Blink rate is associated with drug-induced parkinsonism in patients with severe mental illness, but does not meet requirements to serve as a clinical test: the Curacao extrapyramidal syndromes study XIII
Drug-induced parkinsonism (DIP) has a high prevalence and is associated with poorer quality of life. To find a practical clinical tool to assess DIP in patients with severe mental illness (SMI), the associatio... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 25, 2017 Category: Research Authors: Charlotte L. Mentzel, P. Roberto Bakker, Jim van Os, Marjan Drukker, Glenn E. Matroos, Marina A. J. Tijssen and Peter N. van Harten Tags: Research Source Type: research

Work-focused cognitive behavioral intervention for psychological complaints in patients on sick leave due to work-related stress: Results from a randomized controlled trial
Work-related stress is a global problem with negative implications for individuals and society. The purpose of the current study was to evaluate a stress management intervention for patients on sick leave due ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 22, 2017 Category: Research Authors: Vita Ligaya Dalgaard, Lars Peter S ønderbo Andersen, Johan Hviid Andersen, Morten Vejs Willert, Ole Carstensen and David John Glasscock Tags: Research Source Type: research

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model
A series of human diseases are caused by the misfolding and aggregation of specific proteins or peptides into amyloid fibrils; nine of these diseases, referred to as polyglutamine diseases, are associated with... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 22, 2017 Category: Research Authors: Roel Van Assche, Charline Borghgraef, Jonathan Vaneyck, Mireille Dumoulin, Liliane Schoofs and Liesbet Temmerman Tags: Research Source Type: research

Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort
To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG). (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 26, 2017 Category: Research Authors: Taif A. Azad, Nikhil B. Edward, Altaf A. Kondkar, Hatem Kalantan, Saleh Altuwaijri, Tahira Sultan, Faisal A. Al-Mobarak, Saleh A. Al-Obeidan and Khaled K. Abu-Amero Source Type: research

Behavioral and neural adaptations in response to five weeks of balance training in older adults: a randomized controlled trial
While the positive effect of balance training on age-related impairments in postural stability is well-documented, the neural correlates of such training adaptations in older adults remain poorly understood. T... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 13, 2017 Category: Research Authors: Jan Ruffieux, Audrey Mouthon, Martin Keller, Michael W älchli and Wolfgang Taube Source Type: research

Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs
Medication effect is the sum of its drug, placebo, and drug*placebo interaction effects. It is conceivable that the interaction effect involves modulating drug bioavailability; it was previously observed that ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 23, 2017 Category: Research Authors: Muhammad M Hammami, Ahmed Yusuf, Faduma S. Shire, Rajaa Hussein and Reem Al-Swayeh Source Type: research

Absence of the dermatan sulfate chain of decorin does not affect mouse development
In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functiona... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 17, 2017 Category: Research Authors: Pierre Moffatt, Yeqing Geng, Lisa Lamplugh, Antonio Nanci and Peter J. Roughley Source Type: research

The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype
Gold compounds have shown promise in the treatment of non-communicable diseases such as rheumatoid arthritis and cancer, and are considered of value as anti-microbial agents against Gram-negative and Gram-posi... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 3, 2017 Category: Research Authors: Ruqaiyyah Siddiqui, Farhat Abjani, Chien Ing Yeo, Edward R. T. Tiekink and Naveed Ahmed Khan Source Type: research

Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src
We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-m... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 20, 2017 Category: Research Authors: Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, Pierre-Olivier Harmand, Badr-Eddine Sari, G érard Lefranc and Mourad Aribi Source Type: research

Experimental silicosis does not aggravate collagen-induced arthritis in mice
To investigate the effect of chronic lung inflammation on the incidence and severity of collagen-induced arthritis in mice. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 13, 2017 Category: Research Authors: Robby Engelmann and Brigitte M üller-Hilke Source Type: research

Erratum to: Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?
(Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 8, 2017 Category: Research Authors: Sally Hunter and Carol Brayne Source Type: research

The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases
Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very hete... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 1, 2017 Category: Research Authors: Boubacar Efared, G. Ebang-Atsame, Sani Rabiou, Abdoulsalam S. Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C. Benjelloun, Mounia Serraj, Laila Chbani and Hinde El Fatemi Source Type: research

Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus
The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells di... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 19, 2017 Category: Research Authors: Ragheda Yaseen, Stefanie Blodkamp, Petra L üthje, Friederike Reuner, Lena Völlger, Hassan Y. Naim and Maren von Köckritz-Blickwede Source Type: research

Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients
To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG). (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 2, 2017 Category: Research Authors: Altaf A. Kondkar, Nikhil B. Edward, Hatem Kalantan, Abdullah S. Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A. Azad and Khaled K. Abu-Amero Source Type: research

Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?
Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (A β). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 26, 2017 Category: Research Authors: Sally Hunter and Carol Brayne Source Type: research

Unspecific binding of cRNA probe to plaques in two mouse models for Alzheimer ’s disease
Alzheimer ’s disease (AD) is characterized by the pathological deposition of amyloid-β (Aβ) protein-containing plaques. Microglia and astrocytes are commonly attracted to the plaques by an unknown mechanism tha... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 16, 2016 Category: Research Authors: Anne Schaarschuch, Christoph Redies and Nicole Hertel Source Type: research

False data, positive results in neurobiology: moving beyond the epigenetics of blood and saliva samples in mental disorders
Many psychiatric diseases are influenced by a set of several genetic and environmental factors that genetics alone cannot explain. Specifically, in schizophrenia and bipolar disorder the absence of consistentl... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 12, 2016 Category: Research Authors: A. Cariaga-Martinez and R. Alel ú-Paz Source Type: research

Long-term effect of stents eluting 6-mercaptopurine in porcine coronary arteries
Drug-eluting stents (DES) have dramatically reduced restenosis rates compared to bare metal stents and are widely used in coronary artery angioplasty. The anti-proliferative nature of the drugs reduces smooth ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 5, 2016 Category: Research Authors: Matthijs S. Ruiter, Albert Doornbos, Vivian de Waard, Robbert J. de Winter, Nico J. M. Attevelt, Rob Steendam and Carlie J. M. de Vries Source Type: research

Examining if being overweight really confers protection against dementia: Sixty-four year follow-up of participants in the Glasgow University alumni cohort study
Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipi... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 2, 2016 Category: Research Authors: G. David Batty, Bruna Galobardes, John M. Starr, Mona Jeffreys, George Davey Smith and Tom C. Russ Source Type: research

Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia
Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bon... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - October 26, 2016 Category: Research Authors: Yaling Liu, Eliane H. Dutra, Ernst J. Reichenberger and I-Ping Chen Source Type: research

Polymorphism rs7555523 in transmembrane and coiled-coil domain 1 (TMCO1) is not a risk factor for primary open angle glaucoma in a Saudi cohort
We investigated whether polymorphism rs7555523 (A  > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 29, 2016 Category: Research Authors: Altaf A. Kondkar, Ahmed Mousa, Taif A. Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A. Al-Obeidan and Khaled K. Abu-Amero Source Type: research

Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women
Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein re... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 1, 2016 Category: Research Authors: Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan and Rungsunn Tungtrongchitr Source Type: research

Evaluation of a novel virtual screening strategy using receptor decoy binding sites
This report shows the development and evaluation of a nov... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 23, 2016 Category: Research Authors: Hershna Patel and Andreas Kukol Source Type: research

Gastrokine 1 mRNA in human sera is not informative biomarker for gastric cancer
We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - July 25, 2016 Category: Research Authors: Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa and Paolo Arcari Source Type: research

Is mindfulness protective against PTSD? A neurocognitive study of 25 Tsunami disaster survivors
It has been suggested that mindfulness is a protective factor that buffers individuals from experiencing severe posttraumatic stress following exposure to a trauma. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - July 20, 2016 Category: Research Authors: Christina Hagen, Lars Lien, Edvard Hauff and Trond Heir Source Type: research

Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation
Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 1, 2016 Category: Research Authors: Thomas C. Sauter, Stephan Ziegenhorn, Sufian S. Ahmad, Wolf E. Hautz, Meret E. Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G. Haider and Aristomenis K. Exadaktylos Source Type: research

Investigation of SLA4A3 as a candidate gene for human retinal disease
SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be th... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 23, 2016 Category: Research Authors: Louise M. Downs, Andrew R. Webster, Anthony T. Moore, Michel Michaelides, Robin R. Ali, Alison J. Hardcastle and Cathryn S. Mellersh Source Type: research

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A
Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 11, 2016 Category: Research Authors: Lukas D. Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner and Christoph Arnoldner Source Type: research

Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats
Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex a... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 2, 2016 Category: Research Authors: Michael W. Calik and David W. Carley Source Type: research

Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload
Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 25, 2016 Category: Research Authors: Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer and Heidi Ehrentraut Source Type: research

Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement
Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascula... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 11, 2016 Category: Research Authors: Julio F. Marchini, Ayumi Aurea Miyakawa, Flavio Tarasoutchi, José Eduardo Krieger, Pedro Lemos and Kevin Croce Source Type: research

Targeted drugs and Psycho-oncological intervention for breast cancer patients
Personalized medicine is a new field based on molecular biology and genomics in which targeted tumor therapies are administered to patients. Psycho-oncology is a complementary approach that considers social an... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 1, 2016 Category: Research Authors: Flavio D’Abramo, Ute Goerling and Cecilia Guastadisegni Source Type: research

Topical ocular dexamethasone decreases intraocular pressure and body weight in rats
Recently, topical dexamethasone-induced ocular hypertension and a consequent loss of retinal ganglion cells (RGCs) have been described in mice. This has been proposed as a model of steroid-induced glaucoma. In... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 12, 2016 Category: Research Authors: Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai and Toru Nakazawa Source Type: research

Comparison of serological methods with PCR-based methods for the diagnosis of community-acquired pneumonia caused by atypical bacteria
The diagnosis of community-acquired pneumonia (CAP) caused by Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requir... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 2, 2016 Category: Research Authors: Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Carlos Muskus and Lázaro Agustín Vélez Source Type: research

Thanks to all those who reviewed for Journal of Negative Results in BioMedicine in 2015
A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they are greatl... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 17, 2016 Category: Research Authors: Bjorn R. Olsen and Dirk Mielenz Source Type: research

ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model
In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 3, 2016 Category: Research Authors: Min Liu, Tiantian Lu, Fang Jing, Suying Dang and Wei Zhang Source Type: research

Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study
Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 1, 2016 Category: Research Authors: Dominik G. Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C. Sauter, Valentin Fuhrmann and Aristomenis K. Exadaktylos Source Type: research

Mobile phone use and risk for intracranial tumors
Mobile phone use has been discussed over the last few decades with increased risk for intracranial tumors. The majority of studies have been conducted on gliomas and meningiomas. Although some case-control stu... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 23, 2015 Category: Research Authors: George A. Alexiou and Chrissa Sioka Source Type: research

Substrate stiffness effect and chromosome missegregation in hIPS cells
Ensuring genetic stability in pluripotent stem cell (PSC) cultures is essential for the development of successful cell therapies. Although most instances lead to failed experiments and go unreported in the lit... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 18, 2015 Category: Research Authors: Suehelay Acevedo-Acevedo and Wendy C. Crone Source Type: research

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study
Omega–3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies d... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Mori J. Krantz, Edward P. Havranek, Rocio I. Pereira, Brenda Beaty, Philip S. Mehler and Carlin S. Long Source Type: research

Ethanol exposure during the third trimester equivalent does not affect GABAA or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons
Ethanol exposure during the rodent equivalent to the 3rd trimester of human pregnancy (i.e., first 1–2 weeks of neonatal life) has been shown to produce structural and functional alterations in the CA3 hippocampa... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Brian Charles Baculis and Carlos Fernando Valenzuela Source Type: research

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study
Conclusion: High-dose omega-3 fatty acids did not reduce arterial PWV or markers of inflammation among patients within a Latino-predominant population with hypertension.Clinical trial registrationNCT00935766, registered July 8 2009. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Mori KrantzEdward HavranekRocio PereiraBrenda BeatyPhilip MehlerCarlin Long Source Type: research

Ethanol exposure during the third trimester equivalent does not affect GABA A or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons
Conclusions: We show that an ethanol exposure paradigm known to inhibit synaptic plasticity mechanisms that may participate in the stabilization of GABAergic and glutamatergic synapses in CA3 pyramidal neurons does not produce lasting functional alterations in these synapses, suggesting that compensatory mechanisms restored the balance of excitatory and inhibitory synaptic transmission. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Brian BaculisCarlos Valenzuela Source Type: research

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study
Polymorphisms in the TNF-A gene have been associated with chronic obstructive pulmonary disease (COPD) in some case-control studies. Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 a... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 1, 2015 Category: Research Authors: Jennie M. Gane, Robert A. Stockley and Elizabeth Sapey Source Type: research

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study
Conclusions: This small pilot study did not provide an explanation for the findings of earlier observations of the association of the rs361525 polymorphism with TNF-α in airways secretions. Possible reasons for the lack of concordance include the study of blood rather than tissue cells, the use of a single stimulant rather than biological secretions and the need for far greater subject numbers to overcome intra-subject variation in monocyte TNF-α production. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 1, 2015 Category: Research Authors: Jennie GaneRobert StockleyElizabeth Sapey Source Type: research