination model in understanding metabolic disease progression. Although it is indispensable in both preclinical and pharmaceutical research, a comprehensive review of its use in the investigation of insulin resistance progression and pharmaceutical development is not available.Key findingsC2C12 is a well ‐documented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular l...
Source: Journal of Pharmacy and Pharmacology - August 17, 2020 Category: Drugs & Pharmacology Authors: Chun Y. Wong, Hani Al ‐Salami, Crispin R. Dass Tags: Review Source Type: research

Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ ‐induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes
ConclusionKigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 17, 2020 Category: Drugs & Pharmacology Authors: Oladapo F. Fagbohun, Babatunde Olawoye, Adedeji N. Ademakinwa, Kehinde A. Jolayemi, Titus A. M. Msagati Tags: Research Paper Source Type: research

Recombinant ling zhi ‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
ConclusionsThese data suggest that rLZ ‐8 can antagonize STZ‐induced T1D, and its mechanism may be related to inhibit inflammation and enhance Tregs generation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 16, 2020 Category: Drugs & Pharmacology Authors: Hongyu Xiao, Zhi Fang, Xueling He, Ping Ding, Yongkai Cao, Shamyuen Chan, Shaozhen Hou, Jian Liang Tags: Research Paper Source Type: research

9 ‐PAN promotes tubulin‐ and ROS‐mediated cell death in human triple‐negative breast cancer cells
Conclusions9 ‐PAN exerts its antiproliferative effect by targeting tubulin and elevating ROS level in the cells. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 15, 2020 Category: Drugs & Pharmacology Authors: Prachi Verma, Praveen Kumar Reddy Nagireddy, Shweta Shyam Prassanawar, Jesuthankaraj Grace Nirmala, Ankita Gupta, Srinivas Kantevari, Manu Lopus Tags: Research Paper Source Type: research

Inhibiting the PI3K/Akt, NF ‐κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131
ConclusionsTherefore, addition of SRA to SCC131 cells may provide a promising natural therapeutic strategy against squamous cell carcinomas with potential application in clinical analysis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 12, 2020 Category: Drugs & Pharmacology Authors: Periyannan Velu, Annamalai Vijayalakshmi, Veerasamy Vinothkumar Tags: Research Paper Source Type: research

Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
ConclusionsA loading dose of up to 300  mg of micafungin is needed for the treatment of invasive candidiasis in ICU patients while a maintenance dose of up to 200 mg can be considered in empirical antifungal treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 11, 2020 Category: Drugs & Pharmacology Authors: Iasonas Kapralos, Efstratios Mainas, Efthymios Neroutsos, Stella Apostolidi, Maria Siopi, Olympia Apostolopoulou, George Dimopoulos, Helen Sambatakou, Georgia Valsami, Joseph Meletiadis, Aristides Dokoumetzidis Tags: Research Paper Source Type: research

Recent trends in targeting miRNAs for cancer therapy
AbstractObjectivesMicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development of new diagnostic and therapeutic opportunities.Key findingsMicroRNA dysregulation is commonly associated with cancer, in part because miRNAs are actively involved in the mechanisms like genomic instabilities, aberrant transcriptional control, altered epigenetic regulation and biogenesis machinery defects. MicroRNA...
Source: Journal of Pharmacy and Pharmacology - August 11, 2020 Category: Drugs & Pharmacology Authors: Vandit Shah, Jigna Shah Tags: Review Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 9, Page i-iv, September 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 9, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 9, Page 1287-1287, September 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 9, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Black mulberry fruit extract alleviates streptozotocin ‐induced diabetic nephropathy in rats: targeting TNF‐α inflammatory pathway
ConclusionThe ameliorative effect of BMFE on diabetic nephropathy is not only through its potent antioxidant and hypoglycaemic effects but also through its downregulation of TNF ‐α, VCAM‐1 and fibronectin mRNA expression in renal tissues of diabetic‐treated rats. Therefore, BMFE as dietary supplement could be a promising agent in improving diabetic nephropathy. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Tarek Kamal Abouzed, Kadry M. Sadek, Emad Waded Ghazy, Walied Abdo, Mohmed Atef Kassab, Salma Hago, Samia Abdel ‐Wahab, Engy A. Mahrous, Essam Abdel‐Sattar, Doaa H. Assar Tags: Research Paper Source Type: research

Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra ‐performance liquid chromatography coupled time‐of‐flight mass spectrometry
ConclusionsThis work revealed thein ‐vivo metabolism of FF, and reported the characteristic metabolic reactions of lignans for the first time. It was also provided the foundation for the further investigation on pharmacodynamic components of FF or TCMs containing FF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Feng ‐xiang Zhang, Zi‐ting Li, Chang Li, Min Li, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai Tags: Research Paper Source Type: research

Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus
ConclusionsThe inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components inL.  japonicus. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Grace Gar ‐Lee Yue, Xin‐Xin Liang, Xiao‐Li Li, Julia Kin‐Ming Lee, Si Gao, Hin‐Fai Kwok, Clara Bik‐San Lau, Wei‐Lie Xiao Tags: Research Paper Source Type: research

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu ‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
ConclusionsCYP1A2, 2C19 and UGT1As play an important role in isobavachin metabolism. Isobavachin demonstrated broad ‐spectrum inhibition of CYPs and UGTs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research