Contents of Volume 152
Publication date: May 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 4 (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - May 2, 2015 Category: Pathology Source Type: research

Comparison of the Pathogenesis of Single or Dual Infections with Type 1 and Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Publication date: Available online 11 April 2015 Source:Journal of Comparative Pathology Author(s): K. Choi , J. Lee , C. Park , J. Jeong , C. Chae The aim of this study was to compare the pathogenicity of single or dual infections with type 1 and type 2 porcine reproductive and respiratory syndrome virus (PRRSV) in pigs. Pigs were inoculated intranasally with type 1 or type 2 PRRSV or both viruses together. Pigs infected with type 1 and type 2 PRRSV together had significantly (P <0.05) fewer genomic copies of type 1 PRRSV than did pigs infected with type 1 PRRSV alone. Pigs infected with type 2 PRRSV alone or typ...
Source: Journal of Comparative Pathology - April 12, 2015 Category: Pathology Source Type: research

CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice
This study expands on recently reported microscopical features of GvHD in NSG-hu-BLT mice and suggests a role for CD8+ T lymphocytes in the progression of the disease. NSG-hu-BLT mice represent an excellent model of GvHD, but its prevalence may compromise their use in other fields of biomedical research. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - April 11, 2015 Category: Pathology Source Type: research

Histopathological and Immunohistochemical Features of Atypical Epithelial Tumours of the Gland of the Third Eyelid in Seven Dogs
This report documents the histopathological and immunohistochemical features of atypical epithelial tumours of the gland of the third eyelid (GTE) in seven dogs. Cases 1 and 2 were diagnosed as myoepithelioma, comprising of compressive proliferations of interlacing bundles of neoplastic spindle cells expressing cytokeratin 14, p63, calponin and α-smooth muscle actin. Cases 3, 4 and 5 were diagnosed as complex carcinomas comprising of atypical glandular cells expressing cytokeratin 8/18, together with spindle-shaped or round neoplastic cells expressing cytokeratin 14, p63, calponin and α-smooth muscle actin. Cas...
Source: Journal of Comparative Pathology - April 10, 2015 Category: Pathology Source Type: research

Classification and Epidemiology of Mammary Tumours in Pet Rabbits (Oryctolagus cuniculus)
This study reports basic data on type and location of 119 separate tumours from 109 pet rabbits. The animals were aged 2–14 years (mean 5.5 years) and all 90 rabbits of known gender were female. Cranial and caudal mammary glands were affected equally. The majority of lesions (n = 105) were classified as carcinomas with 32 tubular, 16 papillary, 12 tubulopapillary, 11 solid, nine adenosquamous, nine comedo type, five complex, four ductal, three cribriform, three anaplastic and one spindle -cell carcinoma. Twelve percent of the lesions were benign, with eight intraductal papillary adenomas, three simple tubul...
Source: Journal of Comparative Pathology - April 3, 2015 Category: Pathology Source Type: research

Dental and Temporomandibular Joint Pathology of the Northern Fur Seal (Callorhinus ursinus)
Publication date: Available online 29 March 2015 Source:Journal of Comparative Pathology Author(s): M.T. Aalderink , H.P. Nguyen , P.H. Kass , B. Arzi , F.J.M. Verstraete Skulls from 145 northern fur seals (Callorhinus ursinus) were examined macroscopically according to predefined criteria. The museum specimens were acquired from strandings along the west coast of the USA between 1896 and 2008. Seventy-one skulls (49.0%) were from male animals, 56 (38.6%) from female animals and 18 (12.4%) from animals of unknown sex. Their age varied from juvenile to adult, with 58 adult animals (40.0%) and 87 juvenile animals (60.0%). ...
Source: Journal of Comparative Pathology - March 31, 2015 Category: Pathology Source Type: research

