A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study
This study could be readily applied in therapeutic drug monitoring of major depressive disorder patients receiving such drug combinations.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research
Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites
Publication date: Available online 14 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Ju-Yi Mao, Chih-Ching HuangAbstractNanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can be avoided with the application of nanomaterials as matrices as well as substrates for the LDI-MS to achieve a low background noise in low m/z region and high reproducibility. Surface-assisted LDI ...
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research
Rubiscolin-6 activates opioid receptors to enhance glucose uptake in skeletal muscle
In conclusion, rubiscolin-6 increases glucose uptake, potentially via an activation of AMPK to enhance GLUT4 translocation after binding to opioid receptors in skeletal muscle.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research
Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways
Publication date: Available online 14 August 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yu-Ting Kuo, Chih-Chan Lin, Hsiao-Tzu Kuo, Jui-Hsiang Hung, Ching-Hsuan Liu, Alagie Jassey, Ming-Hong Yen, Shu-Jing Wu, Liang-Tzung LinAbstractType 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia that can lead to long-term complications including heart diseases, stroke, retinopathy, and renal failure. Treatment strategies include stimulating glucose uptake and controlling blood glucose level. Bofutsushosan (BOF) and Daisaikoto (DAI) are two herb-based kampo medicines that have been demonstrate...
Source: Journal of Food and Drug Analysis - August 14, 2018 Category: Food Science Source Type: research
The integration of multi-platform MS-based metabolomics and multivariate analysis for the geographical origin discrimination of Oryza sativa L.
In conclusion, the proposed approach successfully highlighted phospholipids as the better discrimination markers than sugars & sugar alcohols and fatty acids in differentiating white rice between Korea and China.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines, inflammation and oxidative stress
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Chiung-Huei Peng, Huei-Ting Lin, Dai-Jung Chung, Chien-Ning Huang, Chau-Jong WangAbstractMulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interl...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Simultaneous quantification of eight organic acid components in Artemisia capillaris Thunb (Yinchen) extract using high-performance liquid chromatography coupled with diode array detection and high-resolution mass spectrometry
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Fangjun Yu, Hao Qian, Jiayu Zhang, Jie Sun, Zhiguo MaAbstractWe aim to determine the chemical constituents of Yinchen extract and Yinchen herbs using high-performance liquid chromatography coupled with diode array detection and high-resolution mass spectrometry. The method was developed to analyze of eight organic acid components of Yinchen extract (including neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, 1,3-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid and 4,5-dic...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Effect of drying processes on prenylflavonoid content and antioxidant activity of Epimedium koreanum Nakai
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Yudan Zhao, Shifeng Chen, Yadan Wang, Chongning Lv, Jing Wang, Jincai LuAbstractEpimedium koreanum Nakai is a famous Chinese herbal medicine for the treatment of impotence, osteoporosis, immune suppression and cardiovascular diseases. Drying is the most common and fundamental procedure in post-harvest processing of E. koreanum, which contributes to the variations of flavonoid content, especially prenylflavonoids, the bioactive components. In present study, effect of drying processes on flavonoid content and antioxidant activ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Junjun Yang, Jing Yang, Jie Du, Yuxin Feng, Xin Chai, Mingming Xiao, Yuefei Wang, Xiumei GaoAbstractFructus Psoraleae, a traditional Chinese medicine, is widely used for preventing and treating various diseases such as vitiligo, osteoporosis and psoriasis. Coumarin, such as psoralenoside, isopsoralenoside, psoralen and isopsoralen, are important compounds in Fructus Psoraleae. In our study, ultra performance liquid chromatography coupled with diode array detector was employed for an excellent method validation for simultaneo...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Nanoparticle based bio-bar code technology for trace analysis of aflatoxin B1 in Chinese herbs
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Yu-yan Yu, Yuan-yuan Chen, Xuan Gao, Yuan-yuan Liu, Hong-yan Zhang, Tong-Ying WangAbstractA novel and sensitive assay for aflatoxin B1 (AFB1) detection has been developed by using bio-bar code assay (BCA). The method that relies on polyclonal antibodies encoded with DNA modified gold nanoparticle (NP) and monoclonal antibodies modified magnetic microparticle (MMP), and subsequent detection of amplified target in the form of bio-bar code using a fluorescent quantitative polymerase chain reaction (FQ-PCR) detection method. Fir...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Comprehensive two-dimensional APTES-decorated MCF7-cell membrane chromatographic system for characterizing potential anti-breast-cancer components from Yuanhu–Baizhi herbal medicine pair
In this study, a new comprehensive two-dimensional (2D) 3-aminopropyltriethoxysilane (APTES)-decorated MCF7-cell membrane chromatography (CMC)/capcell-C18 column/time-of-flight mass spectrometry system was established for screening potential active components and clarifying the active fraction of Yuanhu–Baizhi pair. APTES was modified on the surface of silica, which can provide an amino group to covalently link cell membrane fragments with the help of glutaraldehyde in order to improve the stability and column life span of the MCF7 CMC column. The comprehensive 2D MCF7-CMC system showed good separation and identification...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of vancomycin hydrochloride in pharmaceuticals and spiked human plasma: Application to degradation kinetics
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Mohie Khaled Sharaf El-Din, Fawzia Ibrahim, Asmaa Kamal El-Deen, Kuniyoshi ShimizuAbstractBased on investigating the relative fluorescence intensity of vancomycin hydrochloride (VCM) in methanol, a simple, highly sensitive, time-saving and specific spectrofluorimetric method was developed and validated. VCM fluorescence was measured at 335 nm when excited at 268 nm. Excellent linearity is obeyed in the concentration range 1–100 ng/mL with a detection limit of 5.94 pg/mL, a quantitation limit of 18.03 pg/mL and a very ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
A validated capillary electrophoretic method for the determination of indacaterol and its application to a pharmaceutical preparation
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Tufan Güray, Muzaffer Tunçel, Ulku Dilek UysalAbstractIndacaterol is a new inhaled ultra-long acting β2-agonist. It has been recently approved in the European Union for the treatment of chronic obstructive pulmonary disease. This paper reports, for the first time, a method for the determination and validation of Indacaterol (IND) using an internal standard in capsules. Capillary electrophoretic separation was performed on an uncoated fused-silica capillary (50 cm effective length, 75 μm i.d.) and background electrolyte...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat
In conclusion, our study provides useful information regarding absorption, distribution, as well as excretion of tangeretin, which will provide a good base for studying the mechanism of its biological effects.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
A new strategy for choosing “Q-markers” via network pharmacology, application to the quality control of a Chinese medical preparation
Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Wei Xiang, Tong-Chuan Suo, Hua Yu, An-Ping Li, Shou-Qing Zhang, Chun-Hua Wang, Yan Zhu, Zheng LiAbstractDue to its chemical complexity, proper quality control for a Chinese medical preparation (CMP) has been a great challenge. Choosing the appropriate quality markers (Q-markers) for quality control of CMP is an important work. Best of all, the chosen Q-markers are the main chemical compounds from the herbals as well as the active constituents of this CMP. Only in this way the established quality control system can really ach...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
