Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata
Publication date: Available online 18 June 2018Source: Journal of Food and Drug AnalysisAuthor(s): Mei-Chuan Chen, Guei-Jane Wang, Yueh-Hsiung Kuo, Yin-Ru Chiang, Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei LeeAbstractSeven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Hantzsch pre-column derivatization for simultaneous determination of alendronate sodium and its pharmacopoeial related impurity: Comparative study with synchronous fluorometry using fluorescamine
Publication date: Available online 18 June 2018Source: Journal of Food and Drug AnalysisAuthor(s): Amira F. El-Yazbi, Eman I. El-Kimary, Rasha M. YoussefAbstractHigh performance liquid chromatographic (HPLC) method with a pre-column derivatization based on Hantzsch condensation reaction was applied for simultaneous determination of alendronate sodium (ALN) and its main related impurity, 4-Aminobutanoic acid (ABA) at its pharmacopeial limit. The separation of colored condensation products of ALN and ABA were achieved on Agilent Zobrax Eclipse SB-C18 analytical column (250 × 4.6 mm, 5 μm) using a mobile phase composed ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Paper based electrochemical biosensor using haemoglobin nanoparticles for detection of acrylamide in processed foods
We describe herein the construction of an electrochemical paper based device (EPAD) for detection of acrylamide, a carcinogen and neurotoxin generated during thermal processing of foods through Maillard reaction. To achieve it, haemoglobin (Hb) nanoparticles (NPs) were prepared by desolvation method and characterized by transmission electron microscopy, UV–visible spectroscopy, X-ray diffraction and atomic force microscopy (AFM). The HbNPs were drop casted onto PAD for electrochemical detection of acrylamide. The EPAD showed the optimum response within 2 s at pH 5.5 and 20 °C. The working range of EPAD was 0.1 nM–1...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Antioxidant activity, neuroprotective properties and bioactive constituents analysis of varying polarity extracts from Eucalyptus globulus leaves
Publication date: Available online 18 June 2018Source: Journal of Food and Drug AnalysisAuthor(s): Elena González-Burgos, Mindaugas Liaudanskas, Jonas Viškelis, Vaidotas Žvikas, Valdimaras Janulis, M. Pilar Gómez-SerranillosAbstractEucalyptus globulus is employed as herbal tea and therapeutical purposes. In this work, it is investigated for first time the neuroprotective activities, based on antioxidant properties, of varying polarity extracts (acetone, ethanol and methanol) from E. globulus leaves and elucidate their main bioactive constituents. Methanol and acetone extracts contained the highest phenolic compounds a...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice
Publication date: Available online 27 June 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yuzuru Iizuka, Hyounju Kim, Satoshi Hirako, Kanako Chiba, Masahiro Wada, Akiyo MatsumotoAbstractThe elderly patients with type 2 diabetes suffer more adverse drug events than young adults due to pharmacokinetic and pharmacodynamic changes associated with aging. Reducing the risks of these medication-related problems are equally important for the clinical care of older type 2 diabetes patients. Pioglitazone is used for treating type 2 diabetes as an oral antidiabetic drug. Despite pioglitazone is used helpful insulin sensitize...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Production of functional peptides with inhibition ability against angiotensin I-Converting enzyme using P. pastoris expression system
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Hsueh-Ming Tai, Ching-Chin Li, Chun-Yu Hung, Li-Jung YinAbstractTo obtain the angiotension-I converting enzyme inhibitor (ACEI), a fusion ACEI polypeptide encoded with 8 DNA sequences of GPL, GPM, IKW, IVY, IRPVQ, IWHHT, IYPRY and IAPG, which were selected and designed and cloned into pGAPZαC and then transformed into Pichia pastoris SMD1168H. After 3 days induction, the fraction with highest ACEI activity was expressed and purified using a Ni Sepharose™ 6 Fast Flow. The IC50 of recombinant ACEI polypeptide was 88.2 μM. ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
A feasible and practical 1H NMR analytical method for the quality control and quantification of bioactive principles in Lycii Fructus
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Li-Ying Hsieh, Hsiu-Hui Chan, Ping-Chung Kuo, Hsin-Yi Hung, Yue-Chiun Li, Chao-Lin Kuo, Yong Peng, Zhong-Zhen Zhao, Daih-Huang Kuo, I-Wen Sun, Tian-Shung WuAbstractLycii Fructus, a solanaceous drug, is widely used as functional foods and in Traditional Chinese Medicine. Samples collected from different regions of China have been found to be not identical in chemical compositions which might affect the biological activities. Although many chromatographic and spectrometric methods have been reported to determine the concentrati...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Quantitative and qualitative analyses of cytotoxic triterpenoids in the rhizomes of Anemone raddeana using HPLC and HPLC-ESI-Q/TOF-MS
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Ying Zhao, Xin Zhang, Chongning Lv, Yang Yu, Yu Zhang, Jincai LuAbstractAnemone raddeana Regel, a Traditional Chinese Medicine, has been demonstrated to possess cytotoxicity and anti-inflammatory activities. The purpose of this study is to establish analytical methods to identify and quantify the major active constituents in Anemone raddeana. A high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (HPLC-ESI-Q/TOF-MS) was used to identify the components i...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Comprehensive quality evaluation and comparison of Angelica sinensis radix and Angelica acutiloba radix by integrated metabolomics and glycomics
