Journal of Geriatric Psychiatry and Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort
In this study, we investigated the association between rs2279590, rs11136000, and rs9331888 single-nucleotide polymorphisms (SNPs) in CLU and apolipoprotein E (APOE) genotypes in a cohort of Turkish patients with late-onset AD (LOAD). There were 183 patients with LOAD and 154 healthy controls included in the study. The CLU and APOE polymorphisms were genotyped using the LightSNiP assay. The "GG" genotype of rs9331888 was significantly more frequent in patients with LOAD. The "CC" genotype of the SNP was significantly more frequent in controls. The rs9331888 "GG" genotype in patients and the "CC" genotype in controls were s...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Alaylıoglu, M., Gezen-Ak, D., Dursun, E., Bilgic, B., Hanagası, H., Ertan, T., Gürvit, H., Emre, M., Eker, E., Uysal, O., Yılmazer, S. Tags: Articles Source Type: research

Association Between Metacognition and Mood Symptoms Poststroke
Discussion: Metacognition is a better determinant of mood symptoms after stroke, especially in regions where illiteracy levels are high in older populations, in comparison to executive function and global cognition. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Donnellan, C., Al Banna, M., Redha, N., Al Sharoqi, I., Al-Jishi, A., Bakhiet, M., Taha, S., Abdulla, F. Tags: Articles Source Type: research

Meta-Analysis of Facial Emotion Recognition in Behavioral Variant Frontotemporal Dementia: Comparison With Alzheimer Disease and Healthy Controls
Behavioral disturbances and lack of empathy are distinctive clinical features of behavioral variant frontotemporal dementia (bvFTD) in comparison to Alzheimer disease (AD). The aim of this meta-analytic review was to compare facial emotion recognition performances of bvFTD with healthy controls and AD. The current meta-analysis included a total of 19 studies and involved comparisons of 288 individuals with bvFTD and 329 healthy controls and 162 bvFTD and 147 patients with AD. Facial emotion recognition was significantly impaired in bvFTD in comparison to the healthy controls (d = 1.81) and AD (d = 1.23). In bvFTD, recognit...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Bora, E., Velakoulis, D., Walterfang, M. Tags: Articles Source Type: research

Comorbidity of Cognitive Impairment and Late-Life Depression Increase Mortality: Results From a Cohort of Community-Dwelling Elderly Individuals in Rural Greece
Conclusion: COGI and depression, 2 entities often coexisting among elderly individuals, appear to increase all-cause mortality and cardiovascular mortality. Gender-specific modes may prevail but their comorbidity should be carefully assessed, as it seems to represent an independent index of increased frailty, which eventually shortens life expectancy. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Georgakis, M. K., Papadopoulos, F. C., Protogerou, A. D., Pagonari, I., Sarigianni, F., Biniaris-Georgallis, S.-I., Kalogirou, E. I., Thomopoulos, T. P., Kapaki, E., Papageorgiou, C., Papageorgiou, S. G., Tousoulis, D., Petridou, E. T. Tags: Articles Source Type: research

Excessive Iron and {alpha}-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease
Conclusion: Patients with PD had high prevalence of pure apathy. Patients with PD having pure apathy had older age. Pure apathy reduced quality of life for patients without worsening motor function. Excessive iron and α-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Wang, F., Yu, S.-Y., Zuo, L.-J., Cao, C.-J., Hu, Y., Chen, Z.-J., Piao, Y.-s., Wang, Y.-J., Wang, X.-M., Chen, S.-D., Chan, P., Zhang, W. Tags: Articles Source Type: research

Apathy in Older Persons With Depression: Course and Predictors: The NESDO Study
Conclusion: Severity of apathy at baseline, but not depression, predicted apathy at follow-up. Incident apathy was predicted by poorer cognitive function, whereas severe apathy at baseline predicted its persistence. Remarkably, new apathy was not associated with worse outcome of depression whereas persistent apathy was. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Groeneweg-Koolhoven, I., Comijs, H. C., Naarding, P., de Waal, M. W. M., van der Mast, R. C. Tags: Articles Source Type: research

Frontal Cortical Atrophy as a Predictor of Poststroke Apathy
The aim of the study was to identify associations between the symptoms of poststroke apathy and sociodemographic, stroke-related (severity of stroke, degree of disability, and performance in activities of daily living), and radiological correlates. We determined the degree of cortical and subcortical brain atrophy, the severity of white matter and basal ganglia lesions on baseline computed tomography (CT) scans, and the localization of acute ischemia on control CT or magnetic resonance imaging scans in subacute stages of stroke. During follow-up examinations, in addition to the assessment of apathy symptoms using the Apath...
Source: Journal of Geriatric Psychiatry and Neurology - June 14, 2016 Category: Genetics & Stem Cells Authors: Mihalov, J., Mikula, P., Budis, J., Valkovic, P. Tags: Articles Source Type: research

