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Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open ‐angle glaucoma in rabbits
ConclusionThe ODSs could be a promising alternative delivery system for eye drops with more compliance to enhance delivery and therapeutic activity of TML in treatment of POAG. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Authors: Yasmin A. El ‐Feky, Dalia A. Mostafa, Majid M. Al‐Sawahli, Rania Farag A. El‐Telbany, Sherin Zakaria, Ahmed M. Fayez, Kawkab A. Ahmed, Ebtesam M. Alolayan, Dalia Farag A. El‐Telbany Tags: Research Paper Source Type: research

TV 3326 for Alzheimer ’s dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer’s‐like neuropathology
AbstractObjectivesAlzheimer ’s disease (AD) is one of the most prevalent neurodegenerative disorders and a well‐recognized cause of dementia with ageing. In this review, we have represented the ChE and MAO inhibitory potential of TV 3326 against AD based on current scientific evidence.Key findingsThe aetiology of AD is quite complex and not completely understood. However, it has been observed that AD involves the deposition of abnormal amyloid beta (A β), along with hyperphosphorylation of tau, oxidative stress, low acetylcholine (ACh) level and biometal dyshomeostasis. Due to the complex nature of AD aetiology, activ...
Source: Journal of Pharmacy and Pharmacology - March 10, 2020 Category: Drugs & Pharmacology Authors: Sahab Uddin, Tanvir Kabir, Motiar Rahman, Bijo Mathew, Muhammad Ajmal Shah, Ghulam Md Ashraf Tags: Review Source Type: research

Taste masking of water ‐soluble drug by solid lipid microspheres: a child‐friendly system established by reversed lipid‐based nanoparticle technique
ConclusionsAtomoxetine hydrochloride ‐reversed lipid‐based nanoparticle‐solid lipid microsphere exhibited excellent taste‐masking effect with negligible leakage in the oral cavity environment and thorough collapse upon lipase stimulation, simultaneously enhancing the bioavailability of ATX. The study paves a new way to efficien tly mask the undesirable taste of some water‐soluble drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 10, 2020 Category: Drugs & Pharmacology Authors: Yadan Zhang, Liao Shen, Tao Wang, Haiyan Li, Ri Huang, Zhen Zhang, Yongan Wang, Dongqin Quan Tags: Research Paper Source Type: research

TV 3326 for Alzheimer ’s dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer’s‐like neuropathology
AbstractObjectivesAlzheimer ’s disease (AD) is one of the most prevalent neurodegenerative disorders and a well‐recognized cause of dementia with ageing. In this review, we have represented the ChE and MAO inhibitory potential of TV 3326 against AD based on current scientific evidence.Key findingsThe aetiology of AD is quite complex and not completely understood. However, it has been observed that AD involves the deposition of abnormal amyloid beta (A β), along with hyperphosphorylation of tau, oxidative stress, low acetylcholine (ACh) level and biometal dyshomeostasis. Due to the complex nature of AD aetiology, activ...
Source: Journal of Pharmacy and Pharmacology - March 8, 2020 Category: Drugs & Pharmacology Authors: Md. Sahab Uddin, Md. Tanvir Kabir, Md. Motiar Rahman, Bijo Mathew, Muhammad Ajmal Shah, Ghulam Md Ashraf Tags: Review Source Type: research

Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves
ConclusionsA low AMF bioavailability was due to extensive glucuronidation, which was mediated by UGT1A1 and UGT1A3. Glucuronidated AMF metabolites had the same antioxidant but had a lower anticancer activity than that of AMF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 8, 2020 Category: Drugs & Pharmacology Authors: Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai, Ling Ye Tags: Research Paper Source Type: research

Clomipramine, a tricyclic antidepressant, and selegiline, a monoamine oxidase ‐B inhibitor, modulate the activity of phagocytic cells after oral administration in mice
ConclusionsBoth clomipramine and selegiline administered in vivo changed the phagocytic activity of blood cells and IL ‐1β and NO production by murine peritoneal macrophages. This effect depended on the drug, the number of doses and the type of phagocytic cells. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 8, 2020 Category: Drugs & Pharmacology Authors: Anna Sobieszcza ńska, Magdalena Lis, Agnieszka Suszko‐Pawłowska, Marianna Szczypka Tags: Research Paper Source Type: research

Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves
ConclusionsA low AMF bioavailability was due to extensive glucuronidation, which was mediated by UGT1A1 and UGT1A3. Glucuronidated AMF metabolites had the same antioxidant but had a lower anticancer activity than that of AMF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 6, 2020 Category: Drugs & Pharmacology Authors: Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai, Ling Ye Tags: Research Paper Source Type: research

