National Comprehensive Cancer Network Recommendations on Molecular Profiling of Advanced Bladder Cancer [SPECIAL ARTICLE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Pal, Agarwal, Boorjian, Hahn, Siefker-Radtke, Clark, Plimack Tags: Diagnosis & Staging, Chemotherapy, Translational Oncology SPECIAL ARTICLE Source Type: research
Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline [ASCO SPECIAL ARTICLE]
Purpose
To provide evidence-based guidance on the optimum management of chronic pain in adult cancer survivors.
Methods
An ASCO-convened expert panel conducted a systematic literature search of studies investigating chronic pain management in cancer survivors. Outcomes of interest included symptom relief, pain intensity, quality of life, functional outcomes, adverse events, misuse or diversion, and risk assessment or mitigation.
Results
A total of 63 studies met eligibility criteria and compose the evidentiary basis for the recommendations. Studies tended to be heterogeneous in terms of quality, size, and populations. Pr...
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Paice, Portenoy, Lacchetti, Campbell, Cheville, Citron, Constine, Cooper, Glare, Keefe, Koyyalagunta, Levy, Miaskowski, Otis-Green, Sloan, Bruera Tags: Pain Control, ASCO Guidelines, Quality of Life, Pain Control ASCO SPECIAL ARTICLE Source Type: research
Effects of Organizational Characteristics on Outcomes and Resource Use in Patients With Cancer Admitted to Intensive Care Units [Health Services and Outcomes]
Conclusion
Organizational aspects, namely the implementation of protocols and presence of clinical pharmacists in the ICU, and close collaboration between oncologists and ICU teams are targets to improve mortality and resource use in critically ill patients with cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Soares, Bozza, Azevedo, Silva, Correa, Colombari, Torelly, Varaschin, Viana, Knibel, Damasceno, Espinoza, Ferez, Silveira, Lobo, Moraes, Lima, de Carvalho, do Brasil, Kahn, Angus, Salluh Tags: Prognostic Studies, Quality of Care, Outcomes Research, Supportive Care Health Services and Outcomes Source Type: research
Subtype-Dependent Relationship Between Young Age at Diagnosis and Breast Cancer Survival [Breast Cancer]
Conclusion
The effect of age on survival of women with early breast cancer seems to vary by breast cancer subtype. Young age seems to be particularly prognostic in women with luminal breast cancers. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Partridge, Hughes, Warner, Ottesen, Wong, Edge, Theriault, Blayney, Niland, Winer, Weeks, Tamimi Tags: Epidemiology, Hormonal Therapy Breast Cancer Source Type: research
Modified FOLFOX6 With or Without Radiation Versus Fluorouracil and Leucovorin With Radiation in Neoadjuvant Treatment of Locally Advanced Rectal Cancer: Initial Results of the Chinese FOWARC Multicenter, Open-Label, Randomized Three-Arm Phase III Trial [Gastrointestinal Cancer]
Conclusion
mFOLFOX6-based preoperative chemoradiotherapy results in a higher pCR rate than fluorouracil-based treatment. Perioperative mFOLFOX6 alone had inferior results and a lower pCR rate than chemoradiotherapy but led to a similar downstaging rate as fluorouracil-radiotherapy, with less toxicity and fewer postoperative complications. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Deng, Chi, Lan, Wang, Chen, Cui, Chen, Cao, Wei, Peng, Huang, Cai, Zhao, Huang, Xu, Zhou, Wei, Zhang, Zheng, Huang, Zhou, Cai, Kang, Huang, Peng, Ren, Wang Tags: Clinical Trials, Surgery, Radiation, Chemotherapy, Combined Modality Gastrointestinal Cancer Source Type: research
Bendamustine in Combination With Gemcitabine and Vinorelbine Is an Effective Regimen As Induction Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma: Final Results of a Multicenter Phase II Study [Hematologic Malignancy]
Conclusion
This phase II study demonstrates that BeGEV is an effective salvage regimen able to induce CR in a high proportion of patients with relapsed or refractory HL before ASCT. These data provide a strong rationale for further development of the BeGEV regimen. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Santoro, Mazza, Pulsoni, Re, Bonfichi, Zilioli, Salvi, Merli, Anastasia, Luminari, Annechini, Gotti, Peli, Liberati, Di Renzo, Castagna, Giordano, Carlo-Stella Tags: Leukemia Hematologic Malignancy Source Type: research
Considering Bone Marrow Blasts From Nonerythroid Cellularity Improves the Prognostic Evaluation of Myelodysplastic Syndromes [Hematologic Malignancy]
Conclusion
