Comparing 3D versus 2D intracellular calcium oscillations using high-throughput fluorescence measurement system (FDSS)
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Sunao Hisada (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Drug-induced neurotoxicity assessment using human iPS cell technology
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Shigeru Yamada, Kazunobu Tsunemoto, Kaoru Sato, Yasunari Kanda (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Human stem cell-derived cardiac spheroids as 3D in vitro model for cardiotoxicity testing
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Ki-Suk Kim (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Development of an impedance based screening assay for cardiac safety and cardiotoxicity detection
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Robert Kirby, Said El Haou, Edward Humphries, John Ridley, Marc Rogers (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Microengineered iPSC-derived neuronal networks for in vitro modeling of electrophysiological connectivity
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Waka Lin, Shusaku Shiomoto, Koichi Muramatsu, Kohei Sawada (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

In vitro assessments of drug-induced delayed cardiotoxicity using human stem cell-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Hua Rong Lu, Eddy Vlaminckx, Danny Geysken, Gabriela T. Carrasqueiro, Mohamed Kreir, Ard Teisman, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Artificial intelligence enables structural toxicity testing for endpoint and multiple-timepoint assays
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Mahnaz Maddah, Kevin Loewke, Alexandre Ribeiro (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison of assay plates and culture conditions to detect positive inotropic effects and delayed QT prolonging effects in imaging-based assay using human iPS-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Tadashi Nagakura, Takayoshi Matsubara, Takashi Yoshinaga (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Biomarker-based prediction of tyrosine kinase inhibitor cardiotoxicity using human iPSC-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Jessica A. Palmer, Alan M. Smith, Michael R. Colwell, Elizabeth L. Donley, Fred R. Kirchner, Robert E. Burrier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of resveratrol on aconitine-induced cardiac arrhythmia in human induced pluripotent stem cell-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Stéphanie Guilbot, Richard Printemps, Marie Le Grand (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Inotropic assessment in engineered 3D cardiac tissue using human induced pluripotent stem cell-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Yusheng Qu, Isabella Pallotta, Rishabh Singh, Nicole Feric, Roozbeh Aschar-Sobbi, Michael P. Graziano, Hugo M. Vargas (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Heterogeneity of hiPSC-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Christina Schmid, Georg Rast (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Functional monitoring approaches for cardiac safety assessments and toxicity
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Elena Dragicevic, Krisztina Juhasz, Oliver Reinhardt, Ulrich Thomas, Ronald Knox, Rodolfo Haedo, Frauke Alves, Sonja Stoelzle-Feix, Niels Fertig (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of proarrhythmic properties using electrical pacing in different type of human iPS cell-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Tomohiko Taniguchi, Eriko Kato, Atsushi Baba, Kohei Sawada, Takashi Yoshinaga (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Profiling cardio-active compound response between high-throughput 2D monolayers, anisotropic and 3-dimensional human induced pluripotent stem cell-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Riccardo Contu, Robert Padilla, Alison Fanton, Brittney Van Hese, Carsten Andersen, Fabian Zanella (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research