Ginseng seed oil ameliorates hepatic lipid accumulation in vitro and in vivo
ConclusionThese findings suggest that GSO has a beneficial effect on NAFLD through the suppression of lipogenesis and stimulation of fatty acid degradation pathway. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson's disease mouse model
ConclusionThese findings indicate that KRG may have therapeutic potential for the treatment of patients with PD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways
ConclusionOur findings suggest that KRGE alleviates spinal demyelination in acute experimental autoimmune encephalomyelitis through inhibiting the activation of the p38 mitogen-activated protein kinase/nuclear factor-κB signaling pathway. Therefore, KRGE might be used as a new therapeutic for autoimmune disorders such as multiple sclerosis, although further investigation is needed. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice
ConclusionThese results suggested that APGP exerted an anti-immunosenescent effect by suppressing thymic involution and modulating several types of immune cells. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells
ConclusionThe results indicate that Rh2 induces epigenetic methylation changes in genes involved in immune response and tumorigenesis, thereby contributing to enhanced immunogenicity and inhibiting the growth of cancer cells. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Influence of phytochemical composition on in vitro antioxidant and reducing activities of Indian ginseng [Withania somnifera (L.) Dunal] root extracts
ConclusionPhytochemical composition and antioxidant and reducing activities of the extracts were positively associated with the use of organic solvents during the extraction process. Alkaloids and flavonoids were the most important contributors in the antioxidant and reducing activities of the extracts. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway
ConclusionThe present study verified that KRGE and Rg3 have a strong antipruritic effect against CQ-induced itch. Thus, KRGE is as a promising antipruritic agent that blocks both histamine-dependent and -independent itch at peripheral sensory neuronal levels. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways
ConclusionCertain ginsenosides inhibit lung inflammatory responses by interrupting these signaling molecules and they are potential therapeutics for inflammatory lung diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
C/N/O/S stable isotopic and chemometric analyses for determining the geographical origin of Panax ginseng cultivated in Korea
ConclusionOur case study elucidates the variation of C, N, O, and S stable isotope ratios in ginseng root depending on cultivation region. Hence, the analysis of stable isotope ratios is a suitable tool for discrimination between the regional origins of ginseng samples from Korea, with potential application to other countries. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
AKT-targeted anti-inflammatory activity of Panax ginseng calyx ethanolic extract
ConclusionThese results suggest that Pg-C-EE may have nuclear-factor-κB-targeted anti-inflammatory properties through suppression of AKT. The calyx of the P. ginseng berry is an underused part of the ginseng plant, and development of calyx-derived extracts may be useful for treatment of inflammatory diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Highly regioselective biotransformation of ginsenoside Rb2 into compound Y and compound K by β-glycosidase purified from Armillaria mellea mycelia
Conclusionβ-Glycosidase purified from A. mellea mycelium can be efficiently used to transform Rb2 into C-Y and C-K. To our best knowledge, this is the first result of transformation from Rb2 into C-Y and C-K by basidiomycete mushroom enzyme. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 12, 2018 Category: Complementary Medicine Source Type: research
Putative multiple-reaction-monitoring strategy for the comparative pharmacokinetics of post-oral-administration Renshen–Yuanzhi compatibility through liquid chromatography–tandem mass spectrometry
ConclusionResults indicated that traditional Chinese medicine (TCM) combinations can produce synergistic effects and diminish possible toxic effects, thereby reflecting the advantages of compatibility. The proposed strategy can solve the quantitative problem of LRS and extend the scopes of PK studies. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 10, 2018 Category: Complementary Medicine Source Type: research
Effect of Red Ginseng NaturalGEL on Skin Aging
ConclusionRG NGEL has the potential as an effective reagent for anti-aging cosmetics to improve wrinkle formation and skin hydration. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 8, 2018 Category: Complementary Medicine Source Type: research
Label-free quantitative proteomic analysis of Panax ginseng leaves upon exposure to heat stress
ConclusionThese results increase our understanding of heat-stress responses in the leaves of ginseng at the protein level, for the first time providing a resource for the scientific community. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 6, 2018 Category: Complementary Medicine Source Type: research
Two new triterpenoid saponins derived from the leaves of Panax ginseng and their anti-inflammatory activity
ConclusionsTwo novel, minor triterpenoid saponins, ginsenoside LS1 (1) and 5,6-didehydroginsenoside Rg3 (2), were isolated from the leaves of P. ginseng. The isolated compounds 1 and 2 were assayed for their inhibitory effect on NO production in LPS-stimulated RAW 264.7 cells and compound 2 showed significant inhibitory effect with IC50 of 37.38 μM compared to that of NG-monomethyl-L-arginine (L-NMA, IC50=90.76 μM). Moreover, compound 2 significantly decreased secretion the cytokines such as prostaglandin E2 (PGE2) and tumor necrosis factor-α (TNF-α). In addition, compound 2 significantly suppressed protein expression ...
Source: Journal of Ginseng Research - October 5, 2018 Category: Complementary Medicine Source Type: research