The Swiss Canine Cancer Registry: A Retrospective Study on the Occurrence of Tumours in Dogs in Switzerland from 1955 to 2008
This study presents the Swiss Canine Cancer Registry, containing case data compiled between 1955 and 2008. The data consist of pathology diagnostic records issued by three veterinary diagnostic laboratories in Switzerland. The tumours were classified according to the guidelines of the International Classification of Oncology for Humans on the basis of tumour type, malignancy and body location. The dogs were classified according to breed, age, sex, neuter status and place of residence. The diagnostic data were correlated with data on the Swiss general dog population and the incidence of cancer in dogs was thus investigated....
Source: Journal of Comparative Pathology - March 30, 2015 Category: Pathology Source Type: research

Renal Lesions in Cetaceans from Brazil
This study reports the occurrence of renal lesions in cetaceans from the coast of Brazil subjected to necropsy examination between 1996 and 2011. The animals (n = 192) were by-caught in fishing nets, were found dead on beaches or died despite attempted rehabilitation. Kidney samples were evaluated grossly and microscopically and, depending on the histopathological findings, immunohistochemical and ultrastructural analyses were conducted. Due to autolysis, a diagnosis was reached in only 128 animals, of which 82 (64.1%) had kidney lesions. Cystic renal disease was the most common lesion observed in 34 cases (26.6%...
Source: Journal of Comparative Pathology - March 30, 2015 Category: Pathology Source Type: research

Dental and Temporomandibular Joint Pathology of the Eastern Pacific Harbour Seal (Phoca vitulina richardii)
Publication date: Available online 29 March 2015 Source:Journal of Comparative Pathology Author(s): M.T. Aalderink , H.P. Nguyen , P.H. Kass , B. Arzi , F.J.M. Verstraete Skulls from 214 Eastern Pacific harbour seals (Phoca vitulina richardii) were examined macroscopically according to predefined criteria. The museum specimens were acquired from strandings along the west coast of the USA between 1909 and 2014. Ninety-eight skulls (45.8%) were from male animals, 108 (50.5%) from female animals and eight (3.7%) from animals of unknown sex. Their age varied from neonate to adult, with 101 adult animals (47.2%), 93 juvenile ...
Source: Journal of Comparative Pathology - March 30, 2015 Category: Pathology Source Type: research

Prototheca zopfii Genotype 2-induced Nasal Dermatitis in a Cat
This report describes Prototheca zopfii genotype 2-induced inflammation of the nasal skin and cutaneous mucosa of the right nostril in a 14-year-old neutered female domestic shorthair cat. Microscopical examination revealed marked pyogranulomatous inflammation with numerous intralesional algae. These had a round to ovoid shape, were 8–21 μm in diameter, formed endospores and displayed a positive immunoreaction for Prototheca zopfii antigen. By 18S rRNA gene amplification and sequencing the intralesional algae were confirmed as Prototheca zopfii and further characterized as Prototheca zopfii genotype 2. This c...
Source: Journal of Comparative Pathology - March 24, 2015 Category: Pathology Source Type: research

Prioritization of Companion Animal Transmissible Diseases for Policy Intervention in Europe
In this study, available epidemiological data for diseases transmissible from companion animals to man were analysed with the aim of developing a procedure suitable for their prioritization within a European framework. A new method and its associated questionnaire and scoring system were designed based on methods described by the World Organisation for Animal Health (OIE). Modifications were applied to allow for the paucity of specific information on companion animal transmissible diseases. The OIE method was also adapted to the subject and to the regional scope of the interprofessional network addressing zoonotic diseases...
Source: Journal of Comparative Pathology - March 24, 2015 Category: Pathology Source Type: research

Left Retrocaval Ureter around the Ipsilateral Limb of a Double Caudal Vena Cava in a Cat
Publication date: Available online 20 March 2015 Source:Journal of Comparative Pathology Author(s): C. Casteleyn , P. Cornillie , S. Van Cruchten , C. Van Ginneken Necropsy examination of an adult neutered male cat, which was humanely destroyed as it had feline immunodeficiency virus (FIV) infection, demonstrated the presence of a left retrocaval ureter that was entrapped around the left limb of a double caudal vena cava. These associated anomalies originate from the complex embryofetal development of the caudal vena cava. Since no clinical signs had been reported and no gross lesions related to this anomaly were observe...
Source: Journal of Comparative Pathology - March 23, 2015 Category: Pathology Source Type: research

