miR-223 induces retinal ganglion cells apoptosis and inflammation via decreasing HSP-70 in vitro and in vivo
ConclusionsIn summary, miR-223 plays a vital role in RGCs by regulating HSP-70 expression, and the new therapeutic strategy might potentially contribute to benefit glaucoma treatment. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 16, 2020 Category: Neuroscience Source Type: research
Editorial Board
Publication date: January 2020Source: Journal of Chemical Neuroanatomy, Volume 103Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 14, 2020 Category: Neuroscience Source Type: research
Calbindin immunostaining in the CA1 hippocampal pyramidal cell layer of the human and mouse: a comparative study
Publication date: Available online 13 January 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Paula Merino-Serrais, Silvia Tapia-González, Javier DeFelipeAbstractImmunostaining for calbindin (CB) is commonly used to label particular populations of neurons. Recently, it has been shown that the CA1 pyramidal cells in the mouse can be subdivided along the radial axis into superficial and deep pyramidal cells and that this segregation in the radial axis may represent a general principle of structural and functional organization of the hippocampus. One of the most widely used markers of the superficial pyramidal cells i...
Source: Journal of Chemical Neuroanatomy - January 13, 2020 Category: Neuroscience Source Type: research
Impact of cochlear ablation on calretinin and synaptophysin in the gerbil anteroventral cochlear nucleus before the hearing onset
Publication date: Available online 13 January 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Ivonne Bazwinsky-Wutschke, Faramarz DehghaniAbstractMammalian auditory system undergoes many structural and functional modifications during postnatal development, which are dependent on the relationship between auditory nerve fibers and their nuclei. In the present study, the cochlea of Meriones unguiculatus was ablated unilaterally on postnatal day 5 or 9 (P5 or P9), before the onset of hearing. Histochemical analysis of synaptophysin (SYN) and calretinin (CR) in anterior anteroventral cochlear nucleus (AVCN-A) was perform...
Source: Journal of Chemical Neuroanatomy - January 13, 2020 Category: Neuroscience Source Type: research
Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampu
ConclusionsIn this study, a new model of AD was developed which showed the underlying mechanisms of AD and its relations with chronic hypoxia. Hypoxia for 30 days decreased seladin-1, Tuj1 expression, increased the number of dark neurons, and also induced memory impairment. These results indicated that chronic hypoxia mediated the dementia underlying AD and AD-related pathogenesis in rat. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 10, 2020 Category: Neuroscience Source Type: research
The influence of early postnatal chronic mild stress stimulation on the activation of amygdala in adult rat
Publication date: Available online 8 January 2020Source: Journal of Chemical NeuroanatomyAuthor(s): A. Ebertowska, B. Ludkiewicz, N. Melka, I. Klejbor, J. MoryśAbstractAmygdala is a limbic structure involved in the stress response. The immunohistochemical and morphometric methods were used to examine whether the chronic mild psychological stress during the early postnatal period would change activation of amygdaloid nuclei in response to the same stressor in adult. In the study we focused on the role of neurons containing calbindin (CB), calretinin (CR), parvalbumin (PV) and nitric oxide synthase (NOS).The rats were divid...
Source: Journal of Chemical Neuroanatomy - January 9, 2020 Category: Neuroscience Source Type: research
Through neuronal avalanches to consciousness: conjectures and elaborations
Publication date: Available online 30 December 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Elena I. Antonakou, Lazaros C. TriarhouAbstractThe concept of the “conduction avalanche” as a mechanism of signal propagation in the central nervous system was introduced in 1895 by Santiago Ramón y Cajal. Through such a mechanism, stimuli received by sensory receptor cells would be augmented as they reached the cerebral cortex through the corresponding anatomical pathways, leading to conscious perception. Cajal applied the concept to the visual, auditory, olfactory and somatosensory systems, and in 1896 extended it t...
Source: Journal of Chemical Neuroanatomy - January 1, 2020 Category: Neuroscience Source Type: research
Expression of the noradrenaline transporter in the peripheral nervous system
Publication date: Available online 28 December 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Natalie Morellini, Jacqueline K. Phillips, Roshana Vander Wall, Peter D. DrummondAbstractThe noradrenaline transporter (NAT) transfers noradrenaline released into the synaptic cleft back into the presynaptic terminal, thus terminating neurotransmission. Although the distribution of NAT within the central nervous system has been well-characterized, less is known about its distribution elsewhere in the peripheral nervous system and in organs such as the skin. To address this in the present study, NAT expression was investiga...
