Targeted Combinations for Hormone Receptor-Positive Advanced Breast Cancer: Who Benefits? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Johnston Tags: Combined Modality, Hormonal Therapy, Translational Oncology, Breast Cancer EDITORIALS Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

Ruxolitinib Enhances Platelet Production in Patients With Thrombocytopenic Myelofibrosis [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Grunwald, Spivak Tags: Biological Therapy DIAGNOSIS IN ONCOLOGY Source Type: research

Epidermal Growth Factor Receptor P753S Mutation in Cutaneous Squamous Cell Carcinoma Responsive to Cetuximab-Based Therapy [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Ganesan, Ali, Wang, Blumenschein, Esmaeli, Wolff, Miller, Stephens, Ross, Palmer, Janku Tags: Translational Oncology, Diagnosis & Staging, Gene Expression and Profiling, Phase I and Clinical Pharmacology DIAGNOSIS IN ONCOLOGY Source Type: research

Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Lamm, Schiefer, Nobauer, Horvat, Speiser, Kostler Tags: Chemotherapy, Unknown Primary Site and Rare Cancers DIAGNOSIS IN ONCOLOGY Source Type: research

Reply to S. Iwase et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Hofheinz, Burkholder, Schneeweiss Tags: CORRESPONDENCE Source Type: research

Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Iwase, Ishiki, Watanabe, Shimada, Chiba, Kinkawa, Tojo Tags: CORRESPONDENCE Source Type: research

Reply to L. Dal Maso et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Coghill, Shiels, Suneja, Engels Tags: CORRESPONDENCE Source Type: research

All-Cause and Cancer-Specific Mortality Among Patients With Cancer Infected or Not Infected With HIV [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Dal Maso, Serraino Tags: CORRESPONDENCE Source Type: research

Reply to A. Addeo and A. Bahl [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Scher, Heller, Molina, Kheoh, de Bono Tags: CORRESPONDENCE Source Type: research

Do All High- and Intermediate-Risk Patients With Metastatic Castration-Resistant Prostate Cancer Really Benefit From Abiraterone? [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Addeo, Bahl Tags: CORRESPONDENCE Source Type: research

Antiemetics: American Society of Clinical Oncology Focused Guideline Update [ASCO SPECIAL ARTICLE]
Purpose To update a key recommendation of the American Society of Clinical Oncology antiemetic guideline. This update addresses the use of the oral combination of netupitant (a neurokinin 1 [NK1] receptor antagonist) and palonosetron (a 5-hydroxytryptamine-3 [5-HT3] receptor antagonist) for the prevention of acute and delayed nausea and vomiting in patients receiving chemotherapy. Methods An update committee conducted a targeted systematic literature review and identified two phase III clinical trials and a randomized phase II dose-ranging study. Results In one phase III trial, the oral combination of netupitant and palo...
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Hesketh, Bohlke, Lyman, Basch, Chesney, Clark-Snow, Danso, Jordan, Somerfield, Kris Tags: Emesis, ASCO Guidelines, Quality of Life, Quality of Care, Emesis ASCO SPECIAL ARTICLE Source Type: research

Mind the Gap: Why Closing the Doughnut Hole Is Insufficient for Increasing Medicare Beneficiary Access to Oral Chemotherapy [Health Services and Outcomes]
Conclusion Out-of-pocket costs for Medicare beneficiaries taking orally administered anticancer medications are high and will remain so after the doughnut hole closes. Efforts are needed to improve affordability of high-cost cancer drugs for beneficiaries who need them. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Dusetzina, Keating Tags: Policy Analysis, Cost of Cancer Care Health Services and Outcomes Source Type: research

Analysis of Impact of Post-Treatment Biopsies in Phase I Clinical Trials [Phase I and Clinical Pharmacology]
Conclusion Despite their increased use, the impact of biopsy-derived pharmacodynamic biomarkers in phase I oncology studies on subsequent drug development remains uncertain. No impact on subsequent dose or schedule was demonstrated. This issue requires further evaluation, given the risk and cost of such studies. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Sweis, Drazer, Ratain Tags: Clinical Trials, Phase I and Clinical Pharmacology, Cancer Biomarkers, Phase I and Clinical Pharmacology Source Type: research

