Dental plaque as a biofilm and a microbial community—Implications for treatment
Conclusion An appreciation of ecological principles can lead to new strategies for treatment by identifying and removing the factors that drive dysbiosis, while actively supporting the growth of the natural oral microbiota. Also, the beneficial activities of the resident oral microbiota are retained and the risk of dysbiosis is reduced. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 22, 2015 Category: Biomedical Science Source Type: research

Dental plaque as a biofilm and a microbial community – implications for treatment
Conclusion An appreciation of ecological principles can lead to new strategies for treatment by identifying and removing the factors that drive dysbiosis, while actively supporting the growth of the natural oral microbiota. Also, the beneficial activities of the resident oral microbiota are retained and the risk of dysbiosis is reduced. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 19, 2015 Category: Biomedical Science Source Type: research

Biomaterial properties of titanium in dentistry
Conclusion This review presents an overview of the properties of titanium that are vital for its use in implant dentistry. From a restorative perspective, interaction between implant restoration metals, intra-oral fluorides and pH may cause titanium to corrode. Therefore, in order to avoid the resulting deleterious effects, an understanding of these interactions is important for long-term prognosis of implant restorations. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 15, 2015 Category: Biomedical Science Source Type: research

Review: Biomaterial properties of titanium in dentistry
Conclusion This review presents an overview of the properties of titanium that are vital for its use in implant dentistry. From a restorative perspective, interaction between implant restoration metals, intra-oral fluorides and pH may cause titanium to corrode. Therefore, in order to avoid the resulting deleterious effects, an understanding of these interactions is important for long-term prognosis of implant restorations. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 12, 2015 Category: Biomedical Science Source Type: research

Alterations of the oral microbiota and oral clinical findings in dry mouth
Conclusion In order to treat the various dry mouth-associated health concerns, an understanding of the qualitative alterations of the oral microbiota occurring in dry mouth and appropriate prophylaxis of oral disease are required. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 23, 2015 Category: Biomedical Science Source Type: research

The sonic hedgehog signaling pathway and the development of pharyngeal arch Derivatives in Haplochromis piceatus, a Lake Victoria cichlid
Conclusions These results suggest that the shh pathway is important for the development of pharyngeal arch derivatives such as teeth, premaxilla, operculum, and gill filaments in H. piceatus. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 18, 2015 Category: Biomedical Science Source Type: research

GLP-1R expression in the major salivary glands of rats
Conclusions This is the first time that GLP-1R expression has been detected in rat PG, SMG, and SLG. Our findings provide new insights into the effects of GLP-1 and GLP-1R in the major salivary glands of rats. Furthermore, our results indicate a new role for GLP-1 in salivary secretion, and potentially a new pathway for glucose metabolism. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 18, 2015 Category: Biomedical Science Source Type: research

Regulation of transcriptional network system during bone and cartilage development
Conclusion Recent advances in our knowledge about transcriptional network systems contributed to understanding the molecular underpinnings of regulation and pathological disease mechanisms in bone and cartilage. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 13, 2015 Category: Biomedical Science Source Type: research

Inhibition of bone morphogenetic protein-induced osteoblast differentiation
Conclusion In addition to BMP-3, NF-κB, and TLE3, numerous inhibitors suppress BMP-induced osteoblast differentiation. Therefore, a precise understanding of mechanisms underlying the inhibition of osteoblast differentiation may help develop novel methods for treating bone-related diseases or for the tissue engineering of the bone. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 7, 2015 Category: Biomedical Science Source Type: research

Responses of pulp vasculature after cavity preparation in rat molars
Conclusions These results suggest that increased vascular flow under neuronal regulation plays an important role in cell proliferation in the dental pulp following cavity preparation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 7, 2015 Category: Biomedical Science Source Type: research

Oral malodorous gases and oral microbiota: From halitosis to carcinogenesis
Conclusion Further analysis of oral malodor might be useful in accessing the risk of aspiration pneumonia and oral cancer. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 27, 2015 Category: Biomedical Science Source Type: research

The downward spiral of periodontitis and diabetes in Alzheimer׳s disease: Extending healthy life expectancy through oral health
Conclusion Effective management of periodontitis may contribute to prevention of AD, as periodontitis is both treatable and preventable. Therefore, brain health, which includes oral health as a contributing factor, is a promising strategy for achieving healthy life expectancy. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 23, 2015 Category: Biomedical Science Source Type: research