Source: Journal of Chemical Neuroanatomy - December 29, 2019 Category: Neuroscience Source Type: research
Bexarotene treatment increases dendritic length in the nucleus accumbens without change in the locomotor activity and memory behaviors, in old mice
In conclusion, the administration of bexarotene improves the plasticity of the NAcc of aged mice, and therefore could be a pharmacological alternative to prevent or delay neuroplasticity disruptions in brain aging.Graphical abstract (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - December 28, 2019 Category: Neuroscience Source Type: research
Evidence for Accessory Chemosensory Cells in the adult Human Nasal Cavity
Publication date: Available online 23 December 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Veronika M. Gebhart, Andrea Rodewald, Enrico Wollbaum, Kay Hertel, Thomas Bitter, Gustav F. JirikowskiAbstractThe existence of functionally relevant accessory olfactory organs in humans is still a matter of controversy. A vomeronasal organ (VNO) with sensory and non-sensory epithelia exists only in macrosmatic mammals. A similar structure is regularly observed in humans during fetal development. The postnatal persistence of a VNO like epithelial duct has been described in about 10%. Here we studied tissue samples of nasal ...
Source: Journal of Chemical Neuroanatomy - December 25, 2019 Category: Neuroscience Source Type: research
Food restriction in adolescence increases emotional disorder-like behaviors in adult rats
This study was designed to investigate the neuronal mechanism underlying the influence of early-life food restriction on the central nervous system and subsequent behaviors in adult rats. Several behavioral paradigms were tested in rats, including sucrose negative contrast test, forced swimming test (FST) and elevated plus maze test (EPM). In vivo intracellular electrophysiological recordings were conducted in the lateral nucleus of the amygdala (LAT). Finally, the levels of neuropeptide Y (NPY) were examined using immunohistochemistry. Food restriction during adolescence reduced sucrose preference in adult rats. Adolescen...
Source: Journal of Chemical Neuroanatomy - December 19, 2019 Category: Neuroscience Source Type: research
Neuroprotective effects of human neural stem cells over-expressing choline acetyltransferase in a middle cerebral artery occlusion model
Publication date: January 2020Source: Journal of Chemical Neuroanatomy, Volume 103Author(s): Jihyun Kim, Kyungha Shin, Yeseul Cha, Young-Hwan Ban, Sung Kyeong Park, Heon Sang Jeong, Dongsun Park, Ehn-Kyoung Choi, Yun-Bae KimAbstractStroke is one of the most-devastating brain diseases causing acute death or permanent disability. Although tissue-type plasminogen activator was approved by Food and Drug Administration for early reperfusion of the occluded vessels, oxidative injury may cause extensive brain infarction. Accordingly, there is a need for effective neuroprotection during reperfusion, and stem cell-based therapeutic...
Source: Journal of Chemical Neuroanatomy - December 17, 2019 Category: Neuroscience Source Type: research
Prenatal Exposure to Oxcarbazepine Increases Hippocampal Apoptosis in Rat Offspring
This study assessed apoptosis in the offspring of rats exposed to oxcarbazepine (OXC) from day 7 to 15 of gestation. Three groups of pregnant Wistar rats were used: 1) Control, treated with saline solution; 2) treated with 100 mg/kg OXC; 3) treated with 100 mg/kg of carbamazepine (CBZ, as a positive control for apoptosis); the route of administration was intragastric. Apoptosis was detected at three postnatal ages using the TUNEL technique in the CA1, and CA3 regions of the hippocampus and in the dentate gyrus (DG); neurogenesis was assessed in the DG using an antibody against doublecortin. The litter characteristics w...
Source: Journal of Chemical Neuroanatomy - December 1, 2019 Category: Neuroscience Source Type: research
Olfactory ensheathing cells facilitate neurite sprouting and outgrowth by secreting high levels of hevin
Publication date: Available online 26 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Lite Ge, Yi Zhuo, Pei Wu, Yisong Liu, Linyu Qi, Xiaohua Teng, Da Duan, Ping Chen, Ming LuAbstractTransplantation of olfactory ensheathing cells (OECs) has been shown to enhance synapse formation. However, the mechanisms underlying this effect are not completely understood. We performed profiling of the OEC and astrocyte secretomes via a proteomics approach, in case hevin secreted by astrocytes might be involved in the formation of synapses. Semi-quantitative proteomic analysis revealed that 25 proteins were highly expresse...
Source: Journal of Chemical Neuroanatomy - November 27, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: December 2019Source: Journal of Chemical Neuroanatomy, Volume 102Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - November 21, 2019 Category: Neuroscience Source Type: research