Racial and Ethnic Variations in Lung Cancer Incidence and Mortality: Results From the Womens Health Initiative [Epidemiology]
This study aimed to evaluate racial/ethnic differences in lung cancer incidence and mortality in the Women’s Health Initiative Study, a longitudinal prospective cohort evaluation of postmenopausal women recruited from 40 clinical centers. Methods Lung cancer diagnoses were centrally adjudicated by pathology review. Baseline survey questionnaires collected sociodemographic and health information. Logistic regression models estimated incidence and mortality odds by race/ethnicity adjusted for age, education, calcium/vitamin D, body mass index, smoking (status, age at start, duration, and pack-years), alcohol, family h...
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Patel, Wang, Kapphahn, Desai, Chlebowski, Simon, Bird, Corbie-Smith, Gomez, Adams-Campbell, Cote, Stefanick, Wakelee Tags: Environmental Risks, Behavioral and Lifestyle Risk Factors, Population and observational studies (SEER, WHI observational, etc.), Epidemiology Source Type: research

Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer [Urologic Oncology]
Conclusion The association of SNP rs1077858 with OS may be a result of differential SLCO2B1 expression and the consequent increased uptake of DHEAS and subsequent resistance to ADT, which, in turn, may contribute to decreased OS. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Wang, Harshman, Xie, Nakabayashi, Qu, Pomerantz, Lee, Kantoff Tags: Statistical Genetics Urologic Oncology Source Type: research

Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options--An Analysis From the Global Germ Cell Cancer Group [Urologic Oncology]
Purpose To define characteristics, treatment response, and outcomes of men with brain metastases (BM) from germ cell tumors (GCT). Patients and Methods Data from 523 men with BM from GCT were collected retrospectively from 46 centers in 13 countries by using standardized questionnaires. Clinical features were correlated with overall survival (OS) as the primary end point. Results BM were present at initial diagnosis in 228 men (group A) and at relapse in 295 men (group B). OS at 3 years (3-year OS) was superior in group A versus group B (48% v 27%; P
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Feldman, Lorch, Kramar, Albany, Einhorn, Giannatempo, Necchi, Flechon, Boyle, Chung, Huddart, Bokemeyer, Tryakin, Sava, Winquist, De Giorgi, Aparicio, Sweeney, Cohn Cedermark, Beyer, Powles Tags: Urologic Oncology Source Type: research

Pregnancy and the Risk of Relapse in Patients Diagnosed With Hodgkin Lymphoma [Hematologic Malignancy]
Conclusion We found no evidence that a pregnancy after diagnosis increases the relapse rate among women whose HL is in remission. Survivors of HL need to consider a range of factors when deciding about future reproduction. However, given the results of this study, the risk of pregnancy-associated relapse does not need to be considered. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Weibull, Eloranta, Smedby, Bjorkholm, Kristinsson, Johansson, Dickman, Glimelius Tags: Epidemiology Hematologic Malignancy Source Type: research

Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia: Time to Move Toward a Minimal Residual Disease-Based Definition of Complete Remission? [Hematologic Malignancy]
Conclusion The similarities in outcomes between patients in MRD-positive morphologic remission and those with active disease at the time of HCT support the use of treatment algorithms that use MRD- rather than morphology-based disease assessments. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Araki, Wood, Othus, Radich, Halpern, Zhou, Mielcarek, Estey, Appelbaum, Walter Tags: Leukemia Hematologic Malignancy Source Type: research