Regardless of the presence of erythroid hyperplasia, calculating the percentage of BM blasts from NECs improves prognostic assessment of MDS. This fact should be considered in future WHO classification reviews. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Arenillas, Calvo, Luno, Senent, Alonso, Ramos, Ardanaz, Pedro, Tormo, Marco, Montoro, Diez-Campelo, Brunet, Arrizabalaga, Xicoy, Andreu, Bonanad, Jerez, Nomdedeu, Ferrer, Sanz, Florensa Tags: Epidemiology, Diagnosis & Staging Hematologic Malignancy Source Type: research
Changes in Clinical Context for Kaposi's Sarcoma and Non-Hodgkin Lymphoma Among People With HIV Infection in the United States [AIDS-Related Cancer]
Conclusion
Over time, KS and NHL occurred at higher CD4 counts and lower HIV RNA values, and KS occurred more frequently after ART initiation. These changes were driven by an increasing proportion of patients with HIV who received effective ART, had higher CD4 counts, and had suppressed HIV RNA and not by increases in cancer risk within these subgroups. An improved understanding of HIV-associated cancer pathogenesis and outcomes in the context of successful ART is therefore important. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Yanik, Achenbach, Gopal, Coghill, Cole, Eron, Moore, Mathews, Drozd, Hamdan, Ballestas, Engels Tags: Incidence trends, Population and observational studies (SEER, WHI observational, etc.), Epidemiology, Diagnosis & Staging, Epidemiology, Diagnosis & Staging, Rhabdo & Other Soft Tissue Sarcomas: AIDS-Related Cancer Source Type: research
Survival Analyses of Patients With Metastatic Renal Cancer Treated With Targeted Therapy With or Without Cytoreductive Nephrectomy: A National Cancer Data Base Study [Urologic Oncology]
Conclusion
CN is performed in three of 10 patients with mRCC who are receiving TT. Several patient and sociodemographic characteristics were associated with receipt of CN. When feasible, CN may offer an OS benefit when combined with TT. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Hanna, Sun, Meyer, Nguyen, Pal, Chang, de Velasco, Trinh, Choueiri Tags: Surgery, Chemotherapy, Combined Modality Urologic Oncology Source Type: research
Randomized Phase II Trial of Gefitinib With and Without Pemetrexed as First-Line Therapy in Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations [Thoracic Oncology]
Conclusion
P+G improved PFS compared with gefitinib alone in East Asian patients with advanced NS NSCLC and activating EGFR mutations. This combination may offer EGFR mutation–positive patients new treatment options and improved clinical outcomes compared with the current standard of care. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Cheng, Murakami, Yang, He, Nakagawa, Kang, Kim, Wang, Enatsu, Puri, Orlando, Yang Tags: Chemotherapy Thoracic Oncology Source Type: research
Randomized Phase III Study Comparing Gefitinib With Erlotinib in Patients With Previously Treated Advanced Lung Adenocarcinoma: WJOG 5108L [Thoracic Oncology]
Conclusion
The study did not demonstrate noninferiority of gefitinib compared with erlotinib in terms of PFS in patients with lung adenocarcinoma according to the predefined criteria. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Urata, Katakami, Morita, Kaji, Yoshioka, Seto, Satouchi, Iwamoto, Kanehara, Fujimoto, Ikeda, Murakami, Daga, Oguri, Goto, Imamura, Sugawara, Saka, Nogami, Negoro, Nakagawa, Nakanishi Tags: Chemotherapy Thoracic Oncology Source Type: research
Endocrine Abnormalities in Aging Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study [Rapid Communication]
Conclusion
Endocrinopathies in survivors increased substantially over time, underscoring the need for lifelong subspecialty follow-up of those at risk. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Mostoufi-Moab, Seidel, Leisenring, Armstrong, Oeffinger, Stovall, Meacham, Green, Weathers, Ginsberg, Robison, Sklar Tags: Long Term Survival & Late Effects, Rapid Communications, Rapid Communications Source Type: research
Estimating the Influence of Obesity on Cancer Risk: Stratification by Smoking Is Critical [COMMENTS AND CONTROVERSIES]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Song, Giovannucci Tags: Behavioral and Lifestyle Risk Factors, Population and observational studies (SEER, WHI observational, etc.) COMMENTS AND CONTROVERSIES Source Type: research
Is Underutilization of Cytoreductive Nephrectomy in Patients With Metastatic Renal Cancer Contributing to Inferior Survival? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Molina, Hu, Nanus Tags: Surgery, Combined Modality EDITORIALS Source Type: research
Evolving Landscape of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 12, 2016 Category: Cancer & Oncology Authors: Kao, Boyer Tags: Translational Oncology EDITORIALS Source Type: research