Development and Validation of the Rappel Indice-24: Behavioral and Brain Morphological Evidence
The primary goals of the present study were to develop and validate the Rappel Indicé 24 (RI-24), a shorter version of the original Rappel Indicé, which includes 48 items (RI-48), and to identify the specific brain regions that were correlated with scores on the RI-24. Using these clinical scales, the present study evaluated 91 elderly Korean participants who were classified into 3 groups: normal control (NC; n = 34), patients with mild cognitive impairment (MCI; n = 29), and patients with Alzheimer disease (AD; n = 28). Of the 91 participants, 77 also underwent magnetic resonance imaging scans. The RI-24 del...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Park, S., Kim, I., Park, H. G., Shin, S. A., Cho, Y., Youn, J.-H., Kim, Y. K., Lee, J.-Y. Tags: Articles Source Type: research

Cortical Amyloid {beta} Deposition and Current Depressive Symptoms in Alzheimer Disease and Mild Cognitive Impairment
Depressive symptoms are frequently seen in patients with dementia and mild cognitive impairment (MCI). Evidence suggests that there may be a link between current depressive symptoms and Alzheimer disease (AD)-associated pathological changes, such as an increase in cortical amyloid-β (Aβ). However, limited in vivo studies have explored the relationship between current depressive symptoms and cortical Aβ in patients with MCI and AD. Our study, using a large sample of 455 patients with MCI and 153 patients with AD from the Alzheimer’s disease Neuroimaging Initiatives, investigated whether current depressi...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Chung, J. K., Plitman, E., Nakajima, S., Chakravarty, M. M., Caravaggio, F., Gerretsen, P., Iwata, Y., Graff-Guerrero, A., for the Alzheimers Disease Neuroimaging Initiative Tags: Articles Source Type: research

Stroke Symptoms With Absence of Recognized Stroke Are Associated With Cognitive Impairment and Depressive Symptoms in Older Adults With Diabetes
We examined relationships between stroke symptoms, cognitive impairment, and depressive symptoms in a high-risk sample: 247 adults aged ≥65 with diabetes. Stroke symptoms were assessed using the Questionnaire for Verifying Stroke-free Status, cognitive impairment was measured with the modified Telephone Interview for Cognitive Status, and depressive symptoms were measured using the 15-item Geriatric Depression Scale. In 206 participants without history of stroke/transient ischemic attack, 27.7% reported stroke symptoms, with sudden loss of comprehension most frequently reported (11.7%). Having >1 versus 0 stroke symp...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Passler, J. S., Clay, O. J., Wadley, V. G., Ovalle, F., Crowe, M. Tags: Articles Source Type: research

Cognitive Function in Older Suicide Attempters and a Population-Based Comparison Group
Conclusion: Older suicide attempters may have cognitive deficits, which may in part be related to the attempt itself. This needs to be taken into account when designing intervention strategies. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Olsson, P., Wiktorsson, S., Sacuiu, S., Marlow, T., Östling, S., Fässberg, M. M., Skoog, I., Waern, M. Tags: Articles Source Type: research

Cognitive Deficits in Healthy Elderly Population With "Normal" Scores on the Mini-Mental State Examination
This study investigated whether healthy older adults with Mini-Mental State Examination (MMSE) scores above 23 exhibit cognitive impairment on neuropsychological tests. Participants completed the MMSE and a neuropsychological battery including tests of 10 domains. Results were compared to published normative data. On neuropsychological testing, participants performed well on measures of naming and recall but showed mild to moderate impairment in working memory and processing speed and marked impairment in inhibition, sustained attention, and executive functioning. Almost everyone (91%) scored at least 1 standard deviation ...
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Votruba, K. L., Persad, C., Giordani, B. Tags: Articles Source Type: research

The Association Between Diabetes and Dementia Among Elderly Individuals: A Nationwide Inpatient Sample Analysis
Conclusion: Patients with a diagnosis of diabetes mellitus had lower odds of having AD. Age, race/ethnicity, depression, stroke, and hypertension modified the relationship between DM and both VaD and AD. Further exploration of the relationship between DM and AD is warranted. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Sherzai, D., Sherzai, A., Lui, K., Pan, D., Chiou, D., Bazargan, M., Shaheen, M. Tags: Articles Source Type: research

Diagnostic Validity and Factor Analysis of Montgomery-Asberg Depression Rating Scale in Parkinson Disease Population
Conclusion: The MADRS has diagnostic utility in major depression in PD. The 3-factor structure of MADRS may help to understand the different dimensions of major depression and identify distinct symptom subgroups in this population. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - April 3, 2016 Category: Genetics & Stem Cells Authors: Ketharanathan, T., Hanwella, R., Weerasundera, R., de Silva, V. A. Tags: Articles Source Type: research

Emotional Decoding Abilities Do Not Influence Neuropsychiatric Disturbances in Patients With Frontotemporal Dementia
The ability to accurately recognize emotional information belongs to very important interpersonal communication skills in humans. Disturbance of emotional processing is present in behavioral variant of frontotemporal dementia (bvFTD), and the severity of pathological behavior may be linked to misunderstanding of other people’s emotions. In our study, we examined hypothesis that patients with worse ability to decode emotions have more behavioral and psychopathological disturbances—the most challenging manifestations of dementia—than those who decode emotions better. We were not able to prove this hypothesi...
Source: Journal of Geriatric Psychiatry and Neurology - February 8, 2016 Category: Genetics & Stem Cells Authors: Klimkowicz-Mrowiec, A., Krzywoszanski, L., Szyper-Maciejewska, A., Dziedzic, T., Pera, J., Slowik, A. Tags: Articles Source Type: research