Evaluation of the Relationship between Selected Reticulocyte Parameters and Inflammation determined by Plasma C-reactive Protein in Dogs
Publication date: Available online 21 March 2015 Source:Journal of Comparative Pathology Author(s): A. Meléndez-Lazo , A. Tvarijonaviciute , J.J. Cerón , M. Planellas , J. Pastor Anaemia secondary to inflammatory disease is one of the main causes of anaemia in veterinary and human medicine and impairment of iron homeostasis due to the release of pro-inflammatory cytokines is one of the aetiological mechanisms involved. Because reticulocytes are recently produced cells, reticulocyte indices are early indicators of iron deficiency anaemia in man and dogs and reticulocyte indices may be affected during the cou...
Source: Journal of Comparative Pathology - March 23, 2015 Category: Pathology Source Type: research

Morphological Changes in Amphibian and Fish Cell Lines Infected with Andrias davidianus Ranavirus
Publication date: Available online 26 February 2015 Source:Journal of Comparative Pathology Author(s): X.C. Gao , Z.Y. Chen , J.D. Yuan , Q.Y. Zhang Andrias davidianus ranavirus (ADRV) is an emerging viral pathogen that causes severe disease in Chinese giant salamanders, the largest extant amphibian in the world. A fish cell line, Epithelioma papulosum cyprinid (EPC), and a new amphibian cell line, Chinese giant salamander spleen cell (GSSC), were infected with ADRV and observed by light and electron microscopy. The morphological changes in these two cell lines infected with ADRV were compared. Cytopathic effect (CPE) be...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

Angiofibroma in a Cockatiel (Nymphicus hollandicus)
Publication date: Available online 26 February 2015 Source:Journal of Comparative Pathology Author(s): G.A. Doss , J.L. Miller , H. Steinberg , C. Mans Human angiofibromas are rare and arise typically in the nasopharynx. In veterinary medicine they have only been described in the dog. Microscopically, angiofibromas consist of irregular groups of blood vessels within a stroma of connective tissue, with oedema and secondary inflammation often present. A cockatiel (Nymphicus hollandicus) was presented with an oral mass that consisted of aggregates of blood vessels surrounded by a connective tissue stroma, with the presence ...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

Lack of Correlation between Mucosal Immunoglobulin A-positive Plasma Cell Numbers and TLR5 Genotypes in German Shepherd Dogs with Idiopathic Chronic Enteropathy
Publication date: Available online 27 February 2015 Source:Journal of Comparative Pathology Author(s): A. Lee , A. Kathrani , S.L. Priestnall , K. Smith , D. Werling , K. Allenspach It has been suggested previously that a deficiency in mucosal immunoglobulin (Ig) A production could be involved in the pathogenesis of chronic enteropathy in German shepherd dogs (GSDs). Recent research has shown that single nucleotide polymorphisms in the gene encoding Toll-like receptor (TLR)-5 are associated with an increased risk of development of chronic idiopathic enteropathy in this breed. IgA is essential for mucosal immunity and stu...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

The CALLISTO Project: A Summary
Publication date: Available online 27 February 2015 Source:Journal of Comparative Pathology Author(s): M.J. Day The European Union (EU) Framework 7-funded project entitled CALLISTO (Companion Animal multisectoriaL interprofessionaL and interdisciplinary Strategic Think tank On zoonoses) ran between 2012 and 2014 and investigated zoonotic infectious diseases transmitted between companion animals and man and food producing animals. There are large numbers of companion animals throughout Europe and these animals, of varied species, play an integral role in human society, providing very real human health and welfare benefits...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