Bridging the gap: A regulator of NF-κB linking inflammation and cancer
Conclusion Here, we briefly summarize the known contact points between inflammation and cancer, including oral cancers, and put into context the identification of κB-Ras proteins as molecular link between two independent pathways important for tumor growth. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 23, 2015 Category: Biomedical Science Source Type: research

Group A Streptococcus translocates across an epithelial barrier via degradation of intercellular junctions
Conclusion Our investigations of interactions of bacteria with intercellular junctions have provided further insight into the mechanisms used by GAS to disrupt the epithelial barrier. Elucidation of molecular mechanisms underlying the initial stage of GAS infections in these studies may expedite development of novel preventive or therapeutic agents for severe invasive GAS infections. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 12, 2015 Category: Biomedical Science Source Type: research

Purification and characterization of hemolysin from Prevotella oris
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Toshiya Sato , Arihide Kamaguchi , Futoshi Nakazawa We observed hemolytic activity in culture supernatant of Prevotella oris. Results from growth-phase experiments show that hemolysin production increased during the logarithmic growth phase and decreased during the stationary phase. The hemolysin produced by P. oris was purified from the culture supernatant by ultrafiltration, diethylaminoethyl (DEAE) and carboxymethyl (CM) ion-exchange chromatography, and gel filtration chromatography; further, we investigated the purified hemol...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Microbial composition of dental plaque microflora on first molars with orthodontic bands and brackets, and the acidogenic potential of these bacteria
Discussion and conclusion These results indicate that there are differences in the microbial composition and acidogenic potential of supragingival plaque from first molars with bands, brackets, or without appliances, and suggest that supragingival plaque on teeth with brackets carries predominantly periodontitis-associated bacteria but less caries-associated bacteria. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Applications of functional magnetic resonance imaging for analysis of oral functions
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Yoshinori Sahara , Takuya Kobayashi , Haruka Toya , Tetsuya Suzuki Functional magnetic resonance imaging (fMRI) has considerably advanced the understanding of peripheral and central neural mechanisms underlying orofacial movements (e.g., chewing, swallowing, digestion, and speech). The principle advantages of fMRI lie in its noninvasive nature, relatively high spatiotemporal resolution, and ability to identify the entire network of brain areas involved in particular tasks. However, there remain substantial and valid criticisms of...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

The virulence factors and pathogenic mechanisms of Streptococcus pyogenes
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Yutaka Terao Streptococcus pyogenes possesses a wide variety of virulence factors and can cause severe invasive infections. Most S. pyogenes express surface-located fibronectin-binding proteins as major invasion molecules. We identified 2 novel fibronectin-binding proteins (FbaA and FbaB) in S. pyogenes isolated from patients with severe invasive infection. Fba-deficient mutant strains showed significantly lower efficiency of invasion of human epithelial cells than that shown by an isogenic wild type strain. Furthermore, compared...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Current status of tuberculosis and recombinant bacillus Calmette-Guérin vaccines
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Naoya Ohara Tuberculosis (TB) is an infectious disease and a global concern of enormous proportions. One-third of the world's population is latently infected with Mycobacterium tuberculosis, and 2 million people die from TB annually. The only currently available vaccine—bacillus Calmette-Guerin (BCG)—is the most extensively used vaccine ever, with a record 3 billion doses administered during the last 4 decades. Because BCG is a live attenuated vaccine, it can be developed by genetic engineering to serve as a foreign a...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Factors affecting susceptibility of Staphylococcus aureus to antibacterial agents
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Miki Kawada-Matsuo , Hitoshi Komatsuzawa Staphylococcus aureus is a major human pathogen that causes suppurative diseases, toxic shock syndrome, pneumonia, food poisoning, and staphylococcal scalded skin syndrome (SSSS). S. aureus can also cause osteomyelitis and radicular cysts that impact dental health. β-lactam antibiotics are frequently used for the treatment of S. aureus infections, but the emergence of methicillin-resistant S. aureus (MRSA) has caused serious problems for the antibiotic treatment of S. aureus infection...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

