Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review
Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti ‐inflammatory, and antibacterial properties; due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer and curcumin has protective effects against skin damage cause d by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability; in this regard, th...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yunes Panahi,
Omid Fazlolahzadeh,
Stephen L. Atkin,
Muhammed Majeed,
Alexandra E. Butler,
Thomas P. Johnston,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Cover Image, Volume 234, Number 2, February 2019
Cover: The cover image is based on the Original Research ArticleHippo pathway functions as a downstream effector of AKT signaling to regulate the activation of primordial follicles in mice by Liao ‐Liao Hu et al., DOI:10.1002/jcp.27024. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Meng ‐Hao Pan,
Fei Wang,
Yujie Lu,
Feng Tang,
Xing Duan,
Yu Zhang,
Bo Xiong,
Shao‐Chen Sun Tags: COVER Source Type: research
Table of Contents, Editor's Choice, Highlights
Journal of Cellular Physiology, Volume 234, Issue 2, Page 987-998, February 2019. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Tags: Issue Information Source Type: research
Exercise ameliorates high ‐fat diet‐induced impairment of differentiation of adipose‐derived stem cells into neuron‐like cells in rats
In this study, we determined the impact of either a 9‐week high‐fat diet (60% fat; HFD) or 9‐week exercise training on the differentiation potential of ADSCs into neuron‐like cells in male Wistar rats. Rats were randomly assigned to a normal diet‐fed (ND‐SED) group, HFD‐fed (HFD‐SED) group, or exercise‐trained HFD‐fed gro up (HFD‐EX). After a 9‐week intervention, ADSCs from all groups differentiated into neuron‐like cells. Expression of neuronal marker proteins (nestin, βIII‐tubulin, and microtubule‐associated protein 2 [MAP2]) and the average length of cell neurites were lower in cells from ...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Hisashi Kato,
Hidemasa Minamizato,
Hideki Ohno,
Yoshinobu Ohira,
Tetsuya Izawa Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Carvacrol induces mitochondria ‐mediated apoptosis via disruption of calcium homeostasis in human choriocarcinoma cells
In this study, we demonstrated that carvacrol exertes antiproliferative effects through suppression of phosphoinositide 3 ‐kinase–protein kinase B and mitogen‐activated protein kinase signaling, generating oxidative stress and altering calcium homeostasis mediated by mitochondrial dysfunction in human choriocarcinoma JAR and JEG3 cells. Therefore, carvacrol has a possibility as a novel therapeutic agent or supple ment for the treatment of choriocarcinoma patients. Carvacrol is a monoterpenoid phenol present in the oils of various plants includingOriganum vulgare (oregano) orOriganum majorana (marjoram). For a long ti...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Whasun Lim,
Jiyeon Ham,
Fuller W. Bazer,
Gwonhwa Song Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The predictive value of a preoperative systemic immune ‐inflammation index and prognostic nutritional index in patients with esophageal squamous cell carcinoma
(a) The preoperative high systemic immune‐inflammation index (SII) and low prognostic nutritional index (PNI) are powerful indicators of aggressive biology and poor prognosis for patients with esophageal squamous cell carcinoma (ESCC). (b) Combination of SII and PNI (coSII–PNI) clearly classified ESCC patients into three independent groups before surgery. (c) The coSII–PNI can enhance the accuracy of prognosis. Growing evidence indicates that systemic inflammation response and malnutrition status are correlated with survival in certain types of solid tumors. The aim of this study is to evaluate the association be...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Hongdian Zhang,
Xiaobin Shang,
Peng Ren,
Lei Gong,
Ashique Ahmed,
Zhao Ma,
Rong Ma,
Xianxian Wu,
Xiangming Xiao,
Hongjing Jiang,
Peng Tang,
Zhentao Yu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis ‐like phenotype in temporomandibular joint via activation of β‐catenin and FGF signaling
We have generated Axin1 conditional knockout (KO) mice by targeting aggrecan ‐expressing condylar cartilage cells in the temporomandibular joint (TMJ). The Axin1 conditional KO mice showed TMJ osteoarthritis (OA)‐like phenotype, probably through activation of β‐catenin and fibroblast growth factor (FGF) signaling. Osteoarthritis (OA) in the temporomandibular joint (TMJ) is a degenerative disease in the adult, which is characterized by the pathological degeneration of condylar cartilage. Axin1 plays a critical role in the regulation of cartilage development and homeostasis. To determine the role of Axin1 in TMJ tissu...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yachuan Zhou,
Bing Shu,
Rong Xie,
Jian Huang,
Liwei Zheng,
Xuedong Zhou,
Guozhi Xiao,
Lan Zhao,
Di Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Effects of carnitine palmitoyltransferases on cancer cellular senescence
This study revealed that carnitine palmitoyltransferase 1C (CPT1C) knockdown exhibited the strongest impact on cell growth arrest and senescence, lipid change and accumulation, and mitochondrial dysfunction among all members of the CPT family. In addition, only knocking down CPT1C could downregulate the protein expression of c ‐Myc and cyclin D1 and upregulate the cell cycle inhibitor p27 significantly, which contributes to the potential molecular mechanism of CPT1C knockdown‐induced cellular senescence. The carnitine palmitoyltransferase (CPT) family is essential for fatty acid oxidation. Recently, we found that CPT1C...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Lihuan Guan,