Pyogranulomatous Panniculitis in Ferrets (Mustela putorius furo) with Intralesional Demonstration of Pseudomonas luteola
Publication date: Available online 27 February 2015 Source:Journal of Comparative Pathology Author(s): B. Baum , B. Richter , M. Reifinger , A. Klang , C. Finnberg , I. Loncaric , J. Spergser , T. Eisenberg , F. Künzel , S. Preis , N. Pantchev , B. Rütgen , A. Guija de Arespacochaga , M. Hewicker-Trautwein One ferret (Mustela putorius furo) from Finland and two ferrets from Austria, aged 1–4.5 years and of both genders, were presented with pyogranulomatous subcutaneous inflammation affecting the inguinal, preputial and femoral regions, respectively. Histologically, microorganisms were detected within the ...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

High-grade Astrocytoma (Glioblastoma Multiforme) in an Atlantic Spotted Dolphin (Stenella frontalis)
This report describes the gross, microscopical and immunohistochemical features of a high-grade astrocytoma (glioblastoma multiforme) in an adult male Atlantic spotted dolphin (Stenella frontalis). On necropsy examination, a 5 × 2.5 × 2 cm, poorly demarcated, red, friable and locally expansile mass effaced the thalamus and the left periventricular region and extended to the left lateral ventricle of the brain. Microscopically, the mass consisted of haphazardly arranged bundles and rows of interweaving polygonal to spindle-shaped cells. These often palisaded along serpentine foci of necr...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

Multiple Intra-abdominal Serosal Myxosarcomas in Two Koalas (Phascolarctos cinereus)
Publication date: Available online 27 February 2015 Source:Journal of Comparative Pathology Author(s): V. González Astudillo , A. Schaffer-White , R. Allavena , C. Palmieri Two adult koalas (Phascolarctos cinereus) were presented for necropsy examination without any clinical history. A diffuse, severe gelatinous effusion was found in the abdominal cavity, while numerous 1–3 mm diameter, round, well-demarcated, multifocal to coalescing, raised, firm nodules containing a clear gelatinous fluid were scattered on the surface of the parietal peritoneum, diaphragm, liver, gastrointestinal tract and mesentery....
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

Immunohistochemical Labelling of Cytokines in Calves Infected Experimentally with Mycoplasma bovis
Publication date: Available online 27 February 2015 Source:Journal of Comparative Pathology Author(s): F. Rodríguez , P. Castro , J.B. Poveda , A.M. Afonso , A. Fernández To gain further insight into the pathogenesis of Mycoplasma bovis-associated pneumonia, cytokine expression in different pulmonary compartments was examined. The expression of tumour necrosis factor (TNF)-α, interleukin (IL)-4 and interferon (IFN)-γ was examined immunohistochemically in the lung of 10 calves infected experimentally with M. bovis. M. bovis antigen was located in respiratory epithelial cells and within inflammato...
Source: Journal of Comparative Pathology - March 3, 2015 Category: Pathology Source Type: research

Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes
Publication date: Available online 7 February 2015 Source:Journal of Comparative Pathology Author(s): B. Banco , C. Giudice , G. Ghisleni , S. Romussi , D.K. Behar , V. Grieco Mixed germ cell sex cord stromal tumours (MGSCTs) are composed of seminiferous tubules, filled with admixed neoplastic Sertoli cells (SCs) and germ cells (GCs). The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenotype of the neoplastic GCs and SCs. Neoplastic SCs were always diffusely labelled for vimentin (VIM), neuron specific enolase (NSE), inhibin (INH)-&alpha...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Validation of Tissue Microarray for Molecular Profiling of Canine and Feline Mammary Tumours
Publication date: Available online 7 February 2015 Source:Journal of Comparative Pathology Author(s): L.V. Muscatello , G. Sarli , G. Beha , P. Asproni , F. Millanta , A. Poli , L.J. De Tolla , C. Benazzi , B. Brunetti Tissue microarray (TMA) is a high-throughput method adopted for simultaneous molecular profiling of tissue samples from large patient cohorts. The aim of this study was to validate the TMA method for the molecular classification of canine and feline mammary tumours. Twelve samples, five feline and five canine mammary tumours and two canine haemangiosarcomas, were collected. TMA construction was based ...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Subspectacular Nematodiasis Caused by a Novel Serpentirhabdias species in Ball Pythons (Python regius)
Publication date: Available online 7 February 2015 Source:Journal of Comparative Pathology Author(s): J.C. Hausmann , C. Mans , J. Dreyfus , D.R. Reavill , A. Lucio-Forster , D.D. Bowman Subspectacular nematodiasis was diagnosed in three captive-bred juvenile ball pythons (Python regius) from two unrelated facilities within a 6-month period. The snakes were presented with similar lesions, including swelling of facial, periocular and oral tissues. Bilaterally, the subspectacular spaces were distended and filled with an opaque fluid, which contained nematodes and eggs. Histopathology showed nematodes throughout the periocu...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Activation of Mammalian Target of Rapamycin in Canine Mammary Carcinomas: An Immunohistochemical Study
Publication date: Available online 7 February 2015 Source:Journal of Comparative Pathology Author(s): L. Delgado , F. Gärtner , P. Dias Pereira Mammalian target of rapamycin (mTOR) is a serine–threonine kinase involved in cell growth, proliferation and survival. Activation of mTOR has been reported in various tumour types, including human breast cancer; however, the expression of mTOR in canine mammary tumours has not been examined. In the present study, expression of the activated form of mTOR (phospho-mTOR [p-mTOR]) was examined immunohistochemically in five normal canine mammary glands, 45 canine mammary ca...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Immunohistochemical Labelling of Cyclooxygenase-2 in Lung Lesions of Calves Infected with Mycoplasma bovis
This study evaluated COX-2 expression immunohistochemically in the inflammatory lesions of calves with naturally occurring and experimentally induced Mb pneumonia. Experimentally infected lungs showed catarrhal bronchointerstitial pneumonia and varying degrees of peribronchiolar mononuclear cell cuffing. Lesions in calves with spontaneously arising disease included exudative bronchopneumonia and extensive foci of coagulative necrosis surrounded by inflammatory cells. Mb antigen was located in epithelial and inflammatory cells in the airway lumina and surrounding areas of necrosis. COX-2 protein was detected in the lung of ...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ Mice
This study expands on recently reported microscopical features of GvHD in NSG-hu-BLT mice and suggests a role for CD8+ T lymphocytes in the progression of the disease. NSG-hu-BLT mice represent an excellent model of GvHD, but its prevalence may compromise their use in other fields of biomedical research. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Neuroendocrine Carcinoma of the Mammary Gland in a Dog
Publication date: Available online 7 February 2015 Source:Journal of Comparative Pathology Author(s): R. Nakahira , M. Michishita , H. Yoshimura , H. Hatakeyama , K. Takahashi A 10-year-old female border collie was presented with a mass (2 cm diameter) in the fifth mammary gland. The mass was located in the subcutis and the cut surface was grey–white in colour. Microscopically, the mass was composed of tumour cells arranged in nests of various sizes separated by delicate fibrovascular stroma. The tumour cells had small, round hypochromatic nuclei and abundant cytoplasm. Metastases were observed in the inguinal...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Mismatch Repair mRNA and Protein Expression in Intestinal Adenocarcinoma in Sika Deer (Cervus nippon) Resembling Heritable Non-polyposis Colorectal Cancer in Man
