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Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo
ConclusionsHuosu Yangwei oral liquid could inhibit mammalian CYPs and modulated the metabolic half ‐life of apatinib bothin vitro andin vivo. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 12, 2020 Category: Drugs & Pharmacology Authors: Sheng ‐Quan Fang, Jian Huang, Feng Zhang, Hong‐Mei Ni, Qi‐Long Chen, Jun‐Ran Zhu, Zhi‐Chao Fu, Liang Zhu, Wei‐Wei Hao, Guang‐Bo Ge Tags: Research Paper Source Type: research

Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity
ConclusionsLayered double hydroxides are good vehicles to improve stability, resistance to degradation of CUR, also they are useful to improve solubility, provide a controlled release and improve the cytotoxic activity. Additionally, it was shown that the composition of the M+2 cation of LDH affects its properties and structure and that this directly influences its biological activity. The findings are important to select the composition of the encapsulation vehicle for a specific activity. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 12, 2020 Category: Drugs & Pharmacology Authors: Filiberto Guti érrez‐Gutiérrez, Cecilia Sánchez‐Jiménez, Itzia Azucena Rangel‐Castañeda, Gregorio Guadalupe Carbajal‐Arízaga, Adriana Macaria Macías‐Lamas, Araceli Castillo‐Romero, Karina Jeanette Parra‐Saavedra Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 5, Page i-iv, May 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 6, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Development of a Gaussian Process – feature selection model to characterise (poly)dimethylsiloxane (Silastic®) membrane permeation
ConclusionsThis study highlights important considerations in the development of relevant models and in the construction and use of the data sets used in such studies, particularly that highly correlated descriptors should be removed from data sets. Predictive models are improved by the methodology adopted in this study, notably the systematic evaluation of descriptors, rather than simply using any and all available descriptors, often based empirically onin vitro experiments. Such findings also have clear relevance to a number of other fields. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 3, 2020 Category: Drugs & Pharmacology Authors: Yi Sun, Mark Hewitt, Simon C. Wilkinson, Neil Davey, Roderick G. Adams, Darren R. Gullick, Gary P. Moss Tags: Research Paper Source Type: research

Pyoluteorin induces cell cycle arrest and apoptosis in human triple ‐negative breast cancer cells MDA‐MB‐231
ConclusionOur studies revealed that pyoluteorin had potent proliferation inhibition against MDA ‐MB‐231 cells through arresting cell cycle at G2/M phase and inducing caspase ‐3‐dependent apoptosis by mitochondrial pathway, implying that pyoluteorin may be a potential lead compound for drug discovery of human triple‐negative breast cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 3, 2020 Category: Drugs & Pharmacology Authors: Ting Ding, Luo ‐Jie Yang, Wei‐Dong Zhang, Yun‐Heng Shen Tags: Research Paper Source Type: research

Design of enamides as new selective monoamine oxidase ‐B inhibitors
ConclusionsThese results encourage further studies on the enamide scaffold as potential drug candidates for the treatment of Alzheimer's and Parkinson's diseases. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 2, 2020 Category: Drugs & Pharmacology Authors: Fathima Sahla Kavully, Jong Min Oh, Sanal Dev, Swafvan Kaipakasseri, Ashique Palakkathondi, Ajeesh Vengamthodi, Rinshana Fathima Abdul Azeez, Anna Rita Tondo, Orazio Nicolotti, Hoon Kim, Bijo Mathew Tags: Research Paper Source Type: research

Pharmaceutical evaluation of matrix tablets prepared using a fused deposition modelling type three ‐dimensional printer – Effect of geometrical internal microstructural factors on drug release from enteric‐polymer tablets containing rebamipide
ConclusionsThe dissolution of 3 ‐D tablets in the small intestine could be controlled by the tablet geometrical structure. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 31, 2020 Category: Drugs & Pharmacology Authors: Yusuke Hattori, Shiho Kubota, Makoto Otsuka Tags: Research Paper Source Type: research

Celastrol ameliorates endoplasmic stress ‐mediated apoptosis of osteoarthritis via regulating ATF‐6/CHOP signalling pathway
ConclusionsThis study reveals that celastrol may prevent OA by inhibiting the ERs ‐mediated apoptosis. All these might supply beneficial hints for celastrol on OA treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 24, 2020 Category: Drugs & Pharmacology Authors: Da Dong Liu, Ben Li Zhang, Ji Bin Yang, Kunpeng Zhou Tags: Research Paper Source Type: research

Renal protection of rhein against 5/6 nephrectomied ‐induced chronic kidney disease: role of SIRT3‐FOXO3α signalling pathway
ConclusionTaken together, rhein protected kidney through SIRT3/FOXO3a involvement. The anti ‐oxidative capacity of rhein contributed to the protective effects including the subsequent antifibrotic responses. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 21, 2020 Category: Drugs & Pharmacology Authors: Xiaoxiao Wu, Meiyou Liu, Guo Wei, Yue Guan, Jialin Duan, Miaomiao Xi, Jingwen Wang Tags: Research Paper Source Type: research

Kruppel ‐like factor 2 disturb non‐small cell lung cancer energy metabolism by inhibited glutamine consumption
ConclusionsKruppel ‐like factor 2 could decrease the level of glutamine, participate in the consumption of glutamine by cancer cells, and then inhibit the energy metabolism of cancer cells. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 21, 2020 Category: Drugs & Pharmacology Authors: Song Xiao, Yan Jin ‐xiang, Tian Long, Lu Xiu‐rong, Gao Hong, Yan Jie‐cheng, Zhang Fei Tags: Research Paper Source Type: research

DDIT3 modulates cancer stemness in gastric cancer by directly regulating CEBP β
ConclusionOur results demonstrated that DDIT3 promotes CSCs stemness by up ‐regulating CEBPβ in GC that provides novel targets for the further GC therapy. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 19, 2020 Category: Drugs & Pharmacology Authors: Hai Lin, Shufang Liu, Weidong Gao, Hongyu Liu Tags: Research Paper Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 4, Page 648-648, April 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 4, Page i-iv, April 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin
ConclusionsAccording to these results, rutin could be classified as BCS classes III (high solubility/low permeability) and IV (low solubility/low permeability), depending on the plant matrix. Further work needs to be done in order to establish how apply the BCS for research and development of new botanical drugs or for bioequivalence purposes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Authors: Gina Paola Dom ínguez Moré, Clarissa Feltrin, Paula Freire Brambila, María Isabel Cardona, Sandra Milena Echeverry, Cláudia Maria Oliveira Simões, Diana Marcela Aragón Tags: Research Paper Source Type: research

1H NMR metabolomic profiling elucidated attenuation of neurometabolic alterations by lercanidipine in MCAo model in rats
ConclusionsPresent study illustrates effect of lercanidipine on neurometabolic alterations which might be mediated through its antioxidant, anti ‐inflammatory, vasodilatory and anti‐apoptotic property in MCAo model of stroke. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Authors: Sangeetha Gupta, Uma Sharma, Naranamangalam R. Jagannathan, Yogendra Kumar Gupta Tags: Research Paper Source Type: research