Journal of Geriatric Psychiatry and Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Symptom Dimensions of Depression and 3-Year Incidence of Dementia: Results From the Amsterdam Study of the Elderly
Conclusion: Our findings suggest that the increased risk of dementia associated with depressive symptoms in many previous studies appears to be heterogeneous, that is, it is likely due to different underlying pathways, including a pathway involving depression itself and a pathway in which cognitive and motivational symptoms reflect subjective cognitive complaints, particularly in the absence of depressed mood. These different pathways might warrant a different treatment approach. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Lugtenburg, A., Zuidersma, M., Voshaar, R. C. O., Schoevers, R. A. Tags: Articles Source Type: research

Clinical Significance of Individual GAD Symptoms in Later Life
Conclusions: These findings suggest that individual GAD symptoms are differentially associated with aspects of clinical significance relevant to daily life, such as social, occupational, and functional ability. The differential impact of individual symptoms on functional status may be diluted when using symptom sum scores. A nuanced approach to assessing the clinical significance of individual GAD symptoms in older adults may be fruitful for efforts aimed at early detection and treatment. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Miloyan, B., Pachana, N. A. Tags: Articles Source Type: research

Psychiatric Conditions in Parkinson Disease: A Comparison With Classical Psychiatric Disorders
Psychiatric conditions often complicate the outcome of patients affected by Parkinson disease (PD), but they differ from classical psychiatric disorders in terms of underlying biological mechanisms, clinical presentation, and treatment response. The purpose of the present review is to illustrate the biological and clinical aspects of psychiatric conditions associated with PD, with particular reference to the differences with respect to classical psychiatric disorders. A careful search of articles on main databases was performed in order to obtain a comprehensive review about the main psychiatric conditions associated with ...
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Buoli, M., Caldiroli, A., Altamura, A. C. Tags: Articles Source Type: research

Neuropsychiatric Symptoms in Posterior Cortical Atrophy and Alzheimer Disease
Conclusion: Prevalence of the 12 NPS examined was similar between patients with PCA and AD. Hallucinations in PCA may be helpful in the differential diagnosis between PCA-AD and PCA-DLB. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Suarez-Gonzalez, A., Crutch, S. J., Franco-Macias, E., Gil-Neciga, E. Tags: Articles Source Type: research

Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences
Discussion: Treatment outcomes in CitAD showed modest, although statistically significant, influence of genetic variation at HTR2A and HTR2C loci. Future studies should continue to examine the interaction of known genetic variants with antidepressant treatment in patients with AD having agitation. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Peters, M. E., Vaidya, V., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D. M., Weintraub, D., Yesavage, J., Lyketsos, C. G., Avramopoulos, D., For the CitAD Research Group Tags: Articles Source Type: research

Updating the Cognitive Performance Scale
This study presents the first update of the Cognitive Performance Scale (CPS) in 20 years. Its goals are 3-fold: extend category options; characterize how the new scale variant tracks with the Mini-Mental State Examination; and present a series of associative findings. Secondary analysis of data from 3733 older adults from 8 countries was completed. Examination of scale dimensions using older and new items was completed using a forward-entry stepwise regression. The revised scale was validated by examining the scale’s distribution with a self-reported dementia diagnosis, functional problems, living status, and distre...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Morris, J. N., Howard, E. P., Steel, K., Perlman, C., Fries, B. E., Garms-Homolova, V., Henrard, J.-C., Hirdes, J. P., Ljunggren, G., Gray, L., Szczerbinska, K. Tags: Articles Source Type: research

Study of Spirituality in Elderly With Subjective Memory Complaints
This study was done to find out whether any relation exists between these 2 variables in elderly. A total of 120 elderly individuals, presenting with subjective memory complaints, were divided into 3 groups — controls, elderly with depression, and elderly with mild cognitive impairment (MCI). Spirituality in them was studied by dividing it into the subdomains of self-transcendence, presence of meaning in life, search for meaning in life, and locus of control. Spirituality was the highest in controls, followed by MCI group, and then depression group. Spirituality had a direct negative relationship with severity of dep...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Trivedi, S. C., Subramanyam, A. A., Kamath, R. M., Pinto, C. Tags: Articles Source Type: research

The Effect of Reminiscence Therapy on Cognition, Depression, and Activities of Daily Living for Patients With Alzheimer Disease
The purpose of this study was, conducted with experimental design, to investigate the effect of reminiscence therapy on cognition, depression, activities of daily living of institutionalized mild and moderate Alzheimer patients. The study was conducted with a total of 62 patients (31 intervention group and 31 control group) in four home care in Ankara, Turkey. Study was done between the July 1, 2013 and December 20, 2014. Reminiscence therapy sessions were held with groups consists of 4-5 patients, once a week with 30-35 minute duration for 12 weeks. Standardized Mini Mental Test was used in sample selection. Patients were...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Duru Asiret, G., Kapucu, S. Tags: Articles Source Type: research