Yixin Chen,
Yongtao Wang,
Huizhen Zhang,
Shicheng Fan,
Yue Gao,
Tingying Jiao,
Kaili Fu,
Jiahong Sun,
Aiming Yu,
Min Huang,
Huichang Bi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Implication of basal lamina dependency in survival of Nrf2 ‐null muscle stem cells via an antioxidative‐independent mechanism
Muscle regeneration ability of Nrf2 ‐null mice is normal. However, in a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in muscle stem cells Nuclear factor erythroid 2 –related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles of Nrf2 for muscle regeneration have been reported. Here, using aged Nrf2‐null and Nrf2–dystrophic double‐null mi...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yusei Takemoto,
Shoya Inaba,
Lidan Zhang,
Kazutake Tsujikawa,
Akiyoshi Uezumi,
So ‐ichiro Fukada Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Inhibition of JNK and p38 MAPK ‐mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin‐induced diabetic cardiomyopathy
This study investigated whether ivabradine exerts a therapeutic effect in DCM. C57BL/6J mice were injected intraperitoneally with streptozotocin (STZ) to induce diabetes; then administered with ivabradine or saline (control). After 12 weeks, the surviving mice were analyzed to determine the cardioprotective effect of ivabradine against DCM. Although treatment with ivabradine did not affect blood glucose levels, it attenuated tumor necrosis factor‐α, interleukin‐1β, and interleukin‐6 messenger RNA (mRNA) expression, inhibi ted c‐Jun N‐terminal kinase (JNK) and p38 mitogen‐activated protein kinase (p38 MAPK) ac...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Guangfeng Zuo,
Xiaomin Ren,
Xuesong Qian,
Peng Ye,
Jie Luo,
Xiaofei Gao,
Junjie Zhang,
Shaoliang Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Identification of key gene modules and pathways of human glioma through coexpression network
In this study, we extracted data sets from GEO (Gene Expression Omnibus) data set by using “glioma” as the keyword. Then, a coexpression module was constructed with the help of WGCNA (Weighted Gene Coexpression Network Analysis) software. Besides, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on the genes in these modules. As a result, the critical modules and target genes were identified. Eight coexpression modules were constructed using the 4,000 genes with a high expression value of the total 141 glioma samples. The result of the analysis of the interaction ...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Tianming Shi,
Jianchun Chen,
Jing Li,
Bing ‐Yin Yang,
Qiao‐Lin Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The effect of high ‐fat diet and inhibition of ceramide production on insulin action in liver
Hepatic insulin resistance induced by high ‐fat diet resulted from an increase in synthesis rate of ceramide and diacylglycerol (DAG). Myriocin treatment improved insulin sensitivity, which was accompanied by a decrease in the synthesis rate and content of ceramide and DAG. Liver, as one of the most important organs involved in lipids and glucose metabolism, is perceived as a key tissue for pharmacotherapy of insulin resistance (IRes) and type 2 diabetes. Ceramides (Cer) are biologically active lipids, which accumulation is associated with the induction of muscle IRes. We sought to determine the role of intrahepatic bioa...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Piotr Zabielski,
Jaros ław Daniluk,
Hady Razak Hady,
Adam R. Markowski,
Monika Imierska,
Jan Górski,
Agnieszka U. Blachnio‐Zabielska Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Protective effects of ex ‐527 on cerebral ischemia–reperfusion injury through necroptosis signaling pathway attenuation
This study provides a new approach to the possible neuroprotective potential of ex‐527 orchestrated by necroptosis pathway inhibition to alleviate ischemia–reperfusion brain injury. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Sara Nikseresht,
Fariba Khodagholi,
Abolhassan Ahmadiani Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma
Our results demonstrated that LCD inhibited the kinase activity of JAK2, soft agar colony formation, and the proliferation of HN22 and HSC4 cells. LCD also induced mitochondrial apoptotic events such as altered mitochondrial membrane potential and reactive oxygen species production and, LCD increased expression of apoptosis ‐associated proteins in oral squamous cell carcinoma cells. These results indicate that the anticancer effect of LCD is due to the direct targeting of JAK2 kinase. Licochalcone (LC) families have been reported to have a wide range of biological function such as antioxidant, antibacterial, antiviral, a...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Ji ‐Hye Seo,
Hyun Woo Choi,
Ha‐Na Oh,
Mee‐Hyun Lee,
Eunae Kim,
Goo Yoon,
Seung‐Sik Cho,
Seon‐Min Park,
Young Sik Cho,
Jung‐Il Chae,
Jung‐Hyun Shim Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells
In conclusion, ECH exerted its antitumor activity via decreasing TREM2 expression and PI3K/AKT signaling. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Ying Ye,
Yanan Song,
Juhua Zhuang,
Guoyu Wang,
Jing Ni,
Wei Xia Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