Preoperative Breast Magnetic Resonance Imaging and Contralateral Breast Cancer Occurrence Among Older Women With Breast Cancer [Breast Cancer]
We examined whether MRI use decreases the occurrence of CBCs and the detection of stages II to IV disease among women who develop a CBC. Patients and Methods Analyzing the SEER-Medicare database, we assessed overall, synchronous (
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Wang, Long, Killelea, Evans, Roberts, Silber, Gross Tags: Epidemiology, Diagnosis & Staging, MRI Breast Cancer Source Type: research

DBCG-IMN: A Population-Based Cohort Study on the Effect of Internal Mammary Node Irradiation in Early Node-Positive Breast Cancer [Breast Cancer]
Conclusion In this naturally allocated, population-based cohort study, IMNI increased overall survival in patients with early-stage node-positive breast cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Thorsen, Offersen, Dano, Berg, Jensen, Pedersen, Zimmermann, Brodersen, Overgaard, Overgaard Tags: Radiation Breast Cancer Source Type: research

Precise Diagnosis of Intraoperative Frozen Section Is an Effective Method to Guide Resection Strategy for Peripheral Small-Sized Lung Adenocarcinoma [Thoracic Oncology]
This study investigated the accuracy of intraoperative frozen section (FS) diagnosis for predicting the final pathology (FP) of peripheral small-sized lung adenocarcinoma and evaluated its usefulness in sublobar resection. Patients and Methods The records of 803 patients with clinical stage I peripheral lung adenocarcinoma who underwent sublobar resection for FS diagnosis to guide surgical strategy were reviewed. The surgical extension was mainly based on FS. The FS were stratified into atypical adenomatous hyperplasia, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma. The...
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Liu, Wang, Zhang, Li, Cheng, Pan, Xiang, Zhang, Chen, Sun Tags: Diagnosis & Staging, Surgery, Pathology Thoracic Oncology Source Type: research

Decision Making in a Data-Poor Environment: Management of Brain Metastases From Testicular and Extragonadal Germ Cell Tumors [ONCOLOGY GRAND ROUNDS]
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 32-year-old man with a history of a mixed germ cell tumor of the testis presented with acute-onset, right-sid...
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Gilligan Tags: Oncology Grand Rounds Source Type: research

Using Minimal Residual Disease to Improve Treatment Response Definitions and Hematopoietic Cell Transplantation Strategy in Acute Leukemia [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Bassan Tags: Leukemia, Diagnosis & Staging, Combined Therapy EDITORIALS Source Type: research

Radiation of the Internal Mammary Nodes: Is There a Benefit? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Haffty, Whelan, Poortmans Tags: Radiation EDITORIALS Source Type: research

An Additional Step Toward Personalization of Surgical Care for Early-Stage Non-Small-Cell Lung Cancer [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Donington Tags: Diagnosis & Staging, Surgery EDITORIALS Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

Extranodal Marginal Zone Lymphoma Presenting As Miliary Lung Disease [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Abramson, Ferry, Muse, Lanuti Tags: Diagnosis & Staging, CT DIAGNOSIS IN ONCOLOGY Source Type: research

Long-Term Disease Control in a Patient With Recurrent Bone-Only Oligometastatic Nasopharyngeal Carcinoma [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Khot, Love, Garg, Haigentz Tags: Combined Modality DIAGNOSIS IN ONCOLOGY Source Type: research

Complete Response of Metastatic Androgen Receptor-Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 25, 2016 Category: Cancer & Oncology Authors: Arce-Salinas, Riesco-Martinez, Hanna, Bedard, Warner Tags: Hormonal Therapy DIAGNOSIS IN ONCOLOGY Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 13, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

Reply to M.C. Chamberlain [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Taphoorn Tags: CORRESPONDENCE Source Type: research

Similar Trials With Differing Outcomes: Reconciliation in Glioblastoma [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Chamberlain Tags: CORRESPONDENCE Source Type: research

Reply to J. Cabezas et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Hwang, Somerfield, Alston-Johnson, Cryer, Feld, Kramer, Sabichi, Wong, Artz Tags: CORRESPONDENCE Source Type: research