Visual Priming and Visual Hallucinations in Parkinsons Disease. Evidence for Normal Top-Down Processes
Conclusions: The study showed that VH in PD are not associated with relatively greater top-down activation, and that the interaction between top-down and bottom-up processes is intact. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Straughan, S., Collerton, D., Bruce, V. Tags: Articles Source Type: research

Strengths and Limitations of the MoCA for Assessing Cognitive Functioning: Findings From a Large Representative Sample of Irish Older Adults
Conclusion: Lack of concordance between the CFA and EFA findings demonstrates that the correspondence between individual tests and their assumed cognitive domains is not robust, reflecting at least in part a current lack of consensus on how core cognitive constructs are defined and on what subcomponents can be subsumed under different cognitive domains. The MoCA should not be viewed as a substitute for more in-depth neuropsychological assessment when domain-specific information is required. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Coen, R. F., Robertson, D. A., Kenny, R. A., King-Kallimanis, B. L. Tags: Articles Source Type: research

Autonomic Nervous System Dysfunction in Patients With Parkinson Disease Having Depression
Conclusion: Depression is associated with neurocirculatory abnormalities—especially orthostatic hypotension—in early PD. Although the association does not imply causation, this result suggests that depression in PD might be associated with functional impairment of the autonomic nervous system and its pathologic substrate. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Park, H.-E., Kim, J.-S., Oh, Y.-S., Park, I.-S., Park, J.-W., Song, I.-U., Lee, K.-S. Tags: Articles Source Type: research

Cognitive and Behavioral Symptoms in ALSFTD: Detection, Differentiation, and Progression
Brief screening tools that detect and differentiate patients with amyotrophic lateral sclerosis and frontotemporal dementia (ALSFTD) from those more subtle cognitive or behavioral symptoms (ALS plus) and motor symptoms only (ALS pure) is pertinent in a clinical setting. The utility of 2 validated and data-driven tests (Mini-Addenbrooke’s Cognitive Examination [M-ACE] and Motor Neuron Disease Behavioral Scale [MiND-B]) was investigated in 70 ALS patients (24 ALSFTD, 19 ALS plus, and 27 ALS pure). More than 90% of patients with ALSFTD scored at or below the cutoff on the M-ACE, whereas this was seen in only about 20% o...
Source: Journal of Geriatric Psychiatry and Neurology - December 9, 2015 Category: Genetics & Stem Cells Authors: Hsieh, S., Caga, J., Leslie, F. V. C., Shibata, M., Daveson, N., Foxe, D., Ramsey, E., Lillo, P., Ahmed, R. M., Devenney, E., Burrell, J. R., Hodges, J. R., Kiernan, M. C., Mioshi, E. Tags: Articles Source Type: research

The Association Between Benzodiazepine Use and Depression Outcomes in Older Veterans
Benzodiazepines (BZDs) are commonly prescribed to older adults with depression, but it is unknown whether they improve antidepressant (AD) adherence or depressive symptoms. We followed 297 older veterans diagnosed with depression and provided a new AD medication prospectively for 4 months. Data include validated self-report measures and VA pharmacy records. At initial assessment, 20.5% of participants were prescribed a BZD. Those with a BZD prescription at baseline were significantly more likely than those without to have a personality disorder, schizophrenia spectrum disorder, or other anxiety disorder, and higher depress...
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Leggett, A., Kavanagh, J., Zivin, K., Chiang, C., Kim, H. M., Kales, H. C. Tags: Articles Source Type: research

Depressed Spousal Caregivers Have Psychological Stress Unrelated to the Progression of Alzheimer Disease: A 3-Year Follow-Up Report, Kuopio ALSOVA Study
Conclusion: During longitudinal caregiving, spousal and depressed caregivers of patients with AD report higher and increasing psychological stress than nonspousal and nondepressed caregivers. Spousal relationship, caregivers’ depressive symptoms, and the severity of patients’ neuropsychological symptoms at the time of AD diagnosis predict the trajectory of psychological distress. The current study highlights the need for evaluating AD caregiver mental health and level of coping. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Välimäki, T. H., Martikainen, J. A., Hallikainen, I. T., Väätäinen, S. T., Koivisto, A. M. Tags: Articles Source Type: research

Risk of Cognitive and Functional Impairment in Spouses of People With Dementia: Evidence From the Health and Retirement Study
We examined whether having (i) a spouse with dementia and (ii) a spouse who requires assistance with activities of daily living predicted cognitive and functional impairments in respondents to the Health and Retirement Study (n = 7965). Respondents who had a spouse who requires care had poorer cognitive functioning, whereby this relationship was significantly stronger for male respondents. Having a spouse with dementia moderated the relationship between income and cognition and predicted caregiver functional impairment, though not when depression was controlled. Although we found no significant differences on any individua...
Source: Journal of Geriatric Psychiatry and Neurology - October 26, 2015 Category: Genetics & Stem Cells Authors: Pertl, M. M., Lawlor, B. A., Robertson, I. H., Walsh, C., Brennan, S. Tags: Articles Source Type: research