SNARE mediates autophagosome–lysosome fusion
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Nobumichi Furuta , Atsuo Amano Autophagy is an intracellular bulk degradation/recycling system that turns over cellular constituents. This system has also been shown to play a crucial role in host defense, termed antimicrobial autophagy (xenophagy), in which it functions to degrade intracellular foreign microbial invaders. Xenophagosomes undergo a stepwise maturation process that consists of fusion with lysosomes, after which the cargo undergoes degradation. We have previously shown that intracellular group A Streptococcus (GAS) ...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Irsogladine maleate regulates barrier function and neutrophil accumulation in the gingival epithelium
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Tsuyoshi Fujita , Hideki Shiba , Hidemi Kurihara Epithelial cells function as mechanical barriers against invasion by pathogenic organisms and promote intercellular communication through cell–cell junction complexes. Therefore, the permeability of the gingival epithelial cell layer indicates a defensive capability against invasion by periodontal pathogens. Accumulation of activated neutrophils is thought to be involved in the onset of inflammation. Here, we review the effects of irsogladine maleate, a medication for gastric...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Role of Smad phosphatases in BMP-Smad signaling axis-induced osteoblast differentiation
In conclusion, SCP1 and PPM1A suppress the osteoblast differentiation induced by BMPs independent of Smad dephosphorylation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Hormones and bioactive substances that affect peripheral taste sensitivity
Publication date: May 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 2 Author(s): Ryusuke Yoshida Taste receptor cells in taste buds detect chemical compounds in foods and drinks and transmit these signals through gustatory nerve fibers to the central nervous system. Sensory signals of taste are essential for animal feeding behavior; animals prefer sweet taste and avoid bitter and sour tastes. Recent studies have demonstrated that the sensitivity of taste receptor cells to tastants is not constant but is subject to regulation by hormones and bioactive substances, such as leptin and endocannabinoids. Leptin sel...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Microbial interaction of periodontopathic bacteria and Epstein-Barr virus and their implication of periodontal diseases
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Kenichi Imai , Yorimasa Ogata , Kuniyasu Ochiai Epstein-Barr virus (EBV) is a ubiquitous human gamma herpesvirus that infects more than 90% of the world's population. EBV infection causes several human diseases, including infectious mononucleosis, autoimmune disorders, and a number of malignancies. Interestingly, evidence accumulated over the past 10 years supports the role for EBV as a pathogenic agent of periodontal disease because bacterial activities alone do not explain several of its clinical characteristics. Despite thi...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Porphyromonas gingivalis FimA fimbriae: Roles of the fim gene cluster in the fimbrial assembly and antigenic heterogeneity among fimA genotypes
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Keiji Nagano , Yuki Abiko , Yasuo Yoshida , Fuminobu Yoshimura In order for bacteria to exert their pathogenicity, they must adhere to and colonize the host tissues. Porphyromonas gingivalis, a periodontal pathogen, primarily exploits FimA fimbriae for adhesion and colonization. FimA fimbriae are polymers composed of FimA protein encoded by the fimA gene. The fimA gene exists as a single copy within the fim gene cluster. This fim gene cluster contains 7 genes: fimX, pgmA, and fimABCDE. In this article, we address the roles of ...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Strategies for targeting the gingipain secretion system of Porphyromonas gingivalis
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Keitarou Saiki , Kiyoshi Konishi Porphyromonas gingivalis is considered the most important etiologic agent in chronic periodontitis. P. gingivalis secretes several proteases that promote disease progression by degrading host cells and proteins. P. gingivalis is asaccharolytic and uses peptides as an energy source; therefore, peptide fragments arising from the digestion of host proteins are important for multiplication of this bacterium. Gingipains are secretory endoproteases of P. gingivalis with trypsin-like activity and are ...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Nuclear dot protein 52, an autophagy-associated protein, regulates Toll-like receptor signaling
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Megumi Inomata , Takeshi Into Toll-like receptors (TLRs) recognize molecular patterns on various microbes and serve as innate immune sensors. After cognate ligand recognition, TLRs activate signaling pathways to induce innate immune defense mechanisms, which eliminate pathogenic microbes, including periodontogenic bacteria, to a certain extent. Recent findings have shown that TLR signaling is linked to induction of autophagy to facilitate direct killing of cytosol-invading bacteria within infected cells. However, whether autop...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Brain activation by the umami taste substance monosodium L-glutamate via gustatory and visceral signaling pathways, and its physiological significance due to homeostasis after a meal
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Kunio Torii Monosodium l-glutamate (MSG) elicits a unique taste sensation termed umami and is widely used as a flavor enhancer in various cuisines. In addition, recent studies have suggested the existence of receptors for l-glutamate (Glu) and transduction molecules in the gut mucosa as well as in the oral cavity. The gastric afferent vagal nerve responds specifically to luminal stimulation by Glu in the stomach and regulates autonomic reflexes. The intragastric infusion of MSG also activates several brain areas (insular corte...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Metabolomic approach to oral biofilm characterization—A future direction of biofilm research
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Nobuhiro Takahashi , Jumpei Washio , Gen Mayanagi Research approaches to biofilm are stratified by a series of analyses: (1) microbial number and species; (2) microbial proteins, such as enzymes; and (3) microbial activity, such as metabolic activity. On the other hand, the hierarchical structure of biology includes the genome, proteome, and metabolome, in which the metabolome is the final output of biological function. Metabolome analysis is the comprehensive analysis of the metabolome, a new strategy for biological research ...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Metagenomic analysis permitting identification of the minority bacterial populations in the oral microbiota
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Yoshiaki Kawamura , Yasuyoshi Kamiya In recent years, genetic techniques have been applied for the analysis of constitutive bacterial species of the oral microbiota. To analyze a wide variety of bacterial species simultaneously, universal PCR amplification using primers targeting the same conserved area of 16S rRNA is commonly used. However, because of PCR competition when using this strategy, only the DNA of the predominant bacterial species is amplified at the expense of the DNA of the minority bacterial species. Hence, many...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Evaluation of salivary microbiota from an ecological perspective
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Toru Takeshita , Yoshihisa Yamashita A variety of bacteria densely colonize the human oral cavity not as individuals, but as members of an indigenous microbiota that exhibit extensive intracellular interactions. To prevent the onset of oral diseases caused by the members of this microbiota, regulation of the total oral microbiota, including the surrounding bacterial environment, is required. In this review, we highlight current knowledge on the global composition of the salivary bacterial population associated with oral condit...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