In this study, untargeted/targeted metabolomics and glycomics were integrated by multiple chromatography-based analytical techniques for qualitative and quantitative characterization of secondary metabolites and carbohydrates in Danggui so as to comprehensively evaluate and compare the quality of ASR and AAR. The results revealed that not only secondary metabolites but also carbohydrates in ASR and AAR were different in type and amount, which should collectively contribute to their quality difference. By providing more comprehensive chemical information, the research results highlighted the need to assess characteristics o...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Simultaneous analysis of 23 illegal adulterated aphrodisiac chemical ingredients in health foods and Chinese traditional patent medicines by ultrahigh performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Xiao-Bing Wang, Jing Zheng, Jun-Jie Li, Hai-Ying Yu, Qi-Yan Li, Li-Hua Xu, Ming-Jie Liu, Rui-Qing Xian, Yang-En Sun, Bing-Jie LiuAbstractThis paper presents an application of ultra high-performance liquid-chromatography-quadrupole-TOF high resolution mass spectrometry (UHPLC-Q-TOF HRMS) for simultaneous analysis of 23 illegal adulterated aphrodisiac type chemical ingredients in health foods and Chinese Traditional Patent Medicines (CTPMs). The mass spectrometer was operated in Information Dependent Acquisition (IDA) mode, whi...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Investigation of aflatoxins contamination in herbal materia medica in a Taiwan pharmaceutical factory
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Mei-Yin Chien, Chih-Min Yang, Chih-Min Huang, Chao-Hsiang ChenAbstractDuring the years 2005–2016, a total of 1067 samples for 24 types of herbal materia medica were investigated for the presence of aflatoxins (AFs) using immunoaffinity column cleanup and HPLC-coupled to a fluorescence detector after post-column derivatization. AFs were detected in 373 (35%) out of the total samples. Among them, Platycladi Semen (65% for total AFs and 79% for AFB1), Corydalis Rhizoma (53% for total AFs and 32% for AFB1), Corni Fructus (3% fo...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Comparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Fawzia Ibrahim, Asmaa Kamal El-Deen, Kuniyoshi ShimizuAbstractIn the present study, we compare the performance of two reversed-phase liquid chromatographic approaches using different eluents either conventional hydro-organic eluent or micellar one for simultaneous estimation of hydrocortisone acetate and pramoxine hydrochloride in presence of their degradants and process-related impurities; hydrocortisone and 4-butoxyphenol, respectively. For conventional reversed-phase liquid chromatography (RPLC), separation of the studied ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Enantioseparation of phenothiazines through capillary electrophoresis with solid phase extraction and polymer based stacking
This study developed a sensitive method involving capillary electrophoresis (CE) coupled with ultraviolet absorption for the simultaneous separation of chiral phenothiazine drugs at nanomolar concentration levels. The method consists of hydroxypropyl-γ-cyclodextrin (Hp-γ-CD) as a chiral selector and poly (diallyldimethylammonium chloride) (PDDAC)-based CE. Five pairs of d,l-phenothiazines were baseline separated using a background electrolyte containing 0.9% PDDAC, 5 mM Hp-γ-CD, and 100 mM tris(hydroxymethyl)aminomethane (Tris)-formate (pH 3.0). The five pairs were successfully stacked on the basis of the difference i...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction
Publication date: July 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 3Author(s): Ku-Chung Chen, Wen-Hsien Hsu, Jhih-Yun Ho, Cheng-Wei Lin, Cheng-Ying Chu, Chithan C. Kandaswami, Ming-Ting Lee, Chia-Hsiung ChengAbstractFlavonoids luteolin and quercetin can inhibit growth and metastasis of cancer cells. In our previous report, luteolin and quercetin was shown to block Akt/mTOR/c-Myc signaling. Here, we found luteolin and quercetin reduced protein level and transactivation activity of RPS19 in A431-III cells, which is isolated from parental A431 (A431-P) cell line. Further investigation the inhibitory mechan...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
Characterization of titanium dioxide and zinc oxide nanoparticles in sunscreen powder by comparing different measurement methods
In this study, we characterized metal oxide NPs according to size, shape, and composition as well as their aggregation/agglomeration characteristics. In order to comprehend quickly the characterization of metal oxide NPs, we employed single particle inductively coupled plasma (SP-ICPMS) to help quantify the size of metal oxide NPs; then, we use transmission electron microscopy (TEM) to corroborate the results. The crystal size and structure was measured by X-ray diffraction (XRD), there are two crystal phase of TiO2 NPs in sunscreen powder showed in XRD. However, SP-ICPMS proved highly effective in determining the size of ...
Source: Journal of Food and Drug Analysis - July 11, 2018 Category: Food Science Source Type: research