Computerized Physician Order Entry-Based System Improves Hepatitis B Virus Screening in Patients Undergoing Chemotherapy [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Cabezas, Sampedro, Hernandez, Crespo Tags: CORRESPONDENCE Source Type: research

Reply to J.M. Snaman et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Hui, Finlay, Buss, Prommer, Bruera Tags: CORRESPONDENCE Source Type: research

Pediatric Palliative Oncology: A New Training Model for an Emerging Field [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Snaman, Kaye, Levine, Joan Chesney, Clay Jackson, Cunningham, Baker Tags: CORRESPONDENCE Source Type: research

Beautiful Imperfections [ART OF ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Boulay Tags: Emotions of the oncologist, All Art of Oncology Articles Source Type: research

Evaluating Intermittent Androgen-Deprivation Therapy Phase III Clinical Trials: The Devil Is in the Details [SPECIAL ARTICLE]
Conclusion No trial to date has demonstrated survival superiority of IAD compared with CAD. Trials concluding IAD is noninferior to CAD were based on wide NIMs that included clinically important survival differences, not likely to be considered comparable by physicians or patients. Interim analyses relying on short follow-up and including a majority of non–prostate cancer deaths will favor a noninferiority conclusion and should be interpreted cautiously. Adequate follow-up is required to ensure capture of prostate cancer deaths in both superiority and noninferiority trials. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Hussain, Tangen, Higano, Vogelzang, Thompson Tags: SPECIAL ARTICLE Source Type: research

Policy Statement on Site-Neutral Payments in Oncology [ASCO SPECIAL ARTICLE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: American Society of Clinical Oncology Tags: ASCO SPECIAL ARTICLE Source Type: research

Survival and Clinical Outcomes in Surgically Treated Patients With Metastatic Epidural Spinal Cord Compression: Results of the Prospective Multicenter AOSpine Study [Surgical Oncology]
Purpose Although surgery is used increasingly as a strategy to complement treatment with radiation and chemotherapy in patients with metastatic epidural spinal cord compression (MESCC), the impact of surgery on health-related quality of life (HRQoL) is not well established. We aimed to prospectively evaluate survival, neurologic, functional, and HRQoL outcomes in patients with MESCC who underwent surgical management. Patients and Methods One hundred forty-two patients with a single symptomatic MESCC lesion who were treated surgically were enrolled onto a prospective North American multicenter study and were observed at le...
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Fehlings, Nater, Tetreault, Kopjar, Arnold, Dekutoski, Finkelstein, Fisher, France, Gokaslan, Massicotte, Rhines, Rose, Sahgal, Schuster, Vaccaro Tags: Surgery, Surgical Oncology Source Type: research

Financial Hardship Associated With Cancer in the United States: Findings From a Population-Based Sample of Adult Cancer Survivors [Health Services and Outcomes]
We examined factors associated with any material or psychological financial hardship using separate multivariable logistic regression models stratified by age group (18 to 64 and ≥ 65 years). Results Material financial hardship was more common in cancer survivors age 18 to 64 years than in those ≥ 65 years of age (28.4% v 13.8%; P
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Yabroff, Dowling, Guy, Banegas, Davidoff, Han, Virgo, McNeel, Chawla, Blanch-Hartigan, Kent, Li, Rodriguez, de Moor, Zheng, Jemal, Ekwueme Tags: Policy Analysis, Cost of Cancer Care Health Services and Outcomes Source Type: research

Associations of Breast Cancer Risk Prediction Tools With Tumor Characteristics and Metastasis [Breast Cancer]
Conclusion Women at high risk for breast cancer based on genetic and lifestyle factors were significantly more likely to be diagnosed with breast cancers with a favorable prognosis. Better knowledge of subtype-specific risk factors could be vital for the success of prevention programs aimed at lowering mortality. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Holm, Li, Darabi, Eklund, Eriksson, Humphreys, Hall, Czene Tags: Epidemiology, Cancer Etiology, Behavioral and Lifestyle Risk Factors Breast Cancer Source Type: research