Publication date: Available online 9 February 2015 Source:Journal of Comparative Pathology Author(s): H. Jahns , J.A. Browne Intestinal adenocarcinomas seen in an inbred herd of farmed sika deer (Cervus nippon) morphologically resembled human hereditary non-polyposis colorectal cancer (HNPCC). Features common to both included multiple de novo sites of tumourigenesis in the proximal colon, sessile and non-polyposis mucosal changes, the frequent finding of mucinous type adenocarcinoma, lymphocyte infiltration into the neoplastic tubules and Crohn's-like lymphoid follicles at the deep margin of the tumour. HNPCC is defined ...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Comparison of Experimental Infection with Northern and Southern Vietnamese Strains of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
Publication date: Available online 9 February 2015 Source:Journal of Comparative Pathology Author(s): T.D. Do , C. Park , K. Choi , J. Jeong , T.T. Nguyen , D.Q. Nguyen , T.H. Le , C. Chae The aim of this study was to compare the virulence of northern and southern Vietnamese strains of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) as assessed by the level of viral replication, gross and microscopical lung lesions and virus distribution in experimentally infected pigs. The northern and southern Vietnamese HP-PRRSV strains share 96.7% (non-structural protein 2) and 99.3% (open reading fra...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Positive Immunolabelling for Feline Infectious Peritonitis in an African Lion (Panthera leo) with Bilateral Panuveitis
Publication date: Available online 9 February 2015 Source:Journal of Comparative Pathology Author(s): M. Mwase , K. Shimada , C. Mumba , J. Yabe , D. Squarre , H. Madarame A 15-year-old male African lion (Panthera leo) was presented with blindness due to bilateral panuveitis with retinal detachment. Feline coronavirus (FCoV) antigen was identified immunohistochemically in ocular macrophages, consistent with a diagnosis of feline infectious peritonitis (FIP) infection. This is the first report of FIP in an African lion and the first report of ocular FIP in a non-domestic felid. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population
This study suggests that high proliferative activity and peripheral invasion should be considered the most significant parameters for the differentiation between benign and malignant sebaceous gland tumours. Furthermore, the incidence of circumanal gland and testicular tumours in these dogs was significantly higher compared with an age-matched control population, suggesting a potential androgen-related pathway for the tumourigenesis of canine sebaceous gland neoplasms. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Isolation and Phylogenetic Characterization of Streptococcus halichoeri from a European Badger (Meles meles) with Pyogranulomatous Pleuropneumonia
This report represents the third description of this bacterium and the first in an animal species other than the grey seal (Halichoerus grypus). It also shows that S. halichoeri can be associated with a pathological process characterized by granulomatous inflammation and resembling tuberculosis. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Pathology of a Bohle-like Virus Infection in Two Australian Frog Species (Litoria splendida and Litoria caerulea)
Publication date: Available online 9 February 2015 Source:Journal of Comparative Pathology Author(s): I.V. Jerrett , R.J. Whittington , R.P. Weir Gross and histopathological examination was performed on seven captive magnificent tree frogs (Litoria splendida) and one green tree frog (Litoria caerulea) that had died or been humanely destroyed while naturally infected with Mahaffey Road virus, a Bohle iridovirus-like ranavirus. Necropsy examination revealed skin lesions consisting of multiple small pale or haemorrhagic papules and ulcers in most frogs. Other common gross findings were perineural haemorrhage affecting the s...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Reconstruction of Canine Diffuse Large B-cell Lymphoma Gene Regulatory Network: Detection of Functional Modules and Hub Genes
This study reports the construction of a comprehensive gene regulatory network (GRN) for canine diffuse large B-cell lymphoma (DLBCL), the most common type of canine lymphoma, and performs analysis for detection of major functional modules and hub genes (the most important genes in a GRN). The canine DLBCL GRN was reconstructed from gene expression data (NCBI GEO dataset: GSE30881) using the STRING and MiMI interaction databases. Reconstructed GRNs were then assessed, using various bioinformatics programmes, in order to analyze network topology and identify major pathways and hub genes. The resultant network from both inte...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Ehlers–Danlos Syndrome Associated with Fatal Spontaneous Vascular Rupture in a Dog
Publication date: Available online 10 February 2015 Source:Journal of Comparative Pathology Author(s): M. Uri , R. Verin , L. Ressel , L. Buckley , N. McEwan A 7-month-old male cross breed dog was presented with hyperextensible skin and atrophic scarring. A diagnosis of Ehlers–Danlos syndrome was made based on clinical signs, histopathology and electron microscopy. Two weeks after presentation, the dog died suddenly. Post-mortem examination revealed haemothorax and rupture of the left subclavian artery. Histological findings, including Goldner's modified Masson's trichrome staining and transmission electron microsc...
Source: Journal of Comparative Pathology - February 13, 2015 Category: Pathology Source Type: research