Discovery and analysis the anti ‐pseudo‐allergic components from Perilla frutescens leaves by overexpressed MRGPRX2 cell membrane chromatography coupled with HPLC‐ESI‐IT‐TOF system
ConclusionsA MRGPRX2/CMC coupled with HPLC ‐ESI‐IT‐TOF system was successfully established and applied to discover the effective components fromP.  frutescens leaves. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 6, 2020 Category: Drugs & Pharmacology Authors: Liu Yang, Yingnan Zeng, Jue Wang, Yongjing Zhang, Yajing Hou, Qiaohong Qin, Weina Ma, Nan Wang Tags: Research Paper Source Type: research

Urinary metabolomics research for Huangqi Jianzhong Tang against chronic atrophic gastritis rats based on 1H NMR and UPLC ‐Q/TOF MS
ConclusionsThe main mechanism of HQJZ might be due to the balance of energy consumption, inflammatory inhibition, improvement of the immune system and oxidative stress on the constructed CAG rats. These findings provided comprehensive metabolic information of TCM by parallel measurements by LC ‐MS and NMR. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 4, 2020 Category: Drugs & Pharmacology Authors: YueTao Liu, Zhidong Jin, Xuemei Qin, QingXia Zheng Tags: Research Paper Source Type: research

Treatment of diabetic peripheral neuropathy: a review
The objectives of this paper are to review current guidelines for the pharmacological management of DPN and to discuss research rel evant to the further development of pharmacological recommendations for the treatment of diabetic neuropathy.SummaryDiabetic neuropathy is a highly prevalent, disabling condition, the management of which is associated with significant costs. Evidence supports the use of specific anticonvulsants and antidepressants for pain management in patients with diabetic peripheral neuropathy. All current guidelines advise a personalised approach with a low ‐dose start that is tailored to the maximum re...
Source: Journal of Pharmacy and Pharmacology - February 19, 2020 Category: Drugs & Pharmacology Authors: Maher R. Khdour Tags: Review Source Type: research

Venetoclax, bortezomib and S63845, an MCL1 inhibitor, in multiple myeloma
ConclusionsRegardless oft(11;14), combination of venetoclax with S63845 is a promising strategy in enhancing venetoclax sensitivity or overcoming venetoclax resistance in myeloma therapy, hence warrant future clinical studies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 18, 2020 Category: Drugs & Pharmacology Authors: Kwan Yeung Wong, Chor Sang Chim Tags: Research Paper Source Type: research

Evodiamine attenuates adjuvant ‐induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance
ConclusionsBased on our results, Evo is a promising antiarthritic agent, potentially due to its inhibitory effect on synovial inflammation and regulatory effects on Treg and Th17 differentiation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 15, 2020 Category: Drugs & Pharmacology Authors: Hui Zhang, Li Yin, Ming Lu, Jun Wang, Ye ‐tian Li, Wei Lu Gao, Zong‐sheng Yin Tags: Research Paper Source Type: research

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice
ConclusionsThese findings demonstrate that OSE has antihyperuricemic and nephroprotective effects on PO ‐induced HUA mice and those results indicate that OSE could be a safe and effective agent or functional ingredient for treating HUA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Wen ‐hao Xu, Han‐tao Wang, Ying Sun, Zhen‐cheng Xue, Ming‐li Liang, Wei‐ke Su Tags: Research Paper Source Type: research

Natural polyphenols prevent indomethacin ‐induced and diclofenac‐induced Caco‐2 cell death by reducing endoplasmic reticulum stress regardless of their direct reactive oxygen species scavenging capacity
ConclusionThe cytoprotective activity of polyphenols against NSAIDs ‐induced toxicity stemmed from either suppression of CHOP‐related ER and mitochondria stresses or other CHOP‐independent pathways, but not from the intrinsic ROS scavenging capacity. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Cherdsak Boonyong, Nontima Vardhanabhuti, Suree Jianmongkol Tags: Research Paper Source Type: research

In vivo antitumour activity of Britanin against gastric cancer through nuclear factor ‐κB‐mediated immune response
ConclusionsBritanin may be a promising candidate for gastric cancer chemotherapy, and its anticancer effect likely depends on an NF ‐κB‐mediated immune response. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Keru Shi, Xinyue Liu, Getao Du, Xiaoxia Cai, Yonghua Zhan Tags: Research Paper Source Type: research