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial [Sarcomas]
Purpose Three years of adjuvant imatinib therapy are recommended for patients with GI stromal tumor (GIST) with high-risk features, according to survival findings in the Scandinavian Sarcoma Group XVIII/AIO (Arbeitsgemeinschaft Internistische Onkologie) trial. To investigate whether the survival benefits have persisted, we performed the second planned analysis of the trial. Patients and Methods Eligible patients had macroscopically completely excised, KIT-positive GIST with a high risk of recurrence, as determined by using the modified National Institutes of Health criteria. After surgery, the patients were randomly assig...
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Joensuu, Eriksson, Sundby Hall, Reichardt, Hartmann, Pink, Ramadori, Hohenberger, Al-Batran, Schlemmer, Bauer, Wardelmann, Nilsson, Sihto, Bono, Kallio, Junnila, Alvegard, Reichardt Tags: Chemotherapy Sarcomas Source Type: research

Radiation Dose-Response Relationship for Risk of Coronary Heart Disease in Survivors of Hodgkin Lymphoma [Treatment-Related Complications]
Purpose Cardiovascular diseases are increasingly recognized as late effects of Hodgkin lymphoma (HL) treatment. The purpose of this study was to identify the risk factors for coronary heart disease (CHD) and to quantify the effects of radiation dose to the heart, chemotherapy, and other cardiovascular risk factors. Patients and Methods We conducted a nested case-control study in a cohort of 2,617 5-year HL survivors, treated between 1965 and 1995. Cases were patients diagnosed with CHD as their first cardiovascular event after HL. Detailed treatment information was collected from medical records of 325 cases and 1,204 mat...
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: van Nimwegen, Schaapveld, Cutter, Janus, Krol, Hauptmann, Kooijman, Roesink, van der Maazen, Darby, Aleman, van Leeuwen Tags: Epidemiology, Radiation, Radiation Oncology Treatment-Related Complications Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis [Clinical Trials]
This study determined the feasibility, safety, and cost of DPYD*2A genotype–guided dosing. Patients and Methods Patients intended to be treated with fluoropyrimidine-based chemotherapy were prospectively genotyped for DPYD*2A before start of therapy. Variant allele carriers received an initial dose reduction of ≥ 50% followed by dose titration based on tolerance. Toxicity was the primary end point and was compared with historical controls (ie, DPYD*2A variant allele carriers receiving standard dose described in literature) and with DPYD*2A wild-type patients treated with the standard dose in this study. Secondary...
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Deenen, Meulendijks, Cats, Sechterberger, Severens, Boot, Smits, Rosing, Mandigers, Soesan, Beijnen, Schellens Tags: Chemotherapy, Translational Oncology, Phase I and Clinical Pharmacology, Chemotherapy, Chemotherapy, Translational Oncology, Chemotherapy, Translational Oncology, Chemotherapy, Translational Oncology, Cost Effectiveness, Phase I and Clinical Pharmacology Source Type: research

Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis [Radiation Oncology]
Conclusion Delivery of higher doses of RT improves LC and OS in inoperable IHCC. A BED greater than 80.5 Gy seems to be an ablative dose of RT for large IHCCs, with long-term survival rates that compare favorably with resection. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Tao, Krishnan, Bhosale, Javle, Aloia, Shroff, Kaseb, Bishop, Swanick, Koay, Thames, Hong, Das, Crane Tags: Radiation, Combined Modality, Radiation Oncology Source Type: research

Adjuvant Imatinib for GI Stromal Tumors: When and For How Long? [ONCOLOGY GRAND ROUNDS]
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 45-year-old woman presented with syncope. She was severely anemic, with a hemoglobin level of 6 g/dL, and was...
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Benjamin, Casali Tags: Oncology Grand Rounds Source Type: research

Intermittent Androgen Deprivation in Prostate Cancer: Are We Ready to Quit? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - January 12, 2016 Category: Cancer & Oncology Authors: Park, Eisenberger Tags: EDITORIALS Source Type: research