Mycobacterium tuberculosis Infection in Captive White Rhinoceroses (Ceratotherium simum simum)
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): E. Karlstam , E. Ågren , T. Möller , G. Ramis , G. Bölske , B. Röken , K. Lyashchenko , D. Gavier-Widén (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

No evidence of Sarcocystis Calchasi involvement in meningoencephalitis of unknown origin in mammals
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): A. Żuraw , S. Plog , R. Klopfleisch , P. Olias , A.D. Gruber (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Mers coronavirus infection of rabbits
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): J.M.A. van den Brand , B.L. Haagmans , L.B. Provacia , V.S. Raj , K.J. Stittelaar , S. Getu , L. de Waal , T.M. Bestebroer , G. van Amerongen , G.M.G.M. Verjans , R.A.M. Fouchier , S.L. Smits , T. Kuiken , A.D.M.E. Osterhaus (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Retrospective molecular study of canine infectious haemolytic anaemias
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): A. Beck , D. Huber , M. Antolić , Ž. Anzulović , I. Reil , R. Beck (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Clinical, macroscopic and histological features of contagious ovine digital dermatitis (Codd)
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): R. Blundell , J.W. Angell , D.H. Grove-White , J.S. Duncan (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Outbreak of ranaviral disease in imported newt from China
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): Y. Une , E. Ri , M. Katou , M. Murakami (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Shedding of infectious borna disease virus in living bicoloured white-toothed shrews
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): D. Nobach , M. Bourg , S. Herzog , H. Lange-Herbst , J.A. Encarnação , M. Eickmann , C. Herden (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Comparison between Abv2 and Abv4 distribution patterns in experimentally infected cockatiels
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): B. Al-Ibadi , A. Piepenbring , S. Herzog , U. Heffels-Redmann , D. Enderlein , M. Lierz , C. Herden (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Effect of Glucan and Low Doses of T-2 Toxin on Mucin, IgA Expression and IgA+ Lymphocytes in the Intestine of Chickens
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): M. Levkut Jr. , V. Revajová , R. Herich , M. Levkutová , Z. Ševčíková , M. Levkut (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Morphological Evaluation of the Liver in Rainbow Trout (Oncorhynchus mykiss Walbaum, 1972) after Kynurenic Acid Exposure
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): J. Szarek , E. Terech-Majewska , E. Kaczorek , A.K. Siwicki , I. Babin′ska , E. Strzy ewska , K. Dublan , J. Małaczewska , R. Wójcik , P. Schulz (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Haemorrhagic Equine Anovulatory Follicles: Surgical Biopsy and Autopsy Specimen
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): J.F. Edwards (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Pathogenic Influence of Deltamethrin on Innate Immunity in Fish
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): E. Kaczorek , A.K. Siwicki , P. Schulz , J. Małaczewska , E. Terech-Majewska , R. Wójcik (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Fumonisin Toxicosis in Horses
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): M. Jovanovic′ , S. Nešic′ , D. Marinkovic′ , V. Kukolj , D. Trailovic′ (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research

Expansion of regulatory T cells in theiler’s murine encephalomyelitis virus-infected C57BL/6 mice
Publication date: January 2015 Source:Journal of Comparative Pathology, Volume 152, Issue 1 Author(s): M.A. Khan , V. Herder , J. Huehn , R. Teich , W. Baumgärtner , A. Beineke (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - January 29, 2015 Category: Pathology Source Type: research