Taxonomy of fungal complex causing red-skin root of Panax ginseng in China
ConclusionFungal complex is the causal agent of red-skin root in P. ginseng. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 6, 2019 Category: Complementary Medicine Source Type: research
Advances in the chemistry, pharmacological diversity and metabolism of 20(R)-ginseng saponins
Publication date: Available online 31 January 2019Source: Journal of Ginseng ResearchAuthor(s): Chaoming Wang, Juan Liu, Jianqiang Deng, Jiazhen Wang, Weizhao Weng, Hongxia Chu, Qingguo MengAbstractGinseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by 13C NMR and X-ray single-crystal diffrac...
Source: Journal of Ginseng Research - February 1, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling-mediated muscular hypertrophy and myoblast differentiation
ConclusionRb1 and Rb2 upregulate myotube growth and myogenic differentiation through activating Akt/mTOR signaling and induce myogenic conversion of fibroblasts. Thus, our first finding indicates that Rb1 and Rb2 have strong potential as a helpful remedy to prevent and treat muscle atrophy, such as age-related muscular dystrophy. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 1, 2019 Category: Complementary Medicine Source Type: research
Overexpression of ginseng patatin-related phospholipase pPLAIIIβ alters the polarity of cell growth and decreases lignin content in Arabidopsis
ConclusionOverexpression of pPLAIIIβ retarded cell elongation in all the tested organs except seeds, which were longer and thicker than those of the controls. Shorter root length is related to auxin-responsive genes and its stunted phenotype showed decreased lignin content. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 24, 2019 Category: Complementary Medicine Source Type: research
Ginseng berry polysaccharides on inflammation-associated colon cancer: inhibiting T-cell differentiation, promoting apoptosis, and enhancing the effects of 5-fluorouracil
ConclusionData from this project suggested that Asian ginseng berry potentially has clinical utility in managing enteric inflammation and suppressing CRC through immunomodulation mechanisms. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 22, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rg3 protects against iE-DAP-induced endothelial-to-mesenchymal transition by regulating the miR-139-5p-NF-κB axis
ConclusionThese results suggest, for the first time, that Rg3 can be used to inhibit inflammation-induced EndMT and may be a novel therapeutic option against EndMT-associated vascular diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 21, 2019 Category: Complementary Medicine Source Type: research
Inhibitory mechanism of ginsenoside Rh3 on granulocyte–macrophage colony-stimulating factor expression in UV-B–irradiated murine SP-1 keratinocytes
ConclusionIn summary, we found that ginsenoside Rh3 impeded UV-B–induced GM-CSF production through repression of PKCδ and ERK phosphorylation in SP-1 keratinocytes. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 12, 2019 Category: Complementary Medicine Source Type: research
1Compatibility Effects of Herb Pair Ginseng and Ligustrum Lucidum Ait on Hematopoietic recovery in mice with Myelosuppression Induced-Cy and Its Material Basis
ConclusionThese results show that G-LLA herb pair might produce synergistic or complementary compatibility effects on bone marrow suppression after chemotherapy. It suggests that the substance basis of G-LLA for treating bone marrow suppression may be effective chemical components. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 12, 2019 Category: Complementary Medicine Source Type: research
Medicinal potential of Panax ginseng and its ginsenosides in atopic dermatitis treatment
Publication date: Available online 7 January 2019Source: Journal of Ginseng ResearchAuthor(s): Laura Rojas Lorz, Mi-Yeon Kim, Jae Youl ChoAbstractAtopic dermatitis (AD) is a chronic and relapsing inflammatory disease that affects 1%-20% of people worldwide. Despite affecting many people, AD current treatments such as corticosteroids and calcineurin inhibitors, have not only harmful secondary effects but are also often ineffective. Therefore, natural non-toxic compounds are on high demand for developing new effective AD treatments. Panax ginseng Meyer, has been used traditionally for its promising healing and restorative pr...
Source: Journal of Ginseng Research - January 7, 2019 Category: Complementary Medicine Source Type: research
Erratum to ‘Antistress effect of red ginseng in brain cells is mediated by TACE repression via PADI4’ [J Ginseng Res 37 (3) (2013) 315–323]
Publication date: January 2019Source: Journal of Ginseng Research, Volume 43, Issue 1Author(s): Eun-Hye Kim, In-Hye Kim, Jung-Ah Ha, Kwang-Tae Choi, Suhkneung Pyo, Dong-Kwon Rhee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 5, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress
ConclusionsJP5 and BG1 protect against oxidative stress and inflammation induced by heat stress and help maintain liver function by preventing liver damage. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 4, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng attenuates type 2 diabetic cardiovascular dysfunction in Otsuka Long-Evans Tokushima Fatty rats
We examined the protective potential of KRG against type 2 diabetic illnesses. The results exhibited that KRG showed significant antihyperglycemic and antioxidative effects in KRG-treated OLETF rats. And, our results proposed the amelioration of cardiac function through normalized ejection fraction, fractional shortening, and vascular reactivity. Furthermore, histopathological abnormalities in the OLETF rats were prevented by KRG treatment. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 4, 2019 Category: Complementary Medicine Source Type: research
Transcriptome analysis of Panax ginseng response to high light stress
ConclusionTranscriptome profiling could be a strategy to comprehensively elucidate the genetic and molecular mechanisms of HL tolerance and susceptibility. This study would provide a foundation for developing breeding and metabolic engineering strategies to improve the environmental stress tolerance of ginseng. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 2, 2019 Category: Complementary Medicine Source Type: research
Autophagy and its regulation by ginseng components
Publication date: Available online 2 January 2019Source: Journal of Ginseng ResearchAuthor(s): Nurinanda Prisky Qomaladewi, Mi-Yeon Kim, Jae Youl ChoAbstractAutophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. Here we describe a plant extract that is well known in Korea, namely Korean ginse...
Source: Journal of Ginseng Research - January 2, 2019 Category: Complementary Medicine Source Type: research
Ginseng berry polysaccharides on inflammation-associated colon cancer: Inhibiting T cell differentiation, promoting apoptosis, and enhancing the effects of 5-fluorouracil
ConclusionData from this project suggested that Asian ginseng berry potentially has a clinical utility in managing enteric inflammation and suppressing CRC through immunomodulation mechanisms. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 2, 2019 Category: Complementary Medicine Source Type: research
