Fibroblast growth factor 2–induced human amniotic mesenchymal stem cells combined with autologous platelet rich plasma augmented tendon-to-bone healing
ConclusionhAMSCs transfected with the FGF-2 gene combined with autologous PRP could augment tendon-to-bone healing in a rabbit extra-articular model.The translational potential of this articlehAMSCs transfected with the FGF-2 gene combined with autologous PRP may be a good clinical treatment for tendon-to-bone healing, especially for acute sports-related tendon–ligament injuries. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - February 14, 2020 Category: Orthopaedics Source Type: research
The shift in macrophages polarisation after tendon injury: A systematic review
This article provided a potential implication on how pan Mφs or M2 Mφs might be associated with ruptured or torn tendon structure. Managing Mφs numbers and phenotypes may lead to possible novel therapeutic approaches to the management of early tendinopathy, early acute tendon rupture, hence, promote healing after restoration surgery. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - February 11, 2020 Category: Orthopaedics Source Type: research
Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering
ConclusionOur findings demonstrate that the stratified manner of fabrication based on the 3D-printed multiphasic scaffold is an effective strategy for tendon-to-bone interface engineering in terms of efficient cell seeding, chondrogenic potential, and distinct matrix deposition in varying phases.The translational potential of this articleWe fabricated a biomimetic tendon-to-bone interface by using a 3D-printed multiphasic scaffold and adopting a stratified cell-seeding manner with GelMA. The biomimetic interface might have applications in tendon-to-bone repair in the rotator cuff. It can not only be an alternative to a bio...
Source: Journal of Orthopaedic Translation - February 9, 2020 Category: Orthopaedics Source Type: research
Periprosthetic fracture fixation in Vancouver B1 femoral shaft fractures: A biomechanical study comparing two plate systems
This study compares two plate systems regarding their biomechanical properties and the handling in periprosthetic fracture fixation of the proximal femur.Materials and methodsUsing eight pairs of fresh, frozen human proximal femora, the locking compression plate/locking attachment plate construct (Group I, DePuy Synthes) was compared with the new LOQTEQ® periprosthetic distal lateral femur plate (Group II, AAP Implantate AG). After implantation of press fit femoral hip stems, a Vancouver B1 fracture model was used. Biomechanical testing was performed by cyclic axial loading with a constant increment of 0.1 N/cycle...
Source: Journal of Orthopaedic Translation - February 9, 2020 Category: Orthopaedics Source Type: research
Reconstruction of large chronic rotator cuff tear can benefit from the bone–tendon composite autograft to restore the native bone–tendon interface
ConclusionsBone–tendon autograft for chronic rotator cuff reconstruction is superior to the primary repair regarding biomechanical property and histological structure. Our study may provide some evidence in support of the reconstruction of a chronic rotator cuff tear using bone–tendon composite autografts in clinical practice. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 31, 2020 Category: Orthopaedics Source Type: research
The effect of thermosensitive hydrogel platelet–rich–plasma complex in the treatment of partial tear of anterior cruciate ligament in rat model
Publication date: Available online 22 January 2020Source: Journal of Orthopaedic TranslationAuthor(s): Yue Li, Sai C. Fu, Yau C. Cheuk, Tim-Yun Ong, Hua Feng, Shu-Hang YungAbstractThe treatment of anterior cruciate ligament (ACL) partial tear is controversial. The reconstructive surgery is invasive, while the prevalence of subsequent insufficiency after conservative treatment has been reported to range from 11% to 62%. Therefore, a new method that promotes tissue regeneration is needed. The aim of this study is to observe the healing of ACL partial tear biomechanically and histologically after the administration of a therm...
Source: Journal of Orthopaedic Translation - January 24, 2020 Category: Orthopaedics Source Type: research
Comparison of bone surface and trough fixation on bone–tendon healing in a rabbit patella–patellar tendon injury model
ConclusionsThese results suggested that raptured tendon fixation in a bone trough resulted in superior bone–tendon healing in comparison with tendon fixation on bone surface in a rabbit PPT injury model.The translational potential of this articleAlthough the structural and functional difference of knee joint between human and rabbit limit the results to be directly used in clinical, our research does offer a valuable reference for the improvement of reattachment between bone and tendon. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 19, 2020 Category: Orthopaedics Source Type: research
Long-term study on the osteogenetic capability and mechanical behavior of a new resorbable biocomposite anchor in a canine model
ConclusionIn summary, the new biocomposite anchor presented in this study had favorable osteogenetic capability, mechanical property, and controlled degradation rate for bone fixation.Translational potential of this articleThe new biocomposite anchor had sufficient initial and long-term fixation stability and bone formation capability in the canine model. It is indicated that the new biocomposite anchor has a potential for orthopedic application. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 15, 2020 Category: Orthopaedics Source Type: research
Population-based design and 3D finite element analysis of transforaminal thoracic interbody fusion cages
ConclusionThe kidney-shaped cage is more stable and experiences lesser stress than the box-shaped cage after thoracic intervertebral fusion, and it is more suitable for Chinese transforaminal thoracic interbody fusion.The translational potential of this articleThis article is about thoracic fusion cage design and FEA analysis based on the thoracic anatomy parameters. For there is currently no suitable thoracic fusion cage for transforaminal thoracic interbody fusion, the results in this article may have the potential of transferring the two designed cages into clinical use. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 10, 2020 Category: Orthopaedics Source Type: research
The influence of sample size and gender composition on the meta-analysis conclusion of platelet-rich plasma treatment for osteoarthritis
ConclusionsAccording to the currently available data, PRP injections are beneficial for pain relief and function improvement in patients with OA. This meta-analysis, however, demonstrated that the efficacy of PRP is related to sample size and gender composition. Thus, more randomised controlled trials of high quality and larger patient size, also including gender aspects, are required to understand this phenomenon.The translational potential of this articleThe translation potential of this meta-analysis is that provided another perspective to analyse the treatment effect of PRP for OA. In future research, phenotypes subpop...
Source: Journal of Orthopaedic Translation - January 7, 2020 Category: Orthopaedics Source Type: research
Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)
Publication date: Available online 6 January 2020Source: Journal of Orthopaedic TranslationAuthor(s): Dewei Zhao, Feng Zhang, Benjie Wang, Baoyi Liu, Lu Li, Shin-Yoon Kim, Stuart B. Goodman, Philippe Hernigou, Quanjun Cui, William C. Lineaweaver, Jiake Xu, Wolf R. Drescher, Ling QinAbstractOsteonecrosis of the femoral head (ONFH) is a common and refractory disease in orthopaedic clinics. The number of patients with ONFH is increasing worldwide every year. There are an estimated 8.12 million patients with nontraumatic osteonecrosis in China alone. Treatment of nontraumatic osteonecrosis has always been a clinical challenge ...
Source: Journal of Orthopaedic Translation - January 7, 2020 Category: Orthopaedics Source Type: research
Hip resurfacing arthroplasty for osteonecrosis of the femoral head: Implant-specific outcomes and risk factors for failure
ConclusionHRA for ONFH using BHR and Conserve Plus implants demonstrated favourable clinical outcomes with high revision-free survival rates at 10 years. However, care should be taken for large necrotic lesions that can lead to femoral neck fracture or aseptic femoral loosening. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - January 7, 2020 Category: Orthopaedics Source Type: research
Surgical consideration for thoracolumbar burst fractures with spinal canal compromise without neurological deficit
ConclusionFor patients with thoracolumbar burst fractures with spinal canal compromise but no neurological deficit, if when the posterior intraoperative fixation is performed, the spinal canal fracture is partially recovered, the posterior vertebral body height of the injured vertebrae is significantly restored, the spinal canal volume ratio is significantly increased, and the large kyphosis is corrected, then the indirect decompression without the posterior laminectomy can be performed.The translational potential of this articleThis study contributes to offer treatment consideration for patients with thoracolumbar...
Source: Journal of Orthopaedic Translation - December 31, 2019 Category: Orthopaedics Source Type: research
Translation of engineering to medicine: A focus on finite element analysis
Publication date: January 2020Source: Journal of Orthopaedic Translation, Volume 20Author(s): Ming Zhang, He Gong (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 27, 2019 Category: Orthopaedics Source Type: research
Clinician-directed treatment guidelines
Publication date: January 2020Source: Journal of Orthopaedic Translation, Volume 20Author(s): Regis O'Keefe, Chelsea Hopkins, Ling Qin (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 27, 2019 Category: Orthopaedics Source Type: research