A multilateral study of the pathogenesis of organ-specific autoimmune diseases
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Naozumi Ishimaru Autoimmune diseases result from complex and multigenic phenotypes that are affected by a variety of genetic and environmental or stochastic factors. Many models have been used to demonstrate autoimmune diseases such as Sjögren's syndrome (SS). However, it remains unclear as to why specific organs such as the salivary or lacrimal glands are targeted by autoimmune responses. This review focuses on the molecular mechanisms involved in the onset of organ-specific autoimmune diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Recent topics in fibrodysplasia ossificans progressiva
Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Takenobu Katagiri Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic bone formation in skeletal muscle tissue. Patients with FOP show malformed digits, osteochondroma, and other skeletal abnormalities due to abnormal patterning during development. Heterozygous mutations in the Activin A receptor type I (ACVR1) gene, which encodes the bone morphogenetic protein (BMP) type I receptor ALK2, have been identified in not only typical FOP patients but also patien...
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Oral biosciences: The annual review 2012
Publication date: February 2013 Source:Journal of Oral Biosciences, Volume 55, Issue 1 Author(s): Hayato Ohshima (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 24, 2015 Category: Biomedical Science Source Type: research

Osteocyte bioimaging
Conclusion The osteocyte network in the bone as well as the microstructure of osteocyte cell processes and the surrounding bone matrix were visualized. We found fluorescence to be useful for studying the osteocyte network morphology. Additionally, the combination of UHVEM and computer simulation is a powerful tool to study the fluid flow in osteocyte canaliculi. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 8, 2015 Category: Biomedical Science Source Type: research

Development and application of fluorescent protein-based indicators for live cell imaging
Conclusion The advantages of FP-based indicators extend their application to understanding the functions of particular molecules and cellular events during physiological responses in live animals. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 8, 2015 Category: Biomedical Science Source Type: research

BK channel in microglia as a potent therapeutic molecular target for neuropathic pain
Conclusion These findings suggest that potent analgesic effects of S-ketamine arise from the inhibition of microglial BK channels, in addition to neuronal NMDA receptors. Thus, BK channels in microglia are a potential target for the treating of neuropathic pain. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 27, 2015 Category: Biomedical Science Source Type: research

