Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan–calcium nanoparticles and its cytotoxic potential against prostate cancer cells
ConclusionGK–OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 22, 2020 Category: Complementary Medicine Source Type: research
The safety, immunological benefits, and efficacy of ginseng in organ transplantation
Publication date: Available online 7 February 2020Source: Journal of Ginseng ResearchAuthor(s): Sun Woo Lim, Kang Luo, Yi Quan, Sheng Cui, Yoo Jin Shin, Eun Jeong Ko, Byung Ha Chung, Chul Woo YangAbstractKorean ginseng (Panax ginseng) is associated with a variety of therapeutic effects, including antioxidative, anti-inflammatory, vasorelaxative, antiallergic, antidiabetic, and anticancer effects. Accordingly, the use of ginseng has reached an all-time high among members of the general public. However, the safety and efficacy of ginseng in transplant recipients receiving immunosuppressant drugs has not yet been elucidated. ...
Source: Journal of Ginseng Research - February 8, 2020 Category: Complementary Medicine Source Type: research
Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation
ConclusionOverall, our results suggest that G-Rb1 exerts cartilage protective effect on MIA-induced ovariectomized OA rats, by inhibiting inflammatory mediators such as IL-6, IL-1β, monocyte chemoattractant protein-1/CCL2, COX-2, and PGE2. These results shed a light on possible therapeutic application of G-Rb1 in OA. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 7, 2020 Category: Complementary Medicine Source Type: research
Comparative transcriptome analysis of the protective effects of Korean red ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice
ConclusionOur data suggest that BPA has commonly influenced inflammatory response effects on both normal and ovariectomized mice. KRG protects against BPA impact of inflammatory response and chemotaxis in ovariectomized mouse models. Our comparative analysis will provide new insight into the efficacy of KRG on endocrine disrupting chemicals (EDCs) and ovariectomized (OVX) mouse.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 7, 2020 Category: Complementary Medicine Source Type: research
Characterisation of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan-calcium nanoparticles and its cytotoxic potential against prostate cancer cells
ConclusionGK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the anti-proliferative effects of GK.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 6, 2020 Category: Complementary Medicine Source Type: research
Physiological and pharmacological features of the non-saponin components in Korean Red ginseng
Publication date: Available online 6 February 2020Source: Journal of Ginseng ResearchAuthor(s): Sun Hee Hyun, Sung Won Kim, Hwi Won Seo, Soo Hyun Youn, Jong Soo Kyung, Yong Yook Lee, In Gyo, Chae-Kyu Park, Chang-Kyun HanAbstractPanax ginseng, a medicinal plant, has been used as a blood-nourishing tonic for thousands of years in Asia, including Korea and China. P. ginseng exhibits adaptogen activity that maintains homeostasis by restoring general biological functions and non-specifically enhancing the body's resistance to external stress. Several P. ginseng effects have been reported. Korean Red ginseng, in particular, has ...
Source: Journal of Ginseng Research - February 6, 2020 Category: Complementary Medicine Source Type: research
Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment
ConclusionThus, the industrial preparation of less-polar ginsenosides from SNG is more efficient and cheaper. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 31, 2020 Category: Complementary Medicine Source Type: research
Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby, interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium (CM) obtained from IR- and L...
Source: Journal of Ginseng Research - January 31, 2020 Category: Complementary Medicine Source Type: research
Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistance in Panax ginseng
ConclusionR. panacihumi DCY116T can be used as potential PGPR and “plant strengthener” for future cultivation of ginseng or other crops/plants that are grown in regions with heavy metal exposure. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 25, 2020 Category: Complementary Medicine Source Type: research
Ginsenoside-Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation
ConclusionOverall, our results suggest that G-Rb1 exerts cartilage protective effect on MIA induced ovariectomized OA rats, by inhibiting inflammatory mediators such as IL-6, IL-1β, MCP1/CCL2, COX-2, and PGE2. These results shed a light on possible therapeutic application of G-Rb1 in OA.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 21, 2020 Category: Complementary Medicine Source Type: research
Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
ConclusionThis is the first report on the synthesis of two novel ginsenosides, namely, glucosyl ginsenoside Rh2 and diglucosyl ginsenoside Rh2 from Rh2 by using recombinant GT isolated from L. rhamnosus. Moreover, diglucosyl ginsenoside Rh2 might be a new candidate for treatment of inflammation, obesity, and skin whiting, and especially for anticancer. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 19, 2020 Category: Complementary Medicine Source Type: research
Phytochemical analysis of Panax species: A review
Publication date: Available online 14 January 2020Source: Journal of Ginseng ResearchAuthor(s): Yuangui Yang, Zhengcai Ju, Yingbo Yang, Yanhai Zhang, Li Yang, Zhengtao WangAbstractPanax species obtain numerous attentions due to various biological effects on cardiovascular, kidney, reproductive disease for a long history. Recently, advanced analytical methods include thin layer chromatography, high performance thin layer chromatography, gas chromatography, high performance liquid chromatography, ultra-high performance liquid chromatography tandem with ultraviolet, diode array detector, evaporative light scattering detector ...
Source: Journal of Ginseng Research - January 15, 2020 Category: Complementary Medicine Source Type: research
Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of ROS
ConclusionsOverall, our results suggest that KRG exerts an anti-inflammatory effect on BPA-treated A549 cells via the suppression of ROS and down-regulation of NF-κB activation and COX-2 expression which leads to a decrease in cellular migration and MMP-9 expression. These results provide a new possible therapeutic application of KRG to protect BPA-induced possible inflammatory disorders.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 15, 2020 Category: Complementary Medicine Source Type: research
Stem-leaves of Panax as a Rich and Sustainable Source of Less Polar Ginsenosides: Comparison of Ginsenosides from Panax Ginseng, American Ginseng and Panax notoginseng Prepared by Heating & Acid Treatment
ConclusionThus, the industrial preparation of less polar ginsenosides from SNG is more efficient and cheaper.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 13, 2020 Category: Complementary Medicine Source Type: research
Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistant in Panax ginseng
ConclusionR. panacihumi DCY116T can be used as a potential PGPR and “plant strengthener” for future cultivation of ginseng or other crops/plants that are grown in regions with heavy metal exposure.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 9, 2020 Category: Complementary Medicine Source Type: research