In vitro and in vivo imaging of intracellular Ca2+ responses in salivary gland cells
Conclusion We successfully visualized agonist-induced Ca2+ dynamics in SMG acinar cells in live animals. This novel experimental system represents a powerful tool for understanding the relationships between Ca2+ responses and salivary secretion in vivo. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 21, 2015 Category: Biomedical Science Source Type: research

Live imaging to elucidate cell dynamics in tooth organogenesis and regeneration
Conclusion Time-lapse imaging is a useful tool for understanding cell movement and cell lineages, and will contribute the elucidation of the mechanisms of tooth development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 20, 2015 Category: Biomedical Science Source Type: research

Cell–extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway
Conclusion Signaling pathways initiated by adhesion molecule-mediated crosstalk between tumor cells and extracellular matrices play important roles in driving and maintaining tumor-specific tissue architecture and contributing to tumor survival, growth, and metastasis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 18, 2015 Category: Biomedical Science Source Type: research

Biodental engineering
Conclusion The newly emerging field of biodental engineering is one such example of integrated research with tremendous potential for facilitating future dental science research. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 7, 2015 Category: Biomedical Science Source Type: research

Oral mucosal fibroblasts overexpressing BMP-2 differentiate into osteoblasts and participate in new bone formation during bone regeneration
Conclusions Transplanted COFs that overexpressed BMP-2 differentiated into osteoblasts and osteocytes during bone regeneration, and participated in new bone formation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 7, 2015 Category: Biomedical Science Source Type: research

The effects of enzymatically synthesized glycogen on the pulpal healing process of extracted teeth following intentionally delayed replantation in mice
Conclusions ESG improved the pulpal healing process of extracted teeth following intentionally delayed replantation, although both ESG and PBS may induce the formation of bone-like tissue. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 7, 2015 Category: Biomedical Science Source Type: research

Quantitative in situ fluorescence imaging to unveil the morphological and functional heterogeneity of osteocytes
Conclusion This short review presents the applications of quantitative fluorescence imaging in histological bone sections and its contribution to osteocyte biology. In osteocyte biology, fluorescence imaging has provided novel evidence on osteocytes being a heterogenic population both morphologically and functionally. Current direction and future applications of quantitative fluorescence imaging are also discussed in this review. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 7, 2015 Category: Biomedical Science Source Type: research

The interplay between iron, haem and manganese in Porphyromonas gingivalis
Conclusion P. gingivalis has novel haem, iron and manganese transporters and metalloregulatory proteins that enable it to switch rapidly between an energy efficient iron-dependent virulent phase and a protective manganese-dependent survival phase. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 24, 2015 Category: Biomedical Science Source Type: research

Oral Biosciences: The annual review 2014
Publication date: Available online 13 January 2015 Source:Journal of Oral Biosciences Author(s): Hayato Ohshima (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 14, 2015 Category: Biomedical Science Source Type: research

Metalloproteases and CCN2/CTGF in dentin–pulp complex repair
Conclusion In this review, we summarize novel roles for metalloproteases, particularly MMP-3 and BMP-1, in dentin–pulp complex repair, with particular emphasis on the effects of CCN2/CTGF expression during regulation of cell migration and tertiary dentinogenesis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 14, 2015 Category: Biomedical Science Source Type: research

Functional roles of V-ATPase in the salivary gland
Conclusion An increasing number of studies reveal that the immunoreactivity of V-ATPase is restricted to ductal cells with species- and gland-specific distribution, and that different subunit isoforms of V-ATPase could be involved in targeting it to various intracellular locations. Considering that the major function of salivary gland duct epithelial cells is the reabsorption of Na+ and Cl−, and secretion of K+ and HCO 3 − , V-ATPase may primarily function in transporting protons out of cells across the plasma membrane, or acidifying compartments, resulting in modifying fluid and electrolyte transport. (Sou...
Source: Journal of Oral Biosciences - December 26, 2014 Category: Biomedical Science Source Type: research

Microbiota profiling of bronchial fluids of elderly patients with pulmonary carcinoma
Conclusions Our results suggest that bacteria in bronchial fluids associated with silent aspiration are derived from saliva, and that the bronchial fluids of elderly patients with an impaired swallowing reflex may have a characteristic microbiota. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 23, 2014 Category: Biomedical Science Source